Satoshi Abe

Publications (8)9.1 Total impact

• Article: Post-stroke apathy and hypoperfusion in basal ganglia: SPECT study.

  Keiichi Onoda, Yoko Kuroda, Yasushi Yamamoto, Satoshi Abe, Hiroaki Oguro, Atsushi Nagai, Hirokazu Bokura, Shuhei Yamaguchi
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  ABSTRACT: Although apathy has been reported as one of the neuropsychiatric symptoms following stroke, there are few studies on regional cerebral blood flow (rCBF) in stroke patients with apathy. The present study compared rCBF between apathetic and non-apathetic patients after stroke. We recruited 102 patients with cerebral infarction within 1 month after stroke and performed neuropsychiatric assessments that included the apathy scale. rCBF was quantitatively measured using N-isopropyl-p-(123)I-iodoamphetamine single-photon emission computed tomography. Thirty-seven patients (36%) had apathy. The apathetic group showed lower cognitive function and a higher depressive state than the non-apathetic group. rCBF in the basal ganglia was reduced for the apathetic group compared with the non-apathetic group. Furthermore, lesions in the left basal ganglia were associated with hypoperfusion in bilateral basal ganglia and the presence of apathy. These findings demonstrate that apathy is a frequent symptom among stroke patients and that hypoperfusion caused by basal ganglia lesions may contribute to post-stroke apathy.
  Cerebrovascular Diseases 10/2010; 31(1):6-11. · 2.72 Impact Factor
• Article: Feedback-related negativity is correlated with unplanned impulsivity.

  Keiichi Onoda, Satoshi Abe, Shuhei Yamaguchi
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  ABSTRACT: Recent studies of electroencephalogram event-related potentials reported aberrant feedback-related negativity (FRN) in neurological and psychiatric diseases, such as alcoholism and attention-deficit hyperactivity disorder. These diseases are characterized by high impulsivity. We investigated the relationship between FRN and impulsivity in healthy people. We performed correlation analyses between FRN amplitude recorded during a gambling task and Barratt Impulsiveness Scale scores. The analysis showed a significant negative correlation between FRN amplitude and the nonplanning impulsiveness score, which assess lack of past planning or future orientation. This suggests that FRN may be a neurophysiological marker of unplanned impulsiveness.
  Neuroreport 07/2010; 21(10):736-9. · 1.66 Impact Factor
• Article: Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole.

  Naoto Kohno, Satoshi Abe, Genya Toyoda, Hiroaki Oguro, Hirokazu Bokura, Shuhei Yamaguchi
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  ABSTRACT: Dopamine D2/3 receptor agonists have been widely used to treat motor symptoms in Parkinson's disease and are also reported to improve cognitive and emotional disturbances. Here we describe a patient who developed severe apathy after cerebral infarction in the prefrontal cortex. After administration of ropinirole, his verbal output and spontaneity in daily life was improved remarkably. This improvement was associated with increased blood flow in the prefrontal cortex and basal ganglia. We suggest that ropinirole may be a treatment option for deficits in motivated behavior after prefrontal damage.
  Journal of Clinical Neuroscience 04/2010; 17(6):804-6. · 1.25 Impact Factor
• Article: [Efficacy of tissue plasminogen activator in older patients].

  Shingo Mitaki, Satoshi Abe, Akira Shirasawa, Ryukichi Matsui, Genya Toyoda, Hirokazu Bokura, Shuhei Yamaguchi
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  ABSTRACT: To evaluate the efficacy, outcome, and side effects of tissue plasminogen activator for cerebral infarction in patients aged 75 years or older. Subjects consisted of 30 patients who had been treated with tissue plasminogen activator between October, 2005 and March 2009, in Shimane University Hospital. We divided the patients into two groups: those less than 75 years old and those 75 years old and older, and evaluated the pattern of disease, therapeutic efficacy, side effects of bleeding, and factors affecting the modified Rankin Scale on discharge. There was no significant difference between groups in the improvement level of NIH Stroke Scale (p=0.66), but modified Rankin Scale 2 or lower patients on discharge were significantly fewer (p=0.02). Multivariate analysis found that age was a factor in significant outcome deterioration (p=0.04, OR1.2). In the older patient group, there were significantly more unfavorable outcomes with anterior infarction. However, there was no significant difference between groups in outcome in patients with ASPECTS-DWI (Alberta Stroke Programme Early CT Score-Diffusion Weight Imaging) > or =8. There was no difference in the rate of hemorrhagic side effect between the two groups. We can expect effects similar to those in patients younger than 75 years if the ischemic lesions of older patients are narrow when coming to the hospital.
  Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics 01/2010; 47(1):58-62.
• Article: Differentiating Alzheimer's disease from subcortical vascular dementia with the FAB test.

  Hiroaki Oguro, Shuhei Yamaguchi, Satoshi Abe, Yuri Ishida, Hirokazu Bokura, Shotai Kobayashi
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  ABSTRACT: The frontal assessment battery (FAB) test is a composite tool for assessing executive functions related to the frontal lobe. Neuropsychological and blood-flow studies indicate distinct patterns of deterioration of anterior and posterior cortical function in Alzheimer's disease (AD) and subcortical vascular dementia (VD) patients. We predict that the FAB score may be useful for discriminating VD from AD. To evaluate the clinical usefulness of the FAB test for differential diagnosis of AD and VD. We compared FAB scores in 25 patients with AD, 27 patients with VD, and 80 age-matched normal control subjects. The AD group was matched for age, education and MMSE score with the VD group. The subtest scores in FAB were also compared among the three groups. The FAB scores were significantly decreased in both the AD and VD groups compared to the control group, and the reduction were greater in the VD group. Among the FAB subtests, mental flexibility (phonological verbal fluency) was the only subtest that significantly discriminated VD from the other two groups. The FAB test can provide useful information for differentiating AD and VD at the bedside.
  Journal of Neurology 12/2006; 253(11):1490-4. · 3.47 Impact Factor
• Article: [Effect of sarpogrelate in enteral feeding of patients with gastroesophageal reflux (GER)].

  Yukie Satou, Hiroaki Oguro, Yo Murakami, Satoshi Abe, Shuhei Yamaguchi, Shotai Kobayashi
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  ABSTRACT: Enteral feeding of patients who are unable to eat or drink because of neurological disorders finally undergo percutaneous endoscopic gastrostomy (PEG) or nasogastric tube feeding. Their most common serious complication is aspiration pneumonia. Our objectives were to evaluate the effect of sarpogrelate (a 5-HT2A receptor blocker) on gastroesophageal reflux (GER) in these patients. This study was performed in 5 elderly patients, aged 70-87 years with neurological disorders (stroke 4, post herpes encephalitis 1), on PEG or nasogastric feeding for 5 weeks-1 year. A 48-hour esophageal pH study was performed using the Degitrapper pH400 (Medtronic Co.). The pH monitor catheter was passed into the esophagus transnasally and positioned with the pH electrode 5cm above the lower esophageal sphincter. During the first 24 hours drug no drug was given, and during the next 24 hours we gave 100mg sarpogrelate 3 times. We analyzed the frequency of acid reflux (when the pH in the esophagus become less than 4.0 for more than 5 seconds, we defined this is 1 episode of acid reflux), frequency of acid reflux and mean pH values between drug-on and drug-off periods. An upright position was maintained for two hours after each meal. When the results of pH monitoring during two half days (from 7 pm to 7 am: 12 hours) was compared between drug-on term and drug-off term, mean pH value was statistically elevated from 6.0 +/- 0.2 (drug-off) to 6.5 +/- 0.4 (drug-on) (mean +/- SD, p< 0.05). Frequency and the total time of acid reflex showed no difference between the two periods. Treatment with sarpogrelate might be effective in patients with GER by blocking activated serotonin receptor in the gastrointestinal system.
  Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics 08/2006; 43(4):492-7.
• Article: [Acute divergence paralysis in the Miller Fisher syndrome].

  Hiroaki Oguro, Shuhei Yamaguchi, Satoshi Abe, Hirokazu Bokura, Shotai Kobayashi
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  ABSTRACT: We experienced a 53-year-old man diagnosed as Miller Fisher syndrome (MFS) associated with anti-GQ1b and anti-GT1a antibodies. He presented acute divergence paralysis, bulbar palsy, ascending hyperesthesia, areflexia and diminished vibration sense. External ophthalmoplegia and convergence paralysis were not seen, but he noticed double vision when looking at an object from the distance of more than 70 cm away on a day 10 of hospitalization. Hess chart test revealed an esotropic pattern, so the diagnosis of divergence palsy was made. Brain MRI was normal. Neurological deficits were treated with plasma exchange, resulting in favorable outcome. Divergence paralysis could be one of the clinical manifestations for MFS and might be due to nuclear or supranuclear damge of vergence-related neurons.
  Rinsho shinkeigaku = Clinical neurology 08/2005; 45(7):524-6.
• Article: Effect of one-shot intravenous 0.42 mega unit urokinase therapy in patients with acute ischemic stroke.

  Hiroaki Oguro, Shotai Kobayashi, Kazuo Takahashi, Satoshi Abe, Genya Toyoda, Kenichi Iijima, Hirokazu Bokura, Shuhei Yamaguchi
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  ABSTRACT: We evaluated the efficacy of intravenous (IV) urokinase (UK) treatment for acute ischemic stroke patients. We treated 45 patients with 0.42 mega units of IV UK and 201 patients with other conventional agents. Clinical severity and outcome were evaluated using National Institutes of Health Stroke Scale (NIHSS) scores and modified Rankin scale (mRS). We defined clinical improvement as a reduction of NIHSS score of > 4 points between admission and discharge. The rate of improvement, as defined earlier, was significantly higher in the UK group (27/45; 60%) than in the non-UK group (67/201, 33%) (P = .0009; chi(2) test). The rate of mRS 0-2 (good outcome) on discharge in the UK group (28/45; 62%) was slightly (but not significantly) higher than that in the non-UK group (99/201; 49%). Baseline characteristics, including risk factors, did not differ between the 2 groups, except for time to treatment and length of hospitalization. We conclude that treatment of acute ischemic stroke patients with 0.42 mega units of IV UK shows better clinical improvement than conventional therapy.
  Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association 15(1):8-13.