Publications (2)4.12 Total impact
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Article: Red blood cell volume as a predictor of fatal reactions in cattle infected with Theileria parva Katete.
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ABSTRACT: A comparison of mean corpuscular volume (MCV) and packed cell volume (PCV) was made between cattle undergoing lethal and non-lethal reactions following experimental infections with the apicomplexan protozoa, Theileria parva Katete. This work confirmed that anaemia occurs in infected animals. However, the fall in PCV was steeper in lethal reactions compared to non-lethal reactions. Our results show that animals with initially lower MCV values are more prone to fatal reaction, despite having normal PCV profiles. The study also found that small red blood cells are more likely to be infected with T. parva. These findings suggest that animals with a higher proportion of small red blood cells in circulation will be more likely to succumb to T. parva infections. The potential for using MCV as a predictor of the outcome of infection challenge is discussed.The Onderstepoort journal of veterinary research 04/2007; 74(1):37-43. · 0.36 Impact Factor -
Article: Lyophilisation and resuscitation of sporozoites of Theileria parva: preliminary experiments.
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ABSTRACT: Lyophilisation of Theileria parva sporozoite stabilates used for immunisation of cattle against East Coast fever would greatly improve vaccine storage and delivery. We report three attempts to lyophilise and resuscitate the sporozoites of T. parva. Sporozoites survived lyophilisation and were effective for immunisation. Lyophilised stabilate survived for 2 weeks at 5 degrees C and for 12 weeks at -20 degrees C. Although the viability of the stabilates was severely reduced during lyophilisation, this work suggests that this method has potential and should be considered for other Apicomplexan parasites such as Babesia sp. or Plasmodium sp.Vaccine 01/2004; 22(2):213-6. · 3.77 Impact Factor
