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ABSTRACT: The genome of human adenovirus (HAdV) D30 was sequenced in depth. Sequence assembly and analysis revealed two distinct viral sequences, each with an identical hexon gene, the same as previously reported for HAdV-D30. However, one of the two viruses was found to be a recombinant of HAdV-D29. Exclusive reliance on serum neutralization can lead to mischaracterization of adenoviruses and miss co-infections. Whole genome sequencing remains the gold standard for proper classification of HAdVs.
Journal of Virology 01/2012; · 5.08 Impact Factor