Advances in Experimental Medicine and Biology. 01/2011; 704.
ABSTRACT: On the basis of continued interest in plant-derived natural products as anticancer agents, a shorter and more efficient synthesis of climacostol is reported. This compound showed an anticancer activity better than that of the natural product. The improved potency and selectivity can be due to the absence of traces of the undesired E-isomer present in the natural climacostol. Furthermore, the versatile strategy developed for this simple molecule such as climacostol could aid in the synthesis of other more complex natural products
Synthesis 01/2010; 9:1550-1556. · 2.47 Impact Factor
Pediatric Allergy and Immunology. 01/2010;