Shusheng Wang

Publications (2)7.31 Total impact

• Article: Purification, structure and immunobiological activity of a new water-soluble polysaccharide from the mycelium of Polyporus albicans (Imaz.) Teng.

  Yongxu Sun, Shusheng Wang, Tianbao Li, Xia Li, Lili Jiao, Liping Zhang
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  ABSTRACT: A new water-soluble intracellular polysaccharide named as PTP, with a molecular mass of 3.7x10(4) Da, was obtained from the mycelium of Polyporus albicans (Imaz.) Teng. Structure features of the purified polysaccharide were investigated by a combination of chemical and instrumental analysis. The results indicated that PTP consisted of a backbone composed of (1-->3)-linked-beta-d-mannopyranosyl, (1-->3,6)-linked-beta-d-mannopyranosyl and (1-->6)-linked-alpha-d-galactopyranosyl residues in the ratio of 3:1:1, and terminated with a single non-reducing terminal (1-->)-beta-d-mannopyranosyl residues at the C-6 position of (1-->3,6)-linked-beta-d-mannopyranosyl, along the main chain. This is the first report describing the isolation and structure elucidation of a new intracellular polysaccharide produced from the mycelium of P. albicans (Imaz.) Teng. Preliminary tests in vitro showed PTP have potent stimulating effects on murine lymphocyte proliferation induced by concanavalin A or lipopolysaccharide and its branches are extremely important for the expression of the enhancement of the immunological activity.
  Bioresource Technology 04/2008; 99(4):900-4. · 4.98 Impact Factor
• Article: Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.

  Shusheng Wang, Dan Liu, Xu Zhang, Shengyu Li, Yongxu Sun, Jia Li, Yifa Zhou, Liping Zhang
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  ABSTRACT: Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against beta-glucosidase (EC.3.2.1.21).
  Carbohydrate Research 08/2007; 342(9):1254-60. · 2.33 Impact Factor