S S Kang

Gyeongsang National University, Shinshū, Gyeongsangnam-do, South Korea

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Publications (74)133.68 Total impact

  • Y H Kim · S Y Park · J Park · Y S Kim · E M Hwang · G S Roh · H J Kim · S S Kang · G J Cho · W S Choi ·
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    ABSTRACT: The study aimed to evaluate the efficacy of recombinant adenovirus expressing αA-crystallin (Ad-αAc-Gfp) in reducing pericyte loss within retinal vasculature in early diabetes. Diabetes was induced by streptozotocin injection into C57BL/6 mice. Ad-αAc-Gfp was delivered by intravitreous injection to the right eyes of mice 2 weeks before induction of diabetes. Vascular leakage was determined by fluorescent angiography, Evans Blue leakage assay and leucocyte adhesion test. Production of αA-crystallin was analysed by immunoblotting and double immunostaining and pericyte loss was analysed by pericyte count. Vessel leakage and pericyte loss were observed in the streptozotocin-induced diabetic retina. Decreased abundance of αA-crystallin in retinas 2 and 6 months after the induction of diabetes was confirmed by two-dimensional electrophoretic analysis, immunoblotting and RT-PCR. Double immunofluorescence staining for αA-crystallin and NG2 chondroitin sulphate proteoglycan revealed that αA-crystallin was predominantly produced in the retinal pericyte and that the number of αA-crystallin-producing pericytes decreased in the diabetic retina. Retinal infection with Ad-αAc-Gfp led to decreased pericyte loss and vascular leakage compared with control. Intravitreal delivery of Ad-αAc-Gfp protects against vascular leakage in the streptozotocin-induced model of diabetes. This effect is associated with the inhibition of diabetic retinal pericyte loss in early diabetes, suggesting that αA-crystallin has a role in preventing the pathogenesis of early diabetic retinopathy.
    Diabetologia 07/2012; 55(10):2835-44. DOI:10.1007/s00125-012-2625-y · 6.67 Impact Factor
  • K. O. Lee · S. K. Hong · Y. K. Kang · H. J. Yoon · S. S. Kang ·
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    ABSTRACT: A double-quenching (D/Q) process is proposed for heat-treating high carbon-chromium bearing steels to improve the fatigue properties through refinement of the microstructure. The new heat treatment method has two steps: The first step is a nitrocarburizing process that results in high surface hardness and lowers the transformation temperature. The second step is the same as in the conventional quenching process but can be conducted at a considerably lower temperature than in conventional quenching. The microstructure in the material that is caused by the D/Q heat treatment is much finer than in the conventional Q/T (quenching and tempering) process. In order to quantify the performance of the proposed heat-treatment process, various mechanical property tests are carried out. The rolling contact fatigue life of double-quenched bearing steels was eight times higher than in bearing steels that were treated by conventional Q/T.
    International Journal of Automotive Technology 12/2009; 10(6):697-702. DOI:10.1007/s12239-009-0082-5 · 0.97 Impact Factor
  • Source
    M.D. Hur · T.Y. Shim · K.O. Lee · G.B. Yu · S.S. Kang ·
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    ABSTRACT: Dual mass flywheel is the newly developed flywheel system which reduces the noise and vibration and make a better and comfortable ride of cars by adding inertia mass and damping device. However, verification of performance for this system should be carried out since this system is under developing status in our country. Especially, the durability for each part of this system should be guaranteed. Durable properties of driver plate which is the key component of dual mass flywheel were first investigated both in the raw (SCM435 in JIS) and heat-treated material. In addition, fatigue life analysis of driver plate was preformed in the real condition and the results were verified by comparison with the results of rig test.
    01/2009; 22(4).

  • S S Kang · C G Kang · S M Lee ·
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    ABSTRACT: The rheoforming of Al7075 using the electromagnetic stirring (EMS) approach is demonstrated. The mechanical properties, chemical composition, and microstructural observations are performed on the produced samples. The rheo-slurry produced by EMS of a 60A stirring current was forged for 20 s at temperatures of 625 degrees C (solid fraction, f(s) = 35 per cent) and 615 degrees C (f(s) = 50 per cent) under applied pressures of 170, 200, 220, and 250 MPa. The highest tensile strength of 404 MPa was recorded for a sample produced at a temperature of 615 degrees C and a pressure of 220 MPa that underwent a T6 heat treatment. The sample produced at 625 degrees C achieved its highest tensile strength for an applied pressure of 200 MPa and a T6 heat treatment. The improvement in the ductility observed in these samples is a result of the removal of a liquid phase that contains Cu and Si from the boundaries between grains of the pure a phase material. The elongation properties of the sample were investigated and correlated with the observed microstructures.
    Proceedings of the Institution of Mechanical Engineers Part B Journal of Engineering Manufacture 12/2008; 222(12):1661-1671. DOI:10.1243/09544054JEM1144 · 0.95 Impact Factor
  • S S Kang · J S Kim · E B Lee ·
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    ABSTRACT: In addition to three known saponins, araloside A, stipuleanosides R 1 and R 2, two new saponins, named durupcosides A and B, have been isolated from the root bark of Aralia elata as their methylesters. Their structures have been established as 3-O-ß-D-glucopyranosyl (1?2)-[a-L-arabinofuranosyl (1?4)]-ß-D-glucuronopyranosyl oleanolic acid and 3-O-a-L-arabinopyranosyl (1?2)-[ß-D-glucopyranosyl (1?3)]-ß-D-glucuronopyranosyl oleanolic acid, respectively, on the basis of spectroscopic data and chemical reactions.
    Pharmaceutical Biology 09/2008; 34(2):119-123. DOI:10.1076/phbi. · 1.24 Impact Factor
  • JK Kim · NR Yun · SH Kim · DU Lee · YS Kim · SS Kang · SM Lee ·

    Planta Medica 07/2008; 74(09). DOI:10.1055/s-0028-1084051 · 2.15 Impact Factor
  • SK Lee · HY Min · YJ Kang · JY Hong · EJ Park · EK Seo · JW Nam · YS Kim · SS Kang ·

    Planta Medica 07/2008; 74(09). DOI:10.1055/s-0028-1084028 · 2.15 Impact Factor
  • LY Guo · EM Shin · HY Zhou · SS Kang · TM Hung · K Bae · HP Kim · YS Kim ·

    Planta Medica 07/2008; 74(09). DOI:10.1055/s-0028-1084099 · 2.15 Impact Factor
  • EM Shin · HY Zhou · LY Guo · SS Kang · JA Kim · SH Lee · I Merfort · HS Kim · Sanghee Kim · YS Kim ·

    Planta Medica 07/2008; 74(09). DOI:10.1055/s-0028-1084100 · 2.15 Impact Factor
  • H Huang · E J Chang · Y Lee · J S Kim · S S Kang · H H Kim ·
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    ABSTRACT: Paeony root has long been used for its anti-inflammatory effects. In this study, the effects of albiflorin, paeoniflorin, and paeonol, compounds from paeony root, on gene expression profiles were examined in macrophages challenged with the inflammation inducer lipopolysaccharide (LPS). The RAW264.7 macrophages were treated with LPS in the presence or absence of albiflorin, paeoniflorin, or paeonol. Global mRNA expression levels were detected by using an oligonucleotide microarray platform covering the mouse whole genome. Treatment with LPS caused expression level changes in 1,270 genes by 2 folds or more. Paeonol attenuated the induction level of 355 LPS-responsive genes. Classification of the genes targeted by paeonol according to the Panther group analysis revealed 20 biological processes, 24 molecular functions, and 22 signaling pathways. The Panther signaling pathways highly affected by paeonol included the 'inflammation mediated by chemokine and cytokine signaling', 'interleukin signaling', and 'Toll receptor signaling'. Our results demonstrate that paeonol has extensive inhibitory effects on the regulation of inflammation associated gene expression by LPS in macrophages. In addition, the predominant effect of paeonol among the tested compounds suggests that paeonol may be a major ingredient for the anti-inflammatory effect of paeony root.
    Inflammation Research 04/2008; 57(4):189-98. DOI:10.1007/s00011-007-7190-3 · 2.35 Impact Factor
  • Y.H. Kim · M.Y. Choi · Y.S. Kim · J.M. Han · J.H. Lee · C.H. Park · S.S. Kang · W.S. Choi · G.J. Cho ·
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    ABSTRACT: We investigated the relationship between phosphorylation of alphaB-crystallin (αBC) and retinal apoptosis in type 2 diabetes. The retinas of male Otsuka Long–Evans Tokushima fatty (OLETF) rats at 24 and 35 weeks were used as an animal model for type 2 diabetes and sex- and age-matched Long–Evans Tokushima Otsuka (LETO) rats were used as controls. In the retinas of 35-week OLETF rats, the interaction between αBC and protein kinase C delta (PKC δ) among the PKC isozymes, αBC phosphorylation at Ser45 (S45p-αBC), TUNEL-positive apoptotic ganglion cells, several apoptotic signs, and co-localization of S45p-αBC and TUNEL significantly increased as compared with other groups while the αBC–Bax interaction greatly decreased. These changes were abolished by rottlerin treatment, a highly specific PKC δ inhibitor. These results suggest that PKC δ is involved in regulation of anti-apoptotic function of αBC in the retina of type 2 diabetes.
    Neurobiology of Disease 01/2008; 28(3-28):293-303. DOI:10.1016/j.nbd.2007.07.017 · 5.08 Impact Factor
  • J H Kang · K O Lee · S S Kang ·
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    ABSTRACT: This study introduces an advanced tool manufacturing method regarding manufacturing procedures. With conventional methods, wire-cutting and lapping operations of the corner and render regions are performed after shrink fitting to ensure the accuracy of the gear profile. However, lapping is very difficult when the corner and render are located deep inside the die. The new tool manufacturing method suggests that wire cutting and lapping are performed after the first shrink fitting to facilitate the lapping operation and increase the accuracy of the corner radius. After lapping is completed, the second die ring is shrink fitted. The amount of elastic deformation by the second shrink fitting and cold forging can be calculated through finite element analysis. Wire-cutting specifications can be offset as predicted in terms of the amount of elastic deformation. Gear dimension comparison of the analysis and forged parts ensures the validity of the new tool manufacturing method.
    Proceedings of the Institution of Mechanical Engineers Part B Journal of Engineering Manufacture 11/2007; 221(11):1601-1606. DOI:10.1243/09544054JEM656 · 0.95 Impact Factor

  • EJC Supplements 09/2007; 5(4):104-104. DOI:10.1016/S1359-6349(07)70489-5 · 9.39 Impact Factor
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    ABSTRACT: Streptozotocin (STZ) has been commonly used to induce in vivo and in vitro hyperglycemic diabetes and its toxicity leads to inflammation and vascular injury. Triamcinolone acetonide (TA), as an anti-angiogenic/anti-inflammatory drug, is clinically used to improve the visual acuity in neovascular and edematous ocular diseases. The aim of this study was to investigate the effect of TA on early inflammation and vascular leakage in the retina of STZ-induced hyperglycemic rats. Hyperglycemia was induced in 8-week-old male Sprague–Dawley (SD) rats by a single intraperitoneal injection of STZ (65 mg/kg); only rats with blood glucose levels > 13.9 mmol/l 1 day after STZ injection were included in STZ-hyperglycemic group. Sex- and age-matched SD rats injected with buffer were used as the control group. One day before STZ and buffer injection, 2 μl TA (4 mg/ml in saline) and 2 μl saline were intravitreal-injected into the right and the left eyes of rats, respectively. Retinal vascular leakage was measured using the Evans-blue method. Changes in pro-inflammatory target genes, such as tumor necrotic factor (TNF)-α, intracellular adhesion molecule (ICAM)-1, and vascular endothelial growth factor (VEGF) were assessed by immunoblottings, immunostaining, and ELISA analyses. Vascular hyperleakage and up-regulation of most pro-inflammatory genes peaked within a few days after STZ injection and had recovered. However, these changes were blocked by TA pretreatment. Our data suggest that TA controls STZ-induced early vascular leakage and temporary pro-inflammatory signals in the rat retina.
    Life Sciences 09/2007; 81(14-81):1167-1173. DOI:10.1016/j.lfs.2007.08.024 · 2.70 Impact Factor
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    ABSTRACT: We examined the effect of triamcinolone acetonide (TA), a corticosteroid, on the relationship between vascular pathophysiology and vascular endothelial growth factor (VEGF) activation in the retina of a rat model of oxygen-induced retinopathy (OIR). OIR was induced by exposure of hyperoxia (80% oxygen) to Sprague-Dawley (SD) rats from P2 to P14 and then returned to normoxic conditions. TA was intravitreal-injected once into the right eye of OIR rats at P15. Effects of TA on vascular pathophysiology or changes of various genes in response to hypoxia and/or proinflammation under hypoxic retina were assessed by the Evans-blue method, fluorescein isothiocyanate-dextran (FITC-D) infusion, immunoblotting, and ELIZA. TA not only reduced retinal neovascularization and vascular leakage in the OIR-rat retina, but also blocked the induction of hypoxia-response proinflammatory genes before it negatively controlled VEGF activation. These findings suggest a potential that TA suppresses retinal neovascular pathophysiology via proinflammation-mediated activation of VEGF during hypoxia.
    Neurobiology of Disease 07/2007; 26(3):569-76. DOI:10.1016/j.nbd.2007.02.002 · 5.08 Impact Factor
  • T S Kim · S P Joo · J K Lee · S Jung · J H Kim · S H Kim · S S Kang · W Yoon ·
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    ABSTRACT: We present our experience with the neuronavigation system as used for surgery of distal anterior cerebral artery (DACA) aneurysm. Between 2001 and 2004, 12 patients with a DACA aneurysm were consecutively treated with direct clipping assisted by the neuronavigation system. We used the BrainLAB Vector Vision neuronavigation system (BrainLAB, Heimstetten, Germany). Seven out of 12 patients presented with subarachnoid hemorrhage. Aneurysms were located at distal A2 in 10 patients and distal A3 in two patients. The size of the aneurysms ranged from 3-10 mm. There were no procedure-related complications or technical problems during application of the neuronavigation system. The registration accuracy ranged from 0.5-1.5 mm (mean: 0.88 mm). The neuronavigation system provided real-time presentation of the DACA and the aneurysm, and allowed for identification of the DACA aneurysm in all patients. No surgical complications developed, and all 12 patients had a good recovery after direct clipping. Although current neuronavigation systems are not available for all intracranial aneurysms, we believe that the DACA aneurysm is a good candidate for its use. The additional benefits of a small craniotomy and precise intraoperative orientation during surgery result in a minimally invasive aneurysm procedure.
    min - Minimally Invasive Neurosurgery 07/2007; 50(3):140-4. DOI:10.1055/s-2007-985151 · 1.14 Impact Factor
  • K.O. Lee · Y. M. Hur · J.H. Kang · S.S. Kang ·
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    ABSTRACT: Hydraulic cylinders are widely used as actuators for construction machines, airplanes and military machines. In the case of these devices, due to their use under severe environmental conditions, such as excessive water, SiO2 and dust seals which has a high packing ability and long service life have normally been required. These characteristics are largely influenced by the material and geometries of seals, such as the approach angle, the round radius of a lip edge and interference. Recently, many studies have been undertaken regarding material, so that many materials have been developed. But the concrete studies including the relationship between the geometry of seals and sealing ability and the optimal geometry design of seals to obtain superior sealing ability have hardly been performed yet. Therefore, in this study, we predicted the deformation behavior and contact pressure distribution of dust seals with the variation of geometry of a seal lip using finite element analysis. Also, we estimated the effect of each design variable on the sealing effect and presented the engineered value of design variables, not experienced ones.
    Journal of Materials Processing Technology 06/2007; 187:215-219. DOI:10.1016/j.jmatprotec.2006.11.160 · 2.24 Impact Factor
  • J.H. Kang · K.O. Lee · J.S. Je · S.S. Kang ·
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    ABSTRACT: This research introduces an advanced manufacturing method for gear part tools. In the conventional method, wire cutting and lapping of the corner region were performed after shrink fitting to ensure the accuracy of the gear profile. But lapping is difficult when the corner region is located inside of the die. The new tool manufacturing method suggests that wire cutting and lapping are performed after the 1st shrink fitting to facilitate lapping operation and to increase the accuracy of the corner radius. Finite element analysis and forging test are performed. Comparison between analysis and measurement of forged part ensures the validity of suggested tool manufacturing methods.
    Journal of Materials Processing Technology 06/2007; 187:14-18. DOI:10.1016/j.jmatprotec.2006.11.161 · 2.24 Impact Factor
  • J.H. Kang · K.O. Lee · S.S. Kang ·
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    ABSTRACT: Because of the elevated temperatures in the warm or hot forging processes, the temperature of tools plays a major role in their service life. To increase tool life in warm or hot forging processes, forging conditions such as lubricants, cooling methods, tool material, heat treatment of tools and workpiece temperature should be optimized. All of these conditions are closely related to the temperature of active tools, so it is difficult to determine which factors are dominant and which ones require an accurate prediction of temperature changes in order to be changed. In warm or hot forging processes, the amount of heat generation by plastic deformation, heat transfer between workpiece and tools and the coolant cooling rate are essential for predicting the exact temperature of the workpiece and active tools. In this research, to determine the convective heat transfer coefficient with respect to different lubricants, the temperature of surface and lubricant was measured using flowing cooling experiments for the heat treated tools made of H13 steel. The convective heat transfer coefficients were calculated using both the measured temperature and inverse method algorithm. The calculations were performed using MPL code, which was developed for thermo-mechanical plastic deformation analysis. The calculated convective heat transfer coefficient was used in finite element analysis and verified.
    Journal of Materials Processing Technology 04/2007; 184(1):338-344. DOI:10.1016/j.jmatprotec.2006.11.124 · 2.24 Impact Factor

Publication Stats

1k Citations
133.68 Total Impact Points


  • 1999-2012
    • Gyeongsang National University
      • College of Veterinary Medicine
      Shinshū, Gyeongsangnam-do, South Korea
  • 2006-2008
    • Pusan National University
      • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
  • 1994-2008
    • Seoul National University
      • • Department of Dentistry
      • • College of Pharmacy
      • • College of Natural Sciences
      • • Department of Pharmacology
      Sŏul, Seoul, South Korea
    • Yeungnam University
      • College of Pharmacy
      경산시, Gyeongsangbuk-do, South Korea
  • 2007
    • Kwandong University
      Gangneung, Gangwon-do, South Korea
    • Chonnam National University
      • Department of Neurosurgery
      Gwangju, Gwangju, South Korea
  • 2004
    • Sungkyunkwan University
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2002
    • Korea Institute of Nuclear Safety
      Sŏul, Seoul, South Korea
  • 1998-2001
    • Chonnam National University Hospital
      Sŏul, Seoul, South Korea
  • 1995
    • University of Seoul
      Sŏul, Seoul, South Korea