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W Wang,
L H Liu,
G Chen,
M Gao,
J Zhu,
F S Zhou,
H Cheng,
H Y Tang,
B Y Wu,
L D Sun, S Yang,
P G Wang,
X J Zhang
Clinical and Experimental Dermatology 06/2012; · 1.20 Impact Factor
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ABSTRACT: We investigate the corrections of the “littlest” Higgs (LH) model and the SU(3) simple group model to single top production at the CERN Large Hadron Collider (LHC). We find that the new gauge bosons WH
± predicted by the LH model can generate significant contributions to single top production via the s-channel process. The correction terms for the tree-level Wqq’ couplings coming from the SU(3) simple group model can give large contributions to the cross sections of the t-channel single top production process. We expect that the effects of the LH model and the SU(3) simple group model on single top production can be detected at the LHC experiments.
European Physical Journal C 04/2012; 48(1):243-249. · 3.63 Impact Factor
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ABSTRACT: Using femtosecond time- and angle-resolved photoemission spectroscopy, we investigated the nonequilibrium dynamics of the topological insulator Bi2Se3. We studied p-type Bi2Se3, in which the metallic Dirac surface state and bulk conduction bands are unoccupied. Optical excitation leads to a metastable population at the bulk conduction band edge, which feeds a nonequilibrium population of the surface state persisting for >10 ps. This unusually long-lived population of a metallic Dirac surface state with spin texture may present a channel in which to drive transient spin-polarized currents.
Physical Review Letters 03/2012; 108(11):117403. · 7.37 Impact Factor
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R. D. Carlini,
J. M. Finn,
S. Kowalski,
S. A. Page,
D. S. Armstrong,
A. Asaturyan,
T. Averett,
J. Benesch,
J. Birchall,
P. Bosted, [......],
E. Tsentalovich,
W. T. H. van Oers,
W. Vulcan,
P. Wang,
S. Wells,
S. A. Wood, S. Yang,
R. Young,
H. Zhu,
C. Zorn
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ABSTRACT: We propose a new precision measurement of parity-violating electron
scattering on the proton at very low Q^2 and forward angles to challenge
predictions of the Standard Model and search for new physics. A unique
opportunity exists to carry out the first precision measurement of the proton's
weak charge, $Q_W =1 - 4\sin^2\theta_W$. A 2200 hour measurement of the parity
violating asymmetry in elastic ep scattering at Q^2=0.03 (GeV/c)^2 employing
180 $\mu$A of 85% polarized beam on a 35 cm liquid Hydrogen target will
determine the proton's weak charge with approximately 4% combined statistical
and systematic errors. The Standard Model makes a firm prediction of $Q_W$,
based on the running of the weak mixing angle from the Z0 pole down to low
energies, corresponding to a 10 sigma effect in this experiment.
02/2012;
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ABSTRACT: In our previous genome-wide association study (GWAS), we identified an association signal of the single-nucleotide polymorphism (SNP) rs4639966 (p = 1.25 x 10(-16), odds ratio [OR] = 1.29) within 11q23.3. The aim of this study was to investigate its relationship with disease subphenotypes, including renal nephritis, photosensitivity, antinuclear antibody (ANA), age at diagnosis, malar rash, discoid rash, immunological disorder, oral ulcer, hematological disorder, neurological disorder, serositis, arthritis and vasculitis. In this study, we used 4199 cases and 8255 controls from our previous GWAS to explore the association between 11q23.3 with subphenotypes of systemic lupus erythematosus (SLE). Data were analyzed with PLINK 1.07 software. Significant associations were found for the SNP rs4639966 of 11q23.3 with SLE of age at diagnosis <20 years (OR = 1.18, p = 0.0049), malar rash (OR = 1.13, p = 0.01) and vasculitis (OR = 1.17, p = 0.02). The study suggested that 11q23.3 might not only play important roles in the development of SLE, but also contribute to the complex phenotypes of SLE.
Lupus 01/2012; 21(14):1538-42. · 2.34 Impact Factor
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X F Tang,
H Y Tang,
L D Sun,
F L Xiao,
Z Zhang,
Y Li,
X B Zuo,
F S Zhou, K L Yang,
P Fang,
Y H Liu,
W D Du,
S Yang,
M L Duan,
X J Zhang
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ABSTRACT: Allergic rhinitis (AR) is one of the most common diseases caused by the combined effects of intrinsic factors (susceptibility genes and immunological status) and the external environment. Analyses of ascendant family history of atopic disease suggest that AR and atopic dermatitis might share a similar genetic background.
To conduct a case-control study in a Chinese Han population to evaluate the potential influence of single nucleotide polymorphisms (SNPs) at FLG, 5q22.1, 11q13.5, 14q11.2 and 20q13.33 on AR.
Ten SNPs--rs11204971 and rs3126085 at FLG, rs10067777, rs7701890, rs13360927, and rs13361382 at 5q22.1, rs6010620 at 20q13.33, rs7936562 and rs7124842 at 11q13.5, and rs4982958 at 14q11.2 were genotyped in 363 cases and 668 controls using the Sequenom MassArray system. Data were analyzed with PLINK 1.07 software.
The T allele of rs4982958 at 14q11.2 was observed to be significantly associated with AR (P = .002, OR = 0.73, P(Bonferront) = .02). Genotype-based association testing revealed that the recessive model might provide the best fit for rs4982958 (P(Bonferroni) = .01). In subphenotype analyses, the rs4982958 T allele was also significantly associated with persistent AR (P = .01) and more than 2 positive skin prick tests (P = .038).
We identified a novel susceptibility locus 14q11.2 for AR that might bear candidate genes conferring susceptibility to AR and affecting disease phenotypes.
Journal of investigational allergology & clinical immunology: official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 01/2012; 22(1):55-62. · 2.27 Impact Factor
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D-Y Hu,
Y-Q Ren,
K-J Zhu,
Y-M Lv,
H Cheng,
Z Zhang,
Y Li,
S-M He,
J Tang,
J-L Liu,
Y Lin,
Y-Y Sun,
X-B Zuo,
G Chen,
L-D Sun, S Yang,
X-J Zhang
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ABSTRACT: Human leucocyte antigen (HLA)-II alleles have been found to be associated with vitiligo in different populations, and several studies also suggested that HLA class II alleles/haplotypes were associated with a different type vitiligo. Of HLA class II alleles, DRB1*07 has consistently shown a positive association with vitiligo in Chinese Han population.
To further explore the relationship between DRB1*07 and vitiligo and to evaluate the DRB1*07 effect on the clinical features of vitiligo in Chinese Han population.
This study investigated DRB1*07 allele distribution in 1178 unrelated Chinese vitiligo patients and 1743 healthy controls using polymerase chain reaction/sequence specific primer method and observed clinical differences between DRB1*07 positive and DRB1*07 negative patients.
The analysis of the 1178 cases and 1743 controls revealed a highly association between DRB1*07 allele and vitiligo [odds ratio (OR) = 1.97, P = 2.13 × 10(-17) ]. DRB1*07 positive patients had early disease onset (OR = 1.49, P = 0.001), higher frequency of family history (OR = 1.44, P = 0.006) compared with DRB1*07 negative patients.
The DRB1*07 showed significant association with vitiligo in the study population. This study confirmed that DRB1*07 positive patients had some obvious clinical differences from DRB1*07 negative patients in the Chinese Han population.
Journal of the European Academy of Dermatology and Venereology 01/2011; 25(11):1299-303. · 2.98 Impact Factor
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C Zhang,
K J Zhu,
H F Zheng,
Y Cui,
F S Zhou,
Y L Chen,
X F Tang,
M Li,
F Y Zhang,
X Fan,
X B Zuo, S Yang,
L D Sun,
X J Zhang
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ABSTRACT: Accumulating evidence indicates that psoriasis is associated with increased risk of overweight and obesity. However, few studies have investigated this relationship in Chinese Han population.
The aim of this study was to explore the relationship between overweight/obesity and psoriasis and to evaluate the overweight/obesity effect on the clinical features of psoriasis in Chinese Han population.
A hospital-based study was conducted, which involved in 4452 patients and 1166 controls of Chinese Han through epidemiological investigation. Controls used in the study were individuals without psoriasis from health examination centre, and other skin disease patients from outpatient department.
Compared with the control group, a significantly greater prevalence of overweight and obesity was observed in psoriasis patients. The estimated ORs were 1.301 (95% CI, 1.105-1.531) and 1.680 (95% CI, 1.134-2.491) respectively. The disease severity of psoriasis measured by psoriasis area and severity index (PASI) was statistically correlated with body mass index (BMI) (r = 0.184, P < 0.01). Moreover, a high proportion of overweight patients had affected hands or/and feet, buttocks, trunk, legs, arms and arthritis (P < 0.01).
Our study suggested that psoriatic patients have a higher prevalence of overweight and obesity compared with non-psoriatic patients in Chinese Han population. Overweight and obesity has different risk effect on severity and manifestations of psoriasis and might be useful for better evaluating psoriasis clinically.
Journal of the European Academy of Dermatology and Venereology 01/2011; 25(1):87-91. · 2.98 Impact Factor
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ABSTRACT: Presented is the notion that the sensitivity of Schottky barrier silicon nanowire field-effect transistors (SB-SiNWFETs) to hydrogen ions is strongly modulated by back-gate voltage. The sensitivity is evaluated by measuring the current variation ratios compared at various back-gate voltages and electrolyte potentials. The characteristics are complemented by monitoring the conductance response to exchange of pH level in the time domain. The response shows that the differential current increases with back-gate voltage, whereas the current variation ratio converges to unity. The conductance response to exchange of pH level reveals that the operation in the subthreshold regime gives rise to 30% enhancement in the sensitivity for the detection of hydrogen ions.
Electronics Letters 11/2010; · 0.96 Impact Factor
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W-S Lu,
W-Y Zhang,
Y Li,
Z-X Wang,
X-B Zuo,
L-Q Cai,
F Zhu,
J-F Wang,
L-D Sun,
X-J Zhang, S Yang
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ABSTRACT: Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There is strong evidence suggesting a genetic susceptibility in individuals affected by keloids including familial heritability, common occurrence in twins, and high prevalence in certain ethnic populations. Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to keloids. HLA class II molecules are critical to the development of CD4(+) T-lymphocyte responses through their role in antigen presentation. No report has been published on HLA-DRB1 association with keloids in Chinese Han individuals. To investigate the etiology of keloids, the polymerase chain reaction sequence-specific primer method was used to analyze the distribution of HLA-DRB1 alleles in 192 patients with keloids and 273 healthy control individuals. Controls were matched by sex, age, and race. The HLA-DRB1*15 allele [19.01% vs 12.09%, odds ratio(OR) = 2.10, Pc = 0.024] was significantly more prevalent among keloid patients than healthy controls, whereas the frequency of the HLA-DRB1*03 allele (1.04% vs 4.95%, OR = 0.19, Pc = 0.022) was lower among keloid patients. Furthermore, through stratified analysis, we found that the HLA-DRB1*15 allele is related to the multiple-site group, severe group, and family history of keloids. This study supports an association between HLA-DRB1 alleles and susceptibility or resistance to keloids in Chinese Han individuals. The association of certain HLA alleles with susceptibility or resistance to keloids provides clues to choosing proper preventive strategies against keloid disease.
Tissue Antigens 10/2010; 76(4):276-81. · 2.59 Impact Factor
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C-F He,
Y-S Liu,
Y-L Cheng,
J-P Gao,
T-M Pan,
J-W Han,
C Quan,
L-D Sun,
H-F Zheng,
X-B Zuo,
S-X Xu,
Y-J Sheng,
S Yao,
W-L Hu,
Y Li,
Z-Y Yu,
X-Y Yin,
X-J Zhang,
Y Cui, S Yang
[show abstract]
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ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical manifestations influenced by genetic and environmental factors. Five novel susceptibility genes (TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1) for SLE have been identified in a recent genome-wide association study of a Chinese Han population. This study investigated their relationships with disease subphenotypes, including renal nephritis, photosensitivity, antinuclear antibody (ANA), age at diagnosis, malar rash, discoid rash, immunological disorder, oral ulcer, hematological disorder, neurological disorder, serositis, arthritis and vasculitis. Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity (odds ratio (OR) = 0.87, p = 0.01) and vasculitis (OR = 1.18, p = 0.04); rs10847697 of SLC15A4 with discoid rash (OR = 1.18, p = 0.02); rs6590330 of ETS1 with SLE of age at diagnosis <20 years (OR = 1.24, p = 8.91 x 10(-5)); rs13385731 of RasGRP3 with malar rash (OR = 1.20, p = 0.01), discoid rash (OR = 0.78, p = 0.02) and ANA (OR = 0.72, p = 0.004); rs4917014 of IKZF1 with renal nephritis (OR = 1.13, p = 0.02) and malar rash (OR = 0.83, p = 0.00038), respectively. The study suggested that these susceptibility genes might not only play important roles in the development of SLE, but also contribute to the complex phenotypes of SLE.
Lupus 09/2010; 19(10):1181-6. · 2.34 Impact Factor
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ABSTRACT: To investigate the capacity for ZD6474, a small molecule tyrosine kinase inhibitor, to enhance anti-tumor and anti-metastasis effects of radiation on human nasopharyngeal carcinoma (NPC).
NPC cell lines and xenograft models were evaluated following treatment with ZD6474 and radiation alone and in combination compared with untreated control mice.
Treatment with ZD6474 enhanced the anti-proliferative effect of radiation on NPC cell lines as detected by cell proliferation and apoptosis assays. ZD6474 also induced a significant increase in the radiosensitivity of NPC cells, with radiation enhancement ratios (RERs) ranging from 1.2 to 1.6. Despite the cytotoxicity exhibited by NPC cells following radiotherapy, the invasion and migration of NPC cells was found to be unaffected. In contrast, treatment with ZD6474 strongly inhibited the invasion and migration of NPC cells. When the administration of radiation and ZD6474 was investigated in vitro, the ability of ZD6474 to inhibit activation of the pro-survival signaling pathways induced by radiation was demonstrated. In vivo, ZD6474 significantly enhanced the anti-metastasis effects of radiation, while treatment with radiation and ZD6474 was found to be well tolerated and resulted in a strong inhibition of tumor growth.
Our results suggest the combination of radiation and ZD6474 represents a promising strategy for the treatment of human NPC.
Current cancer drug targets 09/2010; 10(6):611-22. · 5.13 Impact Factor
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Journal of the European Academy of Dermatology and Venereology 05/2010; 25(1):113-5. · 2.98 Impact Factor
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H Y Tang,
W D Du,
Y Cui,
X Fan,
C Quan,
Q Y Fang,
F S Zhou,
F M Yao,
J F Wang, S Yang,
X Zhang
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ABSTRACT: Epidermolysis bullosa simplex (EBS) is a group of inherited skin diseases, characterized by the formation of intraepidermal blisters. We performed genetic analysis of the keratin 5 (KRT5) gene in two Chinese pedigrees. One novel missense mutation was identified in a patient with sporadic EBS (general, non-Dowling-Meara). Sequence analysis showed a heterozygous T > A transition at nucleotide 1730 of KRT5, changing phenylalanine (Phe) to tyrosine (Tyr) at position 577 of the keratin 5 (K5). In addition, two recurrent mutations c.1649delG (p.Gly550AlafsX77) and c.508G > (p.Glu170Lys) in KRT5 were identified in Chinese patients with mottled pigmentation EBS and localized EBS, respectively. None of the mutations were found in any unaffected family members or in an additional 100 unrelated control samples. These results suggest that these mutations are pathogenic and might be one of the potential causes of EBS in these Chinese patients.
Clinical and Experimental Dermatology 12/2009; 34(8):e957-61. · 1.20 Impact Factor
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Journal of the European Academy of Dermatology and Venereology 07/2009; 23(6):723-4. · 2.98 Impact Factor
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ABSTRACT: Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea in neonatal and postweaning pigs. F41 is one of ETEC fimbriae that adhere to the small intestinal epithelium and lead to development of diarrhoea. The genetic architecture of susceptibility to ETEC F41 remains elusive in pigs. In this study, we determined the in vitro adhesion phenotypes of ETEC F41 in a total of 835 F2 animals from a White Duroc × Erhualian intercross, and performed a genome scan using both F2 and half-sib analyses with 183 microsatellite markers to detect quantitative trait loci (QTL) for porcine susceptibility to ETEC F41. The two analyses consistently revealed a 1% genome-wide significant QTL on pig chromosome 4. Moreover, we determined F41 adhesion phenotypes in 14 purebred Erhualian and 14 White Duroc pigs. The results showed that both the founder breeds are segregating for the F41 adhesion phenotype, while less percentage of Erhualian pigs were adhesive to ETEC F41 compared to White Duroc pigs.
animal 07/2009; 3(7):946-50. · 1.74 Impact Factor
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Y M Lv, S Yang,
Z Zhang,
Y Cui,
C Quan,
F S Zhou,
Q Y Fang,
W H Du,
F R Zhang,
J M Chang,
X P Tao,
A L Zhang,
R H Kang,
W D Du,
X J Zhang
British Journal of Dermatology 04/2009; 160(6):1327-9. · 3.67 Impact Factor
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ABSTRACT: Linkage studies suggest a locus, SLEB2, involved in susceptibility to systemic lupus erythematosus (SLE) and programmed cell death 1 (PDCD1) gene locates in this region. The association of PDCD1 polymorphism (PD1.3A/G) with SLE has been widely investigated, but there are no unambiguous conclusions.
To assess the combined evidence for the association between PD1.3A/G polymorphism and SLE and to summarize the effect size of the polymorphism associated with susceptibility to SLE.
We surveyed studies on the PD1.3A/G polymorphism and SLE using comprehensive PubMed search up to May 2008. The pooled odds ratio (OR) was calculated using a fixed- or a random-effects model. Heterogeneity was identified by sensitivity analysis and publication bias was examined by funnel plot and Egger's test. We also computed the power for a given number of samples.
A total of 20 datasets from eight studies that met our inclusion criteria were included. The studies comprised of a total of 2909 cases and 3995 controls. Stratified meta-analysis demonstrated a significant association between PD1.3A and SLE among non-Spanish European descents [OR, 1.290; 95% confidence interval (95% CI), 1.098-1.516; z = 3.10, P = 0.002], while PD1.3G is the risk allele in Spanish populations (OR = 1.414, 95% CI = 1.075-1.862; z = 2.48, P = 0.013). Both results have sufficient power to support these findings. No publication bias presented in the studies analysed.
This meta-analysis demonstrates a significant association between PD1.3A and SLE among non-Spanish European descents, while a negative association was observed in Spanish population.
Journal of the European Academy of Dermatology and Venereology 03/2009; 23(4):425-32. · 2.98 Impact Factor
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ABSTRACT: A torsional micromechanical scanner was fabricated using photosensitive polymer (SU-8). The scanner consists of two parts; top layer (micro mirror) and bottom layer (an anchor and electrodes). The SU-8 scanner is actuated by electrostatic force generated from the gap-closing electrodes. For the fabricated optical scanner with the mirror area of 3times3 mm<sup>2</sup>, the experimentally determined scanning angles were 0.85deg and 3.1deg for 60 Hz (non-resonant) and 1.13 kHz (resonant) driving frequencies, respectively, at an input voltage of 160 V. A polymer-based actuator offers advantages including a low-cost fabrication process and low frequency operation.
Micro Electro Mechanical Systems, 2009. MEMS 2009. IEEE 22nd International Conference on; 03/2009
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ABSTRACT: Interleukin (IL)-15 is a proinflammatory cytokine and plays a key role in many diseases, including psoriasis. Although its signal transduction pathways in keratinocytes (KC) have been partially elucidated, the effects of IL-15 on expression of IL-15, IL-6 and TNF-alpha in KC are unknown. We have investigated the effects of IL-15 on the expression of the three genes in primary culture of KC by the real-time PCR, Western blot and ELISA. We observed that exogenous IL-15 suppressed the endogenous expression of IL-15, decreased the expression of IL-6 at mRNA and protein levels in KC. The inhibition was blocked by anti-IL-15 monoclonal antibody and by inactive IL-15, I50D mutant IL-15. In contrast, IL-15 increased TNF-alpha transcription in these cells. Mechanistic studies demonstrated that the auto-regulation of IL-15 expression was dependent on activity of ERK1/2 and PI3K. Our studies suggest that there is an auto-inhibitory mechanism controlling cellular IL-15 levels.
Scandinavian Journal of Immunology 11/2008; 68(4):397-404. · 2.23 Impact Factor
