S Sato

National Institute of Radiological Sciences, Tiba, Chiba, Japan

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Publications (1242)3414.9 Total impact

  • Journal of the European Academy of Dermatology and Venereology 11/2015; DOI:10.1111/jdv.13497 · 2.83 Impact Factor

  • Nuclear Instruments and Methods in Physics Research 10/2015; A797:247. DOI:10.1016/j.nima.2015.06.050
  • T. Kurita · K. Morita · S. Sato ·
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    ABSTRACT: Backgroundβ-blockers reduce the tolerance for acute hemodilution by decreasing cerebral oxygenation and may contribute to the incidence of stroke. We hypothesized that β-blockers also increase the risk for cerebral hypoxia when apneic hypoxia occurs.Methods After induction of isoflurane, 14 swine (mean ± SD =25.3 ± 0.8 kg) were studied using 200 μg/kg/min of landiolol or saline (control group) in three sequential stages: before, during, and after landiolol (saline) infusion. In each stage, after 5 min of mechanical ventilation with 100% oxygen, apnea was induced until the time to < 70% oxygen saturation. Hemodynamic and blood gas variables were measured, and the cerebral tissue oxygenation index (TOI) was recorded by near infrared spectroscopy (apnea experiment). After these steps, hemodilution was induced by hemorrhage of 600 ml and infusion of the same volume of hydroxyethylstarch, and the apnea experiments were then conducted before, during, and after landiolol (saline) infusion similarly to before hemodilution.ResultsLandiolol decreased TOI at 1 min after apnea and at SpO2 < 70% by 3.3% and 7.0% from each corresponding value at baseline, and by 13.1% and 20.3% during hemodilution. Landiolol shifted the relationship between TOI and arterial hemoglobin oxygen saturation (SaO2) or arterial partial pressure of oxygen (PaO2) to the left; and reduced TOI at similar arterial blood oxygenation. This phenomenon was marked during hemodilution.Conclusions Landiolol reduces cerebral tissue oxygenation during apneic hypoxia. β-blockers increase the risk for cerebral hypoxia when apneic hypoxia occurs, especially during acute hemodilution.
    Acta Anaesthesiologica Scandinavica 10/2015; DOI:10.1111/aas.12637 · 2.32 Impact Factor
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    ABSTRACT: We present the first measurement of elliptic (v2) and triangular (v3) flow in high-multiplicity He3+Au collisions at sNN=200GeV. Two-particle correlations, where the particles have a large separation in pseudorapidity, are compared in He3+Au and in p+p collisions and indicate that collective effects dominate the second and third Fourier components for the correlations observed in the He3+Au system. The collective behavior is quantified in terms of elliptic v2 and triangular v3 anisotropy coefficients measured with respect to their corresponding event planes. The v2 values are comparable to those previously measured in d+Au collisions at the same nucleon-nucleon center-of-mass energy. Comparisons with various theoretical predictions are made, including to models where the hot spots created by the impact of the three He3 nucleons on the Au nucleus expand hydrodynamically to generate the triangular flow. The agreement of these models with data may indicate the formation of low-viscosity quark-gluon plasma even in these small collision systems.
    Physical Review Letters 09/2015; 115(14). DOI:10.1103/PhysRevLett.115.142301 · 7.51 Impact Factor
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    ABSTRACT: Measurements of anisotropic flow Fourier coefficients ($v_n$) for inclusive charged particles and identified hadrons $\pi^{\pm}$, $K^{\pm}$, $p$, and $\bar{p}$ produced at midrapidity in Cu+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV are presented. The data were collected in 2012 by the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC). The particle azimuthal distributions with respect to different order symmetry planes $\Psi_n$, for $n$~=~1, 2, and 3 are studied as a function of transverse momentum $p_T$ over a broad range of collisions centralities. Mass ordering, as expected from hydrodynamic flow, is observed for all three harmonics. The charged-particle results are compared to hydrodynamical and transport model calculations. We also compare these Cu$+$Au results with those in Cu$+$Cu and Au$+$Au collisions at the same $\sqrt{s_{_{NN}}}$, and find that the $v_2$ and $v_3$, as a function of transverse momentum, follow a common scaling with $1/(\varepsilon_n N_{\rm part}^{1/3})$.
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    ABSTRACT: Background Endothelial protein C receptor (EPCR) predominantly expressed on endothelial cells plays a critical role in the regulation of coagulation system and also mediates various cytoprotective effects by binding and activating protein C. So far, the role of EPCR has not been studied in systemic sclerosis (SSc).Objectives To investigate the potential contribution of EPCR to the development of SSc.MethodsEPCR expression was examined in skin samples and cultivated dermal microvascular endothelial cells by immunostaining, immunoblotting, and/or quantitative reverse transcription PCR. Fli1 binding to the EPCR promoter was assessed by chromatin immunoprecipitation. Serum EPCR levels were determined by enzyme-linked immunosorbent assay in 65 SSc and 20 healthy subjects.ResultsEPCR expression was decreased in dermal small vessels of SSc lesional skin compared with those of healthy control skin. Transcription factor Fli1, whose deficiency is implicated in SSc vasculopathy, occupied the EPCR promoter and EPCR expression was suppressed in Fli1 siRNA-treated endothelial cells and dermal small vessels of Fli1+/- mice. In SSc patients, decreased serum EPCR levels were associated with diffuse skin involvement, interstitial lung disease and digital ulcers. Furthermore, serum EPCR levels inversely correlated with plasma levels of plasmin-α2-plasmin inhibitor complex (PIC). Importantly, bosentan significantly reversed circulating EPCR and PIC levels in SSc patients and the expression of Fli1 and EPCR in dermal small vessels was elevated in patients treated with bosentan compared to untreated patients.Conclusions Endothelial EPCR down-regulation due to Fli1 deficiency may contribute to hyper-coagulation status leading to tissue fibrosis and impaired peripheral circulation in SSc.This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 09/2015; DOI:10.1111/bjd.14183 · 4.28 Impact Factor
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    ABSTRACT: We have studied the dependence of azimuthal anisotropy v2 for inclusive and identified charged hadrons in Au+Au and Cu+Cu collisions on collision energy, species, and centrality. The values of v2 as a function of transverse momentum pT and centrality in Au+Au collisions at sNN=200 and 62.4 GeV are the same within uncertainties. However, in Cu+Cu collisions we observe a decrease in v2 values as the collision energy is reduced from 200 to 62.4 GeV. The decrease is larger in the more peripheral collisions. By examining both Au+Au and Cu+Cu collisions we find that v2 depends both on eccentricity and the number of participants, Npart. We observe that v2 divided by eccentricity () monotonically increases with Npart and scales as Npart1/3. The Cu+Cu data at 62.4 GeV falls below the other scaled v2 data. For identified hadrons, v2 divided by the number of constituent quarks nq is independent of hadron species as a function of transverse kinetic energy KET=mT-m between 0.1<KET/nq<1 GeV. Combining all of the above scaling and normalizations, we observe a near-universal scaling, with the exception of the Cu+Cu data at 62.4 GeV, of v2/(nq··Npart1/3) vs KET/nq for all measured particles.
    Physical Review C 09/2015; 92(3). DOI:10.1103/PhysRevC.92.034913 · 3.73 Impact Factor
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    ABSTRACT: The invariant yields for $J/\psi$ production at forward rapidity $(1.2<|y|<2.2)$ in U$+$U collisions at $\sqrt{s_{_{NN}}}$=193 GeV have been measured as a function of collision centrality. The invariant yields and nuclear-modification factor $R_{AA}$ are presented and compared with those from Au$+$Au collisions in the same rapidity range. Additionally, the direct ratio of the invariant yields from U$+$U and Au$+$Au collisions within the same centrality class is presented, and used to investigate the role of $c\bar{c}$ coalescence. Two different parameterizations of the deformed Woods-Saxon distribution were used in Glauber calculations to determine the values of the number of nucleon-nucleon collisions in each centrality class, $N_{\rm coll}$, and these were found to give significantly different $N_{\rm coll}$ values. Results using $N_{\rm coll}$ values from both deformed Woods-Saxon distributions are presented. The measured ratios show that the $J/\psi$ suppression, relative to binary collision scaling, is similar in U$+$U and Au$+$Au for peripheral and midcentral collisions, but that $J/\psi$ show less suppression for the most central U$+$U collisions. The results are consistent with a picture in which, for central collisions, increase in the $J/\psi$ yield due to $c\bar{c}$ coalescence becomes more important than the decrease in yield due to increased energy density. For midcentral collisions, the conclusions about the balance between $c\bar{c}$ coalescence and suppression depend on which deformed Woods-Saxon distribution is used to determine $N_{\rm coll}$.
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    ABSTRACT: Background: While adjuvant chemotherapy is preferable for high-risk colon cancer, treatment duration is controversial. Oral uracil and tegafur (UFT)/leucovorin (LV) is widely used as a standard adjuvant chemotherapy for colon cancer in Japan. We conducted a phase III trial to investigate the optimal duration of adjuvant chemotherapy for stage IIB/III colon cancer. Methods: Patients (Pts) with curatively resected stage IIB/III colon cancer were eligible for enrollment in this trial. Pts were registered within 6 weeks after surgery and were randomly assigned to receive UFT/LV for 28 of 35 days for 6 months in the control group or for 5 consecutive days per week for 18 months in the study group. The primary endpoint was the disease-free survival (DFS), and the secondary endpoints were overall survival (OS) and safety. Result: A total of 1071 pts were registered from 233 centers. A statistically significant difference in DFS was not observed between the study group and the control group; the 5-year DFS was 69% in the study group and 69% in the control group. The 5-year OS was 85% in the study group and 85% in the control group. Conclusion: Eighteen-month treatment with UFT/LV did not improve DFS or OS compared with 6-month UFT/LV treatment in pts with stage IIB/III colon cancer. The important finding from this study is that not 18 months but 6 months treatment duration is enough for postoperative UFT/LV for Stage IIB/III colon cancer.
    Annals of Oncology 09/2015; DOI:10.1093/annonc/mdv358 · 7.04 Impact Factor
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    ABSTRACT: Invasive tracheal aspergillosis (ITA) is an infection that is unique to patients who have undergone lung transplantation (LT). Although the activity of this disease often appears on imaging, we encountered a case of invasive tracheal aspergillosis (ITA) that became exacerbated, despite few computed tomography (CT) findings, during rituximab combined chemotherapy for diffuse large B-cell lymphoma. ITA developed during immunosuppressive therapy after LT. Because CT findings may show false-negative results, bronchoscopy is recommended for such cases.This article is protected by copyright. All rights reserved.
    Transplant Infectious Disease 09/2015; DOI:10.1111/tid.12458 · 2.06 Impact Factor
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    ABSTRACT: The energy spacing between the ground-state spin doublet of $^4_\Lambda $He(1$^+$,0$^+$) was determined to be $1406 \pm 2 \pm 2$ keV, by measuring $\gamma$ rays for the $1^+ \to 0^+$ transition with a high efficiency germanium detector array in coincidence with the $^4$He$(K^-,\pi^-)$ $^4_\Lambda $He reaction at J-PARC. In comparison to the corresponding energy spacing in the mirror hypernucleus $^4_\Lambda $H, the present result clearly indicates the existence of charge symmetry breaking (CSB) in $\Lambda N$ interaction. It is also found that the CSB effect is large in the $0^+$ ground state but is by one order of magnitude smaller in the $1^+$ excited state, demonstrating that the $\Lambda N$ CSB interaction has spin dependence.
    Physical Review Letters 08/2015; 115(22). DOI:10.1103/PhysRevLett.115.222501 · 7.51 Impact Factor
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    ABSTRACT: The PHENIX experiment has measured $\phi$ meson production in $d$$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV using the dimuon and dielectron decay channels. The $\phi$ meson is measured in the forward (backward) $d$-going (Au-going) direction, $1.2<y<2.2$ ($-2.2<y<-1.2$) in the transverse-momentum ($p_T$) range from 1--7 GeV/$c$, and at midrapidity $|y|<0.35$ in the $p_T$ range below 7 GeV/$c$. The $\phi$ meson invariant yields and nuclear-modification factors as a function of $p_T$, rapidity, and centrality are reported. An enhancement of $\phi$ meson production is observed in the Au-going direction, while suppression is seen in the $d$-going direction, and no modification is observed at midrapidity relative to the yield in $p$$+$$p$ collisions scaled by the number of binary collisions. Similar behavior was previously observed for inclusive charged hadrons and open heavy flavor indicating similar cold-nuclear-matter effects.
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    ABSTRACT: We report the measurement of cumulants ($C_n, n=1\ldots4$) of the net-charge distributions measured within pseudorapidity ($|\eta|<0.35$) in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=7.7-200$ GeV with the PHENIX experiment at the Relativistic Heavy Ion Collider. The ratios of cumulants (e.g. $C_1/C_2$, $C_3/C_1$) of the net-charge distributions, which can be related to volume independent susceptibility ratios, are studied as a function of centrality and energy. These quantities are important to understand the quantum-chromodynamics phase diagram and possible existence of a critical end point. The measured values are very well described by expectation from negative binomial distributions. We do not observe any nonmonotonic behavior in the ratios of the cumulants as a function of collision energy. The measured values of $C_1/C_2 = \mu/\sigma^2$ and $C_3/C_1 = S\sigma^3/\mu$ can be directly compared to lattice quantum-chromodynamics calculations and thus allow extraction of both the chemical freeze-out temperature and the baryon chemical potential at each center-of-mass energy.
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    ABSTRACT: Interleukin (IL)-33 is a recently identified cytokine, which is a member of the IL-1 family and binds to a heterodimeric receptor comprising ST2 (suppression of tumorigenicity 2) and IL-1 receptor accessory protein. Serum levels of IL-33 have been reported to be upregulated in various T helper (Th)1/Th17-mediated diseases, such as rheumatoid arthritis and inflammatory bowel disease. IL-33 expression is increased in lesional skin in patients with psoriasis, but serum levels in patients with psoriasis have not yet been studied. To study serum IL-33 levels in patients with psoriasis, a Th1/Th17-mediated skin disease, before and after anti-tumour necrosis factor (TNF)-α therapy. Serum IL-33 levels were measured in patients with psoriasis vulgaris (PV), psoriatic arthritis (PsA) or pustular psoriasis (PP), and compared with those of healthy controls. Associations between serum IL-33 levels and serum TNF-α, IL-6, vascular endothelial growth factor and C-reactive protein levels were also studied. In addition, the effect of IL-33 stimulation on IL-6, IL-8, TNF-α and VEGF secretion by human keratinocyte was analysed. Serum IL-33 levels in patients with PV, PsA and PP were significantly higher than those in healthy controls. Serum IL-33 levels correlated with serum TNF-α levels in patients with psoriasis, and decreased after anti-TNF-α therapy. IL-33 stimulated IL-6 and IL-8 secretion by human keratinocytes. These results suggest that serum IL-33 levels generally reflect increased inflammation in patients with psoriasis. © 2015 British Association of Dermatologists.
    Clinical and Experimental Dermatology 05/2015; DOI:10.1111/ced.12670 · 1.09 Impact Factor
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    ABSTRACT: We present measurements from the PHENIX experiment of large parity-violating single spin asymmetries of high transverse momentum electrons and positrons from $W^\pm/Z$ decays, produced in longitudinally polarized $p$$+$$p$ collisions at center of mass energies of $\sqrt{s}$=500 and 510~GeV. These asymmetries allow direct access to the anti-quark polarized parton distribution functions due to the parity-violating nature of the $W$-boson coupling to quarks and anti-quarks. The results presented are based on data collected in 2011, 2012, and 2013 with an integrated luminosity of 240 pb$^{-1}$, which exceeds previous PHENIX published results by a factor of more than 27. These high $Q^2$ data provide an important addition to our understanding of anti-quark parton helicity distribution functions.
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    ABSTRACT: We present a systematic study of charged pion and kaon interferometry in Au$+$Au collisions at $\sqrt{s_{_{NN}}}$=200 GeV. The kaon mean source radii are found to be larger than pion radii in the outward and longitudinal directions for the same transverse mass; this difference increases for more central collisions. The azimuthal-angle dependence of the radii was measured with respect to the second-order event plane and similar oscillations of the source radii were found for pions and kaons. Hydrodynamic models qualitatively describe the similar oscillations of the mean source radii for pions and kaons, but they do not fully describe the transverse-mass dependence of the oscillations.
    Physical Review C 04/2015; 92(3). DOI:10.1103/PhysRevC.92.034914 · 3.73 Impact Factor
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    ABSTRACT: The research of 60GHz CMOS transceivers has bloomed due to their capability of achieving low-cost multi-Gb/s short-range wireless communications [1]. Considering practical use of the 60GHz CMOS transceivers, longer operation lifetime with high output power is preferred to provide reliable products. Unfortunately, as indicated in [2], the output power capability of the transmitter will gradually degrade due to the hot-carrier-injection (HCI) effects in the standard CMOS transistors at large-signal operation (e.g. power amplifiers). It is because the inherently large voltage swing at the output of the power amplifiers (PAs) is the main source of the HCI damage. Unfortunately, a thick-oxide transistor, a common solution for reliability issues at lower frequencies, cannot be utilized for 60GHz CMOS PA design due to its limited maximum oscillation frequency (fmax).
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    ABSTRACT: Lipocalin-2 is an adipocytokine implicated in apoptosis, innate immunity, angiogenesis, and the development of chronic kidney disease. To investigate the role of lipocalin-2 in systemic sclerosis (SSc). Serum lipocalin-2 levels were determined by enzyme-linked immunosorbent assay in 50 SSc and 19 healthy subjects. Lipocalin-2 expression was evaluated in the skin of SSc patients and bleomycin-treated mice and in Fli1 deficient endothelial cells by reverse transcript-real time PCR, immunoblotting, and/or immunohistochemistry. Although serum lipocalin-2 levels were comparable between SSc and healthy controls, the prevalence of scleroderma renal crisis was significantly higher in SSc patients with elevated serum lipocalin-2 levels than in those with normal levels. Furthermore, serum lipocalin-2 levels inversely correlated with estimated glomerular filtration rate in SSc patients with renal dysfunction. Among SSc patients with normal renal function, serum lipocalin-2 levels positively correlated with skin score in diffuse cutaneous SSc patients with disease duration of <3 years and inversely correlated with estimated right ventricular systolic pressure in total SSc patients. Importantly, in SSc lesional skin, lipocalin-2 expression was increased in dermal fibroblasts and endothelial cells. In bleomycin-treated mice, lipocalin-2 was highly expressed in dermal fibroblasts, but not in endothelial cells. On the other hand, the deficiency of transcription factor Fli1, which is implicated in SSc vasculopathy, induced lipoclain-2 expression in cultivated endothelial cells. Lipoclain-2 may be involved in renal dysfunction and dermal fibrosis of SSc. Dysregulated MMP-9/lipocalin-2-dependent angiogenesis due to Fli1 deficiency may contribute to the development of pulmonary arterial hypertension associated with SSc. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 03/2015; 173(3). DOI:10.1111/bjd.13779 · 4.28 Impact Factor
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    ABSTRACT: The standard model (SM) of particle physics is spectacularly successful, yet the measured value of the muon anomalous magnetic moment (g - 2)mu deviates from SM calculations by 3.6 sigma. Several theoretical models attribute this to the existence of a "dark photon," an additional U(1) gauge boson, which is weakly coupled to ordinary photons. The PHENIX experiment at the Relativistic Heavy Ion Collider has searched for a dark photon, U, in pi(0), eta -> gamma e(+)e(-) decays and obtained upper limits of O(2 x 10(-6)) on U-gamma mixing at 90% C.L. for the mass range 30 < m(U) < 90 MeV/c(2). Combined with other experimental limits, the remaining region in the U-gamma mixing parameter space that can explain the (g - 2)(mu) deviation from its SM value is nearly completely excluded at the 90% confidence level, with only a small region of 29 < m(U) < 32 MeV/c(2) remaining.
    Physical Review C 03/2015; 91(3). DOI:10.1103/PhysRevC.91.031901 · 3.73 Impact Factor
  • T Miyagaki · M Sugaya · T Oka · H Fujita · S Sato ·
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    ABSTRACT: Vorinostat is the first histone deacetylase inhibitor approved for cutaneous T cell lymphoma (CTCL).(1) Although in vitro effects of this drug on various types of cells have been studied,(2-5) little is known about how this drug has clinical effects on CTCL patients. As many chemokines are reported to reflect disease activity of CTCL, suggesting their important roles in disease progression,(6) we investigated variation of serum chemokine levels during oral vorinostat therapy in a Sézary syndrome (SS) patient. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 02/2015; 173(2). DOI:10.1111/bjd.13696 · 4.28 Impact Factor

Publication Stats

24k Citations
3,414.90 Total Impact Points


  • 2006-2015
    • National Institute of Radiological Sciences
      • Research Center for Charged Particle Therapy
      Tiba, Chiba, Japan
    • University of Wisconsin - Milwaukee
      • Department of Biological Sciences
      Milwaukee, Wisconsin, United States
  • 1992-2015
    • The University of Tokyo
      • • Department of Dermatology and Photolaser Medicine
      • • Department of Surgical Sciences
      • • Institute of Molecular and Cellular Biosciences
      • • Division of Internal Medicine
      Tōkyō, Japan
    • Nitto Denko Corporation
      Ōsaka, Ōsaka, Japan
  • 2013-2014
    • The Graduate University for Advanced Studies
      Миура, Kanagawa, Japan
    • University of Hamamatsu
      Hamamatu, Shizuoka, Japan
  • 2006-2014
    • Japan Atomic Energy Agency
      • • Advanced Science Research Center
      • • Nuclear Science and Engineering Directorate
      Muramatsu, Niigata, Japan
  • 1991-2014
    • Yamagata University
      • • Department of Neurosurgery
      • • School of Medicine
      Ямагата, Yamagata, Japan
  • 2009-2013
    • High Energy Accelerator Research Organization
      Tsukuba, Ibaraki, Japan
  • 2007-2013
    • Kyoto University
      • Department of Nuclear Engineering
      Kioto, Kyōto, Japan
    • Nagaoka University of Technology
      • Department of Chemistry
      Нагаока, Niigata, Japan
    • Charles University in Prague
      Praha, Praha, Czech Republic
  • 2002-2013
    • National Astronomical Observatory of Japan
      Edo, Tōkyō, Japan
    • Academia Sinica
      • Institute of Physics
      Taipei, Taipei, Taiwan
  • 1990-2013
    • Kanagawa Dental University
      • • Department of Orthodontics
      • • Department of Physiology and Neuroscience
      Йокосука, Kanagawa, Japan
  • 2012
    • Tokai University
      • Department of Internal Medicine
      Hiratuka, Kanagawa, Japan
  • 2008-2012
    • National Institutes Of Natural Sciences
      Edo, Tōkyō, Japan
    • Japanese Foundation for Cancer Research
      • Department of Urology
      Edo, Tōkyō, Japan
    • Iwate University
      • Faculty of Engineering
      Morioka-shi, Iwate-ken, Japan
    • Tokyo Medical and Dental University
      • Department of Immune Regulation
      Edo, Tōkyō, Japan
  • 2007-2012
    • Joint Institute for Nuclear Research
      • Bogoliubov Laboratory of Theoretical Physics
      Dubno, Moskovskaya, Russia
  • 1996-2012
    • Nagoya University
      • • Division of Cell Science
      • • Solar-Terrestrial Environment Laboratory
      Nagoya, Aichi, Japan
    • Massachusetts Institute of Technology
      Cambridge, Massachusetts, United States
    • Sasebo City General Hospital
      Nagasaki, Nagasaki, Japan
    • Kanagawa University
      Yokohama, Kanagawa, Japan
  • 1983-2012
    • Tohoku University
      • • Department of Physics
      • • Research Institute of Electrical Communication
      • • Department of Molecular Pathology
      • • Department of Medical Genetics
      Sendai-shi, Miyagi-ken, Japan
  • 1999-2011
    • Hamamatsu University School of Medicine
      • Surgical Operation Center
      Hamamatu, Shizuoka, Japan
    • Chiba University
      Tiba, Chiba, Japan
  • 2010
    • Kochi University of Technology
      • Master in Intelligent Mechanical Systems Engineering
      Kamikawa, Hokkaidō, Japan
    • Tokyo Denki University
      Edo, Tōkyō, Japan
  • 2007-2010
    • University of Colorado at Boulder
      Boulder, Colorado, United States
  • 1991-2010
    • University of Tsukuba
      • • Institute of Community Medicine
      • • Department of Anesthesiology
      Tsukuba, Ibaraki, Japan
  • 1998-2009
    • Keio University
      • • Department of Internal Medicine
      • • School of Medicine
      Edo, Tōkyō, Japan
    • Nagasaki University
      Nagasaki, Nagasaki, Japan
    • The Jikei University School of Medicine
      Edo, Tōkyō, Japan
    • University of Münster
      Muenster, North Rhine-Westphalia, Germany
    • GSI Helmholtzzentrum für Schwerionenforschung
      • ExtreMe Matter Institute EMMI and Research Division
      Darmstadt, Hesse, Germany
    • University of California, San Francisco
      • Department of Medicine
      San Francisco, California, United States
  • 2000-2008
    • Hamamatsu University School Of Medicine
      Hamamatu, Shizuoka, Japan
    • Panjab University
      • Department of Physics
      Chandigarh, Chandīgarh, India
    • International University of Health and Welfare
      Otahara, Tochigi, Japan
    • Philadelphia ZOO
      Philadelphia, Pennsylvania, United States
  • 1999-2008
    • Nippon Medical School
      • Nippon Medical School Hospital
      Edo, Tōkyō, Japan
  • 2004-2007
    • Nagasaki University Hospital
      Nagasaki, Nagasaki, Japan
  • 2000-2007
    • Hiroshima University
      • • Department of Oral and Maxillofacial Pathobiology
      • • Faculty of Dentistry
      Hirosima, Hiroshima, Japan
  • 1999-2007
    • National Defense Medical College
      • • Department of Anesthesiology
      • • Division of Biomedical Information Sciences
      • • Division of Biomedical Engineering
      Tokorozawa, Saitama, Japan
  • 2003-2006
    • Brookhaven National Laboratory
      • Physics Department
      New York City, NY, United States
    • Nagasaki Institute of Applied Science
      Nagasaki, Nagasaki, Japan
  • 1995-2006
    • Kanazawa University
      • • Department of Dermatology
      • • Department of Nuclear Medicine
      Kanazawa, Ishikawa, Japan
    • Japan Tobacco Inc.
      Edo, Tōkyō, Japan
    • National Veterinary Assay Laboratory
      Edo, Tōkyō, Japan
  • 2004-2005
    • Kohnan Hospital
      Sendai, Kagoshima, Japan
  • 2003-2005
    • University of Nantes
      Naoned, Pays de la Loire, France
  • 1999-2004
    • Tokyo Women's Medical University
      • Department of Surgery II
      Edo, Tōkyō, Japan
  • 1999-2003
    • Nagoya City University
      • Graduate School of Natural Sciences
      Nagoya, Aichi, Japan
  • 2001-2002
    • Vanderbilt University
      Nashville, Michigan, United States
    • Mitsui Memorial Hospital
      Edo, Tōkyō, Japan
    • Columbia University
      • Nevis Laboratories
      New York, New York, United States
  • 1998-2001
    • Kanazawa Medical University
      • Department of Dermatology
      Kanazawa, Ishikawa, Japan
  • 1995-2001
    • Osaka Medical Center for Cancer and Cardiovascular Diseases
      Ōsaka, Ōsaka, Japan
  • 1993-2001
    • Kyushu University
      • Faculty of Engineering
      Hukuoka, Fukuoka, Japan
    • Toranomon Hospital
      Edo, Tōkyō, Japan
  • 1998-2000
    • University of Groningen
      Groningen, Groningen, Netherlands
  • 1996-1999
    • Duke University Medical Center
      • Department of Immunology
      Durham, NC, United States
  • 1994-1998
    • Tokyo Junshin Women's College
      • Diabetes Center
      Edo, Tōkyō, Japan
    • Niigata University
      Niahi-niigata, Niigata, Japan
  • 1969-1998
    • Iwate Medical University
      • • Department of Internal Medicine
      • • School of Medicine
      • • Department of Pathology
      Morioka, Iwate, Japan
    • Iwata City Hospital
      Ивата, Shizuoka, Japan
  • 1987-1988
    • National Institute of Animal Health
      Tiba, Chiba, Japan
  • 1966
    • Nara Hospital
      Ikuma, Nara, Japan