Sophie Périé

UPMC, Pittsburgh, Pennsylvania, United States

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Publications (107)148.87 Total impact

  • Medecine Nucleaire 05/2015; 39(3). DOI:10.1016/j.mednuc.2015.03.024 · 0.07 Impact Factor
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    ABSTRACT: Induction TPF regimen is a standard treatment option for squamous cell carcinoma (SCC) of the oropharynx. The efficacy and safety of adding cetuximab to induction TPF (ETPF) therapy was evaluated. Patients with nonmetastatic resectable stage III/IV SCC of the oropharynx were treated with weekly cetuximab followed the same day by docetaxel and cisplatin and by a continuous infusion of 5-fluorouracil on days 1-5 (every 3 weeks, 3 cycles). The primary endpoint was clinical and radiological complete response (crCR) of primary tumor at 3 months. Secondary endpoints were crCR rates, overall response, pathological CR, progression-free survival, overall survival, and safety. Forty-two patients were enrolled, and 41 received ETPF. The all nine planned cetuximab doses and the full three doses of planned chemotherapy were completed in 31 (76%) and 36 (88%) patients, respectively. Twelve (29%) patients required dose reduction. The crCR of primary tumor at the completion of therapy was observed in nine (22%) patients. ETPF was associated with a tumor objective response rate (ORR) of 58%. The most frequent grade 3-4 toxicities were as follows: nonfebrile neutropenia (39%), febrile neutropenia (19%), diarrhea (10%), and stomatitis (12%). Eighteen (44%) patients experienced acne-like skin reactions of any grade. One toxic death occurred secondary to chemotherapy-induced colitis with colonic perforation. This phase II study reports an interesting response rate for ETPF in patients with moderately advanced SCC of the oropharynx. The schedule of ETPF evaluated in this study cannot be recommended at this dosage. © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
    Cancer Medicine 02/2015; 4(5). DOI:10.1002/cam4.408 · 2.50 Impact Factor
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    ABSTRACT: Objectives/Hypothesis: Temporary tracheotomies are commonly performed in head and neck cancer surgery. The aim of this study was to propose a minimum peak inspiratory flow (PIF) as a standardized simple tool for successful decannulation after surgery. Study Design: Prospective review between January 2011 and June 2013 in a university teaching hospital. Methods: Fifty-six patients after head and neck cancer surgery requiring tracheotomies were included. Decannulation failure was defined as the need to recannulate patients within 24 hours. PIF values did not influence the decisions to decannulate or recannulate. Pre- and postdecannulation PIF values, measured with a handheld PIF meter (In-Check Dial), were registered until definitive decannulation. Results: A total of 67 decannulation attempts were performed, with 47 positive and nine negative decannulations at the first attempt. Of the latter, seven were positive at the second attempt and two at the third. All patients were decannulated (mean, 6.3 days). PIF values of 40 L/min appear to be the threshold with the best sensitivity (90%) and specificity (95%) for predicting decannulation success. There was a significant difference (P<.001) between mean PIF in the positive (86 L/min) and negative (20 L/min) decannulation groups and between mean PIF values with (77 L/min) and without cannula (100 L/min). Conclusions: PIF >= 40 L/min with cannula (>60 L/min without) using the In-Check Dial oral method is a threshold associated with decannulation success. PIF is a simple quantitative parameter for evaluating the upper airway, aiding the decision to decannulate safely.
    The Laryngoscope 02/2015; 125(2). DOI:10.1002/lary.24904 · 2.14 Impact Factor
  • Cancer/Radiothérapie 10/2014; 18(5-6):629. DOI:10.1016/j.canrad.2014.07.120 · 1.41 Impact Factor
  • S. Perie · A. Burgess · L. Michaud · J. Talbot
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    ABSTRACT: Context: Preoperative ultrasonography and scintigraphy using (99m)Tc-sestamibi are commonly used to localize abnormal parathyroid glands. In cases of discrepant results between scintigraphy and ultrasonography, it is important to rely on another diagnostic imaging modality. (18)F-fluorodeoxyglucose (FDG) and (11)C-methionine positron emission tomography (PET) have been studied, but are imperfect to detect abnormal parathyroid glands. Recently, first cases of abnormal parathyroid glands taking-up radiolabelled choline were discovered incidentally in men referred to (11)C-choline or (18)F-fluorocholine (FCH)-PET/CT for prostate cancer. We checked if FCH uptake was a general feature of adenomatous or hyperplastic parathyroid glands. Methods: FCH-PET/CT was performed in 12 patients with primary (n = 8) or secondary hyperparathyroidism (1 dialyzed, 3 grafted) and with discordant or equivocal results on preoperative ultrasonography (US) and/or (123)I/(99m)Tc-sestamibi dual-phase scintigraphy. The results of the FCH-PET/CT were evaluated, with surgical exploration and histopathologic examination as the standard of truth. Results: On a per-patient level, the detection rate of FCH-PET/CT (at least one FCH focus corresponding to an abnormal parathyroid gland in a given patient) was 11/12 = 92%. FCH-PET/CT detected 18 foci interpreted as parathyroid glands and correctly localized 17 abnormal parathyroid glands (7 adenomas and 10 hyperplasias). On a per-lesion level, FCH-PET/CT results were 17 TP, 2 false negative ie, a lesion-based sensitivity of 89%, and 1 false positive. Conclusion: As the main result of this pilot study, we show that in patients with hyperparathyroidism and with discordant or equivocal results on scintigraphy or on ultrasonography, adenomatous or hyperplastic parathyroid glands can be localized by FCH-PET/CT with good accuracy. Furthermore, FCH-PET/CT can solve discrepant results between preoperative ultrasonography and scintigraphy and has thus a potential as a functional imaging modality in the detection of abnormal parathyroid glands. Our preliminary results are encouraging and prompt us to further evaluate FCH-PET/CT as a functional imaging agent in patients with biochemical hyperparathyroidism.
    Journal of Clinical Endocrinology &amp Metabolism 09/2014; 99(12):jc20142821. DOI:10.1210/jc.2014-2821 · 6.21 Impact Factor
  • S. Périé · M. Veyrat · J.-P. Haymann · C. Cartery · H. Fessi
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    ABSTRACT: Oral cavity and pharyngeal cancers account for 75% of head and neck cancers and are the fourth most spread cancer in men. Their incidence has decreased since 1980 in men (incidence from 2011 gives 13,930 for lip, oral cavity, pharyngeal and laryngeal carcinomas) but has increased in women, linked to the more recent smoking or alcohol intoxication in women. In addition to the smoking or alcohol consumption risk factors, the EBV role in nasopharyngeal carcinomas, HPV in the oropharyngeal carcinomas and professional exposures in paranasal sinuses cancers are recognized. Head and neck cancers are the fifth most common cancer in men mortality in France. Extended anatomical sites reflect the diagnostic's complexity specific to some locations (sinuses, nasopharynx), possible therapies and prognosis depending on the affected site.
    Bulletin du cancer 05/2014; 101(5):404-410. DOI:10.1684/bdc.2014.1962 · 0.60 Impact Factor
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    ABSTRACT: Oral cavity cancers are frequent: 6,600 cases per year are diagnosed in France. Age of occurrence is around 60. Tobacco is the main risk factor, especially when associated with alcohol. They occur de novo or by evolution of a precancerous lesion. Diagnosis is late in 70% of cases. They must be treated in specialized centers. Pretreatment check-up has to be done according to national guidelines. Treatment often implies primary surgery. Reconstructive surgery progresses allow for wide excisions and still acceptable quality of life. Radiotherapy, eventually potentialized, is usually performed post-operatively. Induction chemotherapy still needs to be evaluated in oral cancers, especially in an organ preservation purpose.
    Bulletin du cancer 05/2014; 101(5):424-428. DOI:10.1684/bdc.2014.1963 · 0.60 Impact Factor
  • Neuromuscular Disorders 03/2014; 24:S1. DOI:10.1016/S0960-8966(14)00057-1 · 2.64 Impact Factor
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    ABSTRACT: Introduction: We undertook a study on a series of laryngeal sarcoidosis (LS), a very rare and often threatening localization to better specify laryngeal manifestations, sarcoidosis clinical expression and long-term follow-up. Methods: This was a retrospective case-control study. All LS patients from two French centers were included and compared to sarcoidosis patients without laryngeal localization with two controls for one patient. Results: Twelve consecutive LS patients were recruited between 1993 and 2011. LS revealed sarcoidosis in eight cases (67%). The most common symptoms were hoarseness (77%), inspiratory dyspnea (38%) and dysphagia (38%). Epidemiological characterisics were not different. Extrapulmonary localizations were significantly more common in LS patients than in controls (92% vs. 54%, p=0.02), particularly lupus pernio (25% vs. 0%, p=0.03) and nasosinusal involvement (83% vs. 4%, p<0.01) while thoracic involvement was less frequent (58% vs 100%, p < 0.01). Treatment rates were higher in the LS group (92% vs. 58%, p=0.04), and treatment duration was longer (median: 81 vs. 13 months, p=0.04), with frequent long-term treatment (67%, N=8/12). Two patients underwent surgery. One patient needed temporary tracheostomy during the course of the disease; Remission rates were lower in LS patients (9% vs. 58% at 2 years p<0.01). Eventually, there was no death nor definitive tracheotomy. Conclusions: LS is a rare condition that is often associated to other loco-regional localizations. LS are often difficult to manage. Survival is good but may require a medico-surgical approach
    Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 01/2014; 31(3):227-34. · 1.17 Impact Factor
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    ABSTRACT: Objectif Évaluer le rôle d’un signe observé en nasofibroscopie, le signe de la marée (SLM), dans le diagnostic et le suivi post-chirurgical dans les diverticules de Zenker. Type d’étude Rétrospective. Patients et méthode Cent quarante-huit patients porteurs de diverticules de Zenker ont été opérés dans notre service. Une étude vidéo-endoscopique de la déglutition était effectuée dans notre service en pré- et en postopératoire et les deux examens étaient comparés en ce qui concerne la présence du SLM. Dans un sous-groupe de 38 patients, la taille du diverticule sur le transit baryté et le délai de survenue du SLM ont été comparés. Résultats Tous les patients présentaient un SLM à l’examen préopératoire. Aucune corrélation n’a été observée entre le délai de survenue du signe et la taille du diverticule. Des données de suivi postopératoire ont pu être obtenues chez 121 patients (suivi moyen : huit mois) : 111 patients ont été significativement améliorés pendant tout le suivi avec une disparition complète du SLM. Une récidive des symptômes a été observée durant la période de suivi chez dix patients ; sept d’entre eux avait une réapparition concomitante du SLM et eurent une chirurgie de reprise. Conclusion Le SLM observé en vidéofibroscopie de la déglutition est un outil supplémentaire pour le diagnostic de diverticule de Zenker et pour l’évaluation de l’efficacité de la chirurgie lors du suivi postopératoire.
    Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-Faciale 12/2013; 130(6):314–317. DOI:10.1016/j.aforl.2013.04.004
  • Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-Faciale 10/2013; 130(4):A4. DOI:10.1016/j.aforl.2013.06.009
  • Neuromuscular Disorders 10/2013; 23(9-10):826. DOI:10.1016/j.nmd.2013.06.649 · 2.64 Impact Factor
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    ABSTRACT: Las alteraciones neurológicas de la faringe pueden ser aisladas o estar integradas en síndromes complejos, lo que convierte su tratamiento en un problema multidisciplinario. A las alteraciones de la deglución suelen asociarse con frecuencia problemas articulatorios por insuficiencia velar y alteraciones respiratorias. El examen otorrinolaringológico es indispensable para orientar el diagnóstico hacia una causa neurológica, periférica, nuclear o supranuclear, o hacia un origen neuromuscular o muscular.
    07/2013; 29(1):1–8. DOI:10.1016/S1632-3475(00)71967-9
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    ABSTRACT: Oculopharyngeal muscular dystrophy (OPMD) is a late onset autosomal dominant genetic disease mainly characterized by ptosis and dysphagia. We conducted a Phase I/IIa clinical study ( NCT00773227) using autologous myoblast transplantation following myotomy in adult OPMD patients. This study included 12 patients with clinical diagnosis of OPMD, indication for cricopharyngeal myotomy, and confirmed genetic diagnosis. The feasibility and safety end points of both autologous myoblast transplantation as well as the surgical procedure were assessed by videoendoscopy in addition to physical examinations. Potential therapeutic benefit was also assessed through videoendoscopy and videofluoroscopy of swallowing, quality of life score, dysphagia grade, and a drink test. Patients were injected with a median of 178 million myoblasts following myotomy. Short and long-term (2 years) safety and tolerability were observed in all patients, with no adverse effects. There was an improvement in the quality of life score for all 12 patients, and no functional degradation in swallowing was observed for 10 patients. A cell dose dependant improvement in swallowing was even observed in this study. This trial supports the hypothesis that a local injection of autologous myoblasts in the pharyngeal muscles is a safe and efficient procedure for OPMD patients.Molecular Therapy (2013); doi:10.1038/mt.2013.155.
    Molecular Therapy 07/2013; 22(1). DOI:10.1038/mt.2013.155 · 6.23 Impact Factor
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    ABSTRACT: Objectif Le but de cette étude était d’évaluer l’intérêt du monitorage des nerfs laryngés inférieurs (NLI) dans la stratégie opératoire des thyroïdectomies et parathyroïdectomies totales. Le risque respiratoire d’une paralysie récurrentielle (PR) bilatérale peut faire discuter une chirurgie en deux temps en cas de non stimulation du premier côté. Patients et méthodes Cette étude prospective a été réalisée chez 100 patients successifs, de mai 2007 à mars 2011. Un monitorage était réalisé par voie translaryngée. Le NLI du premier côté disséqué était stimulé. En cas de stimulation négative, l’abord controlatéral était différé pour éviter le risque de PR bilatérale. Résultats Les indications étaient principalement un carcinome thyroïdien (34 %), une maladie de Basedow (27 %), un goitre multinodulaire (27 %) et une hyperplasie des parathyroïdes (9 %). Il s’agissait d’une reprise chirurgicale chez sept patients. Quatre NLI identifiés du premier côté n’étaient pas stimulables, faisant différer l’abord controlatéral. Une PR unilatérale transitoire était observée chez ces quatre patients et deux PR étaient observées alors que la stimulation était positive. Du second côté, parmi les 96 NLI qui devaient être stimulés, deux n’ont pas été visualisés (une PR transitoire, une PR définitive), deux n’étaient pas stimulables (deux PR définitives) et 92 étaient stimulables (neuf PR transitoires dont deux associées au premier côté paralysé transitoirement, une PR définitive). L’incidence, à l’échelle nerf, des PR transitoires était de 9,6 % et celle des PR définitives (unilatérales) était de 2 %. Conclusion Lorsqu’un abord bilatéral des loges récurrentielles est prévu, le monitorage des NLI présente un intérêt majeur dans le but de limiter le risque de PR bilatérale. Une thyroïdectomie en deux temps, dans l’attente de la récupération fonctionnelle du NLI traumatisé peut ainsi être décidée. Le risque d’une PR bilatérale a été évité chez quatre patients, alors que chez deux patients, une PR bilatérale transitoire a été observée malgré une stimulation positive.
    Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-Faciale 06/2013; 130(3):134–139. DOI:10.1016/j.aforl.2013.01.004
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    ABSTRACT: OBJECTIVE: To evaluate the role of the videoendoscopic "rising tide sign" (RTS) in the diagnosis and assessment of surgical repair of Zenker's diverticulum. Study design: Retrospective. SUBJECTS AND METHODS: A total of 148 patients with Zenker's diverticulum underwent surgery in our department. A videoendoscopic swallowing study (VESS) was performed pre- and postoperatively, and the two examinations compared for the presence of the RTS. VESS characteristics based on the time to RTS onset and the size of diverticulum, as seen on a barium swallow, were also compared in a subset of 38 patients. RESULTS: All patients presented with the RTS on preoperative VESS. No correlation was observed between the time to onset of the sign and size of the diverticulum. Follow-up data were available for 121 patients (mean follow-up: 8months): 111 patients were significantly improved during follow-up, with complete disappearance of the RTS. Recurrence of symptoms was observed at this time in 10 patients. Seven of these 10 patients had concomitant recurrence of the RTS and required repeat surgery after a mean follow-up of 37months. CONCLUSION: The RTS observed by videoendoscopy is a supplementary tool for the diagnosis of Zenker's diverticulum and for evaluation of the efficacy of surgery during the postoperative follow-up.
    European Annals of Otorhinolaryngology, Head and Neck Diseases 05/2013; 130(6). DOI:10.1016/j.anorl.2011.11.005 · 0.82 Impact Factor

Publication Stats

737 Citations
148.87 Total Impact Points


  • 2015
    • UPMC
      Pittsburgh, Pennsylvania, United States
  • 2014
    • Université Paris 13 Nord
      Île-de-France, France
  • 2006–2014
    • Pierre and Marie Curie University - Paris 6
      • • Faculté de médecine Pierre et Marie Curie
      • • Institut de myologie
      Lutetia Parisorum, Île-de-France, France
  • 2013
    • Polytech Paris-UPMC
      Lutetia Parisorum, Île-de-France, France
  • 2006–2013
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2001–2005
    • French National Centre for Scientific Research
      Lutetia Parisorum, Île-de-France, France