Sun Hee Park

Kyungpook National University Hospital, Sŏul, Seoul, South Korea

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Publications (120)234.18 Total impact

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    ABSTRACT: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasingly identified as a cause of acute pyelonephritis (APN) among patients without recent healthcare contact, i.e. community-associated APN. This case-control study compared 75 cases of community-associated ESBL-EC APN (CA-ESBL) to 225 controls of community-associated non-ESBL-EC APN (CA-non-ESBL) to identify risk factors for ESBL-EC acquisition and investigate the impact of ESBL on treatment outcomes of CA-APN caused by E. coli at a Korean hospital during 2007-2013. Baseline characteristics were similar between cases and controls; risk factors for ESBL-EC were age (>55 years), antibiotic use within the previous year, and diabetes with recurrent APN. Illness severity did not differ between CA-ESBL and CA-non-ESBL (mean Acute Physiology and Chronic Health Evaluation II scores 7.7±5.9 vs. 6.4±5.3; P=0.071). Proportions of clinical (odds ratio [OR], 1.76; 95% confidence interval [CI] 0.57-5.38, P=0.323) and microbiological cures (OR 1.16; 95% CI 0.51-2.65; P=0.730) were similar, although CA-ESBL APN patients were less likely to receive appropriate antibiotics within 48 hours. Multivariable Cox proportional hazards analysis of prognostic factors for CA-APN caused by E. coli showed ESBL production was not a significant factor for clinical (hazard ratio [HR] 0.39; 95% CI 0.12-1.30, P=0.126) or microbiological failure (HR 0.49; 95% CI 0.21-1.12, P=0.091). The estimates did not change after incorporating weights calculated using propensity scores for acquiring ESBL-EC. Therefore, ESBL production did not negatively affect treatment outcomes among patients with community-associated E. coli APN. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
    Antimicrobial Agents and Chemotherapy 01/2015; · 4.57 Impact Factor
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    ABSTRACT: Pattern and prognostic impact of “early” acute kidney injury (AKI) after primary percutaneous coronary intervention (PCI) in patients with ST segment elevation myocardial infarction (MI) has not been well established. Between November 2005 and November 2011, 971 post-MI patients who underwent primary PCI were analyzed. Early AKI was defined using absolute change in serum creatinine (SCr; SCr within 24-hour after primary PCI minus admission SCr); no early AKI (SCr change, <0.3mg/dL), mild early AKI (SCr change, 0.3-<0.5 mg/dL), moderate early AKI (SCr change, 0.5-<1.0 mg/dL), and severe early AKI (SCr change, ≥1.0mg/dL). The 1-year major adverse cardiac events (MACEs) were defined as death, non-fatal MI, and revascularizations. Overall, 9.6% had early AKI including 5.7% with mild, 2.5% with moderate, and 1.4% with severe early AKI. Diabetes mellitus (odds ratio [OR] 1.84, p=0.042), left ventricular ejection fraction (OR 0.97, p=0.042), and hemoglobin levels (OR 0.84, p=0.039) were independently associated with early AKI. Early AKI (adjusted hazard ratio 2.80, p=0.005) was an independent predictor of 1-year MACEs. The adjusted HRs of 1-year MACEs from the lowest (reference) to the highest quartile of early AKI were as follows: 1, 2.87 (p=0.012), 3.22 (p=0.021), and 5.83 (p=0.004), respectively. In conclusion, early dynamic change in renal function after primary PCI can sensitively predict worse outcomes.
    European Heart Journal 10/2014; · 14.72 Impact Factor
  • Catalysis Today 09/2014; 232:63–68. · 3.31 Impact Factor
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    ABSTRACT: BackgroundA recent genome-wide association study has identified 5-hydroxytrytamine (serotonin) receptor 7, adenylate cyclase-coupled (HTR7) as a risk gene for alcohol dependence. In addition, the serotonergic system has been considered as a modulator that plays an important role in alcohol use disorders. Functional, pharmacological, and genetic studies of serotonin neurotransmission have revealed that serotonin receptors are potential targets for the treatment of alcohol use disorders. The aim of this study is to investigate whether associations between HTR7 genetic polymorphisms and alcohol dependence could be replicated.Methods This study genotyped a total of 22 common single nucleotide polymorphisms (SNPs) in 459 alcoholic patients and 444 nonalcoholic controls.ResultsLogistic regression analysis of the case–control study, controlling for age and sex as covariates, showed nominal associations of 7 SNPs (p = 0.02 to 0.04; odds ratio = 0.60 to 1.35). In further linear regression analysis based on the Alcohol Use Disorders Identification Test score for alcohol dependence, 8 SNPs and 3 haplotypes showed relatively significant associations with alcohol dependence (minimum p = 0.001; pcorr = 0.02).Conclusions Although further replications and functional evaluations are needed, our findings suggest that genetic variations of HTR7 may contribute to the predisposition for alcohol dependence.
    Alcoholism Clinical and Experimental Research 07/2014; · 3.31 Impact Factor
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    ABSTRACT: Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has become an important cause of community-onset urinary tract infections. We aimed to evaluate the efficacy of non-carbapenem antibiotics for acute pyelonephritis (APN) due to ESBL-producing E. coli.
    Journal of Antimicrobial Chemotherapy 06/2014; · 5.44 Impact Factor
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    ABSTRACT: Objectives: Some patients with suspected ST-segment elevation (STE) myocardial infarction (STEMI) show STE that does not fulfill the current criteria for STEMI. The purpose of this study was to investigate the characteristics and prognoses of patients with minimal STEMI. Methods: Between November 2007 and December 2011, 546 patients who underwent primary percutaneous coronary intervention (PCI) for STEMI were enrolled. Results: The minimal STE group had a higher proportion of women (30.2 vs. 21.0%, p = 0.031), better pre-PCI antegrade flow (Thrombolysis in Myocardial Infarction flow 2-3, 30.2 vs. 18.8%, p = 0.006) and better collateralization (Rentrop score 2-3, 27.4 vs. 18.1%, p = 0.024) compared to the definite STE group. Multivariate analysis showed that each of them were independent predictors for minimal STE. However, 1-year mortality of the minimal STE group did not differ from that of the definite STE group (7.1 vs. 9.3%, log-rank p = 0.315). Conclusions: Female gender, good collateral flow and good pre-PCI antegrade flow were independent predictors for minimal STE in patients with STEMI. However, minimal STE was not related to a good prognosis in patients with STEMI. © 2014 S. Karger AG, Basel.
    Cardiology 05/2014; 128(3):273-281. · 2.04 Impact Factor
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    ABSTRACT: For hypersonic aircraft, increase of flight speeds causes heat loads that are from aerodynamic heat and engine heat. The heat loads could lead structural change of aircraft's component and malfunctioning. Endothermic fuels are liquid hydrocarbon fuels which are able to absorb the heat loads by undergoing endothermic reactions, such as thermal and catalytic cracking. In this study, methylcyclohexane was selected as a model endothermic fuel and experiments on endothermic properties were implemented. To improve heat of endothermic reaction, we applied zeolites and confirmed that HZSM-5 was the best catalyst for the catalytic performance. The objective is to investigate catalytic effects for heat sink improvement. The catalyst could be applied to system that use kerosene fuel as endothermic fuel.
    Journal of the Korean Society of Propulsion Engineers. 04/2014; 18(2).
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    ABSTRACT: Coptidis Rhizoma (CR) is a medical herb from the family Ranunculacease that has been used to treat gastroenteritis, dysentery, diabetes mellitus, and severe skin diseases. To evaluate the no-observed-adverse-effect level (NOAEL) and the toxicity of CR, following repeat oral administration to rats for 13 weeks. CR was administered by oral gavage to groups of rats (n=10/group, each sex) at dose levels of 0 (control), 25, 74, 222, 667 or 2,000mg/kg/day 5 times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, vaginal cytology and sperm morphology, organ weights, gross and histopathological findings were compared between control and CR groups. Urinalysis showed a significant increase in N-acety1-β-glucosaminidase in males in the 2,000mg/kg/day group (P<0.01). However, no mortality or remarkable clinical signs were observed during this 13-week study. No adverse effects on body weight, food consumption, hematology, serum chemistry, organ weights, gross lesion, histopathology, vaginal cytology, sperm motility, or deformity were observed in the males or female rats treated with CR. On the basis of these results, the NOAEL of CR is determined to be 667mg/kg/day for males and 2,000mg/kg/day for females.
    Journal of ethnopharmacology 01/2014; · 2.32 Impact Factor
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    Sun Hee Park
    The Korean Journal of Internal Medicine 01/2014; 29(1):27-30.
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    ABSTRACT: Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used as a dietary supplement. However, information regarding its toxicity is limited. Evodia fruit from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (0, 25, 74, 222, 667, and 2,000mg/kg) was administered orally 5 times per week for 13 weeks. Clinical signs, body weight, food consumption, hematology, serum chemistry, urinalysis, vaginal cytology, sperm morphology, organ weight, and gross and histopathological findings were evaluated. Urinary ketone body excretion was detected in males at 667 and 2,000mg/kg and in females at 2,000mg/kg. An increase in absolute/relative liver weight was observed in both sexes at 2,000mg/kg. Although levels of serum alanine aminotransferase, glucose, total cholesterol, and triglycerides were significantly reduced in males and/or females at 200 and/or 667 and 2,000mg/kg, all values were within normal ranges and were considered non-adverse. In addition, no treatment-related differences in body weight, food consumption, hematology, vaginal cytology, sperm morphology, or gross and histopathological examination were detected. The subchronic no-observable-adverse-effect level for evodia fruit powder following oral administration in rats is greater than 2,000mg/kg.
    Journal of ethnopharmacology 12/2013; · 2.32 Impact Factor
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    ABSTRACT: Genetic polymorphisms of cytochrome P450 enzymes, especially CYP2C19 influence voriconazole pharmacokinetics. However, the impact of CYP2C19 genetic polymorphisms on the therapeutic efficacy and toxicity of voriconazole therapy are not well established. In this prospective observational study, we analyzed all consecutive adult patients with hematologic diseases who were treated for invasive aspergillosis (IA) with voriconazole between January 2011 and June 2012. CYP2C19 genotype and routine therapeutic drug monitoring of voriconazole were performed. The target range for voriconazole trough levels was 1-5.5 mg/L. A total of 104 consecutive patients were enrolled, including 39 homozygous extensive metabolizers (EMs, 38%), 50 heterozygous extensive metabolizers (HEMs, 48%), and 15 poor metabolizers (PMs, 14%). The initial voriconazole trough levels were 1.8, 2.7, and 3.2 mg/L in EMs, HEMs, and PMs, respectively (P = 0.068). Out-of-range initial trough levels were most frequently observed in EMs (46%) followed by HEMs (26%) and PMs (0%) (P = 0.001). The frequency of initial trough levels < 1 mg/L but not > 5.5 mg/L differed significantly among the 3 groups (P = 0.005). However, treatment response, all-cause and IA-attributable mortality, and the occurrence of voriconazole-related adverse events did not differ significantly among the 3 groups (P = 0.399, P = 0.412, P = 0.317, and P = 0.518, respectively). While none of the initial voriconazole trough levels in PMs was outside the target range, subtherapeutic initial trough levels were frequent in EMs. Although there was no significant relationship between CYP2C19 genotype and either the clinical outcomes of IA or toxicity of voriconazole, further large-scale multicenter studies using clinical data from homogeneous populations are required.
    Infection & chemotherapy. 12/2013; 45(4):406-14.
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    ABSTRACT: Vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) is generally associated with the delayed administration of adequate antibiotics. The identification of risk factors and outcomes of VRE BSI is necessary for establishing strategies for managing neutropenic fever in patients with hematological malignancies. We retrospectively analysed consecutive cases of enterococcal BSI in patients with neutropenia after chemotherapy or stem cell transplantation between July 2009 and December 2011 at a single center. During the 30-month period, among 1,587 neutropenic patients, the incidence rate of enterococcal BSI was 1.76 cases per 1,000 person-days. Of the 91 enterococcal BSIs, there were 24 cases of VRE. VRE BSI was associated with E. faecium infection (P < .001), prolonged hospitalization (P = .025) and delayed administration (>=48 hours after the febrile episode) of adequate antibiotics (P = .002). The attributable mortality was 17% and 9% for VRE and vancomycin-susceptible Enterococcus (VSE), respectively (P = .447). The 30-day crude mortality was 27% and 23% for VRE and VSE, respectively (OR 1.38, 95% CI 0.53--3.59; P = .059). Only SAPS-II was an independent predictive factor for death (adjusted OR 1.12, 95% CI 1.08--1.17; P < .001). In conclusion, vancomycin resistance showed some trend towards increasing 30-day mortality, but is not statistically significant despite the delayed use of adequate antibiotics (>=48 hours). Only underlying severity of medical condition predicts poor outcome in a relatively homogeneous group of neutropenic patients.
    BMC Infectious Diseases 10/2013; 13(1):504. · 2.56 Impact Factor
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    ABSTRACT: Electrocardiogram (ECG) and signal-averaged ECG (SAECG) are important as diagnostic tools in arrhythmogenic right ventricular cardiomyopathy (ARVC). The aim of this study was to investigate changes in follow-up ECGs and SAECGs in patients with ARVC. We collected 185 follow-up ECGs from 38 patients and 35 follow-up SAECGs from 18 patients during a mean follow-up period of 64 ± 36 months. On baseline ECG and SAECG, epsilon waves, T-wave inversion (TWI), and terminal activation delay (TAD) of QRS ≥55 ms in right precordial leads, and late potentials (LPs) were observed in six (16%), 11 (29%), 13 (34%), and 23 (68%) patients, respectively. During the follow-up period, 15 (39%) patients had 18 changes in ECG and/or SAECG features included in modified Task Force Criteria (TFC) of ARVC. Two patients developed new epsilon waves, and another two patients had dynamic epsilon waves. Newly developed TAD of QRS ≥55 ms was observed in two patients and disappeared in one patient. Eight patients, seven with and one without TWI in V1 -V3 or beyond, showed dynamic changes. LP developed in three patients. One patient with dynamic change of TWI and another patient with dynamic change of epsilon wave and TAD of QRS ≥55 ms could not satisfy the modified TFC during follow-up. Follow-up ECGs and SAECGs showed changes in 39% of patients with ARVC. Larger studies with a longer follow-up period are needed to investigate the clinical implications of changes in follow-up ECG and SAECG.
    Pacing and Clinical Electrophysiology 10/2013; · 1.75 Impact Factor
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    ABSTRACT: The optimal duration of antibiotic therapy for uncomplicated Gram-negative bacteraemia remains undefined. Our objective was to compare clinical outcomes of receiving short (7-10 days) versus prolonged (>10 days) durations of antibiotic therapy for children with uncomplicated Gram-negative bacteraemia. We conducted a retrospective cohort study of children with uncomplicated Gram-negative bacteraemia at The Johns Hopkins Hospital between 2002 and 2012. We estimated the risk of bacteraemic relapse among children who received short versus prolonged durations of antibiotic therapy using 1 : 1 nearest neighbour propensity score matching without replacement prior to performing regression analysis. There were 170 matched pairs that were well balanced on baseline covariates. The median duration of therapy in the short and prolonged courses was 10 days (IQR 10-10) and 14 days (IQR 14-17), respectively. The 30 day mortality was similar between the groups (OR 1.12; 95% CI 0.96-1.21). A prolonged duration of antibiotic therapy did not reduce the relapse risk compared with shorter durations (adjusted hazard ratio 0.67; 95% CI 0.35-1.27). Similarly, each additional day of antibiotic therapy was not protective against relapse risk (adjusted hazard ratio 0.99 per additional day; 95% CI 0.92-1.03). There was a trend towards an increased subsequent risk of candidaemia in children receiving longer treatment durations (hazard ratio 2.44; 95% CI 0.97-6.19). Antibiotic treatment for more than 10 days for uncomplicated bacteraemia in children does not reduce the risk of microbiological relapse compared with shorter-course therapy, but may be associated with an increased risk of candidaemia. Our findings need to be confirmed in a larger, prospective study.
    Journal of Antimicrobial Chemotherapy 10/2013; · 5.34 Impact Factor
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    ABSTRACT: In this study, a porosity-graded micro porous layer (MPL) was prepared using the double coating method to enhance the water removal ability of the gas diffusion layer (GDL). In the double MPL, the porosity of each layer was controlled using thermal expandable graphite (TEG), which could produce pores in MPL through thermal expansibility. The porosity of the inner layer of the porosity-graded MPL was smaller than the outer layer, so the gradient direction in porosity was from the MPL/catalyst layer interface to the gas diffusion backing layer (GDBL)/MPL interface. In addition, the pore forming ability of TEG and the water removal ability of porosity-graded MPL were characterized. The performance of the porosity-graded MPL was evaluated and compared to the single layer conventional MPL. The porosity-gradient structure in MPL increased the water permeability of GDL and the performance of the single cell in the high current density region. Since the porosity-graded MPL increased the water removal ability of GDL, concentration loss due to water flooding in the high current density region was decreased. These results demonstrate that porosity-graded MPL was beneficial to PEMFC, which has to operate in the high current density region.
    Renewable Energy 10/2013; 58:28-33. · 3.36 Impact Factor
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    ABSTRACT: In this research, the dechlorination of 2-chloro-2-butene in C5 oil from the fluid catalytic cracking (FCC) process was performed through a catalytic reaction. Metal oxides were used as active materials and ZSM-5 was used as the supporting material for the catalysts; the metal was cobalt, iron, or manganese. After the preparation of three types of metal-oxide/ZSM-5 catalysts through the ion-exchange method, the activities and characteristics of each catalyst were evaluated. Through screening tests, the Co3O4/ZSM-5 catalyst was selected as the dechlorination catalyst, and the performance of catalysts containing different amounts of Co3O4 relative to ZSM-5 were tested.
    Journal of Industrial and Engineering Chemistry 09/2013; 19(5):1443-1447. · 2.06 Impact Factor
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    ABSTRACT: Endomyocardial biopsy (EMB) is one of the reliable methods for the diagnosis of various cardiac diseases. However, EMB can cause various complications. The purpose of this study is to evaluate the complication of transfemoral EMB with both fluoroscopic and two-dimensional (2-D) echocardiographic guidance. A total of 228 patients (148 men; 46.0±14.6 yr-old) who underwent EMB at Kyungpook National University Hospital from January 2002 to June 2012 were included. EMB was performed via the right femoral approach with the guidance of both echocardiography and fluoroscopy. Overall, EMB-related complications occurred in 21 patients (9.2%) including one case (0.4%) with cardiac tamponade requiring emergent pericardiocentesis, four cases (1.8%) with small pericardial effusion without pericardiocentesis, two cases (0.9%) with hemodynamically unstable ventricular tachycardia (VT), one case (0.4%) with nonsustained VT, one case (0.4%) with tricuspid regurgitation, twelve cases (5.3%) with right bundle branch block. There was no occurrence of either EMB-related death or cardiac surgery. Left ventricular ejection fraction was significantly lower (32.0±18.7% vs 42.0±19.1%, P=0.023) and left ventricular end-diastolic dimension was larger (60.0±10.0 mm vs 54.2±10.2 mm, P=0.013) in patients with EMB related complications than in those without. It is concluded that transfemoral EMB with fluoroscopic and 2-D echocardiographic guidance is a safe procedure with low complication rate.
    Journal of Korean medical science 09/2013; 28(9):1323-8. · 0.84 Impact Factor
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    ABSTRACT: [This corrects the article on p. 370 in vol. 43, PMID: 23882285.].
    Korean Circulation Journal 08/2013; 43(8):580.
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    ABSTRACT: We investigated the decomposition of exo-tetrahydrodicyclopentadiene (exo-THDCP, C10H16) in the absence and presence of O2 at various temperatures. It was found that conversion of exo-THDCP was faster in the presence of O2 as compared to in its absence. The O2-induced increase in the conversion of exo-THDCP was hardly affected by variations in temperature. In addition, the O2-induced increase in the rate of C10 product formation was higher than those of C10. We proposed the mechanism for the oxidative decomposition of exo-THDCP, which occurs independently of its thermal decomposition and induces distinct product formation near and below its thermal decomposition starting temperature.
    The Journal of Physical Chemistry C 07/2013; 117(31):15933–15939. · 4.84 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the value of a new Revised Cardiac Risk Index (RCRI) that includes consideration of QRS fragmentation (fQRS) as a predictor of cardiac events in patients undergoing noncardiac vascular surgery. Four hundred sixty-seven consecutive patients admitted for noncardiac vascular surgery were studied. Patients were allocated to RCRI 0, 1, 2, or ≥3 groups according to the sum of diabetes, renal insufficiency, and histories of ischemic heart disease, congestive heart failure, and cerebrovascular disease. They were then reallocated to fragmented RCRI (fRCRI) 0, 1, 2, or ≥3 groups after including a score of 1 or 0 corresponding to the presence or absence of fQRS. A major adverse cardiac event (MACE) was defined as a composite of death, myocardial infarction, congestive heart failure, and percutaneous coronary intervention before noncardiac vascular surgery. During index hospitalization, MACE developed in 38 patients (8.1%). fQRS was present in 169 (36.2%), and it was significantly greater in patients with MACE than in those without MACE (63.2% vs 34.3%, p <0.001). The proportions of RCRI 0, 1, 2, and ≥3 were 46.9% (n = 219), 35.3% (n = 165), 12.4% (n = 58), and 5.4% (n = 25), respectively. When fRCRI data were included, 28 patients (48.3%) in RCRI 2 were reclassified as fRCRI ≥3. By multivariate logistic regression analysis, fRCRI (odds ratio 1.529, 95% confidence interval 1.035 to 2.258, p = 0.033) and a left ventricular ejection fraction <50% independently predicted in-hospital MACE. In conclusion, fRCRI is an independent predictor of in-hospital MACE in patients undergoing noncardiac vascular surgery.
    The American journal of cardiology 07/2013; 112(1):122-7. · 3.58 Impact Factor

Publication Stats

671 Citations
234.18 Total Impact Points

Institutions

  • 2009–2014
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
  • 2008–2014
    • Korea University
      • Department of Chemical and Biological Engineering
      Sŏul, Seoul, South Korea
  • 2013
    • West Virginia University
      Morgantown, West Virginia, United States
    • Dong-A University
      • College of Medicine
      Tsau-liang-hai, Busan, South Korea
  • 2012
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • National Health Insurance Corporation Ilsan Hospital
      Sŏul, Seoul, South Korea
    • American Society for Aesthetic Plastic Surgery
      Maryland, United States
  • 2005–2012
    • Catholic University of Korea
      • • Department of Internal Medicine
      • • College of Medicine
      Seoul, Seoul, South Korea
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2011
    • CHA University
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2010–2011
    • Seoul National University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
  • 2005–2011
    • Pusan National University
      • • College of Pharmacy
      • • Department of Molecular Biology
      Pusan, Busan, South Korea
  • 2007
    • Gyeongsang National University
      • Division of Applied Life Science
      Shinshū, South Gyeongsang, South Korea
  • 2006
    • Duksung Women's University
      • College of Pharmacy
      Sŏul, Seoul, South Korea