S Haas

Universität Regensburg, Regensburg, Bavaria, Germany

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Publications (4)8.38 Total impact

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    ABSTRACT: In vitro and in vivo data indicate that stem cells found in the bone marrow (BM) are capable of differentiating into neural cells. The aim of this study was to investigate whether potentially pluripotent hematopoietic stem and progenitor cells are recruited from the BM into the peripheral blood as a reaction to ischemic damage of neural tissues. The number of CD34+ cells, colony-forming cells (CFC) and long-term culture-initiating cells (LTC-IC) was measured within 24 h and on day 7 after stroke onset by flow cytometry, or in functional assays in the peripheral blood of 10 patients with acute middle cerebral artery infarct. The National Institute of Health stroke scale, Barthel index and modified Rankin scale were used to monitor the clinical outcome. In four patients receiving intravenous thrombolytic therapy (tissue plasminogen activator; TPA), no significant increase of CD34+ cells, CFC or LTC-IC was detected. In six patients without thrombolytic treatment, the mean number of CD34+ cells/mL increased significantly from 1181+/-248 at day 1 to 3001+/-881 at day 7. Accordingly, the numbers of CFC and LTC-IC increased 2.7- and 1.7-fold. Granulocyte colony-stimulating factor and neutrophil elastase were monitored by ELISA and remained unchanged during the study period. Our results showed a recruitment of hematopoietic progenitor cells from the BM into the peripheral blood after acute ischemic stroke when no thrombolytic treatment was given. Increased progenitor cell recruitment might be caused by so far unknown signaling stimuli of the ischemic penumbra for stem cell mobilization.
    Cytotherapy 02/2008; 10(3):303-11. · 3.06 Impact Factor
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    ABSTRACT: We report a 73-year-old patient with giant cell arteritis who presented with right arm paresis and dysarthria. Vasculitis of the vertebral arteries induced multiple ischemic cerebral lesions in the vertebrobasilar territory, ultimately leading to death despite intensive immunosuppressive therapy. This case illustrates that prompt relief from symptoms of giant cell arteritis upon steroid treatment does not correspond to a remission of the vasculitic process itself. Clinicians should therefore be aware of the possible occult involvement of the vertebral or other major arteries.
    Der Nervenarzt 01/2006; 76(12):1527, 1529-31. · 0.80 Impact Factor
  • H J Koch, S Haas, T Jürgens
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    ABSTRACT: The loss of cholinergic neurons, particularly in the forebrain, plays an important role in the pathophysiology of Alzheimer's disease (DAT). This concept has lead to the effective treatment of DAT by means of acetylcholine (Ach) esterase inhibitors. G-protein-coupled muscarinic acetylcholine receptors (mAchR) are classified in 5 subtypes, the M1 receptor stimulation and M2 inhibition being especially associated with cognitive skills. Modified cerebral muscarinic receptor profiles in patients with Alzheimer's disease in addition to loss of Ach releasing neurons help us to understand the pathophysiology of dementia and offer potential therapeutic approaches. Specific agonists and antagonists of muscarinic receptors are discussed as possible treatment options in DAT. Experimental results postulate a positive long lasting modulation of the pathological neuronal protein pattern in addition to their cholinomimetic effect.
    Current Medicinal Chemistry 02/2005; 12(24):2915-21. · 3.72 Impact Factor
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    ABSTRACT: Berichtet wird über einen 73-jährigen Patienten mit vordiagnostizierter Arteriitis temporalis, der sich mit einer Parese des rechten Armes sowie einer Dysarthrie vorstellte. Eine entzündliche Mitbeteiligung der Vertebralarterien bei Riesenzellarteriitis (RZA) verursachte multiple zerebrale Ischämien im Bereich des vertebrobasilären Stromgebietes, die trotz intensiver immunsuppressiver Therapie zu einem zentralen Kreislaufversagen führten. Der Fall verdeutlicht, dass ein promptes Ansprechen der Symptome der RZA auf Steroide nicht mit einer Remission des systemischen vaskulitischen Gefäßprozesses gleichzusetzen ist und die Reduktion der Steroiddosis nur sehr langsam erfolgen darf. Eine erhöhte Wachsamkeit für einen möglichen, initial okkulten Mitbefall hirnversorgender Gefäße dieser primär systemischen Vaskulitis ist geboten.
    Der Nervenarzt 01/2005; 76(12):1527-1531. · 0.80 Impact Factor