S Kojima

Publications (8)4.94 Total impact

• Article: Identification of myeloid origin in undifferentiated congenital leukemia by in vitro marrow culture study.

  S Kojima, J Mimaya, T Tonouchi, M Eguchi, H Osada, R Ueda
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  ABSTRACT: A case of congenital leukemia that originally did not express any lineage-specific antigenic markers is presented. The blast cell morphologic appearance was L1 according to French-American-British (FAB) classification and showed lymphoid characteristics by cytochemical staining and transmission electron microscopy. However, immunophenotyping using a variety of monoclonal antibodies did not confirm the lymphoid origin. Furthermore, the immunoglobulin heavy chain and T-cell receptor beta-chain genes were in germ-line configuration. The in vitro culture study defined the leukemia as of myeloid origin. The semisolid methylcellulose culture showed an acute non-lymphocytic leukemia-type growth pattern. Bone marrow blasts underwent myeloid differentiation with positive myeloperoxidase and butyrate esterase activity during a suspension culture. These findings indicate that this case represents an acute undifferentiated leukemia that has probably arisen from the malignant transformation of stem cells of myeloid progeny.
  The American journal of pediatric hematology/oncology 02/1989; 11(3):337-42.
• Article: Philadelphia chromosome positive chronic myelocytic leukemia in children.

  S Kojima, J Yoshida, S Yoshikawa, H Iwamura, T Tonouchi, J Mimaya
  Nippon Ketsueki Gakkai zasshi: journal of Japan Haematological Society 08/1987; 50(4):819-27.
• Article: Megakaryoblastic transformation of chronic myelogenous leukemia in a child.

  S Kojima, J Mimaya, T Tonouchi, M Eguchi
  Nippon Ketsueki Gakkai zasshi: journal of Japan Haematological Society 08/1987; 50(4):828-36.
• Article: Erythropoiesis during an erythroblastic phase of chronic myeloproliferative disorder associated with monosomy 7.

  S Kojima, J Mimaya, T Tonouchi, T Yokochi, S Kajitani
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  ABSTRACT: A chronic myeloproliferative disorder associated with monosomy 7 is described in a 3 1/2-year-old boy. His presenting features closely resembled those of juvenile chronic myeloid leukaemia (JCML). Cytogenetic study of bone marrow cells showed that all of the metaphases examined had chromosome 7 deletions. He developed an erythroblastic phase, characterized by anaemia, marked erythroid hyperplasia of bone marrow and the appearance of nucleated red blood cells in the peripheral blood. During the erythroblastic phase, blood transfusion resulted in a suppression of erythropoiesis as evidenced in both the peripheral blood and bone marrow. The in vitro culture studies showed that the erythroid precursor was dependent upon erythropoietin (Ep) for differentiation and proliferation during the erythroblastic phase. However, the Ep dose-response curve showed that a peak of erythroid colony formation occurred at a lower concentration than in the healthy controls. These findings suggest that although the erythroid precursor remains under the control of Ep, it has an increased sensitivity to Ep during the erythroblastic phase of monosomy 7.
  British Journal of Haematology 05/1987; 65(4):391-4. · 4.94 Impact Factor
• Article: [T-cell type acute lymphoblastic leukemia developing during the course of chronic idiopathic thrombocytopenic purpura in a child].

  T Tonouchi, Y Toyoda, J Mimaya, S Kojima
  [Rinshō ketsueki] The Japanese journal of clinical hematology 07/1985; 26(6):943-50.
• Article: [A case of juvenile chronic myelocytic leukemia with prominent erythroblastosis--studies on erythropoietin-dependent erythropoiesis].

  S Kojima, T Tonouchi, J Mimaya
  [Rinshō ketsueki] The Japanese journal of clinical hematology 10/1984; 25(9):1473-8.
• Article: [46, XX, dir ins (2;11)(q11;q13q23) in an infant with acute monoblastic leukemia].

  S Kojima, T Tonouchi, J Mimaya, T Yokochi
  [Rinshō ketsueki] The Japanese journal of clinical hematology 09/1984; 25(8):1260-5.
• Article: [Chronic liver dysfunction in patients with hemophilia A. Effect of introduction of factor VIII concentrate].

  S Kojima, T Tonouchi, M Ikegaya, J Mimaya
  [Rinshō ketsueki] The Japanese journal of clinical hematology 02/1984; 25(1):31-6.