S Baba

The Jikei University School of Medicine, Edo, Tōkyō, Japan

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Publications (537)1636.47 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A fast-moving abnormal hemoglobin found in a diabetic patient was identified as β140 (H18) ALA→ASP. It comprised about 40 % of the total hemoglobin. The β-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate.
    Hemoglobin 07/2009; 10(2):109-125. DOI:10.3109/03630268609046438 · 0.79 Impact Factor
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    ABSTRACT: Murine cytomegalovirus (MCMV) immediate-early (IE) 2 protein has been reported to be dispensable for growth and latency in mice. Therefore, its role in viral pathogenesis and tissue tropism is not known. Here we prepared specific antibodies to the IE2 and IE3 proteins by using fusion proteins expressed in Escherichia coli as antigens. Immunostaining of MCMV-infected cultured fibroblasts revealed IE2 protein to be expressed diffusely in the nucleoplasm similar to the IE1 protein. In contrast, expression of the IE3 protein, 88 kDa, exhibited a punctate pattern in the nucleus in the early phase of infection then diminished. In the brain of neonatal mice infected with MCMV, both IE2 and IE3 proteins were detected immunohistochemically in the cells of the ventricular walls early in infection. When the infection was prolonged, the IE2 protein was expressed in neurons of the cortex and hippocampus, while the IE3 protein was preferentially expressed in glial cells in the early phase of infection, and its levels declined during the infection. These results suggest that the IE2 protein may play a role in persistent infection in neurons, whereas the IE3 protein, expressed preferentially in glial cells, may play the main role in acute infection.
    Archives of Virology 12/2006; 151(11):2181-96. DOI:10.1007/s00705-006-0793-0 · 2.39 Impact Factor
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    ABSTRACT: We describe four elderly patients (age range 73-85 years) with bile duct carcinoma who were treated with photodynamic therapy. These patients could not be treated surgically because of the presence of cardiopulmonary disease and the extent of the bile duct carcinoma. Prior to photodynamic treatment the patients underwent percutaneous transhepatic biliary drainage (PTBD) to relieve jaundice. The photodynamic therapy was carried out under percutaneous transhepatic cholangioscopy, 2 days after intravenous administration of sodium porfimer (2 mg/kg). Excimer dye laser was used to irradiate the obstructive lesion with an energy dosage of 50 J/cm2 (total irradiation dose 150-250 J/cm2) and stenotic site with a dosage of 50-100 J/cm2. Photodynamic therapy was achieved safely without occurrence of cholangitis in all patients, and was followed by metallic stent placement, resulting in the improvement of performance levels in three patients who did not have liver metastases. Photodynamic therapy via the PTBD route is a safe and promising palliative therapy for selected elderly patients with bile duct carcinoma.
    Endoscopy 02/2004; 36(1):83-7. DOI:10.1055/s-2004-814122 · 5.05 Impact Factor
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    ABSTRACT: The purpose of this study is to evaluate the efficacy of postoperative adjuvant chemotherapy using uracil and tegafur (UFT) for colorectal cancer. In a multicenter trial among 43 institutions for patients who underwent curative resection of Dukes' B or C colorectal cancer, a surgery alone group (control group) and a treatment group (UFT group) to which UFT was administered at 400 mg/day for 2 years following surgery were compared. A total of 320 patients were registered between March 1991 and April 1994, and 289 of these patients were analyzed as a full-analysis set. The 5-year disease-free survival rate was 75.7% in the UFT group and 60.1% in the control group, respectively, and the stratified log-rank test showed the statistical significance ( P=0.0081). This difference was marked in rectal cancer ( P=0.0016) and, in particular, the local recurrence was reduced. No significant difference was observed in the 5-year survival rate. The incidence of adverse reactions on administration of UFT was low, and there was no serious adverse reaction. It is suggested that the consecutive administration of UFT at 400 mg/day was an effective and highly safe therapeutic method as postoperative adjuvant chemotherapy for rectal cancer.
    Langenbeck s Archives of Surgery 04/2002; 386(8):575-81. DOI:10.1007/s00423-002-0278-x · 2.19 Impact Factor
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    ABSTRACT: The origin of damage causing radiation in a beam blanking scanning electron micrograph (BBSEM) was identified and removed for single-event upset (SEU) testing. The improved BBSEM was successfully used to locate SEU sensitive areas in highly integrated silicon devices
    IEEE Transactions on Nuclear Science 01/2002; 48(6-48):2187 - 2192. DOI:10.1109/23.983194 · 1.28 Impact Factor
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    ABSTRACT: We reported on a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with multiple erythematous nodular lesions on the extremities, trunk and face. Histological examination of an excised lesion revealed a dense infiltrate of markedly atypical T-lymphoid cells expressing the CD8+ phenotype located in the subcutaneous tissue with histiocyte-phagocytizing apoptotic cells. The 'bean-bag' histiocytic cells, the characteristic finding of SPTCL, are considered to be products of haemophagocytosis. In our case the 'bean-bag' cells were produced by phagocytosis of apoptotic bodies, as confirmed by electron microscopy. It is suspected that 'bean-bag' cells are related not to haemophagocytosis but to phagocytosis of apoptotic cells in the CD8+ T-cell type of SPTCL.
    Journal of the European Academy of Dermatology and Venereology 04/2001; 15(2):159-62. DOI:10.1046/j.1468-3083.2001.00230.x · 2.83 Impact Factor
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    ABSTRACT: We established a mouse rising dbl quote, left (low)primary tumor resection model" in which a transplanted tumor was resected after an orthotopic transplantation of colorectal cancer tissue to estimate the therapeutic effect of an angiogenesis inhibitor on metastasis. The angiogenesis inhibitor FR-118487 is a member of the fumagillin family. Here, 1 mg / kg / day of FR-118487 was subcutaneously administered to nude mice for 1 week, 2 weeks, or 4 weeks through an osmotic pump. Liver metastasis developed in 7 of 9 control mice, 2 of 6 mice that underwent the tumor resection 2 weeks after transplantation (early resection), and in all 7 of the mice that underwent the tumor resection 4 weeks after transplantation (late resection). In the short treatment trial, the FR-118487 administration immediately after the early resection completely inhibited both hepatic and peritoneal metastases, whereas its administration after the late resection had no effect on liver metastasis. In the prolonged treatment trial, inhibitory effects of prolonged treatment with FR-118487 on both hepatic and peritoneal metastases after the late resection were clearly demonstrated. The mice of the resection-alone group all died within 106 days after tumor inoculation, due to metastases of colon carcinoma. In contrast, half of the mice that underwent resection and then received antiangiogenic therapy were alive at the end of the observation period (160 days after transplantation). In conclusion, the combination of surgery and subsequent antiangiogenic therapy may be useful to prevent the distant metastasis of colorectal cancer and to improve the prognosis of patients with colorectal cancer.
    Japanese journal of cancer research: Gann 02/2001; 92(1):88-94.
  • Transplantation Proceedings 12/2000; 32(7):2047-8. DOI:10.1016/S0041-1345(00)01552-9 · 0.98 Impact Factor
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    ABSTRACT: Background. The effectiveness of adjuvant chemotherapy for colorectal cancers after curative resection has been reported recently; this study was performed to clarify the reasons of for this effectiveness, which have been unclear. Methods. Two joint prospective clinical randomized studies were performed. In the first study, of patients operated on between July 1, 1981 and June 30, 1983, at 41 Centers in the Tokai district, 172 patients with colorectal cancer were allocated to two groups. In the control group, mitomycin C (MMC) was given eight times intravenously in the 4 weeks after surgery. The other group, in addition to receiving the same regimen as the controls, received oral administration of 1-hexylcarbamoyl-5-fluorouracil (HCFU) at 600 mg/day for at least 6 months after the 4-week MMC treatment. In the second study of patients operated at 7 Centers in the Tokai district between October 1, 1987 and September 30, 1990, 173 patients with colorectal cancer were allocated to two groups after surgery, a control group receiving no HCFU, the other group receiving HCFU at 0.8 mg/kg per day orally, for 1 year, beginning 4 weeks after the operation. Results. In the first study, the cumulative 10-year survival rate of the MMC + HCFU group was higher than that of the MMC-alone group (P < 0.05). In the second study, the cumulative 5-year disease-free survival rate of the HCFU group was higher than that of the control group (surgery alone; P < 0.05). In patients with colon cancers, the rate of distant metastases for all evaluable patients was lower in the MMC + HCFU group than in the MMC-alone group in the first study (P < 0.05), and the rate was lower in the HCFU group than in the surgery-alone group in the second study (P < 0.02). Conclusion. The effectiveness of HCFU in reducing the disease-free survival rate appeared to be mainly due to its preventive effect on distant metastases.
    International Journal of Clinical Oncology 02/2000; 5(1):29-35. DOI:10.1007/s101470050006 · 2.13 Impact Factor
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    ABSTRACT: A 45-year-old woman underwent hepatectomy for hepatocellular carcinoma developing after 2 renal transplants. She had a solitary hepatocellular carcinoma and central bisegmentectomy of the liver was performed. Administration of immunosuppressants was continued to maintain renal function in the perioperative period. Although our patient suffered from severe pneumonia postoperatively, she recovered without a decline in renal function. She has been alive for 1 year and 3 months after hepatectomy with hepatocellular carcinoma recurrence in the remnant liver. Any patient undergoing hepatectomy for hepatocellular carcinoma after renal transplantation should be managed as an immunocompromised host. Previously reported cases of hepatectomy for hepatocellular carcinoma in renal transplant recipients were reviewed.
    Hepato-gastroenterology 01/2000; 47(33):835-8. · 0.93 Impact Factor
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    ABSTRACT: The human homologue of the yeast OGG1 gene, hOGG1, has been cloned, and its genetic structure has been determined. Several polymorphisms in the hOGG1 gene were detected in the Japanese populations, and among them, the Ser-Cys polymorphism at codon 326 has been shown to have a functional difference in complementation of mutant Escherichia coli that is defective in the repair of 8-hydroxyguanine. Activity in the repair of 8-hydroxyguanine is greater in hOGG1-Ser326 protein than in hOGG1(326) protein. Because many environmental carcinogens produce 8-hydroxyguanine residue and mismatching to this modified base potentially causes oncogenic mutations, the capacity to repair these lesions can be involved in cancer susceptibility in human beings. We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa. The analyses based on 241 cases and 197 hospital controls disclosed the following findings. (a) Those with the Cys/Cys genotype were at an increased risk of squamous cell carcinoma and nonadenocarcinoma compared to those with the Ser/Cys and those with the Ser/Ser genotypes combined. The odds ratios adjusted for age and smoking history were 3.01 (95% confidence interval, 1.33-6.83) and 2.18 (95% confidence interval, 1.05-4.54), respectively. (b) The odds ratios for other histological subtypes of lung cancer or those in total were not significant. Those for Cys/Cys or Ser/Cys genotype against Ser/Ser did not reach statistical significance in any cell type. (c) The distributions of this polymorphism varied for different populations (Chinese, Japanese, Micronesians, Melanesians, Hungarians, and Australian Caucasians), with much less prevalence of Cys allele in the latter three populations. Although our sample size was limited, these results indicate that the Ser326Cys variant may be related to squamous cell lung cancer susceptibility. The Cys/Cys genotype appears to be more susceptible to squamous cell carcinoma, although the risk is less than that previously reported to be associated with the CYP1A1 gene. Further studies are needed to assess the importance of the interpopulation variation to cancer susceptibility.
    Cancer Epidemiology Biomarkers & Prevention 09/1999; 8(8):669-74. · 4.13 Impact Factor
  • E Ikeda · S Uchigasaki · S Baba · H Suzuki
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    ABSTRACT: The rheumatoid papule has recently been described as the skin manifestation of rheumatoid arthritis (RA). The papules represent leukocytoclastic vasculitis and necrobiosis clinicopathologically. We report a 59-year-old Japanese woman with multiple recurrent rheumatoid papules located on the bilateral extensor forearms in correlation with the level of RA activity and as a cutaneous manifestation of rheumatoid vasculitis. These papules appeared prior to other cutaneous manifestations. It was suggested that rheumatoid papules represent the early stage of rheumatoid vasculitis and that they are a reliable early clinical marker of rheumatoid vasculitis.
    European journal of dermatology: EJD 07/1999; 9(4):313-6. · 1.99 Impact Factor
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    ABSTRACT: How Helicobacter pylori infection affects gastric acid secretion has not been made clear. This study aimed to elucidate the effects of H. pylori infection on H+/K+-adenosine triphosphatase (ATPase) mRNA in gastric fundic gland mucosa. Twenty patients with chronic gastritis and H. pylori infection were treated with lansoprazole and antibiotics. Before and 1 month after treatment gastroduodenoscopy was performed, and changes in the amount of H+/K+-ATPase mRNA in the fundic gland mucosa, gastric juice pH, and serum gastrin levels were determined. The amount of H+/ K+-ATPase mRNA in the fundic gland mucosa was increased in patients with eradication of H. pylori, in whom significant decreases in gastric juice pH and serum gastrin levels were observed. No significant changes were observed in patients without eradication of H. pylori. These results suggest that one of the mechanisms by which H. pylori infection suppresses acid secretion is by the inhibition of proton pump synthesis in parietal cells.
    Scandinavian Journal of Gastroenterology 05/1999; 34(4):384-90. DOI:10.1080/003655299750026399 · 2.36 Impact Factor
  • Transplantation Proceedings 02/1999; 31(1-2):748. DOI:10.1016/S0041-1345(98)01753-9 · 0.98 Impact Factor
  • S Nakamura · S Suzuki · H Konno · S Baba
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    ABSTRACT: Whether extensive surgery improves the prognosis of patients with advanced gallbladder carcinoma remains unclear. Twenty-three patients with stage IV carcinoma underwent resection of tumors at our department over a period of 19 years. The outcome of extensive surgery was analyzed in this group. Resection of segments 4a plus 5, extended right lobectomy or right trisegmentectomy, and hepatopancreatoduodenectomy (HPD) were performed in 5 patients, 7 patients, and 11 patients, respectively. Extrahepatic bile duct resection, regional lymph node dissection and paraaortic node dissection were performed in all patients. The survival rate after operation was compared to that of 39 patients with unresectable tumors. The morbidity rate was high (60.8%), but there were no post-operative deaths. The 1-, 3- and 5-year survival rates were 51%, 17%, and 11%, respectively. The longest survival time of stage IV carcinoma patients was 18 years. The 5-year survival rate of 6 patients undergoing curative resection was significantly better than that of 17 patients undergoing noncurative surgery (p < 0.05). The survival of 11 patients undergoing HPD and 7 patients with para-aortic nodal metastasis were both significantly improved compared to that of patients with unresectable tumors (p < 0.05). The quality of life and the out-of-hospital period were also better. Extensive surgery for stage IV gallbladder carcinoma has a good palliative effect.
    Hepato-gastroenterology 01/1999; 46(28):2138-43. · 0.93 Impact Factor
  • Yumi Okada · Masaki Yoshida · Shigeaki Baba · Kozui Shii
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    ABSTRACT: The aim of this study was to investigate the effect of sodium orthovanadate on the alterations of human erythrocytes insulin receptor autophosphorylation. Human erythrocytes were incubated with insulin in a cell system and then lysed. The autophosphorylated insulin receptors were measured with the aid of a two-site immunofluorometric assay and using a monoclonal anti-insulin receptor antibody to label the insulin receptors and a monoclonal anti-phosphotyrosine antibody to assess tyrosine phosphorylation. When the erythrocytes were treated with insulin and then reincubated in insulin-free medium, vanadate completely inhibited insulin receptor dephosphorylation, although it had no effect on in vitro receptor autophosphorylation. Thus insulin receptor tyrosine phosphatase activity is postulated to be [% (autophosphorylated insulin receptors with vanadate - autophosphorylated insulin receptors without vanadate)/total insulin receptors] under overall steady conditions in a cell system. Using this assay, the insulin receptor tyrosine phosphatase activities of 25 control and 32 diabetic subjects were studied. There was no significant difference in insulin receptor tyrosine phosphatase activity between control subjects and diabetic subjects (0.173 +/- 0.062 vs 0.209 - +/- 0.057 autophosphorylated insulin receptors units/insulin receptors units). The assay used in this study requires only 0.6 ml of whole blood, and so should be a useful tool for detecting patients who are insulin-resistant due to abnormal insulin receptor tyrosine phosphatase activity.
    Diabetes Research and Clinical Practice 10/1998; 41(3):157-63. DOI:10.1016/S0168-8227(98)00076-X · 2.54 Impact Factor
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    ABSTRACT: Distant metastasis of gastrointestinal endocrine neoplasm is resistant to currently available treatments. Because hematogenic metastasis is dominant, anti-angiogenic drugs are expected to be a novel therapy for this neoplasm. In the present study, the therapeutic effect of vascular endothelial growth factor neutralizing antibody (VEGFAb) on liver metastasis of an endocrine neoplasm was investigated experimentally. Cecal transplantation into nude mice of small pieces of EN-1, a xenotransplanted human intestinal endocrine neoplasm, resulted in liver metastasis. A treated group (n = 19) received 100 micrograms/mouse of VEGFAb intraperitoneally on alternate days from day 10 after tumor transplantation, and the control group (n = 19) received saline. Five of the 19 control mice died of tumor progression, of which 2 could not be evaluated. The cecal tumor weighed 6316 +/- 2333 mg (n = 17) in the control group and 1209 +/- 837 mg (n = 19) in the treated group (P < 0.01) 6 weeks after transplantation. Liver metastasis developed in 16 of 17 control mice and in 2 of 19 treated mice (P < 0.01). The VEGF level of the whole cecal tumor in the control group was significantly higher than that in the treated group (305.1 +/- 174.1 vs. 54.7 +/- 41.2 mg; P < 0.001). VEGFAb did not cause any body weight loss (28.52 +/- 1.63 in the control vs. 28.44 +/- 1.71 g in the treated group). These results indicate that VEGFAb may be a novel therapeutic agent for endocrine neoplasm with distant metastasis.
    Japanese journal of cancer research: Gann 10/1998; 89(9):933-9.
  • H Konno · T Tanaka · T Kanai · S Baba
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    ABSTRACT: Angiogenesis is essential for the growth of solid tumors. Antiangiogenic therapy has therefore attracted considerable interest as a novel therapy for various tumors including colorectal carcinoma. We experimentally investigated the therapeutic effect of TNP-470, a nonspecific inhibitor of angiogenic factors, and vascular endothelial growth factor (VEGF)-neutralizing antibody (VEGFAb), was a VEGF-specific inhibitor, on liver metastases of colon carcinoma using a murine orthotopic transplantation model. TK-4 and TK-13 are moderately differentiated adenocarcinoma strains established in our department which express VEGF mRNA and protein. Administration of TNP-470 30 mg/kg significantly inhibited the liver metastases of both strains, as did administration of VEGFAb 100 micrograms/mouse. The therapeutic effect on liver metastases was more dominant with antiangiogenic therapy than with chemotherapy (mitomycin C). Furthermore, the sustained effect of TNP-470 induced tumor dormancy and consequently improved the survival of the animals. These results suggest that antiangiogenic treatment will be a potent therapy for liver metastases of human colorectal carcinoma in the future.
    Nippon Geka Gakkai zasshi 08/1998; 99(7):441-5.
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    ABSTRACT: Although some studies have shown that overexpression of vascular endothelial growth factor (VEGF) mRNA or protein is correlated with the progression of human malignancies, it is still unknown whether the VEGF level in tumor tissue correlates with tumor growth or metastasis. The present clinical study enrolled 26 patients with colon cancer and revealed that the VEGF level in tumor tissue was significantly higher than in adjacent normal tissue (220.93 ± 217.64 pg/mg protein in the tumor tissue; n = 26; 38.93 ± 20.26 in the normal tissue; n = 26) and significantly correlated with tumor size, whereas it did not correlate with other clinicopathological variables. The animal study involved orthotopic transplantation of a human colon cancer strain into nude mice and demonstrated that the VEGF level of transplanted tumor tissue (2,318.5 ± 1,340.9 pg/mg protein) was significantly correlated with tumor weight (1,856.4 ± 928.9 mg), but not with the number of the liver metastatic foci. These results indicate that VEGF produced by primary tumors of colon cancers may mainly promote primary tumor growth.
    European Surgical Research 07/1998; 30(4):273-278. DOI:10.1159/000008587 · 2.47 Impact Factor
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    ABSTRACT: Okinawa, a group of islands that lie between the East China Sea and the Pacific Ocean, 2000 km south of the Japanese main islands, has a different profile of diseases, ethnicities, and cultures than does the rest of Japan. We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based case-control study of lung cancer patients (247 cases and 185 controls) in Okinawa to ascertain the association of this variant with lung cancer. In addition, the distribution of this genotype was studied in populations from different areas of Japan, including Tokyo (n = 69) and Iwate (northern part of Japan; n = 81), as well as in a Chinese group from the Jiangsu province (n = 39) and in an Australian Caucasian group (n = 146). Genotype frequency in controls was not significantly different from area to area in Japan. In Okinawa, however, the genotype encoding Val/Val was associated with a significantly higher risk of lung cancer (odds ratio = 3.32, P = 0.013), especially of squamous cell carcinoma and small cell carcinoma (odds ratio = 4.85 and 9.35, respectively). The Val-encoding allele was less frequent in the Chinese population and was rare in Australian Caucasians. Thus, this study gives support to the value of the cytochrome P450 IA1 Ile462Val polymorphism as a practical high-risk marker of lung cancer in populations, especially those in southeast Asia, in which this variant is more common.
    Cancer Epidemiology Biomarkers & Prevention 06/1998; 7(5):413-7. · 4.13 Impact Factor

Publication Stats

5k Citations
1,636.47 Total Impact Points


  • 2009
    • The Jikei University School of Medicine
      • Department of Internal Medicine
      Edo, Tōkyō, Japan
  • 1992–2006
    • Hamamatsu University School of Medicine
      • • Division of Tumor Pathology
      • • Department of Surgery II
      Hamamatu, Shizuoka, Japan
    • University of Cincinnati
      • Department of Surgery
      Cincinnati, Ohio, United States
  • 1991–2004
    • University of Hamamatsu
      Hamamatu, Shizuoka, Japan
    • Tokyo Medical and Dental University
      • Department of Internal Medicine
      Edo, Tokyo, Japan
    • Showa University
      • Department of Internal Medicine
      Shinagawa, Tōkyō, Japan
  • 1999
    • Surugadai University
      Edo, Tōkyō, Japan
  • 1992–1999
    • Hamamatsu University School Of Medicine
      Hamamatu, Shizuoka, Japan
  • 1993–1998
    • Tokoha University
      • • Department of Surgery II
      • • Division of Biochemistry
      Hamamatu, Shizuoka, Japan
    • Numazu City Hospital
      Sizuoka, Shizuoka, Japan
  • 1997
    • Japan Research Institute
      Akasi, Hyōgo, Japan
    • Tokyo Metropolitan Geriatric Medical Center
      Edo, Tōkyō, Japan
  • 1993–1996
    • Kanagawa Children's Medical Center
      Yokohama, Kanagawa, Japan
  • 1994
    • Nihon University
      • Department of Dermatology
      Edo, Tōkyō, Japan
  • 1973–1991
    • Kobe University
      • • Department of Medicine
      • • Department of Internal Medicine
      Kōbe, Hyōgo, Japan
  • 1989
    • The University of Tokyo
      Tōkyō, Japan
  • 1988
    • Chonnam National University Hospital
      Sŏul, Seoul, South Korea