-
[show abstract]
[hide abstract]
ABSTRACT: The phytochemical investigation of the flower buds of Daphne genkwa yielded four highly oxygenated tigliane diterpene esters (1-4), including two new phorbol derivatives, 12-O-(2'E,4'E-decadienoyl)-7-oxo-5-ene-phorbol-13-acetate (1) and 12-O-neodecanoyl-7-oxo-5-ene-phorbol-13-acetate (2). The molecular structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR.
Journal of Asian natural products research 04/2013; · 0.61 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A phytochemical investigation of the leaves of Clerodendrum trichotomum led to the isolation of five new (2-6) and two known (1 and 7) steroids, whose structures and relative configurations were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Steroids 2 and 5 exhibited moderate cytotoxicity in vitro against HeLa cell line.
Steroids 04/2013; · 2.83 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Phytochemical investigation on the rhizomes of Homalomena occulta resulted in the isolation of five new sesquiterpenoids, namely cadinane-4β,5α,10α-triol (1), 5(11)-epoxycadinane-4β,5β,10β,11-tetraol (2), bullatantiol-1β-methyl malate (3), 1β,4β,7α-trihydroxyeudesmane-1β-methyl malate (6), and 1β,4α,7-trihydroxyeudes-mane (7), together with five known sesquiterpenoids, bullatantriol (4), acetylbullatantriol (5), 1β,4β,7α-trihydroxyeudesmane (8), 1β,4β,7β-trihydroxyeude-smane (9), and pterodontriol (10). Their structures were elucidated on the basis of spectroscopic evidences, including various 1D and 2D NMR and HR-ESI-MS. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis.
Planta Medica 05/2012; 78(10):1010-4. · 2.15 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Molecular imprinted polymers (MIPs) were prepared by thermal polymerization using a non-covalent molecularly imprinting strategy with kirenol as the template, acrylamide (AM) as the functional monomer and ethylene glycol dimethacrylamide (EGDMA) as the cross-linker in the porogen of tetrahydrofuran (THF). The synthesized MIPs were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR). Its molecular recognition property was investigated by UV spectrogram. High-pressure liquid chromatography (HPLC) was used for analysis of target analytes. The polymers were evaluated further by batch rebinding experiments, and from the derived isotherms their binding capacity and binding strength were determined. Then the selectivity of the MIPs was checked toward the selected structurally related compounds and the recognition coefficients for kirenol, darutigenol, and ent-2-oxo-15, 16, 19-trihydroxypimar-8(14)-ene (TD) were 2.47, 3.43 and 3.40, respectively. The properties of MIPs for SPE were also evaluated. The results obtained demonstrate that the good imprinting effect and the excellent selectivity of MIPs were obtained. The optimized molecular imprinted SPE procedure was applied to extract kirenol directly from the extracts of the aerial part of Siegesbeckia pubescens herb. A selective extraction of kirenol from traditional Chinese medicine (TCM) was achieved with extraction yield of 80.9%.
Talanta 01/2012; 89:505-12. · 3.79 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Four new polyacetylenes, namely chrysindins A-D, together with 6 known polyacetylenes, were isolated from the flowers of Chrysanthemum indicum. Their structures were established on the basis of comprehensive spectroscopic analyses. Chrysindins A and B bear a novel carbon skeleton.
Planta Medica 05/2011; 77(16):1806-10. · 2.15 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: To study the chemical constituents of Codonopsis pilosula.
The compounds were isolated and purified by column chromatography and their structures were elucidated through spectroscopic techniques (NMR) and physicochemical properties.
The compounds were isolated as hesperidin(I), n-hexyl beta-sophoroside(II), atractylenolide III (III), lobetyolin(IV), lobetyolinin(V), taraxerol(VI), taraxeryl acetate(VII), alpha-spinasterol(VIII),9,10,13-trihydroxy-(E)-11-octadecenoic acid (IX),beta-sitosterol(X),beta-daucosterol(XI)and sugar(XII).
Compounds 1 -2 and 9 are isolated from this plant for the first time.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 04/2011; 34(4):546-8.
-
[show abstract]
[hide abstract]
ABSTRACT: Phytochemical investigation of the flowers of Inula britannica led to the isolation of nineteen sesquiterpenoids (1- 19), including britanlins E-J ( 2, 3, 5, 8, 13, and 14, respectively) and known sesquiterpenoids (1, 4, 6, 7, 9- 12, and 15- 19). The structures of these isolates were elucidated by detailed spectroscopic analyses and comparison to the previously reported spectroscopic data. The absolute configurations of compounds 12, 15, 17, and 19 were determined by X-ray single crystal diffraction analyses and chemical transformations.
Planta Medica 03/2011; 77(4):362-7. · 2.15 Impact Factor
-
Helvetica Chimica Acta 10/2010; 93(10):2081 - 2085. · 1.48 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Three new flavonoids, oxytropisoflavans A (1) and B (2) and (6aR,11aR)-3,8-dihydroxy-9,10-dimethoxypterocarpan (3), together with 30 known flavonoids (4-33), were isolated from the aerial parts and roots of Oxytropis falcata. The absolute configurations of 3 and C-3 in 1 and 2 were deduced by circular dichroism. The structure of flavonoid 2 was confirmed by single-crystal X-ray diffraction analysis and that of flavonoid 3 by total synthesis of its racemate. Oxytropisoflavan A (1) is an unprecedented chalcan-isoflavan biflavonoid, whereas oxytropisoflavan B (2) possesses a rare modified A-ring. Pterocarpan 3 has good radical-scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.
Journal of Natural Products 08/2010; 73(8):1398-403. · 3.13 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Bidens pilosa is used in various folk medicines such as antimalarial, antibacterial, blood pressure-lowering, and antihyperglycemic agents. Phytochemical investigation of the aerial parts of this plant yielded 10 polyacetylenes and 9 flavonoids, including four new polyacetylenes (5, 7- 9) and one new chalcone glucoside (11). The molecular structures of the isolated compounds were elucidated by comprehensive spectroscopic analysis.
Planta Medica 06/2010; 76(9):893-6. · 2.15 Impact Factor
-
Helvetica Chimica Acta 03/2010; 93(3):595 - 601. · 1.48 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Indole alkaloids, oxytrofalcatins A-F (1-6), together with five other known alkaloids (7-11), were isolated from the roots of Oxytropis falcata. Their structures were elucidated by comprehensive spectroscopic analyses, including using 1D and 2D NMR spectroscopy and mass spectrometry. This is the first report of N-benzoylindoles from a natural source. Compounds 1-6 lacked significant cytotoxicity against SGC-7901 and HL-60 tumor cell lines.
Phytochemistry 03/2010; 71(8-9):1002-6. · 3.35 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The genus Saussurea has been studied from phytochemical and pharmacological viewpoints for years, which resulted in the discovery of hundreds of secondary metabolites with various kinds of bioactivities. This review summarizes the research progress of the genus of Saussurea in the phytochemical and pharmacological viewpoints, which covered the period of 1990-June 2009.
Journal of Asian natural products research 02/2010; 12(2):162-75. · 0.61 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Phytochemical investigation of the above-ground parts of Siegesbeckia pubescens yielded 25 diterpenoids, including five new ent-pimarane diterpenoids (1-3, 11, and 12) and four new ent-kaurane diterpenoids (13-16). The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Single-crystal X-ray diffraction analysis confirmed the structures of 8, 13, and 14. Seven of these diterpenoids were evaluated for cytotoxic activity against HSC-T6, HeLa, and B16 cell lines. Compounds 11 and 14 exhibited moderate cytotoxicity.
Journal of Natural Products 11/2009; 73(1):17-21. · 3.13 Impact Factor
