S Kumar

Postgraduate Institute of Medical Education and Research, Chandigarh, Chandīgarh, India

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Publications (114)127.99 Total impact

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    ABSTRACT: This study was carried out to evaluate the effect of crossing of FecB carrier (FecB BB and FecB B+ ) GM rams with noncarrier (FecB++ ) Malpura ewes on growth performance and FecB status in backcross (GMM) progenies. The results showed that 79.31% progeny of FecB BB rams carries FecB mutation in heterozygous state while only 35.56% progeny of FecB B+ rams carries FecB mutation. There were only 2 genotypes FecBB+ and FecB ++ ) available in the backcrossprogeny. The nonsignificant effect of FecB genotype of rams was observed from birth to 12-months of age except at 6- month body weight. The body weight of non-carrier (FecB++ ) was nonsignificantly higher than the carrier lambs (FecB B+ ). The interaction between FecB genotypes of rams and FecB genotype of lambs was nonsignificant. The result clearly indicates that GMM crosses may be propagated as a new crossbred sheep having FecB gene towards evolving new prolific strain.
    Indian Journal of Animal Sciences. 01/2010; 80(12):1254-1256.
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    ABSTRACT: Chromogenic media are frequently used in direct and rapid identification of yeasts because different Candida species produce unique colors on these media. We used 60 isolates of Candida species including 30 C. albicans, 10 C. parapsilosis, 11 C. glabrata, five C. tropicalis, and four C. dubliniensis, isolated from various clinical specimens, to evaluate the performance of HiChrome Candida agar. These strains had been identified by germ tube test, morphology on cornmeal agar, chlamydospore formation on tobacco agar and sugar assimilation tests. The sensitivity and specificity results were: C. albicans (96.55 and 96.42%); C. parapsilosis (80 and 98.03%), C. glabrata (90.90 and 88.23%), C. tropicalis (100 and 100%) and C. dubliniensis (60 and 96.55%) respectively. HiChrom Candida agaris medium has been useful and capable of presumptive, rapid identification of Candida species within 48 hours.
    Indian Journal of Pathology and Microbiology 01/2010; 53(1):93-5. · 0.68 Impact Factor
  • Obstetric Anesthesia Digest 01/2010; 30(2):123-124.
  • Indian Journal of Pathology and Microbiology 01/2010; 53(1):185-7. · 0.68 Impact Factor
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    ABSTRACT: We present a case of 10 year-old boy with oropharyngeal injury caused by a toothbrush which penetrated the parapharyngeal space. Initial examination revealed broken end of the toothbrush in oral cavity with the head of the toothbrush having bristles, beyond the soft palate. Tongue and palate were lacerated and there were blood and oral secretions in the oral cavity. Patient was having bradycardia. Computed tomography (CT) scan showed the toothbrush head near the carotid artery, the carotid being laterally displaced. The foreign body was surgically removed without any intraoperative or postoperative complications.
    Journal of Indian Society of Pedodontics and Preventive Dentistry 01/2010; 28(2):134-6.
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    ABSTRACT: Estimates of (co)variance components were obtained for weights at birth, weaning and 6, 9 and 12 months of age in Chokla sheep maintained at the Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, India, over a period of 21 years (1980-2000). Records of 2030 lambs descended from 150 rams and 616 ewes were used in the study. Analyses were carried out by restricted maximum likelihood (REML) fitting an animal model and ignoring or including maternal genetic or permanent environmental effects. Six different animal models were fitted for all traits. The best model was chosen after testing the improvement of the log-likelihood values. Direct heritability estimates were inflated substantially for all traits when maternal effects were ignored. Heritability estimates for weight at birth, weaning and 6, 9 and 12 months of age were 0.20, 0.18, 0.16, 0.22 and 0.23, respectively in the best models. Additive maternal and maternal permanent environmental effects were both significant at birth, accounting for 9% and 12% of phenotypic variance, respectively, but the source of maternal effects (additive versus permanent environmental) at later ages could not be clearly identified. The estimated repeatabilities across years of ewe effects on lamb body weights were 0.26, 0.14, 0.12, 0.13, and 0.15 at birth, weaning, 6, 9 and 12 months of age, respectively. These results indicate that modest rates of genetic progress are possible for all weights.
    Journal of Animal Breeding and Genetics 09/2009; 126(4):278-87. · 1.65 Impact Factor
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    ABSTRACT: Although ventriculoperitoneal (VP) shunt infection is a common complication of shunt procedures, fungal infection is considered to be rare. In the present study, we performed retrospective analysis of six cases in which candida infection occurred. In all these six cases, VP shunt was performed in children for hydrocephalus and the onset of symptoms varied between seven days to one month after the surgical procedure was performed. The commonest clinical signs and symptoms were fever (100%), vomiting (100%), and altered sensorium (50%). The commonest isolate was Candida albicans (66.66%) followed by Candida parapsilosis and Candida glabrata in one case each. All the patients were successfully treated with Amphotericin B and there was no mortality recorded.
    Journal of Pediatric Neurosciences 07/2009; 4(2):73-5.
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    ABSTRACT: Single-shot spinal and combined spinal-epidural block, with or without epidural volume extension, can be used for caesarean section. There is no trial comparing their block characteristics and adverse effects under identical conditions. 60 ASA I or II parturients with gestational age 37 weeks or more, scheduled for elective caesarean section under regional anaesthesia, were included in the trial. Women were randomized to three groups: group SSS: single-shot spinal; group CSE: combined spinal-epidural; group EVE: epidural volume extension of a combined spinal-epidural. Intrathecal injection was identical in the three groups (0.5% hyperbaric bupivacaine 9 mg with fentanyl 10 microg) and was injected via a 25-gauge pencil-point spinal needle, either as a single-shot spinal or through the spinal needle of the needle-through-needle CSE set. In group EVE, 5 mL of normal saline was injected through the epidural catheter. All blocks were performed with the women sitting. Haemodynamic parameters and block characteristics were assessed. The onset of maximum sensory and motor block was significantly faster in the SSS group than in the other two. Extent and duration of sensory and motor block and the incidence of adverse effects were similar in the three groups (P>0.05). Intrathecal block is similar in extent and duration whether given as a single-shot spinal or a combined spinal-epidural with or without epidural volume extension when performed for elective caesarean section using hyperbaric bupivacaine in the sitting position.
    International journal of obstetric anesthesia 06/2009; 18(3):231-6. · 1.85 Impact Factor
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    ABSTRACT: We conducted this study to compare the safety and efficacy of transurethral resection of the prostate (TURP) and holmium laser prostatectomy. A total of 30 patients eligible for surgery for symptomatic benign prostatic hyperplasia were included in the study. They were randomized into two groups of 15 each. The patients were evaluated at 3 weeks, 3 and 9 months. Preoperative parameters were comparable between the 2 groups. The mean operative time was longer in the holmium laser enucleation of prostate (HoLEP) group (53 +/- 9.84 vs. 43 +/- 9.36 min; p = 0.001). The intraoperative adverse events were comparable. The mean traction time (26.80 +/- 5.9 vs. 19.60 +/- 3.6 h; p = 0.0001), irrigation time (30 +/- 7.68 vs. 19.40 +/- 1.15 h; p = 0.0001), and duration of indwelling catheter (78.20 +/- 17.84 vs. 46.42 +/- 14.25 h; p = 0.0001) were significantly less in the HoLEP group as compared to the TURP group. Two patients (13.66%) in the TURP group had significant hematuria. Two patients in the HoLEP group vs. none in the TURP group developed urinary incontinence (p < 0.05). Significant improvements were observed in IPSS score, PFRs and PVRs in both the groups and maintained at 9 months. HoLEP is safe and effective in the surgical management of benign prostatic hyperplasia, with the advantage of reduced intraoperative hemorrhage and perioperative morbidity.
    Urologia Internationalis 02/2009; 82(2):130-5. · 1.07 Impact Factor
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    ABSTRACT: Tubercular brain abscess are uncommon and tubercular cerebellar abscess are rarely reported. Most of these cases occur in immunocompromised patients. We report a case of multiple cerebellar abscesses in a 55-year-old HIV seronegative non-diabetic female, who complained of headache, neck pain and unsteadiness of gait since two months. She had been on treatment for pulmonary tuberculosis, diagnosed earlier. Diagnosis was made by CT scan of brain and confirmed by bacteriological examination of drained pus obtained by suboccipital craniotomy. The patient showed signs of recovery.
    Indian journal of medical microbiology 01/2009; 27(4):363-5.
  • A De, A Bindlish, S Kumar, M Mathur
    Indian journal of medical microbiology 01/2009; 27(4):375-6.
  • V P Baradkar, S Kumar
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    ABSTRACT: A total of 60 patients suspected to have AIDS with oral lesions suggestive of oral candidiasis were studied. Candida species were isolated from 50 patients. Candida albicans was the commonest isolate (70 %) followed Candida parapsilosis(15%), Candida glabrata (7.5%) and Candida tropicalis (5%) respectively. Candida dubliniensis was isolated from a single case only. Though the reports from developed countries show more prevalence of the novel species Candida dubliniensis, in our study it was isolated in a single case. All the patients were treated successfully with oral fluconazole for 7 days except for the patients from which Candida glabrata was isolated, who were treated with Amphotericin B.
    Indian Journal of Dermatology 01/2009; 54(4):385-6.
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    ABSTRACT: Though Phaeoacremonium parasiticum is an unusual cause of human disease, subcutaneous infection, eumycetoma, osteomyelitis, arthritis and even disseminated diseases, such as fungemia and endocarditis have been reported. Here, we report a case of subcutaneous abscess on the forearm due to P. parasiticum in a 26-year-old woman. There were no obvious predisposing factors. The patient was treated with surgical debridement followed by intravenous amphotericin B and itraconazole to which she responded well. We report this case, being rare and the first from India.
    Indian journal of medical microbiology 01/2009; 27(1):66-9.
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    ABSTRACT: Spontaneous renal hemorrhage (SRH) is a difficult diagnostic problem with various causes. We report a case of SRH and episodic gross hematuria in a patient with metastatic choriocarcinoma involving both kidneys for which successful angioembolization was carried out for control of hemorrhage. There was no evidence of primary uterine tumor and pulmonary or liver involvement. The patient developed gastrointestinal bleeding due to jejunal metastasis while on chemotherapy and surgical resection of the involved segment was carried. However, the patient acquired nosocomial pneumonia and succumbed to sepsis in the postoperative period.
    Cancer Imaging 01/2009; 9:56-8. · 1.59 Impact Factor
  • Indian Journal of Pathology and Microbiology 01/2009; 52(4):573-4. · 0.68 Impact Factor
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    ABSTRACT: Cases of pulmonary aspergilloma without any predisposing factors are rarely reported. Clinical presentation varies from case to case. Here, we report a case of pulmonary aspergilloma in a 60-year-old male patient who was admitted to the Intensive Respiratory Care Unit with spontaneous pneumothorax. The patient had a history of dyspnea on exertion since 9 months and mild haemoptysis since the last 6 months. A computerised tomographic scan of the lungs showed a lesion in the left main bronchus along with obstructive emphysema of the right lung, moderate pneumothorax and mediastinal emphysema. Bronchoscopy was performed and the biopsy samples were processed for histopathological examination and culture on Sabouraud's dextrose agar, which yielded growth of Aspergillus flavus. Repeat sputum samples also yielded the growth of A. flavus. The patient responded to intravenous liposomaamphotericin B and intercostal drainage.
    Indian journal of medical microbiology 01/2009; 27(3):270-2.
  • Indian Journal of Pathology and Microbiology 01/2009; 52(3):440-1. · 0.68 Impact Factor
  • V P Baradkar, S Kumar
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    ABSTRACT: Saksenaea vasiformis is an emerging zygomycete species, most often associated with cutaneous, subcutaneous and rhino- orbito-cerebral infections. Herein, we report a case of cutaneous zygomycosis of face caused by Saksenaea vasiformis in a 54-year-old immunocompetent female. The diagnosis was carried out by microscopy using KOH mount, Gram staining, Gomori's methenamine silver staining, hemotoxylin and eosin staining and culture on Sabouraud's Dextrose agar without actidione. Slide cultures were put up on Czapek Dox agar, which showed typical flask-shaped sporangium with rhizoids. The patient was treated successfully with intravenous amphotericin B.
    Indian Journal of Dermatology 01/2009; 54(4):382-4.
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    ABSTRACT: Brain abscess is uncommon in the pediatric population. Here, we report one such case due to Candida albicans in one-year-old infant, without any predisposing factors. The child presented with progressively increasing size of head circumference. The diagnosis was confirmed by CT scan of brain and microbiological investigations on the drained pus material. The patient responded to combination of surgery (drainage) and intravenous amphotericin B. Neurological development six months after hospital discharge was normal. The organism being a rare cause of cerebral abscess in pediatric population is reported here.
    Indian journal of medical microbiology 01/2009; 27(1):70-2.
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    ABSTRACT: A total of 573 HIV seropositive and clinically suspected cases of Cryptococcal meningitis were included in the study, from January 2006 to January 2007. CSF samples were processed by negative staining with 10% Nigrosin, cultured on Sabouraud's dextrose agar, biochemical tests, such as urease test and brownish growth in Niger seed agar. The prevalence of Cryptococcal meningitis was found to be 2.79%. The most common signs and symptoms were: fever (100%), headache (100%), altered sensorium (100%), and neck stiffness (90%). All the patients responded to intravenous Amphotericin B treatment.
    Indian Journal of Sexually Transmitted Diseases and AIDS 01/2009; 30(1):19-22.

Publication Stats

305 Citations
127.99 Total Impact Points

Institutions

  • 2007–2014
    • Postgraduate Institute of Medical Education and Research
      • Department of Urology
      Chandigarh, Chandīgarh, India
    • Banaras Hindu University
      • Department of Endocrinology and Metabolism
      Benares, Uttar Pradesh, India
  • 2003–2011
    • Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
      • Department of Microbiology
      Mumbai, State of Maharashtra, India
  • 2010
    • All India Institute of Medical Sciences
      • Department of Surgical Disciplines
      New Dilli, NCT, India
  • 2008–2009
    • Biomedical Informatics Centre
      Chandigarh, Chandīgarh, India
  • 2006–2009
    • Central Sheep and Wool Research Institute
      Mālpura, Rajasthan, India
  • 2001
    • UNICEF
      New York City, New York, United States
    • Medical College Kolkata
      • Department of Community Medicine
      Calcutta, Bengal, India
  • 1998
    • Bankura Sammilani Medical College
      Банкура, Bengal, India
  • 1995
    • Calcutta National Medical College
      Kolkata, Bengal, India
    • AIIMS Bhopal All India Institute of Medical Sciences
      Bhopal, Madhya Pradesh, India
  • 1976–1980
    • Christ Hospital
      Jersey City, New Jersey, United States
  • 1971
    • New York Methodist Hospital
      New York City, New York, United States
    • State University of New York Downstate Medical Center
      • Department of Pediatrics
      Brooklyn, NY, United States