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Publications (4)6.74 Total impact

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    ABSTRACT: Introduction Achondroplasio is a genetically induced disease, by a mutation on FGFR3 gen. Unproportionaly small height, short extremities caused by failure of enchondrial osteogenesis. Frequency is 1:25000 deliveries. Autosomal dominant hereditary disease. Case report Mail neonate born on 02/03/2010. in our Clinic, as a first child from a first uncontrolled pregnancy of a mother with achondroplasio, father-healthy. Parents both mother and father’s-healthy. Delivery by CS: Hondrodysplasio (diagnosed 30 days before the delivery). Head disproportionally bigger, forehead protuberant, nose root subsided, sutures 1cm in diameter. Proximal parts of extremities much shorter (rhisomelia). Restricted excursions in elbow and knee. Fingers much shorter and thicker. Other systems-normal. Brain ultrasound-normal. Genetically check up-Achondroplasio neonati. Discussion Achondroplasio is a hereditary disease recognized after birth. Without hydrocephalus life expectancy, mental and sex development is normal. Therapy options are surgical treatment and hormone supplementation. Cervical and lumbal spinal stenosis, gives neurological, respiratory problems and anesthesiological problems. Strabismus, conductive hearing failure demands ophthalmological and auditive care. Complication prevention is the base of all therapy treatments including a large team: neonatologist, clinical geneticist, pediatrician, neurologist, otorinolaringologist, ophthalmologist, pulmologist, endocrinologist, anesthesiologist, surgeon, psychiatrist, and psychologist. Recurrence risk is over 50%. As prenatal diagnostic is available, to prevent the risk of recurrence, individuals with achondroplasio, motivated to have healthy descendants, during pregnancy planning, are obligated to seek a genetical supervision and thorough pregnancy control. Main mother question: Is it going to look like me? Anamnesticaly -it was a love child!!! Dilemma: Does it have a right for its 50%???
    Journal of Perinatology 03/2011; 24(3):12-14. · 2.25 Impact Factor
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    ABSTRACT: INTRODUCTION Malignant melanoma is a growing problem in pregnant women population. Incidence in literature is from 2.8-10/10000 pregnancies. OBJECTIVE Aim was to see the rate of it in our Maternity ward, during the period of 10 years, and outcome of it, toward mother and neonate. MATERIALS AND METHODS Maternity ward of Clinic Narodni front,Belgrade,had 11 cases of melanoma in last 10 years (69 023 deliveries). All diagnosed during pregnancy-none had any malignancy before. Average gestation of diagnosis-23 weeks. CLINICAL CASES OR SUMMARY RESULTS 4 delivered vaginally,7 by CS. Conservative treatment 3, conservatively + surgically 3, and surgically in 5 cases. Surgical treatments-performed in our Clinic. Chemotherapy of all in Institute Of Oncology, CCS supervised by an obstetrician. Average term of delivery - 33weeks, 4days; Apgar score 7,1/8,0; average body mass 2370 grams ; duration of hospitalization 9,1 days.1 newborn had cutaneous markings-malignant-transferred during cordocenthesis operated one day after delivery. 4 women died in 5 year period, 1 in 10 year. 6 are still in screening protocol. 3 had another child after. Surgical treatment had 8 - operations depended of localization and level of malignancy. 1 patient treated urgently after delivery - metastases inside of the eyeball-removed. CONCLUSIONS Malignancy level was high at the diagnosis. Therapy-radical and prompt-problem of saving the mother, her fertility and after that pregnancy. Incidence growth-300% in 10 years-the most vigorous problem for obstetricians, surgeons and pediatricians in time to come, concerning malignant diseases.
    Perinatal Medicine Today. 01/2010;
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    ABSTRACT: INTRODUCTION Placental Abruption (PA) is one of the leading causes in perinatal morbidity and mortality. It occurs in 1:120 deliveries, makes 15% of perinatal mortality. OBJECTIVE Aim was to analyze neonatal outcome in deliveries with PA. MATERIALS AND METHODS Test group-49 neonates born in 2 year period with PA. Results were classified by gender, gestation, body mass, Apgar score and pH. Neonatal mortality/morbidity was analyzed. Control-154 neonates, born during the same period without PA. Results were statistically tested. CLINICAL CASES OR SUMMARY RESULTS Test-significantly more preterm neonates (18,7%:10,4%).Apgar score 7 and lower, test-(20.86%), control-(9.7%).Acidosis during first hour maintained in test-(35.41%), control-(11.68%). Morbidity analyze gives a high degree of perinatal asphyxia, hypoxic-ischemic encephalopathy, intracranial bleeding and anemia in test group. As a main reason for morbidity/mortality lower gestation and lower body mass were recognized in test group. CONCLUSIONS In our analysis 85.4% of neonates in test group were released as recovered or healthy. Although a small sample, it could be said that on time diagnosis, adequate way of delivery and neonatal care afterward, makes that the outcome of these deliveries could be satisfied.
    Journal of Perinatology 01/2010; · 2.25 Impact Factor
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    ABSTRACT: INTRODUCTION Placental abruption(PA)is one of the most severe complications during pregnancy. In practice it affects 0,5% of all deliveries, our duty is to be very vigilant about it occurrence, namely for it high fatality for mother and infant. OBJECTIVE To see through delivery patients with diagnosed partial and total PA, occurring before 37 gestational weeks (GW).Also to see the conditions of the neonates after delivery, comparing the data with the control group, without PA, with delivery before 37GW. MATERIALS AND METHODS Test group-49 patients with PA. 40 of them had CS. Control group-93 patients with preterm labor, without PA. 17 had a CS. All the results were statistically tested CLINICAL CASES OR SUMMARY RESULTS PA had a much higher rate of CS (81.6:18.3%)-ratio of the duration of hospitalization was 3.6:1, for test group, cost was 6.2 times higher. Deliveries were much shorter in test group, and consumption of blood derivates was 5.3 times higher. Control-neonates had higher Apgar score (8.34:6.71).Control group lost one neonate intrapartum-test had 4. Two postpartum hysterectomies in test-control group none.Average gestation: test 34 GW, control 35 weeks 3 days. CONCLUSIONS Test-much higher rate of previous miscarriages, renal failure, hypertension, gestational diabetes and anemia. Age-no influence. Placental insertion was mainly on the front wall-test, control-evenly spread. Previous uterine operations had 13(26.7%)-test,control-7(7,52%). Even though it makes 0.5% of all deliveries PA is the highest rate killer during delivery, pre or in term-Has to be always on our minds.
    Journal of Perinatology 01/2010; · 2.25 Impact Factor