Publications (2)3.24 Total impact
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Article: Gray matter deficits in young adults with narcolepsy.
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ABSTRACT: The aim of this study was to investigate gray matter volume changes in narcolepsy. An optimized voxel-based morphometry was conducted for 17 young adults with a sole diagnosis of human leukocyte antigen DQB(1) 0602 positive narcolepsy with cataplexy (26.6 +/- 5.2 years old) and 17 comparison subjects (24.6 +/- 4.9 years old) using 3 Tesla scanner. Gray matter volumes in the bilateral hypothalamic voxel of interests (VOI) were also calculated. Compared with the comparison subjects, narcoleptic patients had gray matter volume decrease in the right hypothalamus and other regions including subcortical, prefrontal, limbic and occipital areas. Narcoleptic patients also had lower gray matter volume on predefined VOI at the bilateral hypothalamus, which correlated with the Ullanlinna Narcolepsy Scale score. Current findings suggest that narcoleptic patients have structural abnormalities in hypothalamus, which might be related to the clinical manifestation of narcolepsy with cataplexy.Acta Neurologica Scandinavica 08/2008; 119(1):61-7. · 2.47 Impact Factor -
Article: Effect of microstructural variables on tensile behaviour of A356 cast aluminium alloy
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ABSTRACT: The effects of microstructural variables, including secondary dendrite arm spacing (SDAS), the size of primary α phase, the aspect ratio of eutectic Si particle and the thickness of eutectic wall structure, on tensile behaviour of A356 cast aluminium alloy, were quantitatively identified using linear regression analysis method. For systematic microstructural control of A356 specimen, directional solidification method was used with different solidification rates of 5, 25, 50 and 100 μm s−1 respectively. The linear regression analysis suggests that each microstructural variable affects tensile strength and tensile elongation of A356 cast aluminium alloy in a similar fashion. The change in tensile behaviour with varying microstructural variables in A356 cast aluminium alloy is discussed based on fractographic and micrographic observations.Materials Science and Technology 06/2007; 23(7):810-814. · 0.77 Impact Factor