Ricardo Palacios

Publications (4)23 Total impact

• Article: Anaphylaxis caused by hidden soybean allergens in pillows.

  Alicia Armentia, Fernando Pineda, Blanca Martín, Angel San Miguel, Francisco Javier Martín Gil, Yolanda Puente, Carlos de Lecea, Ricardo Palacios
  The Journal of allergy and clinical immunology 10/2012; · 9.17 Impact Factor
• Source

  Available from: InTech

  Chapter: Hypersensitivity Reaction to Generic Drug-Containing Soybean Oil

  Fernando Pineda, Alicia Armentia, Antonio Duen?as-Laita, Blanca Marti?n, Ricardo Palacios
  04/2011; , ISBN: 978-953-307-219-7
• Article: Sublingual immunotherapy for hazelnut food allergy: a follow-up study.

  Ernesto Enrique, Tamim Malek, Fernando Pineda, Ricardo Palacios, Joan Bartra, Raquel Tella, María Basagaña, Rosario Alonso, Anna Cisteró-Bahíma
  Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 04/2008; 100(3):283-4. · 2.83 Impact Factor
• Article: Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract.

  Ernesto Enrique, Fernando Pineda, Tamim Malek, Joan Bartra, María Basagaña, Raquel Tella, José Vicente Castelló, Rosario Alonso, José Antonio de Mateo, Teresa Cerdá-Trias, María del Mar San Miguel-Moncín, Susana Monzón, María García, Ricardo Palacios, Anna Cisteró-Bahíma
  [show abstract] [hide abstract]
  ABSTRACT: Food allergy may be life-threatening, and patients affected need to receive accurate diagnoses and treatment. Hazelnut has often been implicated as responsible for allergic reactions, and trace quantities can induce systemic reactions. The aim of this study was to evaluate the efficacy and tolerance of sublingual immunotherapy with a standardized hazelnut extract in patients allergic to hazelnut. This was a randomized, double-blind, placebo-controlled study. Inclusion criteria were a history of hazelnut allergy and positive skin prick test and double-blind placebo-controlled food challenge results. Patients were then randomly assigned into 2 treatment groups (hazelnut immunotherapy or placebo). Efficacy was assessed by double-blind, placebo-controlled food challenge after 8 to 12 weeks of treatment. Blood samples were drawn for measurement of specific IgE, IgG(4), and serum cytokines before and after treatment. Twenty-three patients were enrolled and divided into 2 treatment groups. Twenty-two patients reached the planned maximum dose at 4 days. Systemic reactions were observed in only 0.2% of the total doses administered. Mean hazelnut quantity provoking objective symptoms increased from 2.29 g to 11.56 g (P = .02; active group) versus 3.49 g to 4.14 g (placebo; NS). Moreover, almost 50% of patients who underwent active treatment reached the highest dose (20 g), but only 9% in the placebo. Laboratory data showed an increase in IgG(4) and IL-10 levels after immunotherapy in only the active group. Our data confirm significant increases in tolerance to hazelnut after sublingual immunotherapy as assessed by double-blind, placebo-controlled food challenge, and good tolerance to this treatment.
  Journal of Allergy and Clinical Immunology 12/2005; 116(5):1073-9. · 11.00 Impact Factor