Seon Young Choi,
Je Hee Lee,
Yoon-Seong Jeon,
Hye Ri Lee,
Eun Jin Kim,
M Ansaruzzaman,
Nurul A Bhuiyan,
Hubert P Endtz, S K Niyogi,
B L Sarkar,
G Balakrish Nair,
Binh Minh Nguyen,
Nguyen Tran Hien,
Cecil Czerkinsky,
John D Clemens,
Jongsik Chun,
Dong Wook Kim
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ABSTRACT: Atypical Vibrio cholerae O1 strains - hybrid strains (strains that cannot be classified either as El Tor or classical biotype) and altered strains (El Tor biotype strains that produce classical cholera toxin) - are currently prevalent in Asia and Africa. A total of 74 hybrid and altered strains that harboured classical cholera toxin were investigated by multilocus variable-number tandem repeat analysis (MLVA). The results showed that the hybrid/altered strains could be categorized into three groups and that they were distant from the El Tor strain responsible for the seventh cholera pandemic. Hybrid/altered strains with a tandem repeat of the classical CTX prophage on the small chromosome were divided into two MLVA groups (group I: Mozambique/Bangladesh group; group III: Vietnam group), and altered strains with the RS1-CTX prophage containing the El Tor type rstR and classical ctxB on the large chromosome were placed in two MLVA groups (group II: India/Bangladesh group; group III: India/Vietnam group).
Journal of Medical Microbiology 03/2010; 59(Pt 7):763-9. · 2.50 Impact Factor
