Romansky K

Publications (4)1.52 Total impact

• Source

  Available from: Emanuil Naydenov

  Article: Long-term survival with primary glioblastoma multiforme: a clinical study in Bulgarian patients

  Naydenov E, Tzekov Chr, Minkin K, Nachev S, Romansky K, Bussarsky V
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  ABSTRACT: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with an extremely poor prognosis in spite of multimodal treatment approaches. The estimated median survival in cases with GBM is about 12–16 months. Those patients who survive ≥3 years after the initial diagnosis are defined as long-term survivors. In this study, we retrospectively analyze 50 consecutive cases of Bulgarian patients with newly diagnosed GBM surgically treated at our institution for a period of 1 year. Four of them survived for more than 36 months after the initial intervention. The histological reexamination revealed features typical of primary GBM in 3 of these cases, which are described in detail in the present paper. A brief review of the relevant literature is also given.
  Case Reports in Oncology 01/2011;
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  Available from: Emanuil Naydenov

  Article: Clinical, histopathological and cytogenetical findings in six cases with primary glioblastoma multiforme.

  Naydenov E, Tzekov Chr, Minkin K, Hadjidekova S, Dimova I, Nachev S, Bussarsky V, Romansky K, Toncheva D.
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  ABSTRACT: INTRODUCTION: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. There is an increasing amount of data demonstrating that the routine histological examination has limited value to predict the tumor biological behaviour. AIM: To compare the clinical, histological and cytogenetical findings in a group of six patients with primary GBM surgically treated in the Department of Neurosurgery at University Hospital “St. Ivan Rilski”- Sofia, Bulgaria. MATERIAL AND METHODS: The studied group consisted of three women and three men with average age of 51 years and 6 months. In all patients the diagnosis was histologically confirmed. A microarray comparative genomic hybridization (CGH) analysis of fresh-frozen tumor tissue samples was also made. RESULTS: In two of the patients the tumor was localized in frontotemporal region, in another two- in frontoparietal, and in the other two- in parietal and occipital respectively. The onset was with headache in three of the cases. The median time between the onset and admission in the clinic was 70 days. Gross-total tumor removal was performed in one patient. In the other five subtotal excision was made. Three of the patients improved after the intervention. One patient deteriorated after the surgery. All patients demonstrated typical histological findings except one who had giant cell subtype of GBM. The microarray CGH analysis determined chromosome 10 monosomy in five patients, trisomy 7 – in four, trisomy 20 – in three, 3q23 deletion – in three, and Yp11.2 deletion – in three. CONCLUSION: GBMs are genetically heterogeneous tumors with different clinical response to standard multimodal treatment regimens. The microarray CGH analysis is a powerful method which can demonstrate the presence of a number of molecular markers with possible predictive value.
  Khirurgiia (Sofiia). 01/2009; 2-3:49-55.
• Source

  Available from: Emanuil Naydenov

  Article: Cerebellar gangliocytoma presenting with hemifacial spasms: clinical report, literature review and possible mechanisms.

  Minkin K, Tzekov Chr, Naydenov E, Ivanov I, Kalev O, Romansky K, Bussarsky V
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  ABSTRACT: Cerebellar lesions have classically been considered not to cause epilepsy. However, previous reports have attributed seizures, beginning as hemifacial spasms to lesions of the cerebellar peduncles. We report an example of paroxysmal facial contractions associated with a cerebellar gangliocytoma. The seizures began on the first day of life and consisted of paroxysmal contractions involving the left orbicularis oculi, often the left forehead and lower facial muscles, sometimes accompanied by nystagmoid eye movements to the right and by head deviation to the left. Video-EEG monitoring showed only artifacts from muscle contractions. Magnetic resonance imaging showed a mass arising from the left superior cerebellar peduncle and partially occupying the fourth ventricle. The lesion was removed subtotally and partial seizure control was achieved. The neuropathological findings were consistent with a gangliocytoma. The literature in the association of cerebellar lesions with hemifacial spasms is reviewed and its possible mechanisms discussed.
  Acta Neurochirurgica 01/2008; 150:719-724. · 1.52 Impact Factor
• Article: Clinical aspects of the arterial blood supply and venous drainage of the brain.

  Naydenov E, Papantchev V, Romansky K, Shotekov P, Ovtscharoff W.
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  ABSTRACT: Although the human brain makes up only 2 per cent of total body weight, it receives 15 to 20 per cent of cardiac output and accounts for 20 per cent of total body oxygen consumption under normal conditions. Cessation of blood flow results in rapid depletion of energy reserves which can produce ischemic neurological symptoms within seconds. In this paper the authors describe in details the arterial and venous part of the brain circulation as well as the clinical signs and symptoms in the cases with ischemia in them feeding areas.
  Praemedicus since 1925. 01/2005; 26:38-45.