Shlomo Berliner

Tel Aviv Sourasky Medical Center, Tell Afif, Tel Aviv, Israel

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Publications (361)1151.76 Total impact

  • O. Raz · O. Rogowski · T. Rosenzweig · I. Shapira · S. Berliner · M. Boaz
    Atherosclerosis 07/2015; 241(1):e193. DOI:10.1016/j.atherosclerosis.2015.04.942 · 3.99 Impact Factor
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    ABSTRACT: A single self-rated health (SRH) assessment is associated with clinical outcome and mortality, but the biological process linking SRH with immune status remains incompletely understood. To examine the association between SRH and inflammation in apparently healthy individuals. Our analysis included 13,773 apparently healthy individuals attending the Tel Aviv Sourasky Medical Center for periodic health examinations. Estimated marginal means of the inflammation-sensitive biomarkers [i.e., highly sensitive C-reactive protein (hs-CRP) and fibrinogen] for the different SRH groups were calculated and adjusted for multiple potential confounders including risk factors, health behavior, socioeconomic status, and coexistent depression. The group with the lowest SRH had a significantly higher atherothrombotic profile and significantly higher conentrations of all inflammation-sensitive biomarkers in both genders. Hs-CRP was found to differ significantly between SRH groups in both genders even after gradual adjustments for all potential confounders. Fibrinogen differs significantly according to SRH in males only, with low absolute value differences. A valid association exists for apparently healthy individuals of both genders between inflammation-sensitive biomarker levels and SRH categories, especially when comparing levels of hs-CRP. Our findings underscore the importance of assessing SRH and treating it like other markers of poor health.
    The Israel Medical Association journal: IMAJ 04/2015; 17(4):213-8. · 0.90 Impact Factor
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    ABSTRACT: Recent international terror outbreaks notably involve long-term mental health risks to the exposed population, but whether physical health risks are also anticipated has remained unknown. Here, we report fear of terror-induced annual increases in resting heart rate (pulse), a notable risk factor of all-cause mortality. Partial least squares analysis based on 325 measured parameters successfully predicted annual pulse increases, inverse to the expected age-related pulse decline, in approximately 4.1% of a cohort of 17,380 apparently healthy active Israeli adults. Nonbiased hierarchical regression analysis among 27 of those parameters identified pertinent fear of terror combined with the inflammatory biomarker C-reactive protein as prominent coregulators of the observed annual pulse increases. In comparison, basal pulse primarily depended on general physiological parameters and reduced cholinergic control over anxiety and inflammation, together indicating that consistent exposure to terror threats ignites fear-induced exacerbation of preexisting neuro-immune risks of all-cause mortality.
    Proceedings of the National Academy of Sciences 12/2014; 112(5). DOI:10.1073/pnas.1418264112 · 9.81 Impact Factor
  • Yaron Arbel · Shlomo Berliner · Shmuel Banai
    The Canadian journal of cardiology 12/2014; 31(3). DOI:10.1016/j.cjca.2014.12.005 · 3.94 Impact Factor
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    ABSTRACT: Past studies examining the effects of the metabolic syndrome (MS) on prognosis in postangiography patients were limited in size or were controversial in results. The aim of the study was to examine the association of the MS and the risk for long-term mortality in a large cohort of patients undergoing coronary angiography for various clinical indications. Medical history, physical examination, and laboratory values were used to diagnose patients with the MS. Cox regression models were used to analyze the effect of MS on long-term all-cause mortality. We prospectively recruited 3,525 consecutive patients with a mean age of 66 ± 22 years (range 24 to 97) and 72% men. Thirty percent of the cohort had MS. Patients with MS were more likely to have advanced coronary artery disease and acute coronary syndrome (p <0.001). Patients with MS had more abnormalities in their metabolic and inflammatory biomarkers regardless of their clinical presentation. A total of 495 deaths occurred during a mean follow-up period of 1,614 ± 709 days (median 1,780, interquartile range 1,030 to 2,178). MS was associated with an increased risk of death in the general cohort (hazard ratio [HR] 1.27, 95% confidence interval [CI] 1.01 to 1.56, p = 0.02). MS had a significant effect on mortality in stable patients (HR 1.55, 95% CI 1.1 to 2.18, p = 0.01), whereas it did not have a significant effect on mortality in patients with acute coronary syndrome (HR 1.11, 95% CI 0.86 to 1.44, p = 0.42). In conclusion, MS is associated with increased mortality in postangiography patients. Its adverse outcome is mainly seen in patients with stable angina. Copyright © 2014 Elsevier Inc. All rights reserved.
    The American Journal of Cardiology 11/2014; 115(3). DOI:10.1016/j.amjcard.2014.10.037 · 3.43 Impact Factor
  • O. Raz · O. Rogovsky · T. Rosenzweig · I. Shapira · S. Berliner
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    ABSTRACT: Background An increased serum glucose level in patients with acute coronary syndrome (ACS) is associated with adverse clinical outcome. This hyperglycemia has been attributed, at least in part, to acute stress reaction. Our objective was to determine whether hyperglycemia is a stress-related phenomenon or whether it represents a more sustained and possibly significant background dysglycemia.HypothesisHyperglycemia in patients undergoing coronary angiography is related to background dysglycemia.Methods Blood samples were obtained at the time of cardiac catheterization. Patients with hemoglobin A1c >6.5% were excluded to avoid patients with chronic glucose levels above 135 mg/dL. A logistic regression model was created to assess the influence of different variables on hyperglycemia (glucose levels above 140 mg/dL). We also evaluated the effect of glucose levels above 140 mg/dL on major adverse cardiovascular events (MACEs) up to 36 months.ResultsThere were 2554 consecutive patients prospectively recruited. Serum glucose levels above 140 mg/dL was a strong predictor of MACE (hazard ratio: 2.2, 95% confidence interval [CI]: 1.3-3.6, P = 0.002). Both diabetes mellitus and ACS were associated with hyperglycemia (glucose levels above 140 mg/dL). Nevertheless, the incidence of hyperglycemia was doubled in diabetic patients (odds ratio [OR]: 9.4, 95% CI: 3.9-22.4, P < 0.001) compared with patients with ACS (OR: 4.6, 95% CI: 2.3-9.0, P < 0.001). Combining both conditions was associated with a high likelihood of elevated glucose levels (OR: 15.5, 95% CI: 7.4-32.9, P < 0.001).Conclusions Hyperglycemia in patients undergoing cardiac catheterization is a strong predictor of adverse outcome. It is mainly related to background dysglycemia and to a lesser extent to the acute stress accompanying ACS.
    Clinical Cardiology 08/2014; 37(8). DOI:10.1002/clc.22290 · 2.23 Impact Factor
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    ABSTRACT: Introduction High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoing primary angioplasty (PPCI). Material and methods A cohort of 535 STEMI patients undergoing PPCI were divided into two groups (RDW > 14%, RDW ≤ 14%) using CHAID and CART methods. The association between RDW and 5-year all-cause mortality was assessed using Cox’s proportional hazards analysis. Results A total of 37 patients died during follow up of 5 years (mean: 1059, median: 1013, range 2–2130 days). RDW > 14% was associated with increased risk of all-cause mortality (HR = 5, CI 95% 2.7– 9.9, p < 0.001). In multivariate analysis, RDW > 14 remained significantly associated with increased risk for all-cause mortality (HR = 3.8, CI 95% 1.8– 7.99, p < 0.001). Patients with RDW above 14% did not have lower ejection fraction, higher CPK or more conventional risk factors. Conclusion RDW value above 14 is independently associated with increased long term all-cause mortality in patients with STEMI undergoing PPCI.
    Thrombosis Research 08/2014; 134(5). DOI:10.1016/j.thromres.2014.08.016 · 2.43 Impact Factor
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    ABSTRACT: Background Sub-clinical systemic inflammation has been implicated in the pathophysiology of obesity. In addition to impacting body weight, dietary modification may modulate markers of inflammation. Methods Overweight/obese adults were recruited to an eight-week dietary intervention characterized by energy restriction and increased complex carbohydrate intake. Blood samples for inflammatory and metabolic markers as well as anthropometric measurements were taken before and following the intervention. Results The study included 72 overweight or obese participants (BMI 31.8±5.8 kg/m2). Significant reductions from baseline weight, BMI, waist and hip circumference were observed following dietary intervention. Levels of inflammatory markers hs-CRP, ESR, WBC, and ICAM decreased significantly from baseline following the 8-week intervention. Metabolic measures including serum triglycerides, total and low density lipoprotein cholesterol significantly declined from baseline. Insulin and HOMA-IR declined in the subgroup of hyperinsulinemic participants. Conclusion An energy-restricted diet rich in complex carbohydrates is associated with weight loss, reduction of inflammatory markers and improved metabolic profile.
    Bioactive Carbohydrates and Dietary Fibre 07/2014; 4(1). DOI:10.1016/j.bcdf.2014.07.001
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    ABSTRACT: Background: Neutrophil/lymphocyte ratio (NLR) is a novel biomarker that can single out individuals at risk for vascular events. We assessed whether NLR provides additive prognostic value in patients with ST-elevation myocardial infarction (STEMI). Methods: NLR was computed from the absolute values of neutrophils and lymphocytes from the complete blood count of patients who underwent primary coronary angioplasty for STEMI. The cohort was divided into 2 groups according to NLR (NLR >= 6.5%, NLR < 6.5%) using chi(2) automatic interaction detection. The association between NLR and in-hospital clinical complications and left ventricular ejection fraction (EF) was assessed using logistic regression. The association between NLR, 30-day and 5-year all-cause mortality were analyzed using Cox regression models, adjusting for potential clinical, metabolic, and inflammatory confounders. Results: In a group of 538 consecutive STEMI patients, high NLR (NLR >= 6.5%) was independently associated with increased 30-day and 5-years mortality rates (odds ratio, 15.8; 95% confidence interval, 1.6-154; P = 0.018; and hazard ratio, 2.2; 95% confidence interval, 1.04-4.8; P = 0.039, respectively). High NLR was also independently associated with lower EF (49 +/- 8 vs 46 +/- 8; P < 0.001) and fewer hospital complications. Conclusions: In patients presenting with STEMI, high NLR was independently associated with lower EF, fewer hospital complications, and higher mortality rates up to 5 years. NLR value appears additive to conventional risk factors and commonly used biomarkers.
    The Canadian journal of cardiology 05/2014; 30(10). DOI:10.1016/j.cjca.2014.05.010 · 3.94 Impact Factor
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    Journal of the American College of Cardiology 04/2014; 63(12):A1703. DOI:10.1016/S0735-1097(14)61706-X · 15.34 Impact Factor
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    ABSTRACT: Background Neutrophil/lymphocyte ratio (NLR) is a novel biomarker that can single out individuals at risk for vascular events. We assessed whether NLR provides additive prognostic value in patients with ST elevation myocardial infarction (STEMI). Materials and methods NLR was computed from the absolute values of neutrophils and lymphocytes from the complete blood count of patients undergoing primary coronary angioplasty for STEMI. The cohort was divided into 2 groups according to NLR (NLR ≥6.5%, NLR<6.5%) using CHAID and CART methods. The association between NLR and in-hospital clinical complications and left ventricular ejection fraction (EF) was assessed by logistic regression. The association between NLR, 30 days and 5-year all-cause mortality were analyzed using Cox regression models, adjusting for potential clinical, metabolic, and inflammatory confounders. Results In a group of 538 consecutive STEMI patients, high NLR (NLR ≥6.5%) was independently associated with increased 30-day and 5-years mortality rates (OR= 15.8, CI 95% 1.6 – 154, p=0.018, and HR=2.2, CI 95% 1.04-4.8, p=0.039, respectively). High NLR was also independently associated with lower EF (49 ± 8 vs. 46 ± 8, p<0.001) and in hospital complications. Conclusion In patients presenting with STEMI, high neutrophil/lymphocyte ratio is independently associated with lower EF, in hospital complications, and higher mortality rates up to 5 years. NLR value appears additive to conventional risk factors and commonly used biomarkers.
    The Canadian journal of cardiology 04/2014; 63(12). DOI:10.1016/S0735-1097(14)60162-5 · 3.94 Impact Factor
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    ABSTRACT: Background The “Slow Coronary Flow” (SCF) phenomenon in the presence of angiographically normal coronaries is attributed to microvascular and endothelial dysfunction. The microcirculation can be non-invasively assessed by measuring retinal blood flow velocity. The aim of the present study was to evaluate the efficacy of the “Retinal Functional Imager” (RFI) device as a noninvasive method of diagnosing patients with slow coronary flow. Methods Coronary blood flow velocity assessed by corrected TIMI Frame Count and retinal arterioles blood flow assessed by RFI were measured in 28 consecutive patients with normal coronary arteries. The patients were divided into 2 groups: a slow coronary flow (SCF) and a normal coronary flow (NCF) groups. Results Inverse correlation was found between retinal and coronary blood flows so that higher retinal arterial flow velocity was observed in the SCF group (3.8 ± 1.1 mm/s vs. 2.9 ± 0.61 mm/s, respectively, p = 0.022). RFI provided 73% sensitivity and 77% specificity for diagnosing SCF using ROC analysis. Additionally, patients with SCF had higher values of serum LDL cholesterol (104.7 ± 18.93 mg/dl vs. 81.55 ± 14.62 mg/dl in NCF, p = 0.005), Glucose (96.9 ± 23.0 mg/dl vs. 83.55 ± 9.7 mg/dl in NCF, p = 0.024), and lower percentage of statin consumption (40.0% vs. 76.9% in NCF, p = 0.049). Conclusions Slow coronary blood flow can be non-invasively diagnosed with Retinal Functional Imager. Patients with normal coronary arteries and slow coronary blood flow have high retinal arteriolar blood flow. Early non-invasive diagnosis of SCF might help detect individuals who are at higher risk to develop coronary atherosclerosis, and to provide them with early preventive measures.
    Atherosclerosis 01/2014; 232(1):149–154. DOI:10.1016/j.atherosclerosis.2013.10.033 · 3.97 Impact Factor
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    ABSTRACT: The phenomenon of slow coronary flow (SCF) in the presence of normal coronary arteries may indicate endothelial dysfunction, which is characteristic of an early stage in the development of atherosclerosis. Measurement of the Carotid Intima-Media Thickness (CIMT) allows identification of early stages of atherosclerosis. CIMT might offer a non-invasive method of diagnosing SCF patients. Previous studies demonstrated conflicting results regarding the relationship between these two phenomena. In the present study, we examined the association between coronary flow velocity and the degree of CIMT in patients with angiographically normal coronary arteries. Coronary arterial blood flow velocity was measured using two methods - Corrected Thrombolysis in Myocardial Infarction (TIMI) Frame Count (CTFC) and Coronary Clearance Frame Count (CCFC). In addition, we measured the level of the CIMT using a special automated computerized software. Seventy Five consecutive patients were prospectively recruited. No correlation was found between CIMT and mean CTFC (r = -0.08, p = NS) or mean CCFC (r = -0.07, p = NS). In addition, CIMT values did not differ between the SCF and the Normal coronary flow (NCF) groups (0.796 mm vs. 0.805 mm, respectively, p = 0.733). Patients with SCF had higher levels of hematocrit (39.9% vs. 36.1%, p < 0.001), LDL cholesterol (101.1 mg/dl vs. 85.8 mg/dl, p = 0.01) and higher rate of current smokers (28.9% vs. 10.8%, p = 0.05). Patients with angiographically normal coronary arteries and SCF do not have increased CIMT values. However, current smoking, higher LDL cholesterol and hematocrit levels are all related to slower coronary blood flow.
    Clinical hemorheology and microcirculation 01/2014; 56(4). DOI:10.3233/CH-141808 · 2.22 Impact Factor
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    ABSTRACT: Parasympathetic activity influences long-term outcome in patients with cardiovascular disease, but the underlying mechanism(s) linking between parasympathetic activity and the occurrence of major adverse cardiovascular events (MACE) are incompletely understood. The aim of this pilot study was to evaluate the association between serum cholinesterase activities as parasympathetic biomarkers and the risk for the occurrence of MACE. Cholinergic Status (CS) was determined by measuring the cumulative capacity of serum Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) to hydrolyze the selective AChE substrate acetylthiocholine. CS was evaluated in randomly selected patients undergoing cardiac catheterization. The patients were divided into 2 groups of 100 patients in each group, with or without occurrence of MACE during a follow up period of 40 months. Cox regression models adjusted for potential clinical, metabolic, and inflammatory confounders served to evaluate association with clinical outcome. We found that patients with MACE presented lower CS and AChE values at catheterization (1127±422, 359±153 nmol substrate hydrolyzed/min*ml) than no-MACE patients (1760±546, 508±183, p<0.001, p<0.001) whose levels were comparable to those of matched healthy controls (1622±303, 504±126). In multivariate analysis, patients with AChE or total CS values below median showed conspicuously elevated risk for MACE (HR=1.85 (CI 95% 1.09-3.15, p=0.02) and 2.21 (CI 95% 1.22-4.00, p=0.009)) compared to those above median, even after adjusting for potential confounders. We conclude that parasympathetic dysfunction expressed as decreased serum AChE and BChE activities, together constituting CS decline and predicting up to 40 months MACE. Monitoring these parasympathetic parameters might help in the risk stratification of patients with cardiovascular disease.
    Molecular Medicine 12/2013; 20(1). DOI:10.2119/molmed.2013.00139 · 4.82 Impact Factor
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    ABSTRACT: Pre-diabetic state is a major risk factor for the development of diabetes and cardiovascular events. Admission glucose, fasting glucose and HbA1c levels have an effect on prognosis in patients with pre-diabetes and in non-diabetic individuals. The aim of the present study was to investigate which of the following glucometabolic markers (admission glucose, fasting glucose and HbA1c levels) is correlated with the severity of coronary artery disease (CAD) in non-diabetic patients. CAD severity according to SYNTAX score was prospectively evaluated in 226 non-diabetic patients hospitalized with myocardial infarction or stable angina and underwent coronary angiography. Glucose intolerance was assessed by serum admission glucose, fasting glucose and HbA1c levels. Logistic regression analysis was used to evaluate which glucometabolic factor has the strongest correlation with CAD severity. HbA1c was the only glucometabolic factor associated with SYNTAX score above 22 (OR = 3.03, CI 95 % 1.03-8.9, p = 0.04). HbA1c was also significantly associated with CAD severity in subgroup analysis (MI and stable angina). In non-diabetic patients with myocardial infarction or stable angina, HbA1c levels correlate with CAD severity as measured by the SYNTAX score. No correlation was found between admission glucose or fasting glucose levels and CAD severity.
    Clinical Research in Cardiology 11/2013; 103(3). DOI:10.1007/s00392-013-0641-7 · 4.56 Impact Factor
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    ABSTRACT: Accumulating evidence suggests parasympathetic dysfunction and elevated inflammation as underlying processes in multiple peripheral and neurological diseases. Acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (AChE and BChE, respectively), which are also expressed in the serum. Here, we consider the potential value of both enzymes as possible biomarkers in diseases associated with parasympathetic malfunctioning. We cover the modulations of cholinesterase activities in inflammation-related events as well as by cholinesterase-targeted microRNAs. We further discuss epigenetic control over cholinesterase gene expression and the impact of single-nucleotide polymorphisms on the corresponding physiological and pathological processes. In particular, we focus on measurements of circulation cholinesterases as a readily quantifiable readout for changes in the sympathetic/parasympathetic balance and the implications of changes in this readout in health and disease. Taken together, this cumulative know-how calls for expanding the use of cholinesterase activity measurements for both basic research and as a clinical assessment tool.
    Journal of Molecular Neuroscience 11/2013; 53(3). DOI:10.1007/s12031-013-0176-4 · 2.76 Impact Factor
  • Galit Armon · Samuel Melamed · Shlomo Berliner · Itzhak Shapira
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    ABSTRACT: Basal cardiovascular activity may be modulated by positive affect activation levels. In the current study, it was hypothesized that work-related high arousal positive affect (HAPA) will have a U-shaped association with basal cardiovascular activity and low or un-aroused positive affect (LAPA) will be negatively associated with basal cardiovascular activity. Participants were 1807, apparently, healthy adults. HAPA and LAPA were assessed with the Job-related Affective Well-being Scale. Outcome measures were resting heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP) levels. Results for HAPA supported the hypothesized relationships, such that HR and SBP were lower when HAPA was at moderate levels, but higher when HAPA was at high or low levels. LAPA was negatively associated with SBP and DBP. Our findings suggest that HAPA and LAPA have differential consequences regarding cardiovascular function.
    The Journal of Positive Psychology 11/2013; 9(2):146-154. DOI:10.1080/17439760.2013.848375 · 1.67 Impact Factor
  • Y Arbel · D Weitzman · R Raz · A Steinvil · D Zeltser · S Berliner · G Chodick · V Shalev
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    ABSTRACT: Introduction: Red blood cell distribution width (RDW) has been shown to predict cardiovascular mortality in various populations, but studies were less conclusive regarding cardiovascular morbidity. We aimed at evaluating the prognostic effect of RDW on cardiovascular morbidity and all-cause mortality in the largest community cohort to date. Methods: We utilized the computerized database of a large community based healthcare maintenance organization (HMO)in Israel to identify a cohort of 254,473 eligible patients aged 40 or above that performed a blood count during 2006. We evaluated the relationship of RDW values for major adverse cardiac events (MACE) and all-cause mortality over a period of 5 years. Results: During a total of 1.4 million person-years, a total of 23,949 incident cases of MACE and 5236 deaths were documented In a multivariable model, a positive dose response relationship between RDW level and all caused mortality or MACE was found. Compared to patients with a RDW of 12% or lower, patients with RDW>17% had a hazard ratio of 8.2 (95% CI: 4.4-15.2, P<0.001) for all-cause mortality and 1.32 (95% CI: 1.09-1.64, p<0.001) for MACE.
    Thrombosis and Haemostasis 10/2013; 111(2). DOI:10.1160/TH13-07-0567 · 5.76 Impact Factor
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    ABSTRACT: Anemia on admission and during hospitalization is associated with poor short and long term prognosis among patients with acute coronary syndrome (ACS). Our objective was to examine the prognostic implications of longitudinal hemoglobin (Hb) levels following a first acute myocardial infarction (AMI). We utilized data obtained from the computerized database of a large community based health care maintenance organization to identify patients who survived for at least 6months following a first AMI, during the years 2003-2010. Hazard ratios were calculated using Cox proportional regression models with various Hb measurements as dependent variables, and net reclassification improvement (NRI) was applied to evaluate the prognostic usefulness of these Hb measurements. Last Hb measurement during a 6-24month follow-up period was found to have the highest prognostic power. In males, Hb levels below 13g/dL were gradually associated with a higher risk of events, reaching a HR of 4.13 at Hb levels <11g/dL. In females, only Hb levels lower than 11g/dL were significantly associated with a higher event rate (HR=2.42, p=0.003). Hb decrease was significantly associated with an increased risk in both genders, even among non-anemic patients at baseline. Anemia and Hb decrement following a first AMI are associated with worse prognosis and elevated risk of combined all cause mortality and recurrent cardiac events.
    International journal of cardiology 10/2013; 169(5). DOI:10.1016/j.ijcard.2013.09.004 · 6.18 Impact Factor

Publication Stats

4k Citations
1,151.76 Total Impact Points

Institutions

  • 1992–2014
    • Tel Aviv Sourasky Medical Center
      • Division of Internal Medicine
      Tell Afif, Tel Aviv, Israel
  • 1981–2014
    • Tel Aviv University
      • • Department of Internal Medicine
      • • Sackler Faculty of Medicine
      • • Department of Ophthalmology
      • • Department of Pathology
      Tell Afif, Tel Aviv, Israel
  • 2007
    • Università di Pisa
      Pisa, Tuscany, Italy
  • 2004
    • Shaare Zedek Medical Center
      • Department of Pediatrics
      Jerusalem, Jerusalem District, Israel
  • 2002
    • Hebrew University of Jerusalem
      • Department of Pediatrics
      Yerushalayim, Jerusalem, Israel