Raina Shah

South Tees Hospitals NHS Foundation Trust, Middlesborough, England, United Kingdom

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Publications (2)3.6 Total impact

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    ABSTRACT: Comorbidity has been shown to be a determinant in treatment selection and survival in squamous cell cancer of the head and neck at various subsites. The objective of this study is to analyse the effect of comorbidity burden on outcome of nasopharyngeal cancer using the Adult Comorbidity Evaluation-27 (ACE-27) instrument. Retrospective analysis. Tertiary care centres. This study included 59 patients diagnosed with nasopharyngeal carcinoma between 1989-2003 in the North-East of England. Exclusion criteria included non-squamous neoplasms of the nasopharynx. Comorbidity was assessed retrospectively from the notes using standard validated techniques described earlier. Tumour, treatment and survival data were obtained from prospective databases. Data was analysed using SPSS for Windows. Comorbidity and outcome of treatment. Comorbid burden was evident in 44% of patients, with moderate or severe comorbidity in 19%. The cardiovascular system was the most commonly affected system (27%). Cox's proportional hazard model showed age and stage of tumour to have an impact on disease specific survival. Comorbidity was not seen to predict the outcome independent of other factors. The sample size of this study is powered to detect only medium to large effects. We estimate that 614 subjects will be needed to detect a correlation coefficient of 0.1 with 80% power, assuming a type 1 error rate of 5%. This study shows for the first time that the comorbidity burden seen in nasopharyngeal cancer does not affect prognosis independent of the TNM staging.
    Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 01/2008; 32(6):484-8. · 1.87 Impact Factor
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    ABSTRACT: The aim of this study was to assess the quality of life and psychologic profile during radiation therapy for head and neck cancer. The University of Washington QoL instrument and the Hospital Anxiety and Depression Scale were administered to 202 patients at two or three time points during radiation therapy. A total of 118 (54.6%) patients completed the questionnaires at the beginning and at the end of the study. A mid-treatment dataset was also available for 67 (31.0%) patients. There was a statistically significant deterioration in composite QoL scores (P < 0.000) and a statistically significant increase in depression (P < 0.000). There was no difference in anxiety levels (P = 0.276). Patients undergoing radiation are increasingly depressed as treatment progresses, with worsening QoL during the treatment. This study underlines the need for good psychologic support during radiation therapy in head and neck cancer.
    Otolaryngology Head and Neck Surgery 01/2007; 136(1):108-11. · 1.73 Impact Factor

Publication Stats

35 Citations
3.60 Total Impact Points


  • 2008
    • South Tees Hospitals NHS Foundation Trust
      Middlesborough, England, United Kingdom
  • 2007
    • The Newcastle upon Tyne Hospitals NHS Foundation Trust
      Newcastle-on-Tyne, England, United Kingdom
    • Newcastle University
      Newcastle-on-Tyne, England, United Kingdom