Publications (2)1.37 Total impact
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ABSTRACT: To observe the effects of angiotensin II receptor antagonist losartan in experimental glomerulosclerosis. The 5/6 nephrectomized rats were randomly divided into losartan treatment group and control group, the rats with sham operation served as normal control. Urine proteins were measured in the 2nd, 4th and 6th week after operation, and serum BUN, creatinine, total protein and albumin were measured in the 6th week following operation. Renal pathologic changes were evaluated in the 6th week. Losartan not only reduced urine protein, serum creatinine and BUN(P < 0.01), but also significantly ameliorated glomerular mesangial proliferation and glomerular sclerosis. The results suggest that losartan can retard progression of glomerulosclerosis in 5/6 nephrectomized rats.Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 11/2000; 25(5):467-70.
Article: Nephrotoxicity of high- and low-osmolar contrast media. The protective role of amlodipine in a rat model.[show abstract] [hide abstract]
ABSTRACT: To evaluate the nephrotoxicity of high- and low-osmolar contrast media (HOCM, LOCM) on kidneys in Sprague-Dawley rats. The protective role of amlodipine was studied. Forty rats of both sexes were randomly divided into 5 groups (n=8/group) and glycerine for inducing renal failure was given to all rats except controls. In diatrizoate-injected rats, blood urea nitrogen (BUN) and serum creatinine (SCr) were increased; levels of phospholipase A2 (PLA2), lipid peroxide (LPO) and calcium were also increased in renal tissues. There was no significant difference between LOCM (iohexol) animals and glycerol controls either in the renal levels of PLA2, LPO and calcium or in the levels of BUN and SCr. The histologic changes were milder in the LOCM animals than in the HOCM animals. In the group pretreated with amlodipine, no increase in the levels of BUN or SCr was discovered and the renal content of PLA2, LPO and calcium were significantly lower than in the HOCM group; the renal injuries induced by diatrizoate were alleviated. The HOCM, diatrizoate, was more toxic to rat kidneys than the LOCM iohexol; PLA2, LPO and calcium load played a role in producing renal function impairment induced by diatrizoate meglumine; amlodipine protected the renal tissue from nephrotoxicity induced by diatrizoate.Acta Radiologica 10/2000; 41(5):503-7. · 1.37 Impact Factor