Qi-Ming Zhou

Publications (3)9.72 Total impact

• Article: The absence of the ERBB4 hot-spot mutations in melanomas in patients from southern China.

  Qi-Ming Zhou, Wei Li, Yuan-Xiang Guan, Xing Zhang, Xin-Chun Chen, Ya Ding, Xi-Zhi Wen, Rui-Qing Peng, Shu-Mei Yan, Xiao-Shi Zhang
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  ABSTRACT: It has been reported that v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) is somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 archival formalin-fixed and paraffin-embedded melanoma samples from the Sun Yat-Sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hot-spot mutations were detected in our study. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, the targeting of the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
  Chinese journal of cancer 12/2012;
• Article: The mutation profiles of common oncogenes involved in melanoma in southern China.

  Qi-Ming Zhou, Wei Li, Xing Zhang, Yin-Bo Chen, Xin-Chun Chen, Yuan-Xiang Guan, Ya Ding, Xi-Zhi Wen, Qing Xia, Qiang Zhou, Rui-Qing Peng, Jin-Hui Hou, Xiao-Feng Zhu, Yi-Xin Zeng, Xiao-Shi Zhang
  Journal of Investigative Dermatology 03/2012; 132(7):1935-7. · 6.31 Impact Factor
• Source

  Available from: PubMed Central

  Article: The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer.

  Qiang Zhou, Rui-Qing Peng, Xiao-Jun Wu, Qing Xia, Jing-Hui Hou, Ya Ding, Qi-Ming Zhou, Xing Zhang, Zhi-Zhong Pang, De-Sen Wan, Yi-Xin Zeng, Xiao-Shi Zhang
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  ABSTRACT: Although an abundance of evidence has indicated that tumor-associated macrophages (TAMs) are associated with a favorable prognosis in patients with colon cancer, it is still unknown how TAMs exert a protective effect. This study examined whether TAMs are involved in hepatic metastasis of colon cancer. One hundred and sixty cases of pathologically-confirmed specimens were obtained from colon carcinoma patients with TNM stage IIIB and IV between January 1997 and July 2004 at the Cancer Center of Sun Yat-Sen University. The density of macrophages in the invasive front (CD68TFHotspot) was scored with an immunohistochemical assay. The relationship between the CD68TFHotspot and the clinicopathologic parameters, the potential of hepatic metastasis, and the 5-year survival rate were analyzed. TAMs were associated with the incidence of hepatic metastasis and the 5-year survival rate in patients with colon cancers. Both univariate and multivariate analyses revealed that the CD68TFHotspot was independently prognostic of survival. A higher 5-year survival rate among patients with stage IIIB after radical resection occurred in patients with a higher macrophage infiltration in the invasive front (81.0%) than in those with a lower macrophage infiltration (48.6%). Most importantly, the CD68TFHotspot was associated with both the potential of hepatic metastasis and the interval between colon resection and the occurrence of hepatic metastasis. This study showed evidence that TAMs infiltrated in the invasive front are associated with improvement in both hepatic metastasis and overall survival in colon cancer, implying that TAMs have protective potential in colon cancers and might serve as a novel therapeutic target.
  Journal of Translational Medicine 02/2010; 8:13. · 3.41 Impact Factor