Ping Wang

Publications (67)90.36 Total impact

• Article: Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index - CORRIGENDUM.

  Ping Wang, Claus Holst, Arne Astrup, Freek G Bouwman, Sanne van Otterdijk, Will K W H Wodzig, Malene R Andersen, Marleen A van Baak, Lone G Rasmussen, J Alfredo Martinez, Susan A Jebb, Andreas F H Pfeiffer, Anthony Kafatos, Teodora Handjieva-Darlenska, Petr Hlavaty, Wim H M Saris, Edwin C M Mariman
  The British journal of nutrition 02/2013; · 3.45 Impact Factor
• Source

  Available from: Ernest R Smith

  Article: Evaluation of the CERC Formula Using Large-Scale Model Data

  Ernest R. Smith, Ping Wang, Jun Zhang
  [show abstract] [hide abstract]
  ABSTRACT: Longshore transport experiments were conducted in a large-scale physical model to evaluate predictions of the CERC formula with measured longshore sediment transport rates. It was found that the CERC formula produced reasonable estimates if the coefficient K was calibrated and applied to waves with similar breaker type. The calibrated K values are much smaller than values that are commonly used, and there appears to be a strong dependency of transport rate on breaker type. Additional comparisons were made with the formula proposed by Kamphuis (1991). The Kamphuis equation, which includes wave period, a factor that influences breaking, gave good estimates. Examination of the cross-shore distribution of longshore sediment transport indicates that there are three distinct zones of transport: the incipient breaker zone, the inner surf zone, and the swash zone, with each zone contributing a different fraction to the total transport rate. Transport in the incipient breaker zone was influenced by breaker type, transport in the inner surf zone was controlled by depth, and transport in the swash zone showed dependencies on wave height and, in particular, wave period. Swash zone transport was found to have a significant contribution to the total transport rate. (7 figures, 24 refs.)
  11/2012;
• Source

  Available from: Ernest R Smith

  Article: Longshore Sediment Transport as a Function of Energy Dissipation

  Ernest R. Smith, Ping Wang
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  ABSTRACT: Experiments to measure waves, currents, and sediment transport rate for two breaker types, plunging and spilling, were conducted in a large-scale three-dimensional physical model. It was found that there was a large difference in cross-shore distribution and total sediment transport rate between the two breaker types. Total transport rates compared to existing predictive equations. The equations generally did not predict the data well. With the exception of the Kamphuis (1991) equation, which included a dependence on wave period, the predictive equations did not differentiate between breaker types.
  11/2012;
• Article: Influences of Channel Dredging on Flow and Sedimentation Patterns at Microtidal Inlets, West-Central Florida, USA

  Tanya M. Beck, Ping Wang
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  ABSTRACT: Four inlets (Johns Pass and Blind Pass; and New Pass and Big Sarasota Pass) in two multi-inlet systems along the West-central Florida coast were studied. Johns Pass, New Pass, and Blind Pass are dredged every 4-9 years, whereas Big Sarasota Pass has never been dredged. The goal of this study was to investigate the morphodynamics of the four inlets and the influences of channel dredging on the flow patterns over the ebb tidal delta and sediment bypassing. Time-series aerial photographs and bathymetric maps starting from the 1920s were analyzed to assess the pathways of sand bypassing and morphodynamics at the inlets. The Coastal Modeling System (CMS), computing wave, current, sediment transport, and morphology change of tidal inlets, was applied and reproduced the observed medium-term morphology changes. CMS is then used to investigate influences of channel dredging on inlet morphodynamics.
  11/2012;
• Article: Construct validation of patient global impression of severity (PGI-S) and improvement (PGI-I) questionnaires in the treatment of men with lower urinary tract symptoms secondary to benign prostatic hyperplasia.

  Lars Viktrup, Risa P Hayes, Ping Wang, Wei Shen
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  ABSTRACT: BACKGROUND: Lower urinary tract symptoms (LUTS) in aging men are often associated with benign prostatic hyperplasia (BPH). While regulatory evaluations of treatment benefit require an assessment of specific symptoms, a simpler approach to measuring patients' perceptions of severity and symptom change may be particularly useful for clinical practice. The aim of this study was to provide evidence of the validity of the 1-item Patient Global Impression of Severity (PGI-S) and Improvement (PGI-I) questionnaires for use as outcome measures in the treatment of BPH-LUTS. METHODS: This was a secondary analysis of data from 4 randomized placebo-controlled 12-week trials evaluating tadalafil for the treatment of BPH-LUTS (N=1694). Visit 2 (V2 [beginning of a 4-week placebo lead-in period]) and endpoint assessments included International Prostate Symptom Score (IPSS), IPSS Quality of Life Index (IPSS-QoL), BPH Impact Index (BII), and peak urine flow (Qmax). PGI-S was only administered at V2 and PGI-I only at endpoint. Associations between the PGI-S or the PGI-I and the other assessments were analyzed by calculating Spearman rank correlation coefficients and performing analysis of variance (ANOVA). RESULTS: Spearman correlation coefficients were 0.43, 0.43, 0.53, and -0.09, between the PGI-S and IPSS, IPSS-QoL, BII, and Qmax baseline results (all P<0.001). Similar results were seen across race, ethnicity, and baseline severity (moderate LUTS versus severe LUTS). IPSS, IPSS-QoL, BII baseline scores (P <0.001) and Qmax values (P=0.003) were significantly different among the 4 PGI-S severity levels. Spearman correlation coefficients were 0.56, 0.53, 0.47 and -0.15 between the PGI-I and change in IPSS, IPSS-QoL, BII scores, and Qmax values from baseline to endpoint (all P<0.001). Similar results were seen across race, ethnicity, and baseline severity. Change in IPSS, IPSS-QoL, BII scores, and Qmax values (P<0.001) were significantly different among the PGI-I levels (i.e., patient perception of change in urinary symptoms). CONCLUSIONS: This study demonstrated patients' overall perceptions of their severity and change in BPH-LUTS can be captured in a way that is simple, valid, and easily administered in a research setting or clinical practice. Clinical parameters are weakly associated with patients' perception of urinary symptoms, emphasizing the importance of a patient-reported assessment in the evaluation of BPH-LUTS treatment benefit.
  BMC Urology 11/2012; 12(1):30. · 1.45 Impact Factor
• Article: Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans.

  Xuying Wang, Ping Wang, Sheng Sun, Sabrina Darwiche, Alexander Idnurm, Joseph Heitman
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  ABSTRACT: Introduction of DNA sequences into the genome often results in homology-dependent gene silencing in organisms as diverse as plants, fungi, flies, nematodes, and mammals. We previously showed in Cryptococcus neoformans that a repeat transgene array can induce gene silencing at a high frequency during mating (∼50%), but at a much lower frequency during vegetative growth (∼0.2%). Here we report a robust asexual co-suppression phenomenon triggered by the introduction of a cpa1::ADE2 transgene. Multiple copies of the cpa1::ADE2 transgene were ectopically integrated into the genome, leading to silencing of the endogenous CPA1 and CPA2 genes encoding the cyclosporine A target protein cyclophilin A. Given that CPA1-derived antisense siRNAs were detected in the silenced isolates, and that RNAi components (Rdp1, Ago1, and Dcr2) are required for silencing, we hypothesize that an RNAi pathway is involved, in which siRNAs function as trans factors to silence both the CPA1 and the CPA2 genes. The silencing efficiency of the CPA1 and CPA2 genes is correlated with the transgene copy number and reached ∼90% in the presence of >25 copies of the transgene. We term this transgene silencing phenomenon asexual co-suppression to distinguish it from the related sex-induced silencing (SIS) process. We further show that replication protein A (RPA), a single-stranded DNA binding complex, is required for transgene silencing, suggesting that RPA might play a similar role in aberrant RNA production as observed for quelling in Neurospora crassa. Interestingly, we also observed that silencing of the ADE2 gene occurred at a much lower frequency than the CPA1/2 genes even though it is present in the same transgene array, suggesting that factors in addition to copy number influence silencing. Taken together, our results illustrate that a transgene induced co-suppression process operates during C. neoformans vegetative growth that shares mechanistic features with quelling.
  PLoS Genetics 08/2012; 8(8):e1002885. · 8.69 Impact Factor
• Source

  Available from: PubMed Central

  Article: Joint modeling of longitudinal outcomes and survival using latent growth modeling approach in a mesothelioma trial.

  Ping Wang, Wei Shen, Mark Ernest Boye
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  ABSTRACT: Joint modeling of longitudinal and survival data can provide more efficient and less biased estimates of treatment effects through accounting for the associations between these two data types. Sponsors of oncology clinical trials routinely and increasingly include patient-reported outcome (PRO) instruments to evaluate the effect of treatment on symptoms, functioning, and quality of life. Known publications of these trials typically do not include jointly modeled analyses and results. We formulated several joint models based on a latent growth model for longitudinal PRO data and a Cox proportional hazards model for survival data. The longitudinal and survival components were linked through either a latent growth trajectory or shared random effects. We applied these models to data from a randomized phase III oncology clinical trial in mesothelioma. We compared the results derived under different model specifications and showed that the use of joint modeling may result in improved estimates of the overall treatment effect.
  Health Services and Outcomes Research Methodology 06/2012; 12(2-3):182-199.
• Article: [Expression of pSTAT3 in non-small cell lung cancer and its clinical significance].

  Rui-juan Wang, Jian-zhong Zhang, Ping Wang
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  ABSTRACT: To explore the expression of phosphorylated STAT3 (pSTAT3) in non-small cell lung cancer(NSCLC) and its clinical significance. The expression of pSTAT3 was detected in 59 cases of NSCLC and their para-cancerous tissue by immunohistochemical staining. (1) The expression of pSTAT3 in NSCLC was significantly higher than that in para-cancerous tissue. (2) The expression of pSTAT3 was associated with tumor's size and smoking status, which was significantly higher in smaller tumors(diameter<3 cm) and nonsmokers than that in larger tumors(diameter≥3 cm) and smokers, but was not associated with gender, age, lymph node metastasis, clinical stage and differentiation grade. The percentage rate of pSTAT3 expression was higher in adenocarcinoma than that in squamous cell carcinoma but without statistically significant. pSTAT3 may play an important role in the development of NSCLC and the direction of targeted therapy.
  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 03/2012; 28(3):288-90.
• Article: Characterization of Listeria monocytogenes isolates in import food products of China from 8 provinces between 2005 and 2007.

  Ping Wang, Hairong Yang, Yue Hu, Fei Yuan, Guiming Zhao, Yongsheng Zhao, Ying Chen
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  ABSTRACT: A total of 48 Listeria monocytogenes isolates of different import food products from 8 provinces between 2005 and 2008 were characterized. The serotype and virulence were confirmed for each strain and molecular subtyping were analyzed by multilocus sequence typing (MLST). Twenty five strains were assigned to serotype 1/2a, and 11 isolates to serotype 1/2b, serotype 4b were found in 7 isolate, and the remaining 5 strains were grouped into serotypes 1/2c, 4a, and 4e. Molecular subtyping schemes found thirty two sequence types (STs) among these isolates and the majority of L. monocytogenes strains belonged to lineage II (56%), followed by lineage I (38%), lineage III (6%). Two molecular subtype clusters, cluster A included all isolates of lineage II, while cluster B contained the isolates of lineages I and lineages III. Two L. monocytogenes strains were not grouped in either of the two clusters. Fifty three isolates were as virulent as L. monocytogenes reference strain EGD in mouse virulence assay, while the isolates 22213 and 22265 had low pathogenicity. These results provide the first molecular insight into the L. monocytogenes strains isolated from import food products of 8 provinces in China and indicate the potential risk to cause human disease if intake by contaminated foods. MLST could be used as a routine subtyping method of L. monocytogenes isolates. In China, inspection and quarantine strategies of imported foods should be strengthened. PRACTICAL APPLICATION: There is a potential risk of listeriosis in China and routine subtyping of L. monocytogenes isolates is important. It is necessary for food hygiene management to strengthen the supervision of imported foods.
  Journal of Food Science 02/2012; 77(4):M212-6. · 1.66 Impact Factor
• Article: Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cancer cell lines as a synergistic drug to doxorubicin.

  Yuxin Xu, Wenyun Zheng, Tianwen Wang, Ping Wang, Ling Zhu, Xingyuan Ma
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  ABSTRACT: In order to eliminate common side effects to cancer patients and resistance from chemotherapy, a genetic protein TmSm(T34A) was investigated as a sensitizer to doxorubicin. The results indicated TmSm(T34A) enhanced the sensitivity of three breast cancer cell lines to doxorubicin with low dose, and reduced the dose of doxorubicin significantly in contrast to common effective dose. As a synergistic therapy, the TmSm(T34A) also caused strongest apoptotic activity in MCF-7, and the possible molecular mechanisms were explored primarily. The research showed the TmSm(T34A) is promising to be a potential drug in strengthening therapy effects of breast cancer chemotherapy.
  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 02/2012; 66(5):368-72. · 2.24 Impact Factor
• Article: Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth.

  Hailong Chen, Xingyuan Ma, Zhi Li, Qiaoyun Shi, Wenyun Zheng, Yang Liu, Ping Wang
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  ABSTRACT: The delivery of DNA or RNA to cells represents the limiting step in the development of cancer gene therapy and RNA interference protocols. Single walled carbon nanotubes (SWNTs) are of interest as carriers of biologically active molecules because of their ability to cross cell membranes. In this study, we developed a novel strategy for chemical functionalization of SWNTs (f-SWCNTs) with DSPE-PEG-Amine to bind small interfering RNA (siRNA) by disulfide bonds applied to siRNA-mediated gene silencing in breast cancer cells. Results indicated the efficiency of f-SWNTs carrying siRNA reached 83.55%, and the new f-SWNTs-siRNA-MDM2 complexes were successfully introduced into the breast carcinoma B-Cap-37 cells at a concentration of 100 nM in mediums, and caused proliferation inhibition of B-Cap-37 cells significantly. The proliferation inhibition ratio of B-Cap-37 cells was detected as 44.53% for 72 h, and the apoptosis ratio was measured as 30.45%. It was obvious that MDM2 can serve as a novel therapeutic target by an effective carrier system of DSPE-PEG-Amine-functionalized SWNTs, which would be very advanced and significant to therapy of breast cancer further.
  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 02/2012; 66(5):334-8. · 2.24 Impact Factor
• Article: Macroscopic multifunctional graphene-based hydrogels and aerogels by a metal ion induced self-assembly process.

  Huai-Ping Cong, Xiao-Chen Ren, Ping Wang, Shu-Hong Yu
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  ABSTRACT: We report a one-step fabrication of macroscopic multifunctional graphene-based hydrogels with robust interconnected networks under the synergistic effects of the reduction of graphene oxide sheets by ferrous ions and in situ simultaneous deposition of nanoparticles on graphene sheets. The functional components, such as α-FeOOH nanorods and magnetic Fe(3)O(4) nanoparticles, can be easily incorporated with graphene sheets to assemble macroscopic graphene monoliths just by control of pH value under mild conditions. Such functional graphene-based hydrogels exhibit excellent capability for removal of pollutants and, thus, could be used as promising adsorbents for water purification. The method presented here is proved to be versatile to induce macroscopic assembly of reduced graphene sheets with other functional metal oxides and thus to access a variety of graphene-based multifunctional nanocomposites in the form of macroscopic hydrogels or aerogels.
  ACS Nano 02/2012; 6(3):2693-703. · 10.77 Impact Factor
• Article: Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.

  Gui Shen, Erxun Zhou, J Andrew Alspaugh, Ping Wang
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  ABSTRACT: Human Wiskott-Aldrich syndrome protein (WASP) is a scaffold linking upstream signals to the actin cytoskeleton. In response to intersectin ITSN1 and Rho GTPase Cdc42, WASP activates the Arp2/3 complex to promote actin polymerization. The human pathogen Cryptococcus neoformans contains the ITSN1 homolog Cin1 and the WASP homolog Wsp1, which share more homology with human proteins than those of other fungi. Here we demonstrate that Cin1, Cdc42/Rac1, and Wsp1 function in an effector pathway similar to that of mammalian models. In the cin1 mutant, expression of the autoactivated Wsp1-B-GBD allele partially suppressed the mutant defect in endocytosis, and expression of the constitutively active CDC42(Q61L) allele restored normal actin cytoskeleton structures. Similar phenotypic suppression can be obtained by the expression of a Cdc42-green fluorescent protein (GFP)-Wsp1 fusion protein. In addition, Rac1, which was found to exhibit a role in early endocytosis, activates Wsp1 to regulate vacuole fusion. Rac1 interacted with Wsp1 and depended on Wsp1 for its vacuolar membrane localization. Expression of the Wsp1-B-GBD allele restored vacuolar membrane fusion in the rac1 mutant. Collectively, our studies suggest novel ways in which this pathogenic fungus has adapted conserved signaling pathways to control vesicle transport and actin organization, likely benefiting survival within infected hosts.
  Eukaryotic Cell 02/2012; 11(4):471-81. · 3.60 Impact Factor
• Article: Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.

  Guoliang Li, Xiaoan Ruan, Raymond K Auerbach, Kuljeet Singh Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang, [......], Mark Gerstein, Thomas Gingeras, Barbara Wold, Yi Sun, Melissa J Fullwood, Edwin Cheung, Edison Liu, Wing-Kin Sung, Michael Snyder, Yijun Ruan
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  ABSTRACT: Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promoter-centered intragenic, extragenic, and intergenic interactions. These interactions further aggregated into higher-order clusters, wherein proximal and distal genes were engaged through promoter-promoter interactions. Most genes with promoter-promoter interactions were active and transcribed cooperatively, and some interacting promoters could influence each other implying combinatorial complexity of transcriptional controls. Comparative analyses of different cell lines showed that cell-specific chromatin interactions could provide structural frameworks for cell-specific transcription, and suggested significant enrichment of enhancer-promoter interactions for cell-specific functions. Furthermore, genetically-identified disease-associated noncoding elements were found to be spatially engaged with corresponding genes through long-range interactions. Overall, our study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells.
  Cell 01/2012; 148(1-2):84-98. · 32.40 Impact Factor
• Source

  Available from: Fan Wang

  Article: Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution.

  Ping Wang, Tianrui Chen, Katsuyasu Sakurai, Bao-Xia Han, Zhigang He, Guoping Feng, Fan Wang
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  ABSTRACT: Tissue and cell type highly specific Cre drivers are very rare due to the fact that most genes or promoters used to direct Cre expressions are generally expressed in more than one tissues and/or in multiple cell types. We developed a split-intein based split-Cre system for highly efficient Cre-reconstitution through protein splicing. This split-intein-split-Cre system can be used to intersect the expression patterns of two genes or promoters to restrict full-length Cre reconstitution in their overlapping domains. To test this system in vivo, we selected several conserved human enhancers to drive the expression of either Cre-N-intein-N, or intein-C-Cre-C transgene in different brain regions. In all paired CreN/CreC transgenic mice, Cre-dependent reporter was efficiently induced specifically in the intersectional expression domains of two enhancers. This split-intein based method is simpler to implement compared with other strategies for generating highly-restricted intersectional Cre drivers to study complex tissues such as the nervous system.
  Scientific Reports 01/2012; 2:497.
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  Available from: uni-muenchen.de

  Article: Taxing pollution: agglomeration and welfare consequences

  Marcus Berliant, Ping Wang, Washington University, St Louis, Nber
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  ABSTRACT: This paper demonstrates that a pollution tax with a …xed cost component may lead, by itself, to segregation between clean and dirty …rms without heterogeneous preferences or increasing returns. We construct a simple model with two locations and two industries (clean and dirty) where pollution is a by-product of dirty good manufacturing. Under proper assumptions, a completely strati…ed con…guration with all dirty …rms clustering in one city emerges as the only equilibrium outcome when there is a …xed cost component of the pollution tax. Moreover, a strati…ed Pareto optimum can never be supported by a competitive spatial equilibrium with a linear pollution tax. To support such a strati…ed Pareto optimum, however, an e¤ective but unconventional policy pre-scription is to redistribute the pollution tax revenue from the dirty to the clean city residents. JEL Classi…cation: D62, H23, R13.
  12/2011;
• Source

  Available from: ucr.edu

  Article: Progressive Taxation and Macroeconomic (In) stability with Productive Government Spending

  Shu-Hua Chen, Jang-Ting Guo, We Thank, Julen Esteban-Pretel, Sharon Harrison, Minchung Hsu, Toshihiro Ihori, Alan Krause, Kevin Lansing, Teresa Lloyd-Braga, [......], Valerie Ramey, Richard Rogerson, Richard Suen, Yundong Tu, Stephen Turnvosky, Pengfei Wang, Ping Wang, Danyang Xie, Yan Zhang, Seminar Participants
  [show abstract] [hide abstract]
  ABSTRACT: This paper systematically examines the interrelations between a progressive income tax schedule and macroeconomic (in)stability in an otherwise standard one-sector real business model with productive government spending. We analytically show that the economy exhibits indeterminacy and sunspots only if the equilibrium wage-hours locus is positively sloped and steeper than the household's labor supply curve. Unlike in the framework with useless public expenditures, a less progressive tax policy may operate like an automatic stabilizer that mitigates belief-driven cyclical uctuations. Moreover, our quantitative analysis shows that this result is able to provide a theoretically plausible explanation for the discernible reduction in U.S. output volatility after the Tax Reform Act of 1986 was implemented.
  07/2011;
• Source

  Available from: synl.ac.cn

  Article: Combined Effects of Functional Cation and Anion on the Reversible Dehydrogenation of LiBH4

  Zhan-Zhao Fang, Xiang-Dong Kang, Zhu-Xian Yang, Gavin S Walker, Ping Wang
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  ABSTRACT: Catalyst doping has been widely employed as an effective method for improving the H-exchange kinetics of complex hydrides. However, a viable hydrogen storage material requires favorable properties on both kinetic and thermodynamic aspects to allow dehydrogenation and rehydrogenation reactions to proceed at moderate temperatures. In the present study, titanium halides (TiCl3 or TiF3) were mechanically milled with LiBH4 and examined with respect to their effects on the hydrogen storage properties of LiBH4. Experimental study showed that both halides are effective promoters. In particular, TiF3 exhibits a superior promoting effect to its analogue, TiCl3, on the reversible dehydrogenation of LiBH4. Phase characterization and chemical state analysis results showed that both halides react with the host LiBH4, resulting in the in situ formation of the catalytically active Ti hydride. However, the two halogen anions differ substantially from each other in terms of state and function. Associated with the dissolution of LiCl into LiBH4, the Cl– anion can readily replace [BH4]− and exerts a stabilizing effect on the hexagonal phase of LiBH4. By contrast, the F– anion may partially substitute the anionic H in both LiBH4 (hydrogenated state) and LiH (dehydrogenated state) lattices, resulting in a favorable modification of the hydrogen-exchange thermodynamics of LiBH4. The observed promoting effect of TiF3 on the reversible dehydrogenation of LiBH4 should be understood from the combined effects of functional cation and anion. In this regard, TiF3 provides a prototype catalyst that can simultaneously modify the H-exchange kinetics and thermodynamics of complex hydrides.
  J. Phys. Chem. C. 04/2011; 115:11839-11845.
• Source

  Available from: synl.ac.cn

  Article: Hydrogen generation from coupling reactions of sodium borohydride and aluminum powder with aqueous solution of cobalt chloride

  Hong-Bin Dai, Guang-Lu Ma, Xiang-Dong Kang, Ping Wang
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  ABSTRACT: Catalysis Today j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / c a t t o d a b s t r a c t On-demand hydrogen generation from the hydrolysis reactions of chemical hydrides has gained ever-increasing attention as a promising approach for providing mobile/portable hydrogen sources. In this paper, we report a new chemical hydrogen storage system that is composed of sodium borohydride (NaBH 4)/aluminum (Al)/sodium hydroxide (NaOH) solid powder mixture and aqueous solution of cobalt chloride (CoCl 2). Hydrogen generation can be readily controlled by regulating the contact of the aque-ous solution with the solid powder mixture. In comparison with the conventional NaBH 4 /H 2 O or Al/H 2 O systems, the newly developed dual-solid-fuel system exhibits distinct advantages in hydrogen storage density, hydrogen generation rate and fuel conversion. Additionally, the dual-solid-fuel system shows sat-isfactory transient response. The factors influencing the hydrogen generation performance of the system were studied. The reaction by-products were characterized using powder X-ray diffraction and Fourier transform infrared spectroscopy techniques. Our study demonstrated a high-performance dual-solid-fuel hydrogen generation system, and may lay a foundation for developing practical hydrogen generators for mobile/portable applications.
  Catalysis Today 01/2011; 170:50-55. · 3.41 Impact Factor
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  Available from: bham.ac.uk

  Article: Site assessment of multiple sensor approaches for buried utility detection

  Alexander C D Royal, Phil R Atkins, Michael J Brennan, David N Chapman, Huanhuan Chen, Anthony G Cohn, Kae Y Foo, Kevin F Goddard, Russell Hayes, Tong Hao, [......], Nicole Metje, Jen M Muggleton, Adham Naji, Giovanni Orlando, Steve R Pennock, Miles A Redfern, Adrian J Saul, Steve G Swingler, Ping Wang, Christopher D F Rogers
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  ABSTRACT: The successful operation of buried infrastructure within urban environments is fundamental to the conservation of modern living standards. Open-cut methods are predominantly used, in preference to trenchless technology, to effect a repair, replace or install a new section of the network. This is, in part, due to the inability to determine the position of all utilities below the carriageway, making open-cut methods desirable in terms of dealing with uncertainty since the buried infrastructure is progressively exposed during excavation. However, open-cut methods damage the carriageway and disrupt society's functions. This paper describes the progress of a research project that aims to develop a multi-sensor geophysical platform that can improve the probability of complete detection of the infrastructure buried beneath the carriageway. The multi-sensor platform is being developed in conjunction with a knowledge-based system that aims to provide information on how the properties of the ground might affect the sensing technologies being deployed. The fusion of data sources (sensor data and utilities record data) is also being researched to maximize the probability of location. This paper describes the outcome of the initial phase of testing along with the development of the knowledge-based system and the fusing of data to produce utility maps.
  Hindawi Publishing Corporation International Journal of Geophysics. 01/2011; 19.