Paul Taylor

Publications (3)12.53 Total impact

• Source

  Available from: Giovanni E Mann

  Article: Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo.

  Katharina Mahn, Consuelo Borrás, Greg A Knock, Paul Taylor, Imran Y Khan, David Sugden, Lucilla Poston, Jeremy P T Ward, Richard M Sharpe, Jose Viña, Philip I Aaronson, Giovanni E Mann
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  ABSTRACT: Epidemiological evidence suggests that populations consuming large amounts of soy protein have a reduced incidence of coronary heart disease (1-5). The cardiovascular risks associated with conventional hormone replacement therapy in postmenopausal women (5-7) have precipitated a search for alternative estrogen receptor modulators. Here we report that long-term feeding of rats with a soy protein-rich (SP) diet during gestation and adult life results in decreased oxidative stress, improved endothelial function, and reduced blood pressure in vivo measured by radiotelemetry in aged male offspring. Improved vascular reactivity in animals fed an SP diet was paralleled by increased mitochondrial glutathione and mRNA levels for endothelial nitric oxide synthase (eNOS) and the antioxidant enzymes manganese superoxide dismutase and cytochrome c oxidase. Reduced eNOS and antioxidant gene expression, impaired endothelial function, and elevated blood pressure in animals fed a soy-deficient diet was reversed after refeeding them an SP diet for 6 months. Our findings suggest that an SP diet increases eNOS and antioxidant gene expression in the vasculature and other tissues, resulting in reduced oxidative stress and increased NO bioavailability. The improvement in endothelial function, increased gene expression, and reduced blood pressure by soy isoflavones have implications for alternative therapy for postmenopausal women and patients at risk of coronary heart disease.
  The FASEB Journal 11/2005; 19(12):1755-7. · 5.71 Impact Factor
• Article: Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre-eclampsia.

  Dimitrios G Goulis, Lucy Chappell, Richard G J Gibbs, David Williams, Jitendra R Dave, Paul Taylor, Michael de Swiet, Lucilla Poston, Catherine Williamson
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  ABSTRACT: To establish the prevalence of Chlamydia pneumoniae (C. pneumoniae) infection in a pregnant UK population and to investigate whether C. pneumoniae infection is more common in women with a previous history of pre-eclampsia. Prospective study. Academic Hospital. Ninety-one pregnant women (54 parous and 37 nulliparous) at 16-22 weeks of gestation were studied. Of the parous women, 32 had a previous history of pre-eclampsia. Peripheral blood was drawn for C. pneumoniae antibodies between 16-22 and 28-40 weeks of gestation. C. pneumoniae antibodies were measured using a solid-phase enzyme immunoassay. According to pregnancy outcome, women were categorised into normal, gestational hypertension and pre-eclampsia groups. Serum levels of IgG, IgA and IgM C. pneumoniae antibodies. Prevalence of seropositivity to C. pneumoniae was 77%. Parous women had significantly higher levels of IgA and IgM C. pneumoniae antibodies than nulliparous women (P < 0.04). Parous women with previous pre-eclampsia were found to have higher levels of antibodies than parous women with a normal obstetric history (P< or = 0.003). There was no difference in the antibody levels in women with different pregnancy outcomes. The longitudinal data do not indicate an association between C. pneumoniae infection and pre-eclampsia. However, the subgroup analysis of parous women demonstrated raised C. pneumoniae antibodies in the women with previous pre-eclampsia, and therefore suggests that there may be an association between C. pneumoniae and the disease in this group.
  BJOG An International Journal of Obstetrics & Gynaecology 03/2005; 112(3):299-305. · 3.41 Impact Factor
• Article: Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre‐eclampsia

  Dimitrios G. Goulis, Lucy Chappell, Richard G.J. Gibbs, David Williams, Jitendra R. Dave, Paul Taylor, Michael De Swiet, Lucilla Poston, Catherine Williamson
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  ABSTRACT: Objective To establish the prevalence of Chlamydia pneumoniae (C. pneumoniae) infection in a pregnant UK population and to investigate whether C. pneumoniae infection is more common in women with a previous history of pre-eclampsia.Design Prospective study.Setting Academic Hospital.Population Ninety-one pregnant women (54 parous and 37 nulliparous) at 16–22 weeks of gestation were studied. Of the parous women, 32 had a previous history of pre-eclampsia.Methods Peripheral blood was drawn for C. pneumoniae antibodies between 16–22 and 28–40 weeks of gestation. C. pneumoniae antibodies were measured using a solid-phase enzyme immunoassay. According to pregnancy outcome, women were categorised into normal, gestational hypertension and pre-eclampsia groups.Main outcome measures Serum levels of IgG, IgA and IgM C. pneumoniae antibodies.Results Prevalence of seropositivity to C. pneumoniae was 77%. Parous women had significantly higher levels of IgA and IgM C. pneumoniae antibodies than nulliparous women (P < 0.04). Parous women with previous pre-eclampsia were found to have higher levels of antibodies than parous women with a normal obstetric history (P≤ 0.003). There was no difference in the antibody levels in women with different pregnancy outcomes.Conclusions The longitudinal data do not indicate an association between C. pneumoniae infection and pre-eclampsia. However, the subgroup analysis of parous women demonstrated raised C. pneumoniae antibodies in the women with previous pre-eclampsia, and therefore suggests that there may be an association between C. pneumoniae and the disease in this group.
  BJOG An International Journal of Obstetrics & Gynaecology 02/2005; 112(3):299 - 305. · 3.41 Impact Factor