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ABSTRACT: BACKGROUND: Inflammation is involved in the mechanism of obstructive sleep apnoea syndrome (OSAS). Omentin, a newly discovered adipokine, is implicated to play an anti-inflammatory role. This study aims to determine whether serum levels of omentin-1 are associated with the presence and severity of OSAS. METHODS: This study consisted of 192 patients with OSAS and 144 healthy subjects. Serum levels of omentin-1 were measured using enzyme-linked immunosorbent assay. RESULTS: Serum omentin-1 levels were significantly decreased in OSAS patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum omentin-1 levels were inversely associated with the presence of OSAS (odds ratio 0.520, 95% confidence interval 0.433 to 0.623; P < 0.001). Severe OSAS patients had significantly lower serum omentin-1 levels compared with mild and moderate OSAS patients. Spearman correlation analysis showed that serum omentin-1 levels were correlated with the severity of OSAS. Simple linear regression analysis showed that the serum levels of omentin-1 were negatively correlated with waist circumference, body mass index, systolic blood pressure, homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and apnoea-hypopnoea index in patients with OSAS. Furthermore, only HOMA-IR and CRP remained inversely associated with serum omentin-1 after multiple stepwise regression analysis. CONCLUSION: Decreased serum omentin-1 levels could be considered as an independent predictive marker of the presence and severity of OSAS.
Annals of Clinical Biochemistry 04/2013; · 2.17 Impact Factor
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ABSTRACT: Chemerin is implicated to be correlated with obesity and inflammation.
This study aims to investigate whether serum chemerin is associated with the presence of obstructive sleep apnea syndrome (OSAS).
A total of 132 patients with OSAS and 108 healthy subjects were enrolled in this study.
Serum chemerin levels were significantly elevated in OSAS patients (120.93 ± 25.84 µg/L vs. 107.51 ± 20.41 µg/L). Multivariable logistic regression analysis revealed that serum chemerin levels were an independent determinant of the presence of OSAS (OR 1.030, 95% CI 1.016-1.045; p < 0.001). Serum chemerin levels in severe OSAS patients were significantly higher compared with those in mild and moderate OSAS patients (p = 0.015 and p = 0.020, respectively). Spearman correlation analysis indicated that serum chemerin levels were correlated with the severity of OSAS (r = 0.210, p = 0.016). Serum chemerin were positively correlated with waist circumference (r = 0.164, p = 0.008), body mass index (r = 0.158, p = 0.014), systolic blood pressure (r = 0.135, p = 0.037), homeostasis model assessment of insulin resistance (r = 0.140, p = 0.031), C-reactive protein (r = 0.202, p = 0.002), and apnea-hypopnea index (r = 0.152, p = 0.022).
Elevated serum chemerin levels could be an independent predicting marker of the presence and severity of OSAS.
Biomarkers 02/2012; 17(3):248-53. · 2.21 Impact Factor
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ABSTRACT: Chronic mountain sickness (CMS) is a condition in which the hematocrit is increased above the normal level in residents at high altitude. High altitude polycythemia (HAPC) is the most characteristic sign of CMS. However, the pathogenesis of HAPC is poorly understood. The present study aimed to investigate the gene expression profile of HAPC in Han Chinese migrating to the Qinghai-Tibetan Plateau and to identify the pathogenetic mechanisms. A total of 9 differentially expressed genes were identified in HAPC patients using microarrays: 5 were up-regulated and 4 were down-regulated. Functional analysis of the array data revealed that cell division cycle 42 (CDC42) and the human immune response may be key features underlying the mechanism and development of HAPC.
Molecular Medicine Reports 01/2012; 5(1):287-93. · 0.42 Impact Factor
