P M Vogt

Hannover Medical School, Hanover, Lower Saxony, Germany

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Publications (319)293.95 Total impact

  • Optically Induced Nanostructures - Biomedical and Technical Applications, Edited by König K., Ostendorf A., 04/2015: chapter Part II: Biomedical applications: pages 199-216; Walter de Gruyter Inc.., ISBN: 978-3-11-033718
  • DGCH 2015, München; 04/2015
  • P M Vogt
    Der Chirurg 03/2015; 86(3). DOI:10.1007/s00104-014-2827-6
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    ABSTRACT: Prefabrication of bone transplants is a promising option for large defects of the long bones, especially if there is compromised vascularization of the defect. This is especially true for postinfection bone defects and other types of atrophic nonunion. The generation of a foreign body membrane (Masquelet's technique) has been investigated in order to ameliorate the response of the host tissue surrounding the defect. In an experimental animal study, a blood vessel within a bone construct could be used to generate customized, vascularized osteogenic constructs that can be used to treat large bone defects in the future.
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    ABSTRACT: Interdisciplinary collaboration between orthopedic and plastic surgeons is indicated in reconstructive surgery of the extremities for both traumatic orthopedic fractures with extensive soft tissue damage and musculoskeletal tumor resection. We want to emphasize the need for close cooperation starting in the preoperative planning for reconstruction after tumor resection in order to discuss and establish a unified approach. This is particularly important to establish a joint approach with special consideration of possibly necessary adjuvant therapies. One collaborative approach is for the orthopedic surgeon to resect the tumor and the plastic surgeon to carry out the defect reconstruction for exclusive soft tissue coverage including flap surgery as well as for functional reconstruction depending on the location and extent of tumor resection. Thus, careful preoperative and postoperative communication on the precise location, extent of tumor resection and the therapy timing between the orthopedic surgeon and the plastic surgeon will allow the most effective subsequent repair of the resection site.
    Der Chirurg 03/2015; 86(3):234-41. DOI:10.1007/s00104-014-2834-7
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    ABSTRACT: Tumor resection and trauma may leave devastating defects in the head and neck area complicating and preventing patient rehabilitation; therefore, plastic surgery methods are required which are able to prevent further complications and provide efficient functional and aesthetic reconstruction. In this review article typical cases and the interdisciplinary management of plastic surgery are presented.
    Der Chirurg 02/2015; 86(3). DOI:10.1007/s00104-014-2832-9
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    ABSTRACT: The regeneration of tissue lost due to trauma or disease is considered as being ideal for reconstruction with respect to repair in which a donor defect arises in a different part of the body. Through a better understanding of the cellular and molecular mechanisms of healing, possibilities for regenerative therapies have been developed in recent years. To give an exemplary representation of current regenerative therapy approaches and their effect and clinical application. The PubMed database was searched for different regenerative approaches in plastic surgery and various methods are presented in this article. Cell-based approaches, in which autologous mesenchymal stem cells from adipose tissue are preferably used, led to excellent healing results with minimal donor site morbidity. Likewise, growth factor-based approaches or the use of platelet-rich plasma achieve very good results in the field of wound and bone healing. By using different cells or molecules and thus taking advantage of biological mechanisms, the regenerative capabilities of adult organisms could be improved. Many methods have already been implemented in clinical practice, not only in reconstructive but also in aesthetic surgery. However, the success should not conceal the potential risk that is inherent in both cell and growth factor-based approaches. Until long-term experiences of such therapies have been acquired, they should be used cautiously.
    Der Chirurg 02/2015; 86(3). DOI:10.1007/s00104-014-2830-y
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    ABSTRACT: Background: In 2006 NASA published its plans to build a manned lunar station in order to undertake missions to Mars in the future. Thus research projects have been conducted on the influence of Lunar and Martian dust on human health. The present study investigated the effect of Lunar and Martian dust simulants (LDS, MDS) in comparison with earth dust (ED) on viability, migration and inflammatory reaction during wound closure in an ex vivo human skin wound model. Materials and methods: 6 mm full-thickness skin explants, with a central 3 mm epidermal wound were cultured with LDS, MDS or ED for 4 and 8 days and compared to wound closure without dust exposure. Tissue and conditioned medium were submitted to histological, immunohistochemical (Ki67, Caspase-3) and biochemical analyses (hydroxyproline assay, zymography, IL-6, TNF-α and TGF-β ELISA). Results: All dusts increased proinflammatory markers with significant increases in MDS-treated samples (IL-6: p<0.05; MMP-9: p<0.005) and reduced MMP-2 (p<0.05) compared to no dust controls over time. No significant differences were found regarding wound closure, proliferation, apoptosis and tissue degradation. Conclusion: Highly oxidative Martian dust may cause increased cutaneous inflammation. As is currently advocated for wounds contaminated with earth dust, surgical wound debridement should be performed to ensure uncompromised wound healing. © Georg Thieme Verlag KG Stuttgart · New York.
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    ABSTRACT: The benefits and risks of singular and repetitive microneedling (1 mm) have not been thoroughly investigated. The aim of this study was to evaluate the benefits and risks of singular and repetitive skin needling with a microneedling device in an animal model with and without skincare. 30 Sprague Dawley rats were randomized to five groups: control, skin-care only (Vitamin A & C), 1× needling 1 mm, 4× needling 1 mm, 4× needling 1 mm with skin-care. All animals were euthanized after 10 weeks. Skin specimens were stained with HE and Masson's trichrome. Additionally, gene expression analysis with microarray technique for various growth factors (TGFβ1–3, FGF, EGF, VEGF, TNF-α) and real time reverse transcription PCR for collagen I & III were conducted. We showed that singular microneedling matches and repetitive microneedling sessions superposition epidermal and dermal benefits such as an increase of epidermal thickness (up to 658% increase, p value 0.0008) and dermal connective tissue—even more so when combined with skin-care with vitamin A and C. Juvenile collagen I showed itself up-regulated in all groups, while collagen III was down-regulated. Singular and repetitive PCI with a microneedling device can achieve and supersede the results already shown with medical needling.
    Burns: journal of the International Society for Burn Injuries 08/2014; 40(5). DOI:10.1016/j.burns.2013.12.008
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    ABSTRACT: Reconstructive microsurgery is an essential part of plastic surgery. To live up to the high technical demands of today's sophisticated techniques, a structured microsurgical training is required. However, such curricula are rare in Germany. We therefore evaluated the concepts and requests of trainers as well as trainees regarding an optimal microsurgical training. We found that the demands of both sides to be fairly similar. How-ever, there were factors potentially hindering the implementation of such curricula, foremost the increasing economic pressure. Based on our find-ings, representatives of microsurgical trainers and trainees, together with national societies might be able to establish a national curriculum for microsurgical training. The clinical implementation of such a structured train-ing will require significant personal resources. However, this expenditure seems to be justified by the increasing complexity of techniques, the rising demand of patients and the limited time for -surgical training.
    Handchirurgie · Mikrochirurgie · Plastische Chirurgie 08/2014; 46(4):234-241. DOI:10.1055/s-0034-1381996
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    ABSTRACT: The fire beetle, Melanophila acuminata (Coleoptera: Buprestidae), senses infrared radiation at wavelengths of 3 and 10–25 microns via specialized protein-containing sensilla. Although the protein denatures outside of a biological system, this detection mechanism has inspired our bottom-up approach to produce single zinc phosphide microwires via vapour transport for IR sensing. The Zn 3 P 2 microwires were immobilized and electrical contact was made by dielectrophoresis. Photoconductivity measurements have been extended to the near IR range, spanning the Zn 3 P 2 band gaps. Purity and integrity of the Zn 3 P 2 microwires including infrared light scattering properties were confirmed by infrared transmission microscopy. This biomimetic microwire shows promise for infrared chip development.
    06/2014; Vo lume 2014, Article ID 524042,. DOI:10.1155/2014/524042
  • LPM 2014, Vilnius, Litauen; 06/2014
  • 10th International Congress & Exhibition on Nanobiotechnology (NanoBioEurope), Muenster, Germany; 06/2014
  • C Radtke, P M Vogt
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    ABSTRACT: Peripheral nerve injuries are a common clinical problem and can represent a major challenge, especially after trauma. In order to achieve optimal therapy, an early and adequate diagnosis with subsequent therapy is critical for functional preservation and restoration. Especially after complete severance of a peripheral nerve, the surgical techniques for nerve coaptation are an important prerequisite for peripheral nerve regeneration. The importance and necessity of adequate nerve coaptation and nerve transplantation are presented in detail. In addition, the types of primary and secondary nerve reconstruction procedures are described as well as the optimal time point of nerve repair. This article provides a comprehensive overview of the possibilities for diagnosis and intervention after nerve injury, additionally including an algorithm for surgical intervention. Furthermore, possible pitfalls and factors for improving the functional outcome are presented to optimize results with trauma-related nerve injury.
    Der Unfallchirurg 06/2014; 117(6):539-56. DOI:10.1007/s00113-014-2574-7
  • 3rd Conference on Advanced Nanoparticle generation and Excitation by Lasers in Liquids (ANGEL), Matsuyama, Japan; 05/2014
  • Senologie - Zeitschrift für Mammadiagnostik und -therapie 05/2014; 11(02). DOI:10.1055/s-0034-1375435
  • TR Mett, H Henseler, P Vogt
    Senologie - Zeitschrift für Mammadiagnostik und -therapie 05/2014; 11(02). DOI:10.1055/s-0034-1375440
  • Senologie - Zeitschrift für Mammadiagnostik und -therapie 05/2014; 11(02). DOI:10.1055/s-0034-1375407
  • Senologie - Zeitschrift für Mammadiagnostik und -therapie 05/2014; 11(02). DOI:10.1055/s-0034-1375380
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    ABSTRACT: The immune response to an inflammatory stimulus is balanced and orchestrated by stimulatory and inhibitory factors. After a thermal trauma, this balance is disturbed and an excessive immune reaction with increased production and release of proinflammatory cytokines results. The nicotine-stimulated anti-inflammatory reflex offsets this. The goal of this study was to verify that transdermal administration of nicotine downregulates proinflammatory cytokine release after burn trauma. A 30% total body surface area full-thickness rat burn model was used in Sprague Dawley rats (n = 35, male). The experimental animals were divided into a control group, a burn trauma group, a burn trauma group with additional nicotine treatment, and a sham + nicotine group with 5 experimental animals per group. The last 2 groups received a transdermal nicotine administration of 1.75 mg. The concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 were determined in homogenates of hearts, livers, and spleens 12 or 24 hours after burn trauma. Experimental burn trauma resulted in a significant increase in cytokine levels in hearts, livers, and spleens. Nicotine treatment led to a decrease of the effect of the burn trauma with significantly lower concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 compared to the trauma group. This study confirms in a standardized burn model that stimulation of the nicotinic acetylcholine receptor is involved in the regulation of effectory molecules of the immune response. Looking at the results of our study, further experiments designed to explore and evaluate the potency and mechanisms of the immunomodulating effects of this receptor system are warranted.
    Eplasty 01/2014; 14:e46.

Publication Stats

1k Citations
293.95 Total Impact Points

Institutions

  • 2001–2015
    • Hannover Medical School
      • Department of Plastic, Hand and Reconstructive Surgery
      Hanover, Lower Saxony, Germany
  • 2011
    • Klinikum Duisburg
      Duisburg-Hamborn, North Rhine-Westphalia, Germany
  • 2009
    • University of Colorado Hospital
      Denver, Colorado, United States
  • 2008
    • Leibniz Universität Hannover
      • Institute of Technical Chemistry
      Hanover, Lower Saxony, Germany
  • 2007
    • Hochschule Hannover
      Hanover, Lower Saxony, Germany
  • 2002–2007
    • Johns Hopkins University
      • Department of Plastic and Reconstructive Surgery
      Baltimore, MD, United States
  • 2006
    • University Hospital RWTH Aachen
      Aachen, North Rhine-Westphalia, Germany
    • University Medical Center Hamburg - Eppendorf
      Hamburg, Hamburg, Germany
  • 2000–2006
    • Ruhr-Universität Bochum
      • Klinik für Plastische Chirurgie und Schwerbrandverletzte
      Bochum, North Rhine-Westphalia, Germany
  • 1996
    • Weizmann Institute of Science
      Israel
  • 1995
    • Harvard University
      Cambridge, Massachusetts, United States
  • 1992–1994
    • Brigham and Women's Hospital
      • Division of Plastic Surgery
      Boston, MA, United States
    • Harvard Medical School
      • Department of Surgery
      Boston, Massachusetts, United States
  • 1993
    • University of California, Los Angeles
      Los Angeles, California, United States