P S Mortimer

St George's, University of London, Londinium, England, United Kingdom

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Publications (4)13.53 Total impact

  • N Desai, S Heenan, P S Mortimer
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    ABSTRACT: Sirolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is increasingly used as an agent for post-transplant immunosuppression and the treatment of solid organ and haematological malignancies and hamartomas. Its advantages include a lack of nephrotoxicity and a lower incidence of nonmelanoma skin cancers; adverse effects include delayed wound healing, increased lymphocoele formation and rarely lymphoedema. We report a series of eight cases of severe, sustained, unilateral and bilateral lymphoedema in patients receiving sirolimus for post-transplant immunosuppression, classify their lymphoscintigraphy findings and propose a mechanism of aetiology based on the interaction of mTOR with key mediators of lymphangiogenesis.
    British Journal of Dermatology 04/2009; 160(6):1322-6. DOI:10.1111/j.1365-2133.2009.09098.x · 4.10 Impact Factor
  • J K Soo, T.A. Bicanic, S Heenan, P S Mortimer
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    ABSTRACT: Cellulitis is a common cause for admission to hospital, and repeated episodes are thought to damage the lymphatic system. Lymphoedema is recognized as a condition predisposing to cellulitis but there are no data to suggest its prevalence among a population presenting to hospital with acute cellulitis. To ascertain whether lymphatic abnormalities represent a common problem in patients with lower limb cellulitis. Patients admitted with cellulitis of the lower limb were invited to undergo clinical examination and lymphoscintigraphy. Thirty patients agreed to participate in the study. Fifteen underwent lymphoscintigraphy. Thirteen had abnormal scans indicating impaired lymph drainage (seven patients had clinical lymphoedema). Lymphatic abnormalities represent an important but unrecognized problem in patients with leg cellulitis.
    British Journal of Dermatology 07/2008; 158(6):1350-3. DOI:10.1111/j.1365-2133.2007.08423.x · 4.10 Impact Factor
  • J K Soo, P S Mortimer
    British Journal of Dermatology 03/2006; 154(2):376-8. DOI:10.1111/j.1365-2133.2005.07036.x · 4.10 Impact Factor
  • KA Short, G Kalu, P S Mortimer, E M Higgins
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    ABSTRACT: We report a case of vulval squamous cell carcinoma (SCC) arising in chronic hidradenitis suppurativa (HS). The patient had a complex medical history including a 25-year-history of Crohn's disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. We suggest constant vigilance with regard to malignant change in ano-genital HS as the diagnosis can be difficult.
    Clinical and Experimental Dermatology 10/2005; 30(5):481-3. DOI:10.1111/j.1365-2230.2005.01875.x · 1.23 Impact Factor