[show abstract][hide abstract] ABSTRACT: Similar to Makhani et al.,  we saw a case of glatiramer acetate (GA)-induced hepatotoxicity with no history of interferon exposure. A 28-year-old woman with MS developed jaundice, choluria, acholia, elevated AST/ALT (905/1103 U/L), and direct and total bilirubin (4.3/8 mg/dl) after 6 months of GA therapy. Viral and autoimmune hepatitis serologies were negative. Liver biopsy revealed hepatocellular necrosis of zone 3 with portal bridging and portal lymphocytic inflammation consistent with medication-induced hepatocellular injury. Thirty days after GA was discontinued, liver function normalized. Natalizumab was initiated and tolerated without complications for over a year. The FDA Adverse Event Reporting System (FAERS) database contains 95 reports of liver injury suspected to be a result of GA, including 51 cases in which GA was the only medication administered.  The mechanism of hepatotoxicity is still unclear as GA is not known to be metabolized in the liver. Although GA was not found to cause hepatotoxicity in clinical trials, these cases [1,3-5] raise the question whether liver function should be monitored in patients who are initiated on GA. It seems prudent to inform patients about symptoms of hepatotoxicity and advise them to seek immediate attention if these symptoms develop.
[show abstract][hide abstract] ABSTRACT: Background: MA.27 examined the efficacy of 5 yrs of adjuvant aromatase inhibitors (AI), exemestane and anastrozole. Long term outcomes of AI trials may be influenced by unspecified subsequent hormonal therapy so we enquired about its frequency. Methods: Clinical trials (NCIC CTG MA.17R, NSABP B-43) are exploring >5 yrs AI; neither efficacy nor toxicities are known. MA.27 enrolled 7,576 patients June 2003 to July 2008: 5526 (73% in US), 1301 (17% in Canada), 749 (10% outside North America). Clinical cut-off for final follow-up and analysis was April 15 2010: median 4.1 yrs follow-up. Receipt of concomitant medications was routinely reported throughout the trial. Only 345 patients (median age, 64.2 years) completed protocol-specified 5 yrs AI, without breast cancer (BC) relapse, development of contralateral BC, or other second malignancies. Patients were classified by extended endocrine therapy: off trial, physician prescribed specific endocrine therapy; randomized trial endocrine therapy; or no endocrine therapy. Differences in baseline patient and tumor characteristics for these classifications were compared with Fisher’s exact test. Results: From the total group of 345 patients, 320 (93%) received no further endocrine therapy, and 25 (7%) received subsequent therapy. Among the 25, 18 (72%) entered trials and were assigned to endocrine therapy or placebo. Physicians prescribed endocrine therapy to the other 7 (28%). Fourteen (78%) of those who received trial assigned and 7 (100%) of those who received specific additional endocrine therapy were below 70 years of age. Of the 25 patients who received subsequent therapy, only 2 (8%) had >2 cm tumor, and 6 (24%) had node positive tumors. None of the characteristics were significantly different for women who did or did not receive additional therapy. Conclusions: MA.27 is closed to further follow-up, so these results represent the totality of trial information about further endocrine therapy from clinical practices of those who enrolled MA.27 patients. It appears that subsequent hormonal therapy was uncommon (7% of women) after 5 yrs of an AI.
[show abstract][hide abstract] ABSTRACT: Major efforts are under way to define reliable biomarkers of Alzheimer’s disease. Highly significant increases of hyperphosphorylated tau proteins in cerebrospinal fluid have been recently reported in Alzheimer’s disease patients compared to controls by several independent groups, including ours. These findings support the notion that cerebrospinal fluid phosphorylated tau proteins may be very useful biomarkers in the early identification of Alzheimer’s disease in patients with mild cognitive impairment.
[show abstract][hide abstract] ABSTRACT: The unique properties of fiber reinforced carbon composites as well as of newly developed grades of graphite have prompted the interest of high power accelerators such as the multi-MW neutrino superbeam as the material for their performance target. Properties of primary interest are the shock and radiation damage resistance of these materials. To assess their behavior under proton irradiation shock and radiation damage experiments have been performed at Brookhaven National Laboratory. This paper presents results of the prolonged radiation exposure of these materials and assesses their suitability as high performance accelerator targets.
[show abstract][hide abstract] ABSTRACT: This paper demonstrates that numerical modeling tools such as a RANS-VOF model can be applied confidently to reduce the level of uncertainty from empirical guidance and provide for a deterministic quantification of the hydraulic response associated with any arbitrary Caisson breakwater superstructure geometry. The RANS-VOF model used for this paper is first satisfactorily validated against laboratory measurements (surface elevation, overtopping and pressure) of a caisson breakwater on a rubble-mound foundation and then applied to several prototype caisson breakwater superstructure geometries. Numerical simulations presented in this paper for prototype geometries demonstrate that curved/inclined parapets, when compared with vertical face caisson breakwaters with the same crest elevation, can lead to large increases in overtopping as well as downward forces. Expectedly, the landward forces are reduced by the implementation of a curved or recessed and inclined parapet when compared to a caisson with a completely vertical face. During large overtopping events, the model results show that much larger short-duration seaward loads can be generated for curved and inclined superstructures when compared to vertical face geometries. This is in general agreement with previous laboratory experiments as well as field observations of seaward caisson sliding and failure resulting from large overtopping events. Further, numerical experiments indicate that the overtopping response of a superstructure can vary noticeably due to small changes in the recessed length of an inclined or curved parapet. The numerical model also easily provides for the quantification of the variation of instantaneous and peak overtopping discharges along the crest of the caisson superstructure, and which can provide for useful guidance in the design of various crest infrastructure components, such as drainage systems, flow deflectors, wave power devices etc.
Proceedings of the International Conference on Coastal Engineering; No 32 (2010): Proceedings of 32nd Conference on Coastal Engineering, Shanghai, China, 2010.; structures.49.
[show abstract][hide abstract] ABSTRACT: Spectroscopy Now is a comprehensive collection of information and services related to several aspects of spectroscopy. It covers atomic spectroscopy, IR, MRI, MS, NMR, Raman, UV, X-Ray, chemometrics, and proteomics.
[show abstract][hide abstract] ABSTRACT: Aim To test the reliability, robustness, and reproducibility of short tandem repeat (STR) profiling of low template DNA (LT-DNA) when employing a defined set of testing and interpretation parameters. Methods DNA from known donors was measured with a quantitative real time polymerase chain reaction (PCR) assay that consistently detects less than 1 pg/μL of DNA within a factor of 0.3. Extracts were amplified in triplicate with AmpFSTR® Identifiler® reagents under enhanced PCR conditions. Replicates were examined independently and alleles confirmed using a consensus approach. Considering observed stochastic effects inherent to LT-DNA samples, interpretation protocols were developed and their accuracy verified through examination of over 800 samples. Results Amplification of 100 pg or less of DNA generated reproducible results with anticipated stochastic effects. Down to 25 pg of DNA, 92% or more of the expected alleles were consistently detected while lower amounts yielded concordant partial profiles. Although spurious alleles were sometimes observed within sample replicates, they did not repeat. To account for allelic dropout, interpretation guidelines were made especially stringent for determining homozygous alleles. Due to increased heterozygote imbalance, stutter filters were set conservatively and minor components of mixtures could not be resolved. Applying the resultant interpretation protocols, 100% accurate allelic assignments for over 107 non-probative casework samples, and subsequently 319 forensic casework samples, were generated. Conclusion Using the protocols and interpretation guidelines described here, LT-DNA testing is reliable and robust. Implementation of this method, or one that is suitably verified, in conjunction with an appropriate quality control program ensures that LT-DNA testing is suitable for forensic purposes.
Croatian Medical Journal (firstname.lastname@example.org); Vol.50 No.3.
[show abstract][hide abstract] ABSTRACT: Wiley Interscience provides access to journals published by Wiley. Access to the journal`s tables of contents and to abstracs is free. A search across all articles is included. Saving titles, articles or alerts via the My Profile service requires registration. Subscriptions are needed to access full text.
[show abstract][hide abstract] ABSTRACT: We present results from a study in which the magnet con-figuration and internal shielding against energy deposition by secondary particles is optimized for a 4-MW target sta-tion at a Muon Collider or Neutrino Factory.
[show abstract][hide abstract] ABSTRACT: Background and Purpose: Indoor pollutants could be significant public health risks. People in modern societies spend about 90% of their time in indoor environment. In spite of the evidence of harm to human health, poor indoor environments are generally hard to understand. Materials and Methods: There are numerous indoor atmospheric pollutants. Specifically, combustion sources, building materials, volatile organic compounds, central heating and cooling system are described. Results: Indoor home environments are the site of a variety of biological and other environmental hazards. Indoor environmental quality has a significant impact on public health and well-being. These hazards cause and exacerbate a variety of adverse health effects in humans, ranging from acute and chronic respiratory symptoms and diseases to cancer. We review the effects of indoor allergen exposure and sensitization on asthma, focusing on dust mite, fungi, indoor pollutants such as ozone, particulate matter nitrogen dioxide, environmental tobacco smoke, sulfur dioxide, carbon monoxide and dampness of buildings. Additionally, the effects of lead, as well as carcinogenic effects of asbestos, radon, and smoking habits are described. Conclusions: Preventive measures, such as identification of a source of chemical, physical, or biological pollutants that may have deleterious health effects, and improvement of such harmful environmental conditions should be undertaken.
[show abstract][hide abstract] ABSTRACT: The feasibility of multi-MW accelerators, currently under consideration and study, is directly linked to the production target and its survivability under severe shock and high irradiation exposure. The limitations of solid materials to function as high performance targets and in particular the effects of irradiation on key material properties are assessed through an extensive experimental study and findings to-date are presented and discussed.
[show abstract][hide abstract] ABSTRACT: Tilted double vision with a mild headache A 68 year-old Filipino woman s/p thyroidectomy 20 years ago complained of “tilted” double vision with a mild headache beginning 2 weeks prior to presentation. Examination revealed a right hypertropia (4PD) which increased in left gaze (6PD) and right head tilt (7PD); the deviation was unchanged in right gaze (4PD) and decreased in left head tilt (1PD). She had right excyclotorsion of 6. MRI of the brain and orbits revealed an approximately 5mm mass located superiorly in the right orbital apex. Pathology from the initial biopsy showed focal intravascular endothelial proliferation in fibrous tissue consistent with intravascular papillary endothelial hyperplasia (IPEH), or Masson’s lesion. no
32nd Annual North American Neuro-Ophthalmology Society Meeting, 2006 Frank B. Walsh Session.
[show abstract][hide abstract] ABSTRACT: In an effort to address the limitations on high-power accelerator target performance prompted by the elevated dose levels and the associated irradiation damage, an experimental study has been conducted to explore interesting new alloys and composites under the influence of protons and neutrons. Material irradiations were performed using the 200-MeV protons of the BNL Linac operating with an effective power of 18 kW. Selective results of the post-irradiation analysis of composites and "super" alloys depicting the effects on their physical and mechanical properties are presented. The post-irradiation analysis reveals interesting damage reversal by some of the promising candidate materials and unexpected low threshold of radiation resistance by others. Also included is a discussion of the correlation between proton-and neutron-induced damage and of the associated experimental effort to unravel such correlations.
[show abstract][hide abstract] ABSTRACT: The ever-increasing demand for high power accelerators requires high-performance materials that can safely intercept the proton beam either as accelerator targets or collimators. To satisfy the requirements of these multi-MW level machines the envelope of the current knowledge regarding material behavior and endurance for both short and long exposure needs to be extended. For collimating structures intercepting the halo of an intense beam under normal or the entire beam during off-normal conditions, performance issues are essential and directly tied to materials and their ability to maintain key properties and absorb beam-induced shock. The limitations of most materials in playing such pivotal roles have led to an extensive search and experimentation with new alloys and composites appear to possess the right combination of properties satisfying target and /or collimation requirements. This paper presents experimental results on a host of materials explored in recent years for use in the high-power target concepts and the collimators of accelerators currently under consideration or construction.