Online Journal of Bioinformatics. 01/2011; 12:18-33.
ABSTRACT: Global spread of multidrug resistant bacteria like K. pneumoniae and E.coli have raised the alarm for researchers and doctors throughout the world. This new mechanism of resistance as well as the ability of ndm-1 gene to be transferred between the species may end the era of antibiotics treatment. Carbapenems are reliable drug against many multiresistant gram-negative pathogens. A 3-D homology model of NDM-1 was built and analyzed for elucidation of functional site and binding interactions. Present study revealed that Meropenem has good interaction with the active sites of the receptor that could retard the spread of antibiotic resistant bacteria.
International Journal of Bioinformatics Research and Applications 01/2011;
Expert Systems with Applications. 01/2011;
FEBS Letters 01/2011; · 3.54 Impact Factor