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ABSTRACT: Total protein content, alpha 1-antitrypsin, alpha 2-macroglobulin and plasminogen levels and measles antibody titers were determined in serum and plasma from patients affected with multiple sclerosis and patients affected with non-neurological diseases. The results were compared with those from a control group of healthy donors. Both multiple sclerosis patients and patients affected with non-neurological diseases differed from controls for the following parameters: total protein, plasminogen and measles antibody activity. However, when studied longitudinally the different parameters were not altered to the same degree in multiple sclerosis and non-neurological diseases, a fact which is translated in the difference of significance levels. Individual plasminogen values were very often higher in non-neurological diseases than in multiple sclerosis, whereas for increased measles antibody titers it was the reverse. Also, there were no notable changes in alpha 1-antitrypsin and alpha 2-macroglobulin values in multiple sclerosis, whereas in some non-neurological disease patients particularly high alpha 1-antitrypsin and alpha 2-macroglobulin values were observed. In the multiple sclerosis patients, no correlations existed between the duration of the disease and disturbed biochemical parameters, or between the disturbed parameters themselves.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 11/1984; 22(10):653-9.
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ABSTRACT: Several biochemical parameters, the most important of which are total IgG, kappa and lambda light chain distribution and thin layer isoelectric focusing, were determined in the cerebrospinal fluid of 36 multiple sclerosis patients. Their ages and the evolution period of their disease are widely spread and no sex differentiation was made.
Journal of Neurology 05/1976; 212(2):151-8. · 3.47 Impact Factor
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[show abstract]
[hide abstract]
ABSTRACT: Several biochemical parameters, the most important of which are total IgG, kappa and lambda light chain distribution and thin
layer isoelectric focusing, were determined in the cerebrospinal fluid of 36 multiple sclerosis patients. Their ages and the
evolution period of their disease are widely spread and no sex differentiation was made.
Bei 36 Patienten mit multipler Sklerose wurden im Liquor eine Reihe von biochemischen Parametern bestimmt: Gesamt-IgG, leichte
Immunglobulinketten vom Kappa- und Lambda-Typ und Dünnschichtelektrofocusierung. Das Alter und die Dauer der Erkrankung war
bei den Patienten ganz unterschiedlich, und es wurde nicht auf das Geschlecht geachtet.
Key wordsMultiple sclerosis-Cerebrospinal fluid-Immunoglobulins-Light chain distribution
Journal of Neurology 04/1976; 212(2):151-158. · 3.47 Impact Factor
