N Y Haboubi

University Hospital Of South Manchester NHS Foundation Trust, Manchester, England, United Kingdom

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Publications (99)394.55 Total impact

  • Najib Haboubi, Emil Salmo
    Colorectal Disease 07/2013; 15(7):775-7. · 2.08 Impact Factor
  • E Salmo, Y El-Dhuwaib, N Y Haboubi
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    ABSTRACT: Locally advanced rectal cancer is commonly treated by neoadjuvant therapy and the resultant tumour response can be quantified histologically. This therapy may also induce radiation colitis, which also can be graded. The aim of this study was to assess the grading of tumour regression and of radiation colitis and their relationship to other prognostic parameters. Between 2000 and 2006, 75 patients (23 women; median duration of follow up, 58 months) with rectal cancer were evaluated. Sixty-three had short-course radiotherapy and 12 had long-course radiotherapy. Tumour regression was graded histologically using the three-point Ryan system: patients with grades 1 and 2 were considered as responders and patients with grade 3 were considered as nonresponders. Radiation colitis was graded histologically as mild, moderate or severe, as described previously (J Pathol 2006; 210: P25). Twenty-nine patients were classified as responders and 46 as nonresponders. The former were less likely to be lymph node positive compared with the latter (P=0.001). Tumour response did not correlate with local recurrence. Responders showed a disease-free survival (not overall survival) advantage at 2 and 5 years over nonresponders. Responders showed a higher rate of postoperative abdominal complications. Histological evidence of regression was demonstrated in patients treated with short-course radiotherapy. There was no relationship between radiation colitis grade and abdominal complications. Radiation colitis grade does not correlate with postoperative complications. More abdominal complications occurred in patients receiving long-course radiotherapy.
    Colorectal Disease 10/2011; 13(10):1100-6. · 2.08 Impact Factor
  • Source
    Emil Salmo, Najib Haboubi
    08/2011; , ISBN: 978-953-307-568-6
  • Emil Salmo, Najib Haboubi
    Polish Journal of Surgery 02/2011; 83(2):108-16.
  • Najib Haboubi
    Colorectal Disease 05/2010; 12(5):395-6. · 2.08 Impact Factor
  • Source
    E N Salmo, N Y Haboubi
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    ABSTRACT: Pre-operative radiotherapy may induce radiation colitis and tumour regression. Histological evaluation of radiation colitis needs to be reproducible to assess disease progression. The severity of radiation colitis can be assessed and graded according to its histological features. Increased severity of disease appears to be associated with a higher degree of cellular atypia and a lesser eosinophilic infiltrate. The severity of histological changes does not appear to be associated with post-operative complications. Tumour regression is an interesting phenomenon, the histological grading of which is of prognostic importance. Patients treated with long course radiotherapoy appear to have more incidences of postoperative complications. However, these are though to be related to the degree of tumour regression rather than to the type of radiotherapy.
    Acta chirurgica iugoslavica 01/2010; 57(3):51-4.
  • Najib Haboubi
    Colorectal Disease 11/2009; 11(9):891-2. · 2.08 Impact Factor
  • Peter J Mitchell, Najib Y Haboubi
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    ABSTRACT: Adenomas are the precursors to colorectal cancer. Malignant adenomas represent an early form of colorectal cancer, in which cancer has invaded by direct continuity through the muscularis mucosa into the submucosa. The management of these malignant adenomas depends upon their histological risk factors and the patient's general condition. A literature review of publications regarding the malignant adenoma/polyp using Medline was performed. The three main histological characteristics associated with an increased risk of residual disease and the potential for metastases are completeness and margin of excision, degree of differentiation and Haggitt level of invasion. The dilemma as to which course of action is in the best interest of the patient with high-risk adenoma, be it either therapeutic polypectomy alone or surgical resection, is best resolved by a multidisciplinary team involving the surgeon, pathologist and endoscopist, taking the patient's condition and wishes into account.
    Surgical Endoscopy 08/2008; 22(7):1563-9. · 3.43 Impact Factor
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    ABSTRACT: The early molecular changes preceding the onset of mucosal inflammation in colitis and their temporal relationship with gut permeability remain poorly defined. This study investigated functional and transcriptomic changes in mdr1a(-/-) mice lacking the intestinal transporter P-glycoprotein, which develop colitis spontaneously when exposed to normal enteric flora. Mdr1a(-/-) mice were housed in specific pathogen-free conditions to slow colitis development and compared to congenic controls. Mucosal permeability and cytokine secretion were analyzed in ex vivo colon. Gene expression in colonic mucosal and epithelial preparations was analyzed by microarray and qPCR. Colonocyte responsiveness to bacterial antigens was measured in short-term culture. Colon from 4-5-week-old, disease-free mdr1a(-/-) mice was histologically normal with no evidence of increased permeability compared to controls. However, these tissues display a distinctive pattern of gene expression involving significant changes in a small number of genes. The majority of upregulated genes were associated with bacterial recognition and the ubiquitin-proteasome system and were gamma-interferon (IFN-gamma) responsive. Expression of the antiinflammatory factor pancreatitis-associated protein (PAP) and the related gene RegIIIgamma were markedly reduced. Colonocytes from 4-5-week mdr1a(-/-) exhibit similar transcriptomic changes, accompanied by higher basal chemokine secretion and increased responsiveness to LPS. Significant increases in colonic permeability were associated with older (12-16-week) mdr1a(-/-) mice displaying molecular and functional evidence of active inflammation. These studies show that early epithelial changes associated with altered responsiveness to bacteria precede increased permeability and mucosal inflammation in this model of colitis, highlighting the importance of P-glycoprotein in regulating interactions with the commensal microflora.
    Inflammatory Bowel Diseases 06/2008; 14(5):620-31. · 5.12 Impact Factor
  • P J Mitchell, E Salmo, N Y Haboubi
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    ABSTRACT: Patients with ulcerative colitis and colonic Crohn's disease are at an increased risk of developing colorectal malignancy. The reporting of such cases in the literature has led to the identification of a number of risk factors for the development of mucosal dysplasia and cancer. The diagnosis of dysplasia and the subsequent management, however, are not without controversy, as is the practice of surveillance colonoscopy that is commonly performed in an attempt to reduce the risk of cancer.
    Techniques in Coloproctology 01/2008; 11(4):299-309. · 1.54 Impact Factor
  • P J Mitchell, M Y Rabau, N Y Haboubi
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    ABSTRACT: The term indeterminate colitis has been used to describe cases of inflammatory bowel disease that cannot be classified as ulcerative colitis or Crohn's disease. However, this term has suffered varying definitions, which in addition to numerous difficulties in diagnosing inflammatory bowel disease has led to much confusion. The term indeterminate colitis should only be used in cases where a colectomy has been performed and the overlapping features of Crohn's disease and ulcerative colitis do not allow a definitive diagnosis. Over time the majority of patients remain with a diagnosis of indeterminate colitis, or show symptoms similar to ulcerative colitis. Ileal pouch-anal anastomosis surgery can be performed in such patients, with outcomes of pouch failure and functional outcome that are similar to those in patients with ulcerative colitis but with increased risk of postoperative pouch complications. This review addresses the definition of indeterminate colitis, its pathology, natural history, and outcomes of restorative proctocolectomy.
    Techniques in Coloproctology 07/2007; 11(2):91-6. · 1.54 Impact Factor
  • N Y Haboubi, M W Edilbe, J Hill
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    ABSTRACT: The currently accepted first line treatment for epidermoid anal cancer is chemoradiotherapy (CRT). Tumour size and adjacent organ involvement are the key in the pretreatment assessment for T1-T4 tumours respectively. Residual or recurrent disease following initial CRT, is best treated by salvage anorectal excision. Pathological staging systems of resections were historically validated when surgery was the primary treatment and are therefore in need of revision. We propose a new pathological staging system for salvage anorectal excision specimens to allow improved prognostic guidelines postoperatively.
    Colorectal Disease 04/2007; 9(3):238-44. · 2.08 Impact Factor
  • Najib Haboubi
    Colorectal Disease 10/2006; 8(7):537-8. · 2.08 Impact Factor
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    ABSTRACT: This review presents an up-to-date analysis of the importance of accurate pathological lymph node staging in colorectal cancer. Lymph node staging is reliant on the technique of the surgeon and the pathologist as well as methods employed in the histopathology laboratory, and is vital for determining appropriate therapy. The significance of micrometastatic nodal disease is evaluated and new techniques for pathological evaluation are discussed. Recommendations for evaluation of lymph node status in colorectal cancer are provided based on current scientific evidence, and standardization of pathological dissection and laboratory handling is advocated.
    Colorectal Disease 08/2006; 8(6):460-70. · 2.08 Impact Factor
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    Najib Haboubi
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    ABSTRACT: Dysplasia in ulcerative colitis was defined as an unequivocal neoplastic change that is intraepithelial and within the confinement of the glandular basement membrane. Although that definition has stood the test of time and the classification is still the golden standard, the recommendations of treatment and follow up has significantly debated and changed. The purpose of this lecture is to outline the difficulties and controversies associated with dysplasia.
    Acta chirurgica iugoslavica 02/2006; 53(2):31-3.
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    N Pranesh, N Y Haboubi, S T O'Dwyer
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    ABSTRACT: Familial adenomatous polyposis (FAP) is an autosomal dominant condition with near complete penetrance, characterised by the presence of numerous adenomatous polyps of the colon and rectum. Melanosis coli describes the brownish-black discolouration of the colon resulting from the accumulation of a granular pigment in the phagosomes of macrophages in the colonic lamina propria. The presence of melanosis pigment in pericolonic lymph nodes has been reported in patients with coincidental melanosis coli, following segmental colonic resection. We report a unique case of FAP with melanosis pigment in lymph nodes in the small bowel mesentery that initially prevented a restorative proctocolectomy but that resolved following a colectomy, subsequently facilitating formation of an ileo-anal pouch.
    Annals of The Royal College of Surgeons of England 08/2005; 87(4):W1-4. · 1.33 Impact Factor
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    ABSTRACT: Pilonidal sinus (PNS) is a common condition, which warrants surgical intervention. A number of surgical options have been suggested with variable recurrence rate. This study proposes a modification of a standard method. A total of 51 patients with sacrococcygeal PNS were sequentially treated by the standard method devised by one Consultant Colorectal Surgeon (IA). The principle is based on: 1, after excising the PNS ensure obliteration of the natal cleft by releasing the fat pad from the gluteal fascia; 2, avoid tension and 3, encourage patients to lie on their back immediately after the operation. Follow-up was available from 51 patients ranging from 14 to 49 months. All patients were discharged within 48 h. There was only one recurrence, which was successfully treated. Our results suggest that PNS can be successfully treated by our hitherto undescribed method, patients can be discharged early and there is very low recurrence rate.
    Colorectal Disease 02/2005; 7(1):81-5. · 2.08 Impact Factor
  • M S Absar, N Y Haboubi
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    ABSTRACT: The biological behaviour of the polyp depends entirely on its histological subtype. Adenomas are the classic precursors to carcinoma. Polyp biopsy can differentiate neoplastic (adenoma and carcinoma) from non-neoplastic polyps (hyperplastic, inflammatory, hamartomatous). Due to potential sampling error, biopsy does not always differentiate between adenoma and carcinoma. Our aim was to investigate the degree of this potential sampling error. We carried out a study to compare the results of biopsies vs. total tissue examinations in a cohort of 433 neoplastic polyps. In this study 18.5% of carcinomatous polyps show definitive malignant elements only when the entire polyp is presented to the pathologist. We have therefore adopted a special reporting template if the polypoidal tumour is either biopsied or incompletely excised. The study also showed that within adenomas there could be variance of architectural patterns between the biopsy and the whole specimen. In this series, biopsying malignant colonic polyps gives rise to 18.5% false negative results and therefore it is significantly less efficient in the diagnosis of malignancy compared to total polyp examination.
    Techniques in Coloproctology 01/2005; 8 Suppl 2:s257-60. · 1.54 Impact Factor
  • J Mathew, I M Aldean, F A Ghafar, N Y Haboubi
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    ABSTRACT: Intussusception of the appendix is a rare condition. We present the case of a 72-year-old woman with multiple polyps in the colon with an appendix completely intussuscepted into a polyp within the caecum. The clinical features, preoperative diagnosis, classification and treatment of this condition are discussed with reference to literature.
    Techniques in Coloproctology 09/2004; 8(2):113-5. · 1.54 Impact Factor
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    ABSTRACT: Although colonic biopsies have become a major source of information to the clinician investigating cases of inflammatory bowel diseases (IBD), there are still some difficulties in making definitive diagnoses. This article looks into these challenges and possible ways of dealing with them. We strongly recommend supplying the pathologist with full clinical, radiological and endoscopic information with the request form. The pathologist may then issue a preliminary working report, while the final report should be reached at the much needed regular clinicopathological conference.
    Techniques in Coloproctology 09/2004; 8(2):117-21. · 1.54 Impact Factor

Publication Stats

1k Citations
394.55 Total Impact Points

Institutions

  • 1987–2013
    • University Hospital Of South Manchester NHS Foundation Trust
      Manchester, England, United Kingdom
  • 2011
    • Bolton NHS Foundation Trust
      Bolton, England, United Kingdom
  • 2007
    • Lancashire Teaching Hospitals NHS Foundation Trust
      Chorley, England, United Kingdom
  • 2006
    • National Health Service
      • Department of Cellular Pathology
      Radditch, England, United Kingdom
  • 1994–2002
    • The Christie NHS Foundation Trust
      Manchester, England, United Kingdom
  • 1988–1999
    • The University of Manchester
      • School of Psychological Sciences
      Manchester, ENG, United Kingdom
  • 1992
    • Institute of Cancer Research
      Londinium, England, United Kingdom