N Kato

Kanazawa Medical University, Kanazawa-shi, Ishikawa-ken, Japan

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Publications (1)3.22 Total impact

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    ABSTRACT: The endopiriform nucleus (EPN) is a large group of multipolar cells located in the depth of the piriform cortex (PC). Although many studies have suggested that the EPN plays a role in temporal lobe epilepsy, the normal function of the EPN remains to be elucidated. By using optical imaging of coronal brain slice preparations with voltage-sensitive dye, we found signal propagation from the PC or gustatory cortex (GC) to the EPN in normal medium. In our previous research, we failed to elicit a reliable signal reproducibly in the EPN by single stimulation either to the PC or GC. In our current research, we found that a double-pulse stimulation to either the PC or GC (interpulse interval: 20-100 ms) induced robust signal propagation to the EPN through excitation in the agranular division of the insular cortex (AI), with further extension to the claustrum. Finally, double site paired-pulse stimulation to the PC and GC also evoked excitation in the AI, claustrum, and EPN. These results suggest that the EPN has dual roles: 1) further processing of modality-specific olfactory and gustatory information from the PC and GC, respectively and 2) synergistic integration of PC-derived olfactory information and GC-derived gustatory information.
    Chemical Senses 04/2012; 37(8):681-8. · 3.22 Impact Factor

Publication Stats

2 Citations
3.22 Total Impact Points

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Institutions

  • 2012
    • Kanazawa Medical University
      • Department of Physiology
      Kanazawa-shi, Ishikawa-ken, Japan