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ABSTRACT: Oral implantation surgery is performed under sedation without monitoring consciousness, but BIS monitor is useful for evaluation of sedation level. Therefore we investigated whether BIS monitor is useful for this surgery.
Sixty-four patients scheduled for oral implant surgery were analyzed retrospectively. Patients were classified into two groups; BIS monitor was used (Group B) or not (Group A). We investigated the dose of midazolam necessary for intraoperative sedation, and for patient's satisfaction.
The dose of midazolam in Group B was greater than that in Group A. The dose in Group B was higher than that in Group A according to patient's satisfaction.
BIS monitor is useful for oral implant surgery.
Masui. The Japanese journal of anesthesiology 04/2009; 58(3):357-9.
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ABSTRACT: Our recent study has shown that the intracerebroventricular administration of d-serine, an endogenous and selective agonist for the glycine site of the N-methyl-d-aspartate receptor, alone or in combination with morphine, leads to the potentiation of antinociception on the tail-flick response. Although there is a variety of information concerning the effects of benzodiazepines on opioid-induced antinociception, little is known about the effect of benzodiazepines on the N-methyl-d-aspartate receptor agonist-induced antinociception. To clarify the analgesic interactions among the benzodiazepine/GABA(A), N-methyl-d-aspartate and opioid receptors at the supraspinal level, we investigated the effects of intracerebroventricular administration of midazolam, a benzodiazepine receptor agonist, on the antinociception evoked by the intracerebroventricular application of d-serine or morphine. The intracerebroventricular administration of midazolam alone produced hyperalgesia on the tail-flick response in a benzodiazepine receptor antagonist, flumazenil-reversible manner. The antinociception induced by the intracerebroventricular application of d-serine or morphine was attenuated by the intracerebroventricular administration of midazolam. In addition, this inhibitory effect of midazolam on the antinociception of d-serine or morphine was antagonized by the intracerebroventricular administration of flumazenil. Together with the facts that d-serine and midazolam act as selective agonists for the glycine site of the N-methyl-d-aspartate receptor and benzodiazepine/GABA(A) receptor, respectively, these observations suggest a functional interaction between the NMDA and benzodiazepine/GABA(A) receptors in the regulation of antinociception at the supraspinal level.
European Journal of Pharmacology 06/2008; 586(1-3):139-44. · 2.52 Impact Factor
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ABSTRACT: Dexmedetomidine may be suitable for postoperative sedation of patients with mandibular osteotomy.
Twenty patients were sedated with dexmedetomidine (group D) employing loading infusion at 1.0 microg x kg(-) x hr(-1) and then continuous infusion at 0.7 mg x kg(-1) x hr(-1). Other twenty patients were sedated with midazolam 0.1 mg x kg(-1) (group C). Ramsay score was recorded at 3 hours and 12 hours after infusing sedative drugs. Then, we questioned patients, nurses and doctors.
Ramsay score in the group D was higher than that in the group C (P < 0.01). Hypotension and respiratory depression did not occur. But bradycardia occurred in two cases. By adding propofol, group D showed more effective sedation.
This study shows that sedation with dexmedetomidine is more suitable than that with midazolam.
Masui. The Japanese journal of anesthesiology 08/2007; 56(8):942-4.
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Masanobu Yoshikawa,
Kenji Ito, Miho Maeda,
Kazuhito Akahori,
Shigeru Takahashi,
Xing Lu Jin,
Mitsumasa Matsuda,
Toshiyasu Suzuki,
Tetsuo Oka,
Hiroyuki Kobayashi,
Atsushi Hashimoto
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ABSTRACT: Although there is a variety of information concerning the effects of the N-methyl-D-aspartate (NMDA) receptor on opioid-induced antinociception at the spinal level, little is known about the effects at the supraspinal level. To clarify the role of the NMDA receptor on the morphine-induced antinociception at the supraspinal level, we investigated the effects of the intracerebroventricular (i.c.v.) administration of D-serine, a selective agonist for the glycine site of the NMDA receptors, alone or in combination with morphine using the tail-flick test. The i.c.v. administration of D-serine, but not L-serine, alone produced a dose-dependent antinociception in the tail-flick response. D-Serine also dose-dependently potentiated the antinociceptive effect induced by the i.c.v. administration of morphine and the simultaneous administration produced an additive effect. The potentiation of the antinociception produced by both D-serine alone or in combination with morphine was dose-dependently attenuated by the i.c.v. administration of L-701,324, a selective antagonist for the glycine site of the NMDA receptors. In addition, the potentiation of the D-serine-induced antinociception was antagonized by the i.c.v. administration of naloxone, a nonselective opioid receptor antagonist. These observations, together with the fact that D-serine is an endogenous and selective co-agonist for the glycine site of the NMDA receptors, strongly suggested that the activation of the supraspinal NMDA receptors by D-serine leads to the potentiation of the antinociception in the tail-flick test and that endogenous D-serine could modulate the mu-opioid receptor mediated antinociception via the glycine site of the NMDA receptors at the supraspinal level.
European Journal of Pharmacology 07/2007; 565(1-3):89-97. · 2.52 Impact Factor
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ABSTRACT: The catheter straight advancement rate for introduction into the epidural space was investigated using a radiopaque catheter. One hundred patients were divided into two groups and underwent thoracic or lumbar epidural punctures, with one of two different puncture methods: the median approach or paramedian approach. Two different angles of epidural puncture needle insertion, 50-60 degrees and 90 degrees to skin surface plane, were used. A catheter was inserted into the epidural space about 5 cm cephalad and the course of the inserted catheter was ascertained by radiography. The results have shown that punctures performed at an insertion angle of 50-60 degrees yielded higher catheter straight advancement rates than those performed at an angle of 90 degrees in both thoracic and lumbar epidural punctures.
The Tokai journal of experimental and clinical medicine 07/2004; 29(2):27-33.
