Min Wang

Beijing Proteome Research Center, Peping, Beijing, China

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Publications (244)440.01 Total impact

  • min wang, Feng Wang, Jiping Ma, Jie Xu
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    ABSTRACT: Precise control over size, morphology and composition of coordination polymers (CPs) is challenging but important for extending these hybrid materials to many more applications. Herein, we report a protocol of preparing unitary and multinary metal-carboxylic acid coordination polymers without additive. We found the CPs morphology was controlled by the geometric angle (∠) of carboxylic groups in organic linkers. At the ∠120 o, the mono-dispersed and uniform spherical CPs were obtained with the central distribution size ranging from nanoscale to microscale, adjusted by the precursor concentration and reaction time. We also obtained a series of spherical metal-CPs including transition and rare earth metal (Mg, Ni, Zn, In, Y, Sm, Eu, Gd, Er, Ho, Yb and Lu) and homogeneously distributed multinary metal-CP. Moreover, the calcination of these CPs generated unitary and multinary metal oxides with the yolk-shell structure. In addition, metal-CPs contain the coordinatively unsaturated metal sites, confirmed by probe molecule adsorption-IR spectroscopy, and could catalyze the cyanosilylation of carbonyl substrates at 25 oC. Sixteen examples were tested with good to excellent yields over Eu-CPs.
    J. Mater. Chem. A. 07/2014;
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    ABSTRACT: Mesoporous solid strong base was applied to support cobalt oxide to obtain a strong base-type catalyst, which showed good performance in the heterogeneous oxidation of ethylbenzene under solvent free conditions during the temperature range of 373-403 K. It was demonstrated that the reported strong base-type catalyst could facilitate the decomposition of 1-phenyl-ethylhydroperoxide and high reaction rate (2.89*10-5 S-1) could be obtained at 403 K.
    Catal. Sci. Technol. 07/2014;
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    ABSTRACT: A new strategy was developed to introduce gold nanoparticles into the yolk-shell type porous organic networks under the assistance of a phenyl modified SiO2-based template. The obtained material showed good properties such as thermal-stability and anti-aggregation, and can be used as an efficient nanoreactor for the catalytic decomposition of cyclohexyl hydroperoxide.
    Chemical communications (Cambridge, England). 07/2014;
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    ABSTRACT: This study aimed to investigate the role in metastasis and prognostic value of KAP-1 in pancreatic cancer (PC). The expression of KAP-1 was analyzed by quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemical staining in 91 human PC tissue samples. Capan-2 cells were transfected with a lentiviral vector expressing KAP-1 (Capan-2/KAP-1) or the empty vector (Capan-2/vector); cell migration and invasion were assayed in vitro using Transwell migration and wound-healing assays, and in vivo using a xenograft model in nude mice. KAP-1 was found to be overexpressed in human PC, and the expression of KAP-1 correlated with clinical stage. Overexpression of KAP-1 increased the invasion and migration of Capan-2 cells in vitro. Furthermore, overexpression of KAP-1 promoted the growth and metastatic ability of PC cells in a xenograft model in nude mice. Moreover, overexpression of KAP-1 induced the epithelial-mesenchymal transition (EMT) in PC cells both in vitro and in vivo, as indicated by increased expression of mesenchymal markers such as vimentin and decreased expression of E-cadherin. This study indicates that KAP-1 may promote metastasis in PC by regulating the EMT and suggests that KAP-1 may have potential as a predictor of metastasis in patients with pancreatic cancer.
    Medical oncology (Northwood, London, England). 07/2014; 31(7):25.
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    ABSTRACT: A solar radio burst was observed in a coronal mass ejection/flare event by the Solar Broadband Radio Spectrometer at the Huairou Solar Observing Station on 2004 December 1. The data exhibited various patterns of plasma motions, suggestive of the interaction between sunward moving plasmoids and the flare loop system during the impulsive phase of the event. In addition to the radio data, the associated white-light, Hα, extreme ultraviolet light, and soft and hard X-rays were also studied.
    Research in Astronomy and Astrophysics 07/2014; 14(7):843. · 1.35 Impact Factor
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    ABSTRACT: A new calibration model of a radio telescope that includes pointing error is presented, which considers nonlinear errors in the azimuth axis. For a large radio telescope, in particular for a telescope with a turntable, it is difficult to correct pointing errors using a traditional linear calibration model, because errors produced by the wheel-on-rail or center bearing structures are generally nonlinear. Fourier expansion is made for the oblique error and parameters describing the inclination direction along the azimuth axis based on the linear calibration model, and a new calibration model for pointing is derived. The new pointing model is applied to the 40m radio telescope administered by Yunnan Observatories, which is a telescope that uses a turntable. The results show that this model can significantly reduce the residual systematic errors due to nonlinearity in the azimuth axis compared with the linear model.
    Research in Astronomy and Astrophysics 06/2014; 14(6):733. · 1.35 Impact Factor
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    ABSTRACT: G protein-coupled receptor kinase-interactor 2 (GIT2) regulates thymocyte positive selection, neutrophil-direction sensing, and cell motility during immune responses by regulating the activity of the small GTPases ADP ribosylation factors (Arfs) and Ras-related C3 botulinum toxin substrate 1 (Rac1). Here, we show that Git2-deficient mice were more susceptible to dextran sodium sulfate (DSS)-induced colitis, Escherichia coli, or endotoxin-shock challenge, and a dramatic increase in proinflammatory cytokines was observed in Git2 knockout mice and macrophages. GIT2 is a previously unidentified negative regulator of Toll-like receptor (TLR)-induced NF-κB signaling. The ubiquitination of TNF receptor associated factor 6 (TRAF6) is critical for the activation of NF-κB. GIT2 terminates TLR-induced NF-κB and MAPK signaling by recruiting the deubiquitinating enzyme Cylindromatosis to inhibit the ubiquitination of TRAF6. Finally, we show that the susceptibility of Git2-deficient mice to DSS-induced colitis depends on TLR signaling. Thus, we show that GIT2 is an essential terminator of TLR signaling and that loss of GIT2 leads to uncontrolled inflammation and severe organ damage.
    Proceedings of the National Academy of Sciences of the United States of America. 05/2014;
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    ABSTRACT: With an aim of accelerating the charge transfer between polyaniline (PANi) and graphene, polyaniline-graphene (PANi-graphene) complexes are synthesized by a reflux technique and employed as counter electrodes (CEs) for dye-sensitized solar cells (DSSCs). Owing to the easy charge-transfer between PANi (N atoms) and graphene (C atoms) by a covalent bond, electrical conduction and electrocatalysis of PANi-graphene complex CEs, and therefore power conversion efficiency of their DSSCs have been elevated in comparison with that of PANi-only CE. The resultant PANi-graphene complex CEs are characterized by spectral analysis, morphology observation, and electrochemical tests. The DSSC employing PANi-8 wt‰ graphene complex CE gives an impressive power conversion efficiency of 7.78%, which is higher than 6.24% from PANi-only and 6.52% from Pt-only CE based DSSCs.
    ACS Applied Materials & Interfaces 05/2014; · 5.01 Impact Factor
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    ABSTRACT: EphB2 is an important member of the receptor tyrosine kinases. Recently, EphB2 was shown to facilitate T-cell migration and monocyte activation. However, the effects of EphB2 on B cells remain unknown. In this study, the expression of EphB2 on B cells was tested by Western blot, and the roles of EphB2 in B-cell proliferation, cytokine secretion, and immunoglobulin (Ig) production were evaluated using EphB2 siRNA interference in human B cells from healthy volunteers. Our study revealed that EphB2 was distributed on naive B cells and was up-regulated on activated B cells. Moreover, B-cell proliferation (decreased by 22%, P<0.05), TNF-α secretion (decreased by 40%, P<0.01) and IgG production (decreased by 26%, P < 0.05) were depressed concordantly with the down-regulated EphB2 expression. Subsequently, we screened microRNAs that could regulate EphB2 expression in B cells, and discovered that miR-185 directly targeted to EphB2 mRNA and suppressed its expression. Furthermore, miR-185 overexpression inhibited B-cell activation, and the inhibitor of miR-185 enhanced B-cell activation. Moreover, abatement of EphB2 through miR-185 mimics or EphB2 siRNA attenuated the activation of Src-p65 and Notch1 signaling pathways in human B cells. Our study first suggested that EphB2 was involved in human naive B cell activation through Src-p65 and Notch1 signaling pathways and could be regulated by miR-185.-Yu, M., Liang, W., Wen, S., Zhao, T., Zhu, M.-X., Li, H.-H., Long, Q., Wang, M., Cheng, X., Liao, Y.-H., Yuan, J. EphB2 contributes to human naive B-cell activation and is regulated by miR-185.
    The FASEB Journal 05/2014; · 5.70 Impact Factor
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    ABSTRACT: A surface organic modification strategy is utilized to design and prepare a series of superhydrophobic SiO2-based nanocomposites with cobalt ions in the bulk phase and different organic groups on the surface. Physical properties such as BET surface area, surface hydrophilicity/hydrophobicity, and water adsorption amount changed significantly with the introduction of organic groups of various chain lengths, which was confirmed by TEM, SEM, FTIR, 29Si-NMR, N2 adsorption–desorption, sessile water contact angle, and TG-DTA measurements. Surface hydrophilicity/hydrophobicity altered from hydrophilic to superhydrophobic with an increase in carbon chain length, which showed an obvious effect on the catalytic performance in selective oxidation of hydrocarbons such as ethylbenzene. Superhydrophobicity was guaranteed for high catalytic activity, and the carbon chain length of the organic group was also an important factor. Superhydrophobic Pr–Co–SiO2 that contained the propyl group was the most efficient catalyst, and the conversion of ethylbenzene reached 70.4% with O2 as an oxidant under solvent-free conditions at 393 K for 7 h, which is nearly nine times that of the hydrophilic Co–SiO2 without surface organic modification.
    J. Mater. Chem. A. 05/2014; 2(21).
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    ABSTRACT: Co-inhibitory molecules of T cell immune responses have received considerable attention for their successful clinical effects during immunotherapy for the treatment of multiple cancers. LSECtin, a cell-surface member of the C-type lectin DC-SIGN family, has been shown to inhibit T cell responses and viral clearance in the liver. However, its role in antitumor immunity and tumor growth remains unclear. Herein, we detected LSECtin expression in approximately 50% of melanoma samples in a human tumor tissue array. In a B16 melanoma model, we revealed that LSECtin, when expressed on B16 cells, promoted tumor growth and LSECtin blockade resulted in significantly slower tumor growth in both WT and LSECtin KO mice; this LSECtin-mediated tumor-promoting effect was abrogated in Rag1-/- mice or in response to CD4+ or CD8+ T cell depletion. We further determined that LSECtin inhibited the proliferation of tumor-specific effector T cells by downregulating cell cycle-regulating kinases such as CDK2, CDK4, and CDK6. Consistently, LSECtin expressed on B16 tumor cells inhibited tumor-specific T cell responses in vivo and in vitro. Importantly, we indicated that LSECtin interacted with LAG-3, and LAG-3 blockade restored the reduced IFN-γ secretion mediated by melanoma-derived LSECtin. Together, LSECtin expressed on melanoma cells appears to be a novel possible mechanism of immune escape of melanoma cells and provides a foundation for potential combinatorial immunotherapy strategies.
    Cancer Research 04/2014; · 9.28 Impact Factor
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    ABSTRACT: We here demonstrate a simple, efficient and eco-friendly protocol for the direct synthesis of imines from amines via a facile α-MnO2 catalyzed-procedure at rt. Up to 13 benzylic, heterocyclic, and normal aliphatic imines were synthesized with 95–99% selectivity at 82–99% conversion.
    Green Chemistry 04/2014; 16(5). · 6.83 Impact Factor
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    ABSTRACT: Background & objectives: a0 ngiotensin II receptor type 1 (AT1) is known to be involved in the pathogenesis of hypertension. t0 his study was undertaken to explore the effect of active immunization against AT1 receptor on blood pressure and small artery remodelling in spontaneously hypertensive rat (SHR). Methods: Male SHR and Wistar rats aged two months were actively immunized with different peptides (ATR12185ͱͲATR10014 and ATR12181) corresponding to particular sequences of rat AT1 receptor, while another SHR group was given losartan (10 mg/kg/day) orally once a day. Anti-AT1 receptor antibodies were detected by ELISA and blood pressure was measured. The effect of the antibodies on the artery and vascular smooth muscle cells (VSMCs) proliferation was studied. Results: all immunized animals produced antibodies against the particular peptides. The systolic blood pressure was decreased in the SHR immunized with peptide-ATR12181 compared with the control. However, no changes were observed in the SHR immunized with other two peptides. The Wistar rats immunized with the three peptides did not show any changes in blood pressure. The media/lumen area ratio of the mesenteric artery was reduced in SHR immunized with ATR12181 and similar to that of the SHR treated with losartan. The antibody from SHR immunized with ATR12181 had no effect on the proliferation of VSMC. But it could inhibit the proliferation caused by angiotensin II and its effect at the titre of 1:40 was similar to that of 1µmol/l losartan. Interpretation & conclusions : Our findings demonstrated that the antibody from SHR immunized with ATR12181 had the effect of reducing blood pressure and target organ protection similar to losartan. Active immunization against AT1 receptor may be a promising strategy in future for the treatment of hypertension.
    The Indian journal of medical research. 04/2014; 139(4):619-24.
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    ABSTRACT: Endothelial microparticles (EMPs) are small vesicular structures that serve as a marker of endothelial function. Angiotensin II receptor type 1 autoantibody (AT1-AA) can cause endothelial dysfunction. However, whether AT1-AA promotes EMPs formation and the mechanism remains obscure. The titres of sera AT1-AA of 126 hypertensive patients and 30 normotensive individuals were evaluated by ELISA. EMPs in the sera and the supernatants of human umbilical vein endothelial cells (HUVECs) were measured by flow cytometry. The phosphorylation levels of mitogen-activated protein kinase (MAPK) pathways in HUVECs treated by AT1-AA were assessed and their correlation with microparticle formation was also analysed. Furthermore, the production of intracellular reactive oxygen species (ROS) and nitric oxide in HUVECs was examined after incubation with 'injured' endothelial microparticle (iEMPs) (EMPs derived from AT1-AA treated HUVECs). The positive rate of AT1-AA in 126 hypertensive patients was 21.4% (27/126), and higher than that in normotensive individuals [3.3% (1/30), P < 0.01]. Circulating EMP (CD31+/CD42b-) levels were corresponding to the AT1-AA titres in hypertensive group (r = 0.3661, P < 0.01). AT1-AA promoted EMPs generation from HUVECs in a time and dose-dependent manner than the vehicle or nonspecific IgG. Meanwhile, AT1-AA significantly elevated phosphorylation level of P38 and ERK in HUVECs. Lorsartan and P38 inhibitor could suppress the AT1-AA's stimulation effect on EMPs generation. Moreover, the iEMP greatly increased ROS production and reduced nitric oxide synthesis in HUVECs. Our findings showed that circulating EMPs levels positively correlate to the serum AT1-AA titres in essential hypertension patients. The AT1-AA could promote EMPs generation in HUVECs through activation of P38 MAPK signalling pathway, and this effect could be effectively inhibited by losartan or p38 inhibitor. Angiotensin receptor blockers (ARBs) may be more suitable for AT1-AA(+) hypertensive patients on account of suppressing the AT1-AA's stimulation effect on EMPs generation.
    Journal of Hypertension 04/2014; 32(4):762-770. · 4.22 Impact Factor
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    ABSTRACT: Utilizing 1GHz RSOAs and 4GS/s DACs/ADCs, record-high 17.125Gb/s real-time dual-band OOFDM transmissions with 7dB receiver sensitivity improvements over IMDD-based 25km SSMFs are experimentally demonstrated, which show excellent robustness to 20dB variations in RSOA-injected optical powers.
    Optical Fiber Communication Conference; 03/2014
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    ABSTRACT: A new concept of synthesizing hexagonal polyaniline (PANi) fibers with polyacrylamide (PAAm) pendants in PAAm oligomer (oligo-PAAm) colloid is proposed. The size and morphology of the composite fibers can be controlled by adjusting the synthesis conditions. A possible growth mechanism of the PANi microstructures based on typical PAAm–crystals interactions in a mild aqueous solution is proposed. The amide ligands decorated oligo-PAAm chains are able to coordinate with –C6H4–NH+C6H4NH+–C6H4–NH–C6H4–NH– sections, leading to a lower surface energy and growth along c-directions to form fibriform morphology. The fibers have uniform diameter ranging from 200 to 400 μm, and length varying from several millimeters to 6 cm. Fourier transform infrared measurement indicates that the fiber exhibits a main PANi chain with PAAm pendants, and ultraviolet–visible spectra reveal that the PANi is in high conductive emeraldine state. Acrylamide feed significantly affects the morphology, however, the conductivity and yield of the fiber depend on hydrochloric acid and potassium peroxydisulfate concentrations in the preparation process. The hexagonal composite fibers show an electrical conductivity of 2.2 S·cm−1 and yield of higher than 95%. Polymer-directed crystal growth may provide promising routes to rational synthesis of various ordered organic materials with complex form and structural specialization. POLYM. COMPOS., 35:253–262, 2014. © 2013 Society of Plastics Engineers
    Polymer Composites 02/2014; 35(2). · 1.48 Impact Factor
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    ABSTRACT: With an aim of significantly enhancing charge-transfer ability of counter electrodes and therefore photovoltaic performances of dye-sensitized solar cells (DSSCs), here we pioneerly report the complexation of polyaniline (PANi) and graphene as well as their employment as counter electrodes (CEs) in efficient DSSCs. Owing to the covalent bond between PANi (N atoms) and graphene (C atoms), charge transfer kinetics is dramatically elevated, which can be confirmed by the enhancement on electrocatalytic activity toward triiodides and a decrease in charge-transfer resistance. A power conversion efficiency of 7.70% is determined from DSSC using PANi−8 wt‰ graphene complex CE in comparison with 6.40% from pure PANi CE-based DSSC. The high conversion efficiency, facile charge-transfer in combination with simple preparation, relatively low cost, and scalability demonstrates the potential use of PANi−graphene complexes in robust DSSCs.
    Journal of Power Sources 01/2014; 256:8–13. · 5.26 Impact Factor
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    ABSTRACT: In order to make an exact prediction for the density of the lead-acid battery electrolyte, this paper proposes a method by using a genetic algorithm to optimise the support vector regression. In this AGA-SVR model, a kind of adaptive genetic algorithm is exploited to choose the model parameters of support vector regression for obtaining better prediction performance. The proposed predicting model is applied to the density predicting for lead-acid battery. The experimental results indicate that both GA and AGA have good efficiency on parameter optimisation. Furthermore, the AGA-SVR model provides a superior prediction performance than the other three models including SPSO-SVR model, IPSO-SVR model and GA-SVR model. Therefore, the AGA method could be considered as an effective alternative method for predicting electrolyte density.
    Int. J. of Modelling. 01/2014; 21(1):29 - 37.
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    ABSTRACT: A magnetically recyclable acid catalyst consisting of an Fe3O4 core and a thin sulfonic acid functionalized silica shell has been prepared using a reverse microemulsion method and subsequently used for the dehydration of in fructose to 5-hydroxymethylfurfural (HMF). This process gave a fructose conversion of approximately 99% and an 82% yield of HMF after 3 h in DMSO at 110 °C.
    Chinese Journal of Catalysis 01/2014; 35(5):703–708. · 1.30 Impact Factor

Publication Stats

803 Citations
440.01 Total Impact Points


  • 2009–2014
    • Beijing Proteome Research Center
      Peping, Beijing, China
  • 2000–2014
    • Chinese Academy of Sciences
      • • State Key Laboratory of Catalysis
      • • Research Center for Molecular and Developmental Biology
      • • Yunnan Astronomical Observatory
      Peping, Beijing, China
  • 1970–2014
    • Huazhong University of Science and Technology
      • • Department of Biliary-Pancreatic Surgery
      • • Department of Cardiology
      • • Department of Control Science and Engineering
      Wu-han-shih, Hubei, China
  • 2006–2013
    • Wuhan Union Hospital
      Wu-han-shih, Hubei, China
  • 2002–2013
    • Northeast Institute of Geography and Agroecology
      • • State Key Laboratory of Catalysis
      • • State Key Laboratory of Structural Chemistry
      • • Yunnan Astronomical Observatory
      Peping, Beijing, China
  • 2007–2010
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2008–2009
    • Nanjing University of Aeronautics & Astronautics
      • College of Mechanical and Electrical Engineering
      Nan-ching, Jiangsu Sheng, China
  • 2003
    • Korean Institute of Ocean Science and Technology
      Anzan, Gyeonggi Province, South Korea