Osvaldo Mazza

Hospital Italiano de Buenos Aires, Buenos Aires, Buenos Aires F.D., Argentina

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Publications (6)2.29 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objetivos: La mayoría de los tumores de riñón se detectan actualmente como una masa renal pequeña en pacientes asintomáticos, por el uso generalizado de la ecografía y otras modalidades no invasivas de exploración abdominal. La cirugía conservadora de riñón de estas masas renales pequeñas es el tratamiento de elección, tanto en pacientes con el riñón contralateral sano como en aquellos pacientes que presentan algún grado de deterioro en la función renal o son monorrenos funcionales o anatómicos. Revisamos retrospectivamente nuestra experiencia en cirugía conservadora de riñón en masas tumorales, a cielo abierto y por la vía laparoscópica. Método: Se revisaron las historias clínicas de aquellos pacientes a los cuales se diagnosticó una masa ocupante renal y se los trató con cirugía conservadora renal en el Hospital Británico de Buenos Aires y Hospital Alemán desde el año 1995 y el Hospital Universitario Austral desde el año 2000. Se tabularon todos los datos de interés de 246 pacientes, se analizaron las técnicas empleadas, complicaciones y resultados y se compararon con otras series de referencia. Resultados: Se realizaron 254 cirugías conservadoras de riñón. La cirugía a cielo abierto fue realizada en 220 casos y la nefrectomía parcial laparoscópica desde el año 2001 en 34 pacientes. La indicación fue electiva o relativa en 236 pacientes, 8 pacientes presentaron tumores bilaterales y hubo 18 cirugías en pacientes monorrenos. El clampeo del pedículo se realizó en 168 procedimientos, con hibernación en 43 pacientes con un tiempo promedio de 24,7 minutos. El promedio del tamaño tumoral tratado fue de 3,49 cm. El examen histopatológico demostró un carcinoma renal en 193 procedimientos, siendo el porcentaje de lesiones benignas del 24% (n=61). Un paciente presentó márgenes quirúrgicos positivos en diferido, se le realizó la nefrectomía al mes y no se constató tumor residual. Un paciente presentó una imagen pseudotumoral del lecho quirúrgico por TAC y RMN, se realizó una nefrectomía sin hallazgo de tumor residual. Se presentaron complicaciones postoperatorias en 20 pacientes (7,9 %). El control oncológico en el 84% de los pacientes con un promedio de 46,6 meses demostró una progresión con metástasis en 8 pacientes. La recurrencia local se observó en 4 pacientes (2%). Un paciente desarrolló un tumor en el riñón contralateral a los 20 meses y otro a los 10 años. La sobrevida específica por cáncer fue del 98% y la sobrevida global del 95%. En el último año el abordaje laparoscópico duplicó las indicaciones de todos los años previos. Conclusiones: La cirugía conservadora renal, actualmente considerada el gold standard del tratamiento de los tumores renales pequeños, es una técnica segura y confiable para el tratamiento de dichos tumores. La evolución tecnológica y el entrenamiento laparoscópi-co nos permite para casos seleccionados reproducir la cirugía a cielo abierto por la vía laparoscópica, obteniendo similares resultados.
    Archivos españoles de urología 01/2010; 63(1).
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    ABSTRACT: To report a case of laparoscopic radical cystectomy and pelvic lymphadenectomy with vaginal extraction of the surgical specimen in an elderly patient with muscle invasive bladder tumor. A 78 year old patient with history of hematuria was diagnosed of muscle invasive bladder cancer. Laparoscopic radical cystectomy and pelvic lymphadenectomy with vaginal extraction of the surgical specimen was performed without incident. Operative time was 240 minutes, surgical bleeding was 200 ml and hospital stay 8 days. The patient evolved uneventfully and remains disease free after 9 months of follow-up. Laparoscopic radical cystectomy provides adequate oncologic results with decreased morbidity, making this surgery an attractive alternative for the management of patients in a delicate condition.
    Archivos españoles de urología 06/2009; 62(4):305-8.
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    ABSTRACT: Objetivo: Presentar la utilidad de una técnica minimamente invasiva como herramienta terapéutica en el tratamiento de un paciente de edad avanzada portador de cáncer de vejiga musculoinvasor. Método: Paciente femenina de 78 años con cáncer de vejiga avanzado que debuta con hematuria. Se realiza cistectomía radical con linfadenectomía pelviana por vía laparoscópica con extracción de pieza quirúrgica por vía vaginal. Resultados: El tiempo operatorio fue de 240 minutos con un sangrado de 200 ml y una estadía hospitalaria de 8 días. La paciente evolucionó favorablemente y tras un seguimiento de 6 meses se encuentra sin evidencia de recidiva tumoral. Conclusión: El bajo impacto quirúrgico permite que este abordaje pueda ser utilizado en casos seleccionados para evitar la severa morbilidad indefectiblemente asociada a la progresión local del cáncer de vejiga avanzado.
    Archivos españoles de urología 01/2009; 62(4).
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    ABSTRACT: We perform a retrospective review of renal tumors operated with a maximum size of 4 cm to determine if the diagnostic methodology was adequate, the TMN staging prognostic accuracy (UICC 2002) and the goal surgical treatment. Between 1984 to 2005, 78 renal units form 74 patients (4 bilateral synchronous) operated at the Service of Urology of the Hospital Alemán de Buenos Aires. Age distribution, sex, presentation form (incidental and symptomatic), diagnostic methodology, laboratory variables, surgical treatment (partial or radical surgery), histopathology, Fuhrman grade, tumor size, bilaterality, multicentricity, TNM staging, evolution and survival (Kaplan Meier) were analyzed. 78 renal units from a total of 192, 40.62% were analyzed. The median age was 58.72 years. 69% were male and 31% female. The presentation form was 91.90 % incidental and symptomatic 8.10% (Hematuria in 5 and lung metastasis in 1). The diagnosis was performing with ultrasound and CT scan 63 cases, in 4 was also used resonance magnetic imaging (RMI) and in 7 ultrasound and RMI. Arteriography was used in 11 cases, 3 showed tumor and 8 were normal. Biopsy was performing in 5 cases, all positive for clear cells carcinoma. Globular sedimentation was the only one laboratory abnormality in 12 cases. Surgical treatment was radical surgery in 35 renal units (44.87%) and conservative surgery in 43 units (55.13%). Pathology clear cells carcinoma (CCC) 79.48%, papillary carcinoma 1.28%, angiomyolipoma (AML) 8.97%, oncocytoma 7.69% and adenoma 2.56%. The Fuhrman grade was 1 in 76.19%; 2 in 20.63% and 3 in 3.18%. Bilateral tumor were found in 4 cases 2 CCC, 1 CCC and AML and 1 CCC and adenoma. Tumor median size was 2.93 cm. Staging was T1a 96.82%, T3a 1.59% and T3aM+ 1.59%. Follow-up could be made in 54 of 61 cases. At median follow-up of 52.25 months, 50 cases were disease free, 3 died by progression at 18, 33 and 82 months and all of them were symptomatic tumors, 1 died by a non related cause. Survival rate was 94%. 1)Ultrasound and CT scan obtained a highest diagnostic accuracy for solid renal mass. Biopsy in selective cases could contribute to achieve a correct treatment strategy. 2) Conservative surgery was the goal treatment in selected tumors up to 4 cm. and we believe that TNM staging should contemplate the presentation form to improve the prognostic value.
    Actas urologicas españolas 10/2006; 30(8):772-83. · 1.14 Impact Factor
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    ABSTRACT: SOLID RENAL MASS UP TO 4 CM. ANALYSIS OF THE DIAGNOSTIC PROCEDURES, TNM STAGING AND SURGICAL TREATMENT Objectives: We perform a retrospective review of renal tumors operated with a maximum size of 4 cm to determine if the diagnostic methodology was adequate, the TMN staging prognostic accuracy (UICC 2002) and the goal surgical treatment. Material and method: Between 1984 to 2005, 78 renal units form 74 patients (4 bilateral synchronous) operated at the Service of Urology of the Hospital Alemán de Buenos Aires. Age distribution, sex, presentation form (incidental and symptomatic), diagnostic met- hodology, laboratory variables, surgical treatment (partial or radical surgery), histopathology, Fuhrman grade, tumor size, bilaterality, mul- ticentricity, TNM staging, evolution and survival (Kaplan Meier) were analyzed. Results: 78 renal units from a total of 192, 40.62% were analyzed. The median age was 58.72 years. 69% were male and 31% fema- le. The presentation form was 91.90 % incidental and symptomatic 8.10% (Hematuria in 5 and lung metastasis in 1). The diagnosis was performing with ultrasound and CT scan 63 cases, in 4 was also used resonance magnetic imaging (RMI) and in 7 ultrasound and RMI. Arteriography was used in 11 cases, 3 showed tumor and 8 were normal. Biopsy was performing in 5 cases, all positive for clear cells car- cinoma. Globular sedimentation was the only one laboratory abnormality in 12 cases. Surgical treatment was radical surgery in 35 renal units (44.87%) and conservative surgery in 43 units (55.13%). Pathology clear cells carcinoma (CCC) 79.48%, papillary carcinoma 1.28%, angiomyolipoma (AML) 8.97%, oncocytoma 7.69% and adenoma 2.56%. The Fuhrman grade was 1 in 76.19%; 2 in 20.63% and 3 in 3.18%. Bilateral tumor were found in 4 cases 2 CCC, 1 CCC and AML and 1 CCC and adenoma. Tumor median size was 2.93 cm. Staging was T1a 96.82%, T3a 1.59% and T3aM+ 1.59%. Follow-up could be made in 54 of 61cases. At median follow-up of 52.25 months, 50 cases were disease free, 3 died by progression at 18, 33 and 82 months and all of them were symptomatic tumors, 1 died by a non related cause. Survival rate was 94%. Conclusions: 1)Ultrasound and CT scan obtained a highest diagnostic accuracy for solid renal mass. Biopsy in selective cases could contribute to achieve a correct treatment strategy. 2) Conservative surgery was the goal treatment in selected tumors up to 4 cm. and we believe that TNM staging should contemplate the presentation form to improve the prognostic value
    Actas urologicas españolas 01/2006; 30(8). · 1.14 Impact Factor
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    ABSTRACT: The majority of renal cell carcinomas are now incidentally detected as small renal masses in asymptomatic patients due to the widespread use of ultrasound and new improved noninvasive abdominal imaging modalities. Nephron-sparing surgery is the treatment of choice for patients with small renal masses in presence of normal contralateral kidney or in presence of an anatomic or functional solitary kidney. We reviewed retrospectively our experience in open and laparoscopic partial nephrectomy. The records for all patients who underwent nephron-sparing surgery for a renal mass since 1995 at British Hospital of Buenos Aires and Hospital Aleman and since 2000 at Hospital Universitario Austral were reviewed. The most relevant data of 246 patients were collected, with special focus on demographic data, operative details, pathology results, complications and outcome in cancer control. We have performed 254 nephron-sparing surgeries. Open partial nephrectomy was performed in 220 procedures and the laparoscopic partial nephrectomy since 2001 in 34 patients. The indication was elective or relative in 236 patients with 8 patients with bilateral tumors and 18 tumors in a solitary kidney. The pedicle was clamped in 168 procedures with hypothermia in 43 patients. Mean ischemia time was 24.7 minutes. Average tumor size was 3.49 cm. The pathologic findings demonstrate a carcinoma in 193 cases and benign lesions in 61 patients (24%). One patient presented a positive surgical margin in the pathologic examination, but subsequent nephrectomy was negative for residual tumor. One patient presented a pseudo-tumoral mass on follow-up on CT scan and MRI, but nephrectomy was negative for residual tumor. There were postoperative complications in 20 patients (7.9 %). Oncologic follow up was available in 84% of the patients for an average of 46.6 months showing progression with metastasis in 8 patients. Local recurrence was observed in 4 patients (2%). One patient developed a tumor in the contralateral kidney 20 months after partial nephrectomy and another one 10 years later. The cancer specific survival and overall survival rates were 98 % and 95% respectively. In the last year the laparoscopic approach duplicated the indications of all previous years. Open partial nephrectomy is considered nowadays the gold standard treatment of small renal masses, and in our experience it is a safe and effective technique of treatment of these tumors. The evolution of the technology and the acquirement of laparoscopic skills allow us in selected cases to duplicate the open approach in a laparoscopic way, obtaining similar results.
    Archivos españoles de urología 63(1):62-9.

Publication Stats

2 Citations
2.29 Total Impact Points

Institutions

  • 2009
    • Hospital Italiano de Buenos Aires
      Buenos Aires, Buenos Aires F.D., Argentina
  • 2006
    • Hospital Alemán
      Buenos Aires, Buenos Aires F.D., Argentina