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ABSTRACT: Self-assessed masticatory ability has been shown to be significantly related to general health among elderly persons.
To identify oral factors associated with the self-assessed masticatory ability.
Cross-sectional study.
A total of 736 community-dwelling elderly persons.
Data on background factors and the self-assessed masticatory ability were collected by questionnaire. An intraoral examination examined the pattern of posterior occluding pairs of natural teeth (POPs), the WHO Community Periodontal Index of Treatment Needs (CPI) and denture-related factors such as use of dentures, pain when using dentures and stability and retention of dentures. Chi-squared tests examined the relationships between the self-assessed masticatory ability and the background factors and oral conditions. Ordinal regression models were constructed with the self-assessed masticatory ability as the dependent variable and oral conditions as the principal independent variables, to adjust for the potential confounding variables.
Self-assessed impairment of masticatory ability was associated with lost POPs (p < 0.001) and CPI (p = 0.012). In the participants with lost POPs, self-assessed impairment of masticatory ability was associated with not using dentures and pain when using dentures (p < 0.001). In the totally edentulous subjects, impairment of masticatory ability was not associated with stability and retention of dentures (p = 0.070).
Factors affecting self-assessed masticatory ability include the pattern of POPs, periodontal status, denture use and pain when using dentures.
Community dental health 03/2012; 29(1):39-44. · 0.75 Impact Factor
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ABSTRACT: In order to selectively remove pathogenic macromolecular reactants, a biological affinity type adsorbent (a DNA colloidin charcoal column or protein A sepharose CL4R = Prosorba) has been developed and used for the treatment of immune disorders, alloimmunization and cancer. However, because physiologically active materials are required in this procedure, it is difficult to ensure an adequate supply of raw materials (and their handling, sterilization and preservation as an immunoadsorbent. TO overcome the above-mentionned problems, ve developed physico-chemical type immunoadsorbents IM-TR and IM-PH, which consist of polyvinyl alochol gel where tryptophan, in the former, and phenylalanine, in the latter, is used as a ligand. IM-PH has a better selectivitity than IM-TR, however, IM-TR is a more efficient adsorbent of anti-acethylcholine receptor antibody than IM-PH. IM-PH plasma perfusion has been successfully used with patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).
07/2009; 17(2):117-124.
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Therapeutic Apheresis and Dialysis 03/2000; 4(1):54-7.
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Z Yamazaki,
Y Fujimori,
K Sanjo,
Y Kojima,
M Sugiura,
T Wada, N Inoue,
T Sakai,
T Oda,
N Kominami,
U Fujisaki,
K Kataoka
Therapeutic Apheresis and Dialysis 03/2000; 4(1):23-5.
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T Abe,
T Sakurai,
K Inagaki,
N Kominami,
Z Yamazaki,
Y Fujimori,
K Sanjo,
Y Kojima,
M Sugiura,
T Wada, N Inoue,
T Sakai,
T Oda
Therapeutic Apheresis and Dialysis 03/2000; 4(1):26-8.
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ABSTRACT: AST-120 is a specially synthesized carbonaceous adsorbent for oral use. It mainly adsorbs low to middle molecules in the alimentary tract. In the present study, AST-120 was administered to hepatic failure dogs, and blood metabolites were analyzed by high performance liquid chromatography (HPLC). Thirty adult mongrel dogs underwent posta-cavae (P-C) shunts with 40% and 70% hepatectomies. They were divided into two groups, the AST group (n = 19) and control group (n = 11). The AST group received about 0.5 g/kg of the adsorbent intermittently with diet after the operation. The control group was fed the ordinary diet. Body weight, blood ammonia, plasma bile acids were measured, and blood metabolites were analyzed by the multi-column HPLC system. P-C shunt dogs with 70% hepatotectomies died within three months showing about 40-50% body weight loss. HPLC analysis of their plasma showed some specific peaks for middle molecules, about 3000-5000 daltons. After administration of the adsorbent, these peaks were not detected, so it was considered that these substances had been adsorbed.
The International journal of artificial organs 03/1989; 12(2):114-20. · 1.86 Impact Factor
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ABSTRACT: In order to selectively remove pathogenic macromolecular reactants, a biological affinity type adsorbent (a DNA colloidin charcoal column or protein A sepharose CL4B = Prosorba) has been developed and used for the treatment of immune disorders, alloimmunization and cancer. However, because physiologically active materials are required in this procedure, it is difficult to ensure an adequate supply of raw materials (and their handling, sterilization and preservation as an immunoadsorbent. To overcome the above-mentioned problems, we developed physicochemical type immunoadsorbents IM-TR and IM-PH, which consist of polyvinyl alcohol gel where tryptophan, in the former, and phenylalanine, in the latter, is used as a ligand. IM-PH has a better selectivity than IM-TR, however, IM-TR is a more efficient adsorbent of anti-acethylcholine receptor antibody than IM-PH. IM-PH plasma perfusion has been successfully used with patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).
Biomaterials, artificial cells, and artificial organs 02/1989; 17(2):117-24.
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ABSTRACT: Nafamostat mesilate (FUT-175) is a strong protease inhibitor and is used as an anticoagulant in extracorporeal circulation. In the present study, we administered FUT and dipyridamole as anticoagulants during donor plasmapheresis, and the additional effect of dipyridamole was examined. In dogs weighing about 15 Kg, donor plasmapheresis was performed using a cellulose triacetate membrane plasmaseparator (PEX-15, Nipro), and 300 ml of filtrated plasma was obtained within 30 minutes. These dogs were divided into two groups, 50 mg/h of FUT alone was infused (group A, n = 10), and the same dose of FUT and 25 mg/h of dipyridamole were infused (group B, n = 5) during plasmapheresis. Changes of the coagulation system, blood cell counts and complement system were investigated. In clinical cases, an artificial liver support therapy using FUT as an anticoagulant was performed on 8 patients with acute liver failure, and blood compatibility was examined. In dogs, RBC counts and hematocrits were almost stable, but WBC counts were decreased to about 70% of the previous value. Platelets counts were about 60% and 80% of the previous value, in group A and group B, respectively, at the end of the plasmapheresis (P less than 0.01). Clotting factor VII was diminished to about 20% and 35% of the previous value in group A and B, respectively. In clinical cases, all patients received the plasma exchange combined with hemodialysis using FUT as an anticoagulant, and no distinct side effect was observed during plasma exchange.
The International journal of artificial organs 06/1988; 11(3):212-6. · 1.86 Impact Factor
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ABSTRACT: Our hepatic assist device is composed of a membrane plasma separator, blood and plasma pumps, hemodialyzer and controller. Using this device, the patients plasma is replaced with fresh donor plasma in a 5000 ml amount daily. This procedure of plasma exchange takes place in the intensive care unit, until the patient recovers consciousness or cerebral death is confirmed. In the initial results of this plasma exchange, 5 out of 10 patients with fulminant hepatic failure survived. Even with fatal cases, prolongation of survival time was observed. Our hepatic assist device, performing an easy and safe procedure for plasma exchange, appears to be the most promising method of providing long-term hepatic support for acute liver failure at the present time.
Medical Progress Through Technology 02/1987; 12(1-2):17-24.
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ABSTRACT: As a means of selectively removing pathogenic macromolecular substances, an affinity adsorbent or immunoadsorbent has been investigated in experimental and clinical studies on blood purification in the treatment of immune diseases. There are several affinity adsorbents currently available for clinical application. The authors developed physicochemical affinity adsorbents Immusorba IM-TR and IM-PH, whose experimental and clinical evaluations have been satisfactory in several immune diseases, such as rheumatoid arthritis, myasthenia gravis, systemic lupus erythematosus and multiple sclerosis.Absorptive cell separation, for leucocyte-free blood transfusion or for cytapheresis, has been developed using a leucocyte removal filter, whose container has fine, long fibers of polyester which are densely packed. The filters Sepacell and Cellsorba are used for erythrocyte transfusion and cytapheresis, respectively. In experimental and clinical trials, they provide efficient removal of leucocytes. Erythrocytes can be recovered virtually without loss. Clinical evaluation is now being conducted.In conclusion, the above-mentioned new methods provide promising immunomodulations for the treatment and for the clearification of pathphysiology of immune diseases.
MRS Proceedings. 12/1986; 110.
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ABSTRACT: Based on the assumption that middle molecules that induce hepatic coma occur in the plasma of patients with fulminant hepatic failure (FHF), the authors have developed a hemodiafiltration (HDF) method using a large-pore poly(methylmethacrylate) (PMMA) membrane that allows proteins to pass through. PMMA HDF resulted in complete recovery of deep coma and long-term survival in a patient with severe FHF. Although a large-scale controlled trial is needed, PMMA HDF is believed to be promising as a future artificial liver support.
Artificial Organs 11/1986; 10(5):417-9. · 2.00 Impact Factor
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ABSTRACT: In Wistar rats subjected to a 6-h exposure to ethylene oxide at the concentration of 250 parts per million once, 5 times a week for 9 months, histopathologic studies of myelinated fibers of the proximal sural, distal sural and peroneal nerves and of the fasciculus gracilis at the 5th thoracic and 3rd cervical segments of the spinal cord were performed to observe whether ethylene oxide of such a concentration would lead to degeneration of primary sensory neurons. Throughout the study, no definite abnormality of the gait or posture was observed in both control and test rats. Qualitative histologic studies disclosed preferential distal axonal degeneration of myelinated fibers in both sural nerves and gracile fascicles in the test rats, although the extent of the distribution and the severity of the degenerative findings were variable. Such findings are consistent with mild axonal degeneration found among patients suffering from ethylene oxide toxicity. Therefore, in rats, exposure to 250 ppm ethylene oxide produces central-peripheral distal axonal degeneration of primary sensory neurons.
Journal of the Neurological Sciences 08/1986; · 2.35 Impact Factor
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Z. YAMAZAKI,
F. KANAI,
M. HIRAISHI,
K. OHNISHI,
Y. IDEZUKI,
T. TAKAHAMA,
Y. FUJIMORI,
K. ASANO, N. INOUE,
Y. SHIBATA,
Y. TAKENAKA,
H. KAMATA,
J. ISHIHARA,
S. SUGIYAMA,
H. NISHI,
K. FUKUMI
ASAIO Journal 06/1986; 32(1):405-409. · 1.39 Impact Factor
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ABSTRACT: An artificial liver should in fact be called an artificial liver assist device or system because at this point in its development it is unable to prolong the life of an ahepatic animal, whereas, an artificial heart or an artificial kidney enables the animal to live without a heart or kidneys for a long period of time. The hepatic assist devices are classified into three types: Artificial (charcoal hemoperfusion, PAN membrane dialysis or filtration); biological (baboon liver perfusion, cross dialysis between pig liver and patients systemic circulation); and hybrid (combined form of artificial and biological). Our hepatic support system is composed of a membrane plasma separator, blood and plasma pumps, hemodialyzer and controller. Using this system, the patients plasma is replaced with fresh donor plasma in amount of 5,000 ml daily. This procedure are taken place in the intensive care unit, until the patient recovers consciousness or his cerebral death is confirmed. A national survey of the patients with fulminant hepatic failure, revealed that the survival rate of the patients treated with plasma exchange was 34.1% (15/45), while that of the patient untreated with plasma exchange was 14.3% (5/35). The difference is statistically significant. However, plasma exchange requires a large amount of fresh plasma which occasionally induce hepatitis or allergy and its detoxication of the patients plasma was insufficient in severe cases. To overcome these problems, specific adsorpton of hepatic toxins and a combined therapy of blood purification with plasma exchange will be studied further.
Nippon Geka Gakkai zasshi 10/1985; 86(9):1027-30.
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Transactions - American Society for Artificial Internal Organs 02/1985; 31:451-8.
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Transactions - American Society for Artificial Internal Organs 02/1983; 29:704-8.
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Transactions - American Society for Artificial Internal Organs 02/1982; 28:318-23.
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S. Yoshida,
N. Hayashida,
K. Honda,
M. Honda,
S. Imaizumi, N. Inoue,
K. Kadota,
F. Kakimoto,
K. Kamata,
S. Kawaguchi,
N. Kawasumi,
Y. Matsubara,
K. Murakami,
M. Nagano,
H. Ohoka,
M. Teshima,
I. Tsushima,
H. Yoshii
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ABSTRACT: We report the first result on the cosmic ray energy spectrum above 3 × 1018 eV measured by the Akeno Giant Air Shower Array (AGASA) from July 1990 to February 1994. The analysis method and the energy resolution of the AGASA experiment are described in some detail. The flattening of the spectrum around 1019 eV (ankle) is observed with a significance of 2.9σ. If we express the differential energy spectrum of cosmic rays of energy E (in eV) with an ankle energy Ea as , γ for 1018.5 eV ≤ E ≤ Ea is in good agreement with that from the previous experiment and is 3.2 ± 0.1. The slope γ above Ea depends strongly on the value Ea. For the case Ea = 1019 eV, κ = (2.3−0.2+0.1) × 10−33 and γ = 2.3−0.3+0.5 for 1019 eV ≤ E ≤ 1020 eV. If Ea = 1018.8 eV, then κ = (1.0 ± 0.1) × 10−32 and γ = 2.7−0.4+0.2 for 1018.8 eV ≤ E ≤1020 eV, after correcting for both the statistical error and the energy resolution of the present experiment. If we interpret the present results assuming an extragalactic origin for cosmic rays above 1019 eV, the observed data is consistent with either a homogeneous and isotropic distribution of sources or with localized sources at redshift of greater than ∼ 0.1. A (1.7–2.6) × 1020 eV event was observed on December 3, 1993 from the direction of l = 131° and b = −41°. This shower energy is a factor 3 larger than the second highest energy event.
Astroparticle Physics.
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S Masuzaki,
K Akaishi,
H Funaba,
M Goto,
K Ida,
S Inagaki, N Inoue,
K Kawahata,
A Komori,
Y Kubota, [......],
H Suzuki,
Y Takeiri,
K Tanaka,
T Tokuzawa,
T Watanabe,
K Tsuzuki,
T Hino,
Y Matsumoto,
S Kado,
O Motojima
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ABSTRACT: The large helical device (LHD) is the largest heliotron type superconducting device. Its operation was started on 31 March 1998. Three experimental campaigns have been completed until the end of 1999. Wall conditioning mainly by cleaning discharges using ECRF or glow discharges worked well even without high temperature baking. The plasma production with ECRH and auxiliary heating with NBI and/or ICRF in the LHD configuration equipped with open helical divertor were well performed. The divertor material was SS316L in the first and second campaigns, and was replaced by the graphite in the third campaign. The influences of the different divertor materials were investigated. Our understanding of the edge and the divertor plasma has progressed. Long-pulse discharges 80 and 68 s heated by NBI (0.5 MW) or ICRF (0.9 MW) have been achieved, respectively. No severe limitation of the duration has appeared.
Journal of Nuclear Materials.
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M. Aglietta,
B. Alpat,
E.D. Alyea,
P. Antonioli,
G. Anzivino,
G. Badino,
Y. Ban,
G. Bari,
M. Basile,
A. Benelli, [......],
Z. Xu,
V.F. Yakushev,
I. Yamamoto,
A. Zallo,
G.T. Zatsepin,
X. Zhou,
Q. Zhu,
X. Zhu,
B. Zhuang,
A. Zichichi
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ABSTRACT: The first angular distribution data from 5547 hours of operation of the LVD detector are presented. The technique of track reconstruction is described. A total of 452 657 single muons were reconstructed for this period. The data are acceptance corrected in our final plots. The total single muon flux (the total flux from above impinging on a sphere of unit cross sectional area) in the Gran Sasso Laboratory is 1.03 muons per hour per square meter. The total flux crossing a unit horizontal area from above is 0.79 muons per hour per square meter. The acceptance-corrected intensity at cos θ = 1 is 0.349 muons per hour per square meter per steradian (9.7× l0−9 muons per second per square centimeter per steradian). We present, for the first time from Gran Sasso Laboratory, data at near-horizontal zenith angles.
Astroparticle Physics.
