Min Soo Kim

The California Institute for Biomedical Research, San Diego, California, United States

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Publications (271)584.63 Total impact

  • Sang Hee Jeon · Min Soo Kim ·

    International Journal of Greenhouse Gas Control 12/2015; 43:225-232. DOI:10.1016/j.ijggc.2015.10.011 · 3.95 Impact Factor
  • Syahrizal Muttakin · Min Soo Kim · Dong-Un Lee ·
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    ABSTRACT: The effects of jet-milling on the physicochemical and sensorial properties of defatted soybean flour (DSF) were investigated. Superfine DSF powder (DSF-JM; D50=4.3±0.1μm) was prepared from DSF powder (DSF-150; D50=257.0±1.7μm) via conventional sifting followed by jet-milling. The jet-milled DSF showed significant increases in hydration properties, with increases in the water-holding capacity, water-solubility index, and swelling capacity of 24%, 39%, and 32%, respectively. Soluble dietary fibre and fat-binding capacity of DSF-JM also increased significantly (p<0.05). A quantitative descriptive analysis by trained panelists indicated that the sensorial properties of DSF were also modified by jet milling. The DSF-JM showed significant reductions in bitterness and roughness, but sweetness increased, and the colour of DSF-JM changed to a brighter achromatic colour. These results indicate that superfine DSF could be an ingredient used to modify physical and sensorial properties of food. Copyright © 2015. Published by Elsevier Ltd.
    Food Chemistry 11/2015; 187. DOI:10.1016/j.foodchem.2015.04.104 · 3.39 Impact Factor
  • Min Soo Kim · Won Sung Lee · Joon Jeong · Seong-Jin Kim · Wook Jin ·
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    ABSTRACT: In metastatic breast cancers, the acquisition of metastatic ability, which leads to clinically incurable disease and poor survival, has been associated with acquisition of epithelial-mesenchymal transition (EMT) program and self-renewing trait (CSCs) via activation of PI3K/AKT and IL6/JAK2/STAT3 signaling pathways. We found that TrkB is a key regulator of PI3K/AKT and JAK/STAT signal pathway-mediated tumor metastasis and EMT program. Here, we demonstrated that TrkB activates AKT by directly binding to c-Src, leading to increased proliferation. Also, TrkB increases Twist-1 and Twist-2 expression through activation of JAK2/STAT3 by inducing c-Src-JAK2 complex formation. Furthermore, TrkB in the absence of c-Src binds directly to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased total JAK2 and STAT3 levels, which subsequently leads to JAK2/STAT3 activation and Twist-1 upregulation. Additionally, activation of the JAK2/STAT3 pathway via induction of IL-6 secretion by TrkB enables induction of activation of the EMT program via induction of STAT3 nuclear translocation. These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program and self-renewing trait in breast cancer.
    Oncotarget 10/2015; DOI:10.18632/oncotarget.5522 · 6.36 Impact Factor
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    ABSTRACT: Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for restoring cardiac function after myocardial injury, but the technique thus far has been slow and inefficient. To improve the efficiency of reprogramming fibroblasts to cardiac-like myocytes (iCMs) by cardiac transcription factors [Gata4, Hand2, Mef2c, and Tbx5 (GHMT)], we screened 192 protein kinases and discovered that Akt/protein kinase B dramatically accelerates and amplifies this process in three different types of fibroblasts (mouse embryo, adult cardiac, and tail tip). Approximately 50% of reprogrammed mouse embryo fibroblasts displayed spontaneous beating after 3 wk of induction by Akt plus GHMT. Furthermore, addition of Akt1 to GHMT evoked a more mature cardiac phenotype for iCMs, as seen by enhanced polynucleation, cellular hypertrophy, gene expression, and metabolic reprogramming. Insulin-like growth factor 1 (IGF1) and phosphoinositol 3-kinase (PI3K) acted upstream of Akt whereas the mitochondrial target of rapamycin complex 1 (mTORC1) and forkhead box o3 (Foxo3a) acted downstream of Akt to influence fibroblast-to-cardiomyocyte reprogramming. These findings provide insights into the molecular basis of cardiac reprogramming and represent an important step toward further application of this technique.
    Proceedings of the National Academy of Sciences 09/2015; 112(38). DOI:10.1073/pnas.1516237112 · 9.67 Impact Factor
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    Min Soo Kim · Jeong Rim Lee · Eun Mi Choi · Eun Ho Kim · Seung Ho Choi ·
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    ABSTRACT: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
    Yonsei medical journal 09/2015; 56(5):1415-20. DOI:10.3349/ymj.2015.56.5.1415 · 1.29 Impact Factor
  • Young Chang Cho · Min Soo Kim ·

    06/2015; 20(3):11-18. DOI:10.9723/jksiis.2015.20.3.011
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    ABSTRACT: Candida albicans colonization is required for invasive disease. Unlike humans, adult mice with mature intact gut microbiota are resistant to C. albicans gastrointestinal (GI) colonization, but the factors that promote C. albicans colonization resistance are unknown. Here we demonstrate that commensal anaerobic bacteria-specifically clostridial Firmicutes (clusters IV and XIVa) and Bacteroidetes-are critical for maintaining C. albicans colonization resistance in mice. Using Bacteroides thetaiotamicron as a model organism, we find that hypoxia-inducible factor-1α (HIF-1α), a transcription factor important for activating innate immune effectors, and the antimicrobial peptide LL-37 (CRAMP in mice) are key determinants of C. albicans colonization resistance. Although antibiotic treatment enables C. albicans colonization, pharmacologic activation of colonic Hif1a induces CRAMP expression and results in a significant reduction of C. albicans GI colonization and a 50% decrease in mortality from invasive disease. In the setting of antibiotics, Hif1a and Camp (which encodes CRAMP) are required for B. thetaiotamicron-induced protection against C. albicans colonization of the gut. Thus, modulating C. albicans GI colonization by activation of gut mucosal immune effectors may represent a novel therapeutic approach for preventing invasive fungal disease in humans.
    Nature medicine 06/2015; 21(7). DOI:10.1038/nm.3871 · 27.36 Impact Factor
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    ABSTRACT: Circulating carbohydrates are an essential energy source, perturbations in which are pathognomonic of various diseases, diabetes being the most prevalent. Yet many of the genes underlying diabetes and its characteristic hyperglycaemia remain elusive. Here we use physiological and genetic interrogations in D. melanogaster to uncover the 'glucome', the complete set of genes involved in glucose regulation in flies. Partial genomic screens of ∼1,000 genes yield ∼160 hyperglycaemia 'flyabetes' candidates that we classify using fat body- and muscle-specific knockdown and biochemical assays. The results highlight the minor glucose fraction as a physiological indicator of metabolism in Drosophila. The hits uncovered in our screen may have conserved functions in mammalian glucose homeostasis, as heterozygous and homozygous mutants of Ck1alpha in the murine adipose lineage, develop diabetes. Our findings demonstrate that glucose has a role in fly biology and that genetic screenings carried out in flies may increase our understanding of mammalian pathophysiology.
    Nature Communications 05/2015; 6:7102. DOI:10.1038/ncomms8102 · 11.47 Impact Factor
  • Sang Hee Jeon · Min Soo Kim ·
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    ABSTRACT: Recently, CCS (carbon dioxide capture and sequestration) has been receiving considerable attention as a possible means of dealing with emissions of CO2, a greenhouse gas. To this end, EOR (enhanced oil recovery) and EGR (enhanced gas recovery) are regarded as being viable options for economically sequestrating large amounts of CO2. A feasible approach would involve capturing CO2 from large-scale CO2 emission sources such as power plants, and then transporting that captured gas to near-depleted oil and gas wells to maintain the reservoir pressure and enhance the oil/gas recovery rate. In the future, CO2 will be transported large distances from emission sources in developed countries to oil/gas producing regions by pipelines or ships. The long-distance ship-based transport of CO2 would require that the gas be compressed or liquefied (LCO2). Furthermore, an LCO2 transport ship would have to be capable of processing boil-off gas while at sea.
    Applied Thermal Engineering 05/2015; 82. DOI:10.1016/j.applthermaleng.2015.02.080 · 2.74 Impact Factor
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    ABSTRACT: PurposeThe purpose of this study was to determine the effect of a newly designed titanium mesh (TM) for preserving the buccal bone around an immediately placed implant following tooth extraction in dogs.Materials and Methods Immediate implant placements were performed bilaterally in the mesial socket of the fourth premolar in five dogs. In one site, the TM was affixed to the fixture using its own stabilization components (TM group), and the contralateral site was left untreated (control group). All surgical sites were intended to be submerged with primary flap closure. Histologic and histomorphometric analyses were performed 16 weeks postoperatively.ResultsAll implants were histologically osseointegrated, and buccal bone resorption was evident in both groups with the high rate of TM exposure (4/5). The most coronal level of bone-implant contact and the bone crest were not statistically different between the TM and the control group. A dense connective tissue layer consistently predominated under the TM, where mineralized tissue was not observed, and the vascularity and cellularity were minimal.Conclusions It can be conjectured that preservation of buccal plate by using the TM in immediate implantation was not predictable due to vulnerability to wound dehiscence and substantial pseudoperiosteum formation beneath the TM.
    Clinical Implant Dentistry and Related Research 03/2015; 17. DOI:10.1111/cid.12302 · 3.59 Impact Factor
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    ABSTRACT: Obesity has been reported to impair immune functions and lead to low-grade long-term inflammation; however, studies that have investigated the impact of weight loss on these among the young and slightly obese are limited. Thus, we investigated the effect of a 12-week weight management program with behavioral modifications on cell-mediated immune functions and inflammatory responses in young obese participants. Our hypothesis was that weight loss would result in improved immune functions and decreased inflammatory responses. Sixty-four participants (45 obese and 19 normal weight) finished the program. Obese (body mass index ≥25) participants took part in 5 group education and 6 individual counseling sessions. Normal-weight (body mass index 18.5-23) participants only attended 6 individual sessions. The goal for the obese was to lose 0.5 kg/wk by reducing their intake by 300 to 500 kcal/d and increasing their physical activity. Program participation resulted in a modest but significant decrease in weight (2.7 ± 0.4 kg, P < .001) and lipopolysaccharide-stimulated interleukin-1β production (from 0.85 ± 0.07 to 0.67 ± 0.07 ng/mL, P < .05) in the obese. In the obese group, increase in phytohemagglutinin-stimulated interleukin-10 production, a TH2 and anti-inflammatory cytokine, approached significance after program participation (from 6181 ± 475 to 6970 ± 632 pg/mL, P = .06). No significant changes in proliferative responses to the optimal concentration of concanavalin A or phytohemagglutinin were observed in the obese after program participation. Collectively, modest weight loss did not change the cell-mediated immune functions significantly but did attenuate the inflammatory response in young and otherwise healthy obese adults. Copyright © 2015. Published by Elsevier Inc.
    Nutrition Research 02/2015; 35(4). DOI:10.1016/j.nutres.2015.02.004 · 2.47 Impact Factor
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    ABSTRACT: Chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) provide a potent anti-tumor response and have become a promising treatment option for cancer. However, despite their efficacy, CAR-T cells are associated with significant safety challenges related to the inability to control their activation and expansion, and terminate their response. Herein, we demonstrate that a bifunctional small molecule "switch" consisting of folate conjugated to fluorescein isothiocyanate (folate-FITC) can redirect and regulate FITC-specific CAR-T cell activity towards folate receptor (FR)-overexpressing tumor cells. This system was shown to be highly cytotoxic to FR-positive cells with no activity against FR-negative cells, demonstrating the specificity of redirec-tion by folate-FITC. FITC-CAR-T cell activation and prolifer-ation was strictly dependent on the presence of both folate-FITC and FR-positive cells and was dose titratable with folate-FITC switch. This novel treatment paradigm may ul-timately lead to increased safety for CAR-T cell immunotherpy.
    Journal of the American Chemical Society 02/2015; 137(8). DOI:10.1021/jacs.5b00106 · 12.11 Impact Factor
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    ABSTRACT: This study proposes a method for assessing the risk of ship hull collapse following a collision. A probabilistic approach is applied to establish the relationship between the exceedance probability of collision and the residual ultimate longitudinal strength index. A set of credible collision scenarios which represent the entire range of possible collision accidents is selected using a sampling technique based on probability density distributions of influencing parameters. The amount and location of collision damage for selected individual collision scenarios are characterised using the LS-DYNA nonlinear finite element method. The ultimate hull girder strength of a ship with predefined collision damage is then calculated using the ALPS/HULL intelligent supersize finite element method. To demonstrate the applicability of the proposed method, applied examples are given, involving collisions with a hypothetical Suezmax-class double-hull oil tanker. Based on the results, design formulations for predicting the residual strength index of damaged ship hulls are derived in an empirical manner. The examples show that the proposed method will be very useful for evaluating the risk of collapse of a ship's hull after sustaining collision damage, which may contribute to a collision risk-based design framework. Moreover, the method will be useful in rescue and salvage operations immediately after a collision by permitting a rapid assessment of the structural safety of a damaged ship.
    Ships and Offshore Structures 01/2015; DOI:10.1080/17445302.2014.993110 · 0.58 Impact Factor
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    ABSTRACT: Background Supraglottic airway devices with noninflatable cuff have advantages in omitting the cuff pressure monitoring and reducing potential pharyngolaryngeal complications. Typical devices without cuff inflation available in children are the i-gel™ and the self-pressurized air-Q™ intubating laryngeal airway (air-Q SP). To date, there is no comparative study between these devices in pediatric patients.AimThe purpose of this randomized study was to compare the i-gel™ and the self-pressurized air-Q™ intubating laryngeal airway (air-Q SP) in children undergoing general anesthesia.Methods Eighty children, 1–108 months of age, 7–30 kg of weight, and scheduled for elective surgery in which supraglottic airway devices would be suitable for airway management, were randomly assigned to either the i-gel or the air-Q SP. Oropharyngeal leak pressure and fiberoptic view were assessed three times as follows: after insertion and fixation of the device, 10 min after initial assessment, and after completion of surgery. We also assessed insertion parameters and complications.ResultsInsertion of the i-gel was regarded as significantly easier compared to the air-Q SP (P = 0.04). Compared to the air-Q SP group, the i-gel group had significantly higher oropharyngeal leak pressures at all measurement points and significantly lower frequencies of gastric insufflation at 10 min after initial assessment and completion of surgery. The air-Q SP group had better fiberoptic views than the i-gel group at all measurement points.Conclusion Our results showed that the i-gel had easier insertion and better sealing function, and the air-Q SP provided improved fiberoptic views in children requiring general anesthesia.
    Pediatric Anesthesia 01/2015; 25(4). DOI:10.1111/pan.12609 · 1.85 Impact Factor
  • Mo Se Kim · Chang Soo Shin · Min Soo Kim ·
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    ABSTRACT: Carbon dioxide (CO2) is one of the replacements of the synthetic refrigerants whose properties are good as a refrigerant with no ozone depletion and a very little global warming effect. However, its low critical temperature makes a CO2 refrigeration system to form trans-critical cycle and determination of an optimal heat rejection pressure becomes an important problem for the best performance. Until now, number of studies have been published which correlate preliminarily obtained data map with some major operating parameters. In this study, a generally usable real time optimal control method is introduced. This real time optimal control method does not require preliminarily obtained correlations and makes the system operate in a nearly optimal region. Additionally, its limitations which produce undesirable errors and bias of controlled value were also treated in this paper. Three causes of errors were discussed and it is helpful to improve the control method.
    International Journal of Refrigeration 12/2014; 48. DOI:10.1016/j.ijrefrig.2014.09.014 · 2.24 Impact Factor
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    ABSTRACT: In this study, we isolated a bacteriophage T7-resistant mutant strain of Escherichia coli (named S3) and then proceeded to characterize it. The mutant bacterial colonies appeared to be mucoid. Microarray analysis revealed that genes related to colanic acid production were upregulated in the mutant. Increase in colanic acid production was shown in the mutant bacteria when L-fucose was biochemically measured, and protective capsule formation was observed under an electron microscope. We found a point mutation in the lon gene promoter in S3, the mutant bacteria. Overproduction of colanic acid was observed in some phage-resistant mutant bacteria after infection with other bacteriophages, T4 and lambda. Colanic acid overproduction was also observed in clinically isolated strains of E. coli upon phage infection. The overproduction of colanic acid resulted in the inhibition of bacteriophage adsorption to the host. Biofilm formation initially decreased shortly after infection, but eventually increased after 48 hours of incubation by the emergence of the mutant bacteria. The bacteriophage PBECO4 was shown to infect the colanic acid-overproducing mutant strains of E. coli. We confirmed that gene product of ORF 547 of PBECO4 harbored colanic acid degrading enzymatic (CAE) activity. The mixed infection of T7 and PBECO4 or its purified enzyme (CAE) to the T7-resistant bacteria led to the successful infection of T7. Biofilm formation decreased with the mixed infection, too. This represents a novel strategy for overcoming phage-resistant mutant bacteria where phage cocktails different from those exploiting solely receptor differences are used. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
    Applied and Environmental Microbiology 11/2014; 81(3). DOI:10.1128/AEM.02606-14 · 3.67 Impact Factor
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    ABSTRACT: 1unprecedented properties, have gained great attraction for the repair of tissues, particularly for those requiring electrical stimuli. While most reports have demonstrated in vitro neural cell responses of the CNTs, little has performed on the in vivo efficacy of CNT-interfaced biomaterials in the repair and regeneration of neural tissues. Thus, here we report for the first time the in vivo functions of CNT-interfaced nerve conduits in the regeneration of rat transected sciatic nerve. Aminated CNTs were chemically tethered onto a surface of aligned phosphate glass microfibers (PGFs) and the CNT-interfaced PGFs (CNT-PGFs) were embedded into three-dimensional poly(-L/D-lactic acid) (PLDLA) tube successfully. In vitro study confirmed that neurites of dorsal root ganglion outgrew actively along the aligned CNT-PGFs and that CNT interfacing significantly increased the maximal neurite length. Sixteen weeks after implantation of a CNT-PGFs nerve conduit into a 10 mm-gap transected sciatic nerve in rats, the number of regenerating axons crossing the scaffold, the cross-sectional area of the re-innervated muscles and the electrophysiological findings were all significantly improved by the interfacing with CNTs. This first in vivo effect of CNT-interfaced scaffold in the regeneration process of a rat transected sciatic nerve strongly supports the potential use of CNT-interfaced PGFs at the interface of nerve conduit and peripheral neural tissues.
    Acta Biomaterialia 11/2014; 13. DOI:10.1016/j.actbio.2014.11.026 · 6.03 Impact Factor
  • Young Chang Cho · Min Soo Kim ·

    10/2014; 19(5):25-31. DOI:10.9723/jksiis.2014.19.5.025
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    ABSTRACT: Takayasu's arteritis is a chronic inflammatory disorder that mainly involves medium to large sized arteries. Although it affects coronary and pulmonary arteries occasionally, physicians should consider the possibility of involvement of coronary or pulmonary arteries in patients with Takayasu's arteritis with chest pain or exertional dyspnoea. We report a case of Takayasu's arteritis who presented with exertional dyspnoea and generalised oedema due to severe bilateral pulmonary and left main coronary arterial stenoses. The patient was successfully treated by a one-stage percutaneous transluminal balloon angioplasty and stent implantation of the involved left main coronary and pulmonary arteries. The endovascular treatment may be one of the treatment options for the stenotic vascular lesions in patients with Takayasu's arteritis. Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
    Heart, Lung and Circulation 10/2014; 24(2). DOI:10.1016/j.hlc.2014.09.007 · 1.44 Impact Factor
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    ABSTRACT: Background There is a need for an adjuvant agent of caudal block that prolongs its duration and improves the analgesic efficacy to fasten functional recovery. Magnesium is an N-methyl-D-aspartate receptor antagonist that functions as an analgesic. This study was aimed to evaluate whether magnesium as an adjuvant for caudal block in children can improve postoperative analgesia and functional recovery.Methods Eighty children, 2–6 years of age, undergoing inguinal herniorrhaphy, were included in this prospective, randomized, double-blinded study. For caudal block, Group R received ropivacaine 1.5 mg·ml−1, 1 ml·kg−1 and Group RM received the same dose of ropivacaine mixed with 50 mg of magnesium. The Parents' Postoperative Pain Measure (PPPM) score, analgesic consumption, functional recovery, and adverse effects were evaluated at 6, 24, 48, and 72 h after surgery, as well as daily thereafter until the child showed full functional recovery.ResultsThe PPPM score after hospital discharge was significantly lower for Group RM than for Group R at all times (P < 0.05). Children in Group RM required less fentanyl for rescue analgesia in the recovery area (16.2% vs 39.5%, P = 0.034) and less oral analgesics after discharge (20.5% vs 52.6%, P = 0.007). The time to return of normal functional activity was shorter in Group RM (P < 0.05). The incidence of adverse effects did not differ between groups.Conclusions As an adjuvant for caudal analgesia, 50 mg magnesium provided superior quality of analgesia and faster return of normal functional activity than local anesthetic alone in children.
    Pediatric Anesthesia 10/2014; 24(12). DOI:10.1111/pan.12559 · 1.85 Impact Factor

Publication Stats

2k Citations
584.63 Total Impact Points


  • 2015
    • The California Institute for Biomedical Research
      San Diego, California, United States
  • 2014-2015
    • University of Texas Southwestern Medical Center
      • Department of Clinical Sciences
      Dallas, Texas, United States
    • Chonbuk National University
      • Department of Mechanical Design Engineering
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
    • Dankook University
      • Institute of Tissue Regeneration Engineering (ITREN)
      Eidō, Chungcheongbuk-do, South Korea
    • Chungnam National University Hospital
      Sŏul, Seoul, South Korea
  • 2011-2015
    • Chung-Ang University
      • • School of Food Science and Technology
      • • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Inha University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2007-2015
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Catholic University of Korea
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2002-2015
    • Yonsei University
      • • College of Dentistry
      • • Department of Mechanical Engineering
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Kookmin University
      Sŏul, Seoul, South Korea
  • 1994-2015
    • Seoul National University
      • • Department of Food and Nutrition
      • • School of Mechanical and Aerospace Engineering
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2012-2014
    • Seoul National University Bundang Hospital
      • Department of Anaesthesiology and Pain Medicine
      Sŏul, Seoul, South Korea
    • Inje University
      • Department of Medicine and Premedicine
      Kŭmhae, Gyeongsangnam-do, South Korea
    • University of Nevada, Reno
      • Department of Chemistry
      Reno, Nevada, United States
  • 2010-2014
    • Chonnam National University
      • • Division of Food and Nutrition
      • • Department of Anatomy
      Gwangju, Gwangju, South Korea
    • Inje University Paik Hospital
      Sŏul, Seoul, South Korea
  • 2009-2014
    • Hankuk University of Foreign Studies
      • Department of Bioscience and Biotechnology
      Sŏul, Seoul, South Korea
  • 2007-2014
    • Hallym University
      • Department of Food Science and Nutrition
      Sŏul, Seoul, South Korea
  • 2013
    • San Diego State University
      San Diego, California, United States
  • 2012-2013
    • Georgia Institute of Technology
      • School of Electrical & Computer Engineering
      Atlanta, Georgia, United States
  • 2011-2013
    • Gachon University
      • Lee Gil Ya Cancer and Diabetes Institute
      Sŏngnam, Gyeonggi-do, South Korea
  • 2010-2013
    • CHA University
      • Department of Neurosurgery
      Sŏul, Seoul, South Korea
  • 2009-2013
    • Hanyang University
      • • School of Business
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Korea Electrotechnology Research Institute-KERI
      Tsau-liang-hai, Busan, South Korea
  • 2003-2013
    • Yeungnam University
      • • Department of Neurosurgery
      • • Department of Electronic Engineering
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2010-2012
    • Keimyung University
      • Dongsan Medical Center
      Sŏul, Seoul, South Korea
  • 1999-2012
    • Korea Advanced Institute of Science and Technology
      • • Department of Computer Science
      • • Department of Biological Sciences
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2009-2010
    • Korea University
      • Department of Chemical and Biological Engineering
      Sŏul, Seoul, South Korea
  • 2008-2010
    • Toyohashi University of Technology
      • Department of Electrical and Electronic Information Engineering
      Toyohasi, Aichi, Japan
    • Dongguk University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • National Cancer Center Korea
      Kōyō, Gyeonggi-do, South Korea
    • University of California, Berkeley
      Berkeley, California, United States
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
    • Korea Institute of Radiological & Medical Sciences
      Sŏul, Seoul, South Korea
    • University of Seoul
      Sŏul, Seoul, South Korea
    • Ajou University
      Sŏul, Seoul, South Korea
    • Sogang University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2008-2009
    • Kangwon National University
      • College of Pharmacy
      Shunsen, Gangwon, South Korea
  • 2004-2009
    • Korea Research Institute of Bioscience & Biotechnology KRIBB
      • Chemical Biology Research Center
      Anzan, Gyeonggi Province, South Korea
  • 2004-2008
    • Pusan National University
      • Department of Polymer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2006-2007
    • Pohang University of Science and Technology
      • Department of Mechanical Engineering
      Geijitsu, Gyeongsangbuk-do, South Korea
  • 2002-2006
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea
  • 2005
    • Chungnam National University
      • College of Pharmacy
      Sŏngnam, Gyeonggi Province, South Korea