Michael Fischer

Publications (2)2.58 Total impact

• Article: Immune recovery after conventional and non-myeloablative allogeneic stem cell transplantation

  Dr Axel Schulenburg, Michael Fischer, Peter Kalhs, Margit Mitterbauer, Werner Rabitsch, Hildegard T. Greinix, Gerda Leitner
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  ABSTRACT: The immune recovery of 66 patients undergoing allogeneic stem cell transplantation with either conventional or non-myeloablative conditioning regimen was studied. Infections post-transplant were enumerated and quantitative immunoglobuilins (IgG, IgA, IgM) and lymphocyte sub-sets 3, 6 and 12 months post-transplant were measured. A significant difference was found in the immunologic recovery of non-myeloablative and conventional ASCT in the patient population. The T-helper cell reconstitution was significantly faster after NMA than conventional transplantation and the recovery of B cells was faster after conventional transplantation. Regarding immunoglobulin levels, a faster recovery of IgM levels after NMA-ASCT and a delayed recovery of IgA levels was observed in both groups. These were accompanied by a significant difference in the frequency and severity of infectious episodes.
  06/2009; 46(12):1755-1760.
• Article: Immune recovery after conventional and non-myeloablative allogeneic stem cell transplantation.

  Axel Schulenburg, Michael Fischer, Peter Kalhs, Margit Mitterbauer, Werner Rabitsch, Hildegard T Greinix, Gerda Leitner
  [show abstract] [hide abstract]
  ABSTRACT: The immune recovery of 66 patients undergoing allogeneic stem cell transplantation with either conventional or non-myeloablative conditioning regimen was studied. Infections post-transplant were enumerated and quantitative immunoglobuilins (IgG, IgA, IgM) and lymphocyte sub-sets 3, 6 and 12 months post-transplant were measured. A significant difference was found in the immunologic recovery of non-myeloablative and conventional ASCT in the patient population. The T-helper cell reconstitution was significantly faster after NMA than conventional transplantation and the recovery of B cells was faster after conventional transplantation. Regarding immunoglobulin levels, a faster recovery of IgM levels after NMA-ASCT and a delayed recovery of IgA levels was observed in both groups. These were accompanied by a significant difference in the frequency and severity of infectious episodes.
  Leukemia and Lymphoma 01/2006; 46(12):1755-60. · 2.58 Impact Factor