M W Wilson

University of California, San Francisco, San Francisco, California, United States

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Publications (5)22.75 Total impact

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    ABSTRACT: We describe a reference device that provides accurate correlations between anatomic and functional brain images. The reference device, which generates fiduciary reference points on sequential scan planes, is positioned adjacent to the orbitomeatal line of the subject, and held in place by a framework anchored to the external auditory meatus. The reference system was tested on 17 subjects undergoing Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HM-PAO) brain single photon emission computed tomography (SPECT) and cranial computed tomography (CT) scans. The centers of the caudate nuclei, thalami, brain stem, and cerebellar vermis were identified independently on CT and SPECT. The average difference +/- 1 sd between structure locations (x, y, and z) on SPECT and CT were calculated as 1.86 +/- 1.5, 2.16 +/- 1.4, and 1.83 +/- 1.9 mm, respectively. The relevance of the method to clinical applications is illustrated by the localization of a recurrent viable glioma and an epileptogenic focus. This reference system provides an accurate, rapid, and noninvasive patient-specific method for the correlation of brain structure with brain function.
    Computerized Medical Imaging and Graphics 01/1994; 18(3):163-74. · 1.50 Impact Factor
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    ABSTRACT: We have performed initial clinical studies using the high resolution single photon ring tomograph (SPRINT) and Tc-99m HMPAO. To determine what additional anatomic detail can be depicted using this high resolution, dedicated head, multidetector SPECT device compared to conventional SPECT, six patients with stroke and one normal volunteer were imaged after the injection of 20 mCi Tc-99m HMPAO on a conventional rotating Anger gamma camera (GE-400AC), followed immediately by imaging on SPRINT. Imaging acquisition on the GE-400AC gamma camera was performed using 360 degrees rotation, 64 stops, at 30 sec/stop, yielding an average of 985,714 counts for a 10.0 mm thick slice. GE-400AC images were of good quality, having in-plane full width half maximum (FWHM) resolution of approximately 15 mm. SPRINT acquisition of image data was performed using both the high resolution and high sensitivity apertures, with data collection over 15 or 20 minutes of imaging time accumulating approximately 500,000 counts and 1,000,000 counts, respectively, from patients in a 10.0 mm thick slice, achieving an in-plane FWHM resolution of approximately 8 mm and 10 mm for the two apertures, respectively. Both image resolution and contrast for visualization of gray, white, and cerebral spinal fluid filled brain structures were improved using SPRINT compared with the GE-400AC. We conclude that SPRINT is well suited for brain imaging with Tc-99m HMPAO and is of particular value for applications demanding high resolution.
    Clinical Nuclear Medicine 09/1991; 16(8):562-7. · 2.86 Impact Factor
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    ABSTRACT: Assessment of cerebral perfusion on patients with subarachnoid haemorrhage (SAH) in the Neurologic Intensive Care Unit is difficult since nuclear medicine imaging modalities capable of measuring cerebral blood flow (CBF) are not generally available. We performed 101 quantitative (ml 100g-min) bedside CBF measurements on 40 individual patients to correlate SAH grade with CBF and to assess the effect of surgical intervention on CBF. Global CBF (G-CBF) and bihemispheric CBF (B-CBF) asymmetry were correlated with the grade of SAH pre- and post-operatively. Data analysis showed that pre-operative patients with low grade SAH (Hunt and Hess grades 0 to 2) had higher mean G-CBF values [44.2 +/- 71] than those with high grade SAH (Hunt and Hess grades 3 to 4): [mean G-CBF = 34.1 +/- 1.7]. Post-surgery there was a significant improvement in G-CBF; CBF increased [5.3 +/- 1.07] in the group of patients with low grade SAH. Patients with high grade SAH showed no significant improvement in their G-CBF during the first week post-operatively compared to pre-operative values. We conclude that portable units capable of measuring bedside CBF values are useful in monitoring CBF changes in patients with SAH. Patients with low grade SAH have G-CBF within normal limits both pre-operatively and post-operatively, with a statistically significant increase in CBF during two weeks post-operatively. Patients with high grade SAH show no significant increase in CBF one week post-operatively compared to their pre-operative measures.
    Acta Neurochirurgica 02/1991; 109(1-2):30-3. · 1.79 Impact Factor
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    ABSTRACT: The present study was undertaken to clarify some of the conflicting findings of previous reports on the effect of state anxiety on cerebral blood flow (CBF). Seven subjects with simple phobia of small animals were studied to permit the generation of wide ranges of anxiety. Each subject received five positron emission tomography (PET) scans in a rest-fear-rest-fear-rest, repeated-measures paradigm. A population of eight normal controls was employed. The phobic stimuli produced significant increases in state anxiety during fear and significant differences in physiologic measurements between the fear and rest scans. Absolute global and regional CBF was significantly lower during fear scans than during rest scans; however, when hypocapnia resulting from anxiety-induced hyperventilation was taken into account, the pattern vanished, and all global and regional CBF differences among scans became not significant. Resting global and regional CBF values in the phobic subjects did not significantly differ from those of the normal controls. That a relationship between anxiety and CBF was not found in 35 scans among seven subjects strongly suggests that CBF changes induced by state anxiety are either not presently measurable by PET techniques or that such a relationship may not exist. These findings should also reduce concerns that subject anxiety may confound CBF measurements during routine PET scanning.
    Archives of General Psychiatry 07/1989; 46(6):501-4. · 13.75 Impact Factor
  • J M Mountz, H Malinoff, M W Wilson
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    ABSTRACT: Bone imaging of the body is often requested to rule out metastatic disease. A patient with suspected breast carcinoma underwent bone imaging which revealed a focal area of uptake that appeared to be localized in the right posterior calvarium. The initial interpretation was possible solitary metastatic breast carcinoma to the skull. Skull radiographs and head computed tomography (CT) were suggested for follow-up evaluation. The skull series was performed immediately after bone imaging and was negative. Further clinical information revealed that the patient recently had undergone total right internal carotid artery ligation for treatment of a large, surgically inaccessible right cavernous aneurysm. SPECT imaging of the head localized the region of abnormal uptake adjacent to the calvarium, which suggested the uptake was due to a recent brain infarction or metastatic disease to the brain. A CT scan performed 4 days later demonstrated generalized cerebral atrophy, but was otherwise normal, ruling out metastatic breast carcinoma. This case emphasizes the importance of SPECT imaging when a solitary skull lesion is found on bone imaging. SPECT can localize the lesion to be within the brain and/or skull and can aid in further investigative management. A lesion located at the periphery of the brain may be due to an occult stroke. This finding is of particular consideration in the elderly in whom there is a relatively high incidence of coexisting cancer and silent brain infarction.
    Clinical Nuclear Medicine 08/1988; 13(7):498-501. · 2.86 Impact Factor

Publication Stats

54 Citations
22.75 Total Impact Points


  • 1994
    • University of California, San Francisco
      San Francisco, California, United States
  • 1988–1991
    • Concordia University‚ÄďAnn Arbor
      Ann Arbor, Michigan, United States