Min Zhang

Jiangsu University, Chenkiang, Jiangsu Sheng, China

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Publications (87)184.35 Total impact

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    ABSTRACT: The aim of this study was to evaluate the efficacy and safety of entecavir (ETV) combined treatment with adefovir (ADV) on chronic hepatitic B (CHB) patients who failed to respond to nucleotide (acid) analog (NA) treatment. On this basis, the possible factors in the combined treatment of these patients will be analyzed. The safety, biochemical index, and the possible factors that might affect the ETV and ADV combined treatment at different points in time were retrospectively analyzed. The biochemical index included the following: virological response, hepatitis B virus (HBV) DNA decline, primary nonresponse, biochemical response, and the hepatitis B virus E antigen/hepatitis B virus E antibody seroconversion rate. There were 94 CHB patients and compensated liver cirrhosis patients who received ETV plus ADV treatment for over 12 weeks after failure of treatment with NAs. The authors have also investigated 76 CHB patients (80.9%) and 18 hepatitis B cirrhosis patients (19.1%) in this study. The HBV DNA baseline was 4.4 ± 1.4 log10 IU/mL, and the positive rate of HBeAg before salvage treatment was 78.7% (74/94). The sample sizes were 94, 78, 42, 10, 6, and 1 for follow-up of 24, 48, 96, 144, 192, and 240 weeks, respectively. The virological responses (HBV DNA < 2 log10 IU/mL) and biochemical responses were 52.1%, 74.3%, and 90.4% and 63.1%, 61.6%, and 81.1%, respectively, at 24, 48, and 96 weeks, which showed significant differences (P < 0.001 and P < 0.005, respectively). The HBV DNA decline was presented as mean ± SEM, which were 1.53 ± 1.23, 1.75 ± 1.37, 2.07 ± 1.54, and 2.39 ± 1.77 log10 IU/mL at 12, 24, 48, and 96 weeks, respectively. They showed significant differences compared with the baseline (χ = 8.084, P < 0.05). The rate of primary nonresponse was 30.9% (29/94), and the primary treatment failure rates were 26.6% (25/94), 24.4% (19/78), and 4.8% (2/42) at 24, 48, and 96 weeks, respectively. They all have statistical difference (P = 0.011 < 0.05). There were 23 patients who experienced virological breakthrough after the HBV DNA levels were undetectable, whereas after follow-up for 12-24 weeks, the HBV DNA levels were back to undetectable again. ETV plus ADV treatment is an efficient and safe treatment for CHB and compensated liver cirrhosis patients who experienced NA treatment failure. The high quantity of baseline HBV DNA level is a risk factor for poor efficacy of salvage treatment.
    American journal of therapeutics 04/2015; Publish Ahead of Print. DOI:10.1097/MJT.0000000000000262 · 1.13 Impact Factor
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    ABSTRACT: To analyze the clinical features and mutation of MUT gene in a Chinese patient with isolated methylmalonic acidemia. The clinical characteristics and laboratory tests data were collected. Genomic DNA was extracted from peripheral blood leukocytes. The 13 exons and their flanking sequences of the MUT gene were amplified with polymerase chain reaction and subjected to direct DNA sequencing. The patient has featured failure to thrive, lethargy, seizure, hypotonia, severe ketoacidosis and hyperammonemia. Tandem mass results showed reduction of multiple acylcarnitine. Urine organic acid testing showed pronounced increase in methylmalonate excretion. Homocysteine was normal. The patient showed no response to vitamin B12 treatment. The above results suggested that the patient had isolated methylmalonic acidemia. DNA sequencing analysis confirmed that the patient has carried two MUT gene mutations, c.755dupA and a novel mutation c.944dupT. Inherited metabolic disease screening plays an important role in the diagnosis of clinical diseases. However, to confirm the results will need gene mutation analysis.
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 04/2015; 32(2):218-221. DOI:10.3760/cma.j.issn.1003-9406.2015.02.014
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    ABSTRACT: To evaluate the efficiency of one-step multiplex RT-PCR for identifying four common fusion transcripts (TEL/AML1, E2A/PBX1, MLL/AF4 and BCR/ABL) in children with acute lymphoblastic leukemia (ALL). Total RNA was extracted from bone marrow samples of 76 children who were newly diagnosed with ALL between January 2003 and December 2010. These RNAs were analyzed for TEL/AML1, E2A/PBX1, MLL/AF4 and BCR/ABL by one-step multiplex RT-PCR or common nested-multiplex PCR. The PCR products were confirmed by DNA sequencing. TEL/AML1 was found in 12 cases (the length of products was 298 bp in 9 cases and 259 bp in 3 cases), E2A/PBX1 was found in 3 cases (the length of products was 373 bp), BCR/ABL was found in 1 case (the length of products was 2 124 bp), and MLL/AF4 was found in 7 cases (the length of products was 427 bp in 1 case and 673 bp in 6 cases) using one-step multiplex RT-PCR combined with DNA sequencing. The results were consistent with those using common nested-multiplex PCR. One-step multiplex RT-PCR may be another alternative for detection of common fusion transcripts in children with ALL.
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 04/2015; 17(4):332-336.
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    ABSTRACT: A series of novel benzo[c]phenanthridine derivatives 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l, 2m and 3a, 3b, 3c, 3d, 3e, 3f bearing an alkylamino side chain at their 6-position were synthesized. All of the target compounds were confirmed by 1H NMR, 13C NMR, and HRMS, and some of them were also characterized by IR and 19F NMR. The preliminary bioassays showed that the target compounds displayed fungicidal activities; for example, compound 2l showed 60.0% and 70.0% inhibitive activity against Alternaria solani and Cercospora arachidicola at 50 mg/L, respectively, and some compounds also displayed plant growth-regulating activities.
    Journal of Heterocyclic Chemistry 03/2015; DOI:10.1002/jhet.2410 · 0.87 Impact Factor
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    ABSTRACT: The demand for petroleum has risen rapidly due to increasing industrialization and modernization of the world. The limited reserve of the fossil fuels is also dwindling alongside escalation in the prices. The threats from these and food insecurity are, however, drawing the attention of researchers for alternative fuel which can be produced from renewable feedstocks. Biodiesel as the most promising alternate is currently produced from conventionally grown edible plant oils such as rapeseed, soybean, sunflower and palm. The use of the edible oils is worsening the current competition of oil for food and for fuel. Focus on the use of non-edible resources is presently directed to jatropha, mahua, pongamia, calophyllum tobacco, cotton oil, etc. Discrepancies between the expectation and realities regarding these non-edible oils are necessitating efforts for diversification of the feedstocks to resources that could guarantee energy production without affecting food security. Neem, karanja, rubber and jatropha are evergreen multipurpose non-edible plants that are widely available and can be grown in diverse socio-economic and environmental conditions. These plants are described as golden trees that have multiple uses such as for fuels, medicines, dyes, ornamentals, feeds, soil enrichment, afforestation, etc. This study was therefore undertaken to explore the multipurpose of these four non-edible tree plants. Among the highlights of this expatiate review include oil as feedstock for biodiesel, the need for non-edible feedstocks, neem, karanja, rubber, jatropha and their value chains, methods of modifying oil to biodiesel, factors affecting biodiesel production, application of the selected non-edible seed biodiesels to engines for performance and emission characteristics and the outlook.
    Renewable and Sustainable Energy Reviews 03/2015; 43:495-520. DOI:10.1016/j.rser.2014.11.049 · 5.51 Impact Factor
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    ABSTRACT: In this study, the adsorption/desorption characteristics of mulberry anthocyanins (MA) on five types of macroporous resins (XAD-7HP, AB-8, HP-20, D-101 and X-5) were evaluated, XAD-7HP and AB-8 showed higher adsorption/desorption capacities. On the basis of static adsorption test, XAD-7HP and AB-8 resins were selected for kinetics, isotherms and thermodynamics. The adsorption mechanism indicated that the process was better explained by pseudo-first-order kinetics and the Langmuir isotherm model, and the thermodynamics tests showed that the processes were exothermic, spontaneous and thermodynamically feasible. Dynamic tests were performed on a column packed with XAD-7HP and AB-8, and breakthrough volume was reached at 15 and 14 bed volumes of MA solution, respectively. The purity of the fraction by 40% ethanol elution on XAD-7HP reached 93.6%, from which cyanidin-3-glucoside and cyanidin-3-rutinoside were identified by HPLC-ESI-MS/MS. The method could be used to prepare high purity anthocyanins from mulberry fruits as well as other plants. Chemical compounds studies in this article: Cyanidin-3-glucoside (PubChem CID:12303203); Cyanidin-3-rutinoside (PubChem CID:29231); Cyanidin (PubChem CID:128861); Hexose (PubChem CID:169005); Rutinose (PubChem CID:441429); Methanol (PubChem CID:887); Ethanol (PubChem CID:702); Ammonium sulfate (PubChem CID:6097028); Acetic acid (PubChem CID:176); Muriatic acid (PubChem CID:313)
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    ABSTRACT: To develop a direct microbial sugar conversion platform for the production of lipids, drop-in fuels and chemicals from cellulosic biomass substrate, we chose Yarrowia lipolytica as a viable demonstration strain. Y. lipolytica is known to accumulate lipids intracellularly and is capable of metabolizing sugars to produce lipids; however, it lacks the lignocellulose-degrading enzymes needed to break down biomass directly. While research is continuing on the development of a Y. lipolytica strain able to degrade cellulose, in this study, we present successful expression of several xylanases in Y. lipolytica. The XynII and XlnD expressing Yarrowia strains exhibited an ability to grow on xylan mineral plates. This was shown by Congo Red staining of halo zones on xylan mineral plates. Enzymatic activity tests further demonstrated active expression of XynII and XlnD in Y. lipolytica. Furthermore, synergistic action in converting xylan to xylose was observed when XlnD acted in concert with XynII. The successful expression of these xylanases in Yarrowia further advances us toward our goal to develop a direct microbial conversion process using this organism.
    PLoS ONE 12/2014; 9(12):e111443. DOI:10.1371/journal.pone.0111443 · 3.23 Impact Factor
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    ABSTRACT: Background Yarrowia lipolytica is an oleaginous yeast capable of metabolizing glucose to lipids, which then accumulate intracellularly. However, it lacks the suite of cellulolytic enzymes required to break down biomass cellulose and cannot therefore utilize biomass directly as a carbon source. Toward the development of a direct microbial conversion platform for the production of hydrocarbon fuels from cellulosic biomass, the potential for Y. lipolytica to function as a consolidated bioprocessing strain was investigated by first conducting a genomic search and functional testing of its endogenous glycoside hydrolases. Once the range of endogenous enzymes was determined, the critical cellulases from Trichoderma reesei were cloned into Yarrowia. Results Initially, work to express T. reesei endoglucanase II (EGII) and cellobiohydrolase (CBH) II in Y. lipolytica resulted in the successful secretion of active enzymes. However, a critical cellulase, T. reesei CBHI, while successfully expressed in and secreted from Yarrowia, showed less than expected enzymatic activity, suggesting an incompatibility (probably at the post-translational level) for its expression in Yarrowia. This result prompted us to evaluate alternative or modified CBHI enzymes. Our subsequent expression of a T. reesei-Talaromyces emersonii (Tr-Te) chimeric CBHI, Chaetomium thermophilum CBHI, and Humicola grisea CBHI demonstrated remarkably improved enzymatic activities. Specifically, the purified chimeric Tr-Te CBHI showed a specific activity on Avicel that is comparable to that of the native T. reesei CBHI. Furthermore, the chimeric Tr-Te CBHI also showed significant synergism with EGII and CBHII in degrading cellulosic substrates, using either mixed supernatants or co-cultures of the corresponding Y. lipolytica transformants. The consortia system approach also allows rational volume mixing of the transformant cultures in accordance with the optimal ratio of cellulases required for efficient degradation of cellulosic substrates. Conclusions Taken together, this work demonstrates the first case of successful expression of a chimeric CBHI with essentially full native activity in Y. lipolytica, and supports the notion that Y. lipolytica strains can be genetically engineered, ultimately by heterologous expression of fungal cellulases and other enzymes, to directly convert lignocellulosic substrates to biofuels. Electronic supplementary material The online version of this article (doi:10.1186/s13068-014-0148-0) contains supplementary material, which is available to authorized users.
    Biotechnology for Biofuels 12/2014; 7(1):148. DOI:10.1186/s13068-014-0148-0 · 6.22 Impact Factor
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    ABSTRACT: A multi-step synthesis of 4,6-dimethoxyaurone derivatives was carried out from phloroglucinol and chloroacetonitrile, and the products were characterized by 1H NMR, 13C NMR, and HRMS. The preliminary bioassays showed that some products exhibited herbicidal activity against dicotyledonous plant Brassica campestris L.
    Journal of Heterocyclic Chemistry 12/2014; DOI:10.1002/jhet.2298 · 0.87 Impact Factor
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    ABSTRACT: Background Natural killer (NK) cells are abundant in the liver and constitute a major innate immune component that contributes to immune-mediated liver injury. However, few studies have investigated the phenotypes and functions of NK cells involved in hepatitis B related liver failure (LF), and the precise mechanism underlying NK cell regulation is not fully understood.Methods We detected the percentage and function of peripheral NK cells both in hepatitis B related LF patients and healthy volunteers by flow cytometry and isolated the liver myofibroblasts (LMFs) from hepatitis B related LF livers. To determine the possible effects of LMFs on NK cells, mixed cell cultures were established in vitro.ResultsWe found a down-regulated percentage of peripheral NK cells in hepatitis B related LF patients, and their NK cells also displayed decreased activated natural cytotoxicity receptors (NCRs) and cytokine production. In a co-culture model, LMFs sharply attenuated IL-2-induced NK cell triggering receptors, cytotoxicity, and cytokine production. The inhibitory effect of LMFs on NK cells correlated with their ability to produce prostaglandin (PG) E2.Conclusion These data suggest that LMFs may protect against immune-mediated liver injury in hepatitis B related LF patients by inhibiting NK cell function via PGE2.
    Journal of Translational Medicine 11/2014; 12(1):308. DOI:10.1186/s12967-014-0308-9 · 3.99 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the mRNA expression levels of suppressor of cytokine signaling 1 (SOCS1) in patients with systemic lupus erythematosus (SLE) compared with healthy controls. The associations of systemic lupus erythematosus disease activity index scores and clinical features of SLE with the expression levels of SOCS1 mRNA were also evaluated. Real-time quantitative reverse transcription-polymerase chain reaction was applied to detect the mRNA expression levels of SOCS1 in peripheral blood mononuclear cells from 34 patients with SLE and 34 healthy controls. The mRNA expression level of SOCS1 was significantly decreased in SLE patients in comparison with healthy controls (Z = −4.207, P < 0.001). Lower SOCS1 mRNA expression was detected in active SLE patients when compared with inactive ones (Z = −2.428, P = 0.015). There was no significant difference found for the SOCS1 mRNA levels between SLE patients with nephritis and those without (Z = −0.642, P = 0.521). The presence of photosensitivity, proteinuria, positive antinuclear antibody, and C4 decline were associated with SOCS1 mRNA levels in SLE patients (all P < 0.05). Furthermore, the SOCS1 mRNA expression was negatively correlated with disease activity (r s = −0.372, P = 0.030). Our results suggest that the dysregulation of SOCS1 might be associated with the pathogenesis of SLE.
    Clinical and Experimental Medicine 10/2014; 15(3). DOI:10.1007/s10238-014-0309-2 · 2.96 Impact Factor
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    ABSTRACT: Africa is a continent full of untapped natural resources ranging from biodiversity to vast water bodies but faced with food and energy crises. Prices of fuel are also escalating. With researchers and experts scrambling for the solution, biodiesel from vegetable oil will receive more attention. But the edible feedstock as the obvious cheapest choice will not be sustainable enough for the increasing energy and food demand; hence, there is a need for guaranteed feedstock. This study was therefore undertaken to explore feedstock that would not be suitable for food but useful for biodiesel in Africa. Among the highlight areas of the study include current energy situation in Africa, technologies of biodiesel production, current state of biodiesel in Africa, driving forces for increase in biodiesel production, current existing problems of biodiesel commercialization, potential benefits of biodiesel processes, need for non-edible oil plants, potential non-edible biodiesel feedstock, biology, distribution and chemistry of the selected non-edible oil plants. The study also throws light on the implication of biodiesel on the environment and the outlook. From the study, the use of non-edible oils can be guaranteed as sustainable feedstock for biodiesel since most of the non-edible plants can be grown on wastelands to reclaim them, not compete with food crops for limited lands, are relatively cheap, available and offer similar or even higher yields of biodiesel and fuel properties as the edibles. Developing biodiesel industry in Africa can help curb the high rate of unemployment through job creation as well as increase in income level of the rural populace. Weaning African economies from oil import dependencies could also be an economic achievement. It can be deduced from the study that there are promising non-edible oil resources in the system for biodiesel industrialization in Africa.
    Renewable and Sustainable Energy Reviews 10/2014; 38:461–477. DOI:10.1016/j.rser.2014.06.002 · 5.51 Impact Factor
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    ABSTRACT: A variety of 3-N-substituted amino-6-benzyloxypyridazine derivatives were designed and synthesized in satisfactory yields. Their structures were confirmed by IR, H-1-NMR, and elemental analysis; compound 5j was further determined by X-ray diffraction crystallography. Their herbicidal activities were evaluated through barnyard grass and rape cup tests in laboratory bioassays. Most of the title compounds 5 displayed moderate herbicidal activities against the dicotyledonous plant Brassica campestris L. The most active compounds in the laboratory were also evaluated in the greenhouse.
    Journal of Heterocyclic Chemistry 09/2014; 51(5):1404-1409. DOI:10.1002/jhet.1831 · 0.87 Impact Factor
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    Annals of Dermatology 08/2014; 26(4):522-3. DOI:10.5021/ad.2014.26.4.522 · 0.95 Impact Factor
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    ABSTRACT: Abstract Objectives: Previous published data indicated that interleukin-21 (IL-21) gene polymorphisms were shown to associate with multiple autoimmune diseases (ADs), but the results remain inconclusive. The aim of this study was to perform a meta-analysis to assess the overall association between IL-21 gene polymorphisms (rs907715, rs2221903) and multiple ADs. Methods: All eligible case-control studies were searched in the PubMed and Embase database. A meta-analysis was conducted on the association between the IL-21 gene variants and ADs using: (1) allelic contrast, (2) homozygote contrast, (3) the recessive model, and (4) the dominant model. Results: A total of 12 relevant studies including 10 535 cases and 19 356 controls were enrolled in this meta-analysis. A significant association between IL-21 rs907715 gene polymorphism and AD was found under the allelic (OR: 1.102, 95% CI: 1.057-1.149, p = 0.000), homozygous (OR: 1.220, 95% CI: 1.089-1.368, p = 0.001), dominant (OR: 1.160, 95% CI: 1.027-1.309, p = 0.017), and recessive genetic model (OR: 1.119, 95% CI: 1.055-1.187, p = 0.000) among Caucasian populations. However, there was no significant association between IL-21 rs2221903 polymorphism and AD in different genetic models. Conclusions: Data from the present study suggest that the IL-21 rs907715 polymorphism might be associated with multiple ADs susceptibility in Caucasians. Especially, the allele G of intronic rs907715 in IL-21 confers increased risk of ADs.
    Autoimmunity 07/2014; 48(2):1-9. DOI:10.3109/08916934.2014.944262 · 2.75 Impact Factor
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    ABSTRACT: The aim of this study was to determine the risk factors for avascular necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Four electronic databases (PubMed, EMBASE, Ovid, and Science Direct) were searched for. The search was performed to identify the articles as to SLE with AVN before September 2013. The clinical and laboratory data were extracted, and a meta-analysis was performed to identify the risk factors for AVN in patients with SLE. Publication bias was assessed with funnel plot and Egger's test. A total of 995 papers were found from the four databases; 16 studies were finally included. Pooled analysis showed the following result. The result showed that arthritis (odds ratio (OR) = 2.448, 95 % confidence interval (CI) = 1.617-3.707), cushingoid (OR = 3.890, 95 % CI = 1.591-9.510), gastrointestinal involvement (OR = 2.054, 95 % CI = 1.283-3.290), hypertension (OR = 1.482, 95 % CI = 1.093-2.008), oral ulcers (OR = 1.877, 95 % CI = 1.182-2.979), pleuritis (OR = 2.302, 95 % CI = 1.325-4.001), renal disease (OR = 1.475, 95 % CI = 1.124-1.936), and vasculitis (OR = 2.591, 95 % CI = 1.358-4.944) were relevant with AVN in SLE patients. Cytotoxic drug (OR = 1.834, 95 % CI = 1.065-3.156, P = 0.029), the total cumulative dose (Standard Mean Difference (SMD) = 1.104, 95 % CI = 0.118-2.090, P = 0.028), maximum daily dose (SMD = 0.484, 95 % CI = 0.288-0.678, P < 0.001), and mean daily dose (SMD = 1.305, 95 % CI = 0.061-2.549, P = 0.040) were significantly higher in AVN group. There were no significantly laboratory features that appeared in this pooled analysis. We conclude that arthritic, cushingoid, gastrointestinal involvement, hypertension, oral ulcers, pleuritis, renal disease, vasculitis, cytotoxic drug, and steroid treatment may contribute to AVN in SLE patients.
    Inflammation 05/2014; 37(5). DOI:10.1007/s10753-014-9917-y · 2.21 Impact Factor
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    ABSTRACT: Abstract The purpose of this study was to evaluate whether a single-nucleotide polymorphism (SNP), rs2243188 of interleukin-19 (IL-19), show significant evidence for association with SLE in a Chinese population. A total of 545 SLE patients and 613 healthy controls were collected in the present study. The genotyping of IL-19 rs2243188 polymorphism was detected by TaqMan allele discrimination assay on the 7300 real time polymorphism chain reaction system. The minor C allele of rs2243188, relative to the major A allele, appeared to have a significantly lower frequency in SLE patients (31.0%) as compared with controls (35.5%) (χ(2) = 5.19, p = 0.023). We also discovered a statistical significance in the dominant model (CC + CA versus AA: OR = 0.755, 95% CI = 0.598-0.953, p = 0.018). However, no significant difference in genotype distribution was found between SLE patients and controls (p = 0.056). Furthermore, an increased frequency of CC genotype were also detected in lupus nephritis (LN) groups as compared with non-LN groups (p = 0.024). Besides, the individuals with CC genotype had a 2.201-fold higher risk for the susceptibility to LN than those A allele carriers (AA + CA) (p = 0.006). Unfortunately, the analyses on the relationship of IL-19 rs2243188 with several clinical manifestations of SLE failed to find any significant results. In conclusion, our observations suggested the minor C allele of SNP rs2243188 might be a protective factor for SLE in a Chinese Han population. Moreover, the subgroup analysis highlighted that IL-19 rs2243188 SNP was associated with the susceptibility to LN patients.
    Autoimmunity 05/2014; 47(6):1-5. DOI:10.3109/08916934.2014.914505 · 2.75 Impact Factor
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    Ling Tao · Xin He · Eric C. D. Tan · Min Zhang · Andy Aden
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    ABSTRACT: This work presents a detailed review and comparative analysis of the process design and economics of n-butanol production using corn grain and corn stover. This includes reviewing the most recent n-butanol technologies; demonstrating the impact of key parameters (e.g. plant capacity, raw material pricing, yield) on the overall n-butanol process economics; and comparing how cellulosic biomass conversion technologies and challenges differ from traditional sugar-based n-butanol conversion technology. A major challenge of n-butanol production is the low n-butanol yield (compared to ethanol), resulting in higher production costs. However, recent research efforts have achieved significant yield improvements using a combination of genetic engineering, fermentation techniques, and integrated process development using continuous fermentation with online stripping to remove n-butanol during fermentation. This study presents the advances in n-butanol research for both sugar-based (corn) and cellulosic (corn stover) feedstocks, and also provides a comparison of overall process technologies and process economics. In addition, the results of a sensitivity analysis comparing various technologies, sugar yields, and coproduct distributions are discussed in order to provide research guidance. © 2013 Society of Chemical Industry and John Wiley & Sons, Ltd
    Biofuels Bioproducts and Biorefining 05/2014; 8(3). DOI:10.1002/bbb.1462 · 4.26 Impact Factor
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    ABSTRACT: Abstract Objective: To determine whether the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) CT60 polymorphism (rs3087243) confers susceptibility to autoimmune thyroid disease (AITDs). Methods: A meta-analysis was performed using: (1) allelic contrast, (2) recessive model and (3) dominant model. Electronic search of PubMed, Medline and Chinese National Knowledge Infrastructure (CNKI) was conducted to select studies. Results: Finally, a total of 20 separate studies were available for the current meta-analysis: Graves' disease (GD): 18 studies including 1 Iranian, 6 Caucasian and 11 Asian populations; Hashimoto's thyroiditis (HT): seven studies including one Iranian, three Caucasian and three Asian populations. A significant association was found between the CTLA-4 CT60 polymorphism (rs3087243) and GD, with regard to comparisons between allele and genotype frequencies (all p < 0.001). After stratification by ethnicity, significant relationships were consistently identified both in Caucasian and Asian populations. Furthermore, the association between this allelic variant and HT risk was also found in overall and Asian populations (OR: 1.26, 95% CI: 1.10-1.44; OR: 1.45, 95% CI: 1.19-1.76, respectively). Conclusion: Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
    Endocrine Research 04/2014; 39(4). DOI:10.3109/07435800.2013.879167 · 1.41 Impact Factor
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    ABSTRACT: To evaluate the efficacy and safety of tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) after failure of nucleoside-analogues (NAs).

Publication Stats

563 Citations
184.35 Total Impact Points


  • 2009–2015
    • Jiangsu University
      • School of Chemistry and Chemical Engineering
      Chenkiang, Jiangsu Sheng, China
  • 2013–2014
    • Sun Yat-Sen University
      • Department of Infectious Diseases
      Shengcheng, Guangdong, China
  • 2012–2014
    • Anhui Medical University
      • Department of Epidemiology and Biostatistics
      Luchow, Anhui Sheng, China
    • Sun Yat-Sen University of Medical Sciences
      • Department of Infectious Diseases
      Shengcheng, Guangdong, China
  • 2005–2014
    • Nankai University
      • • Institute of Elemento-Organic Chemistry
      • • State Key Laboratory of Elemento-Organic Chemistry
      T’ien-ching-shih, Tianjin Shi, China
  • 2002–2014
    • National Renewable Energy Laboratory
      • Biosciences Center
      گلدن، کلرادو, Colorado, United States
  • 2008
    • Shenzhen Children's Hospital
      Shechenzhuang, Jiangsu Sheng, China