Mi Kyung Kim

Dankook University, Eidō, Chungcheongbuk-do, South Korea

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Publications (127)279.26 Total impact

  • Shin Hyuk Kang · Tae Hui Bae · Woo Seob Kim · Han Koo Kim · Mi Kyung Kim ·

    The Journal of craniofacial surgery 10/2015; DOI:10.1097/SCS.0000000000002137 · 0.68 Impact Factor
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    ABSTRACT: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis. We investigated the anti-proliferative and apoptosis mechanisms of ergosterol peroxide associated with its anticancer activities in human colorectal cancer (CRC) cell lines and tested its anti-tumor effect on colitis-induced CRC developed by Azoxymethane (AOM) / Dextran sulfate sodium (DSS) in a mouse model. We used MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays, flow cytometry assays, Western blot analysis, colony formation assays, reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry (IHC), and AOM/DSS mouse models to study the molecular mechanism of metastatic activities in CRC cells. Ergosterol peroxide inhibited cell proliferation and also suppressed clonogenic colony formation in HCT116, HT-29, SW620 and DLD-1 CRC cell lines. The growth inhibition observed in these CRC cell lines was the result of apoptosis, which was confirmed by FACS analysis and Western blotting. Ergosterol peroxide inhibited the nuclear levels of β-catenin, which ultimately resulted in reduced transcription of c-Myc, cyclin D1, and CDK-8. Ergosterol peroxide administration showed a tendency to suppress tumor growth in the colon of AOM/DSS-treated mice, and quantification of the IHC staining showed a dramatic decrease in the Ki67-positive staining and an increase in the TUNEL staining of colonic epithelial cells in AOM/DSS-treated mice by ergosterol peroxide for both prevention and therapy. Our data suggest that ergosterol peroxide suppresses the proliferation of CRC cell lines and effectively inhibits colitis-associated colon cancer in AOM/DSS-treated mice. Ergosterol peroxide down-regulated β-catenin signaling, which exerted anti-proliferative and pro-apoptotic activities in CRC cells. These properties of ergosterol peroxide advocate its use as a supplement in colon cancer chemoprevention. Copyright © 2015. Published by Elsevier Ireland Ltd.
    Journal of ethnopharmacology 07/2015; 173. DOI:10.1016/j.jep.2015.07.030 · 3.00 Impact Factor
  • Gayoung Lee · Chian Kwon · Soohong Kim · Mi Kyung Kim · Jun Lim · Jae Bok Heo · Hye Sup Yun ·
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    ABSTRACT: Ca2+ as in other cellular signaling pathways plays a key signal-mediating function in plant immune responses. However, a negative immune activity of some Ca2+-binding calmodulins implicates a rather confusing function of Ca2+ despite its importance in plant immunity. We therefore studied here an effect of Ca2+ on Arabidopsis disease resistance to an adapted Golovinomyces orontii powdery mildew fungus. Pre-treatment with Ca2+ enhanced plant defense against G. orontii especially during late pathogenesis. A similar inhibition of G. orontii growth by Ca2+ was also observed in the salicylic acid-depleted nahG plants. Golovinomyces orontii-dependent induction of defense genes by Ca2+ suggests that it acts as a defense-priming factor in plant post-invasive resistance to adapted powdery mildew fungal pathogens.
    Genes & genomics 06/2015; 37(6). DOI:10.1007/s13258-015-0283-4 · 0.60 Impact Factor
  • Ilchan Song · Do Sun Kim · Mi Kyung Kim · Arshad Jamal · Kyung-A Hwang · Kisung Ko ·
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    ABSTRACT: Various horticultural crops have been considered as potential heterologous expression systems for plant-made recombinant pharmaceutical proteins. However, there is little information concerning the total soluble protein (TSP) levels of major horticultural crops. Ten major horticultural crops-Chinese cabbage, broccoli, garlic, onion, cabbage, bunching onion, cucumber, zucchini, radish, and carrot, along with tobacco and Arabidopsis, were selected to investigate the TSP levels in their individual tissues. In tobacco, SDS-PAGE assay showed that leaf tissues had stronger protein bands than stem tissues, and freshly harvested samples had slightly stronger band density than the −70°C frozen samples, suggesting that fresh leaf should be used to measure the total soluble proteins without any protein loss or degradation. Bicinchoninic acid (BCA) protein assay revealed that among various horticultural crops, garlic (41.4 mg·g−1 FW), broccoli (21.9 mg·g−1 FW), and Chinese cabbage (11.9 mg·g−1 FW) had the highest TSP levels suggesting that these horticultural crops could be good candidates for plant molecular biofarming to produce highly valuable recombinant proteins. The inner clove tissue in garlic, the flower tissue in broccoli, and the green leaf tissue in Chinese cabbage showed the strongest protein band density as compared to other tissues. The TSP of Arabidopsis tissues was quantified by SDS-PAGE, BCA, and Nano-drop methods. In general, the middle leaf tissue showed the highest TSP levels. To evaluate TSP levels of various horticultural crops, these three different methods were compared. The correlation and regression analyses between SDS-PAGE and BCA, and SDS-PAGE and Nano-drop suggested that there were significant correlations between SDS-PAGE and BCA protein assays as compared to SDS-PAGE and Nano-drop assays, indicating that BCA assay is reliable to quantify TSP levels. In conclusion, the TSP levels varied depending on the horticultural crops and their tissue types, and BCA assay could be applied to quantify the TSP.
    Horticulture, Environment and Biotechnology 03/2015; 56(1):123-129. DOI:10.1007/s13580-015-0097-y · 0.73 Impact Factor
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    ABSTRACT: Capsular contracture is the most troublesome complication in breast implant surgery. Although capsule formation can be seen as a normal reaction to a foreign body, it can induce pain, hardness, deformity, and other pathologic problems. Surgical intervention is required in severe cases, but even surgery cannot guarantee a successful outcome without recurrence. This experimental study confirms that single topical administration of leukotriene antagonist zafirlukast (Accolate, Astrazeneca) reduces peri-implant capsule formation and prevents capsular contracture. Twelve smooth-surfaced cohesive gel implants were implanted in New Zealand White rabbits. These miniature implants were designed to be identical to currently used products for breast augmentation. The rabbits were divided into 2 groups. In the experimental group (n=6), the implant and normal saline with zafirlukast were inserted in the submuscular pocket. In the control group (n=6), the implant and normal saline alone were used. Two months later, the implants with peri-implant capsule were excised. We evaluated capsule thickness and collagen pattern and performed immunohistochemical staining of myofibroblasts, transforming growth factor (TGF)-β1, 2. The thickness of the capsules in the experimental group was reduced in both dorsal and ventral directions. The collagen pattern showed parallel alignment with low density, and the number of myofibroblasts as well as the amounts of TGF-β1 and TGF-β2 were reduced in the experimental group. We suggest that single topical administration of leukotriene antagonist zafirlukast can be helpful in reducing capsule formation and preventing capsular contracture via myofibroblast suppression, modulation of fibroblastic cytokines, and anti-inflammatory effect.
    Archives of Plastic Surgery 03/2015; 42(2):179-85. DOI:10.5999/aps.2015.42.2.179
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    ABSTRACT: Primary retroperitoneal mucinous cystic neoplasm is very rare and its histogenesis is unclear. This paper presents the case of a 31-year-old female in whom an incidentally detected retroperitoneal cystic mass, 6.5cm in size, was successfully resected through laparoscopic approach. Pathologic examination revealed a mucinous cystadenoma. The postoperative course was uneventful, and the patient remained free of recurrence six months after surgery. Literature review showed that male sex (p=0.019), and solid nodules in cysts (p<0.001) were both significantly associated with malignancy. When confronted with a cystic mass in the retroperitoneum, a primary mucinous cystic neoplasm should be considered and complete surgical removal of the tumor without spillage is recommended. Copyright © 2015 Z. Published by Elsevier Ltd.. All rights reserved.
    International Journal of Surgery Case Reports 02/2015; 125. DOI:10.1016/j.ijscr.2015.02.050
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    ABSTRACT: Sonographic findings of a prescrotal superficial angiomyxoma have never been reported in the English literature. Here, we describe a case of left prescrotal superficial angiomyxoma, which was depicted on ultrasonography as a well-circumscribed, heterogeneously, and mildly echogenic, unilocular complex, posterior acoustic-enhanced, and dermally attached subcutaneous mass without increased vascular flow.
    Japanese journal of radiology 02/2015; 33(4). DOI:10.1007/s11604-015-0395-4 · 0.84 Impact Factor
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    ABSTRACT: Dickkopf-3 (DKK3) may act as a tumor suppressor as it is down-regulated in various types of cancer. This study assessed the DKK3 protein expression in gastric cancer and its potential value as a prognostic marker. DKK3 expression was evaluated by immunohistochemistry in 158 gastric cancer samples from patients who underwent gastrectomy from 2002 to 2008. Clinicopathological parameters and survival data were analyzed. Loss of DKK3 expression was found in 64 of 158 (40.5 %) samples, and it was associated with advanced T stage (p < 0.001), lymph node metastasis (p < 0.001), UICC TNM stage (p < 0.001), tumor location (p = 0.029), lymphovascular invasion (p = 0.035), and perineural invasion (p = 0.032). Patients without DKK3 expression in tumor cells had a significantly worse disease-free and overall survival than those with DKK3 expression (p < 0.001, and p = 0.001, respectively). TNM stage (p = 0.028 and p < 0.001, respectively) and residual tumor (p < 0.001 and p = 0.003, respectively) were independent predictors of disease-free and overall survival. Based on the preoperative clinical stage assessed by computed tomography (CT), loss of DKK3 expression was predominantly associated with worse prognosis in patients with clinically node-negative advanced gastric cancer (AGC). The combination of DKK3 expression status and CT increased the accuracy of CT staging for predicting lymph node involvement from 71.5 to 80.0 % in AGC patients. Loss of DKK3 protein expression was significantly associated with poor survival in patients with gastric cancer and was strongly correlated with the TNM stage. DKK3 might be a potential biomarker of lymph node involvement that can improve the predictive power of CT.
    World Journal of Surgery 01/2015; 39(4). DOI:10.1007/s00268-014-2886-3 · 2.64 Impact Factor
  • Shin Hyuk Kang · Tae Hui Bae · Han Koo Kim · Woo Seob Kim · Mi Kyung Kim ·
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    ABSTRACT: We report a case of unicystic ameloblastoma associated with an ectopic third molar in the right maxillary sinus, which was misdiagnosed as a dentigerous cyst on preoperative small incisional biopsy. Surgical enucleation of the cystic lesion was performed under general anesthesia with immediate reconstruction of the maxillary sinus using titanium mesh plate. The patient's postoperative recovery was uneventful, and there was no evidence of tumor recurrence during the 7-month follow-up period.
    Journal of Craniofacial Surgery 01/2015; 26(1):e53-5. DOI:10.1097/SCS.0000000000001072 · 0.68 Impact Factor
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    ABSTRACT: Irisin is a recently found myokine that aids obesity control and improves glucose homeostasis by acting on white adipose tissue cells and increases total energy consumption. The aim of this study was to evaluate serum irisin levels in patients with non-alcoholic fatty liver disease (NAFLD) and to compare these levels with those of normal controls. Among 595 health screen examinees who had visited our institute between January 2013 to March 2013, 355 patients (84 NAFLD patients and 271 normal controls) were enrolled depending on whether they gave written informed consents and their history of alcohol intake, blood tests, and abdominal ultrasonographic findings. Age; sex; laboratory test parameters; homeostasis model assessment-insulin resistance; and levels of leptin, adiponectin, and irisin were assessed. Serum irisin levels (ng/ml) were significantly higher in the NAFLD group than in normal controls (63.4±32.6 vs. 43.0±29.7, p<0.001) and higher in the mild fatty liver group than in the moderate-to-severe fatty liver group (68.3±38.2 vs. 56.6±21.2, p<0.001). Additionally, serum irisin levels were not different between the non-obese and obese groups (48.4±34.2 vs. 45.8±22.9, p = 0.492); however, the levels were significantly lowest in normal controls and highest in the mild fatty liver group in the non-obese (44.9±31.7 vs. 73.1±48.5 vs 59.7±18.0, p<0.001) and obese groups (35.0±17.0 vs. 62.9±21.2 vs. 54.6±23.3, p<0.001). Serum irisin levels were significantly higher in NAFLD patients, which is not consistent with the results of previously published studies. Therefore, more studies are needed to confirm the role of irisin in NAFLD.
    PLoS ONE 10/2014; 9(10):e110680. DOI:10.1371/journal.pone.0110680 · 3.23 Impact Factor
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    ABSTRACT: Paecilomyces tenuipes is entomogenous fungus that is called snow-flake Dongchunghacho in Korea. Although it is widely used in traditional medicines, its safety has not yet been comprehensively investigated. Therefore, the aim of this study was to evaluate the genotoxicity, acute and subchronic toxicity of P. tenuipes. The acute oral LD50 of P. tenuipes extract in rats was estimated to be greater than 2,000 mg/kg of body weight. In the subchronic study, the oral treatment of rats with 500, 1,000 or 2,000 mg/kg P. tenuipes extract daily for 13 weeks did not induce any dose-related changes (body weight, food consumption, clinical observation, urinalysis, hematology, clinical chemistry and organ weight). In contrast, histopathological observation revealed that P. tenuipes extract induced karyomegaly in outer medulla of kidney in all treated rats. Importantly, P. tenuipes extract exerted the mutagenic potential in Ames assay. Since karyomegalic alterations have been known to be associated with carcinogenicity, our finding on the mutagenicity of P. tenuipes extract supports the possibility on the potential involvement of P. tenuipes in carcinogenicity at least partially. In conclusion, the subchronic oral exposure of P. tenuipes may induce kidney abnormality at the concentration higher than 500 mg/kg body weight, although further studies using other animal models are needed to identify the toxicity of P. tenuipes.
    Regulatory Toxicology and Pharmacology 09/2014; 70(2). DOI:10.1016/j.yrtph.2014.09.003 · 2.03 Impact Factor
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    ABSTRACT: Breast cancer is heterogeneous in clinical behavior by subtypes, but it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the difference in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Korea women. From the Seoul Breast Cancer Study (SEBCS), a total of 3,058 breast cancer patients were included in the analyses. Tumor subtypes were classified based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. The epidemiological factors of each subtype were compared through case-case analyses using multivariate a polytomous logistic regression model adjusted for age and recruiting centers. The distribution of the subtypes was as follows: 1,714 HR+ HER2- (56.0%), 414 HR+ HER2+ (13.5%), 423 HR- HER2+ (13.9%), and 507 HR- HER2- (16.6%) breast cancer patients. There were significant differences in age, menopausal status, age at menarche, number of children, age at first full-term pregnancy (FFTP), duration of breastfeeding, and duration of endogenous estrogen exposure between tumor subtypes (P<0.05). When compared with HR+ HER2- patients, the other subtype patients showed more frequency in having more numbers of children and less frequency in having earlier menarche, later FFTP, and longer endogenous estrogen exposure. While HR- HER2+ patients were less obese, HR- HER2- patients were younger and more obese. In conclusion, age, body mass index, and reproductive factors were differentially associated with breast tumor subtypes suggesting a possible distinct etiology for tumor progression. © 2013 Wiley Periodicals, Inc.
    International Journal of Cancer 08/2014; 135(3). DOI:10.1002/ijc.28685 · 5.09 Impact Factor
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    ABSTRACT: A visible light-curable polysaccharide conjugate was prepared and was included with epidermal growth factor (EGF) for wound healing application. Alginate was modified with furfurylamine, and the furfuryl alginate (F-alginate) was mixed with Rose Bengal for visible light reactivity. The introduction of furfuryl group was confirmed by 1H-NMR and UV/vis spectroscopy. Visible light-induced crosslinking was evaluated by micropatterning and weight measurement. Swelling ratio was also determined. To verify its applicability in wound healing applications, EGF was included in the system of F-alginate and Rose Bengal. After the confirmation of no cytotoxicity of F-alginate and murine EGF release from the system, cell proliferation, antibacterial activity, and animal test were performed on the system. In conclusion, it was demonstrated that the system was useful for wound healing. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40113.
    Journal of Applied Polymer Science 07/2014; 131(14). DOI:10.1002/app.40113 · 1.77 Impact Factor
  • Tae Hui Bae · Shin Hyuk Kang · Han Koo Kim · Woo Seob Kim · Mi Kyung Kim ·
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    ABSTRACT: Clear cell hidradenocarcinoma is a rare tumor of eccrine sweat gland origin that has a predilection for the head and neck. It has an indolent growth pattern and a higher incidence of regional and distant metastases. Metastasizing adnexal carcinomas are rare; thus, currently there is no uniform treatment guideline. We report a case of an 89-year-old female patient with clear cell hidradenocarcinoma manifesting in the right ear helix that metastasized to the right parotid gland who was treated by wide local excision and radiation therapy.
    Journal of Craniofacial Surgery 07/2014; 25(4):e316-e317. DOI:10.1097/SCS.0000000000000581 · 0.68 Impact Factor
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    ABSTRACT: The purpose of this study was to elucidate the origin and cellular composition of retrocorneal membranes (RCMs) associated with chemical burns using immunohistochemical staining for primitive cell markers. Six cases of RCMs were collected during penetrating keratoplasty. We examined RCMs with hematoxylin and eosin (H&E), periodic acid-Schiff (PAS) staining and immunohistochemical analysis using monoclonal antibodies against hematopoietic stem cells (CD34, CD133, c-kit), mesenchymal stem cells (beta-1-integrin, TGF-β, vimentin, hSTRO-1), fibroblasts (FGF-β, α-smooth muscle actin), and corneal endothelial cells (type IV collagen, CD133, VEGF, VEGFR1). Histologic analysis of RCMs revealed an organized assembly of spindle-shaped cells, pigment-laden cells, and thin collagenous matrix structures. RCMs were positive for markers of mesenchymal stem cells including beta-1-integrin, TGF-β, vimentin, and hSTRO-1. Fibroblast markers were also positive, including FGF-β and α-smooth muscle actin (SMA). In contrast, immunohistochemical staining was negative for hematopoietic stem cell markers including CD34, CD133 and c-kit as well as corneal endothelial cell markers such as type IV collagen, CD133 except VEGF and VEGFR1. Pigment-laden cells did not stain with any antibodies. The results of this study suggest that RCMs consist of a thin collagen matrix and fibroblast-like cells and may be a possible neogenetic structure produced from a lineage of bone marrow-derived mesenchymal stem cells. Graphical Abstract
    Journal of Korean Medical Science 06/2014; 29(6):846-51. DOI:10.3346/jkms.2014.29.6.846 · 1.27 Impact Factor
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    ABSTRACT: Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism in melanogenesis remains unclear. In the present study, we investigated the effect of CTM on melanin production using ELISA reader and the expression of proteins involved in melanogenesis by Western blotting, and examined the involvement of transglutaminase-2 (Tgase-2) in SK-MEL-2 human melanoma cells by gene silencing. In the results, CTM dose-dependently suppressed melanin production and dendrite extension in α-MSH-induced melanogenesis of SK-MEL-2 human melanoma cells. CTM also suppressed α-MSH-induced chemotactic migration as well as the expressions of melanogenesis factors TRP-1, TRP-2 and MITF in α-MSH-treated SK-MEL-2 cells. Meanwhile, gene silencing of Tgase-2 suppressed dendrite extension and the expressions of TRP-1 and TRP-2 in α-MSH-treated SK-MEL-2 cells. Overall, these findings suggested that CTM suppresses α-MSH-induced melanogenesis via Tgase-2 inhibition and that therefore, Tgase-2 might be a new target in hyperpigmentation disorder therapy.
    Biomolecules and Therapeutics 05/2014; 22(3):207-12. DOI:10.4062/biomolther.2014.031 · 1.73 Impact Factor
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    ABSTRACT: The insulin-like growth factor (IGF) signaling pathway plays an important role in cancer biology. The IGF 1 receptor (IGF1R) overexpression has been associated with a number of hematological neoplasias and solid tumors including breast cancer. However, molecular mechanism involving IGF1R in carcinogenic developments is clearly not known. We investigated the genetic variations across the IGF1R polymorphism and the risk of breast cancer risk in Korean women. A total of 1418 individuals comprising 1026 breast cancer cases and 392 age-matched controls of Korean were included for the analysis. Genomic DNA was extracted from whole blood and single nucleotide polymorphisms (SNPs) were analyzed on the GoldenGate Assay system by Illumina's Custom Genetic Analysis service. SNPs were selected for linkage disequilibrium (LD) analysis by Haploview. We genotyped total 51 SNPs in the IGF1R gene and examined for association with breast cancer. All the SNPs investigated were in Hardy-Weinberg equilibrium. These SNPs tested were significantly associated with breast cancer risk, after correction for multiple comparisons by adjusting for age at diagnosis, BMI, age at menarche, and age at first parturition. Among 51 IGF1R SNPs, five intron located SNPs (rs8032477, rs7175052, rs12439557, rs11635251 and rs12916884) with homozygous genotype (variant genotype) were associated with decreased risk of breast cancer. Fisher's combined p-value for the five SNPs was 0.00032. Three intron located SNPs with heterozygous genotypes also had decreased risk of breast cancer. Seven of the 51 IGF1R SNPs were in LD and in one haplotype block, and were likely to be associated with breast cancer risk. Overall, this case-control study demonstrates statistically significant associations between breast cancer risk and polymorphisms in IGF1R gene.
    PLoS ONE 01/2014; 9(1):e84532. DOI:10.1371/journal.pone.0084532 · 3.23 Impact Factor
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    ABSTRACT: Most scrub typhus patients have normal electrocardiography (ECG) findings. Recently, however, several cases with ECG changes were reported. However, few studies have examined the ECG changes in scrub typhus.
    01/2014; 86(3):301. DOI:10.3904/kjm.2014.86.3.301
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    Mi Kyung Kim ·
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    ABSTRACT: Obesity prevalence is increasing worldwide, including in Korea. It is associated with increased risk of metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease. However, certain obese individualsfall into the category of metabolically healthy obesity (MHO) and do not have cardiometabolic risk characteristics such as dyslipidemia, insulin resistance and hypertension. Diet and lifestyle intervention are the main therapeutic strategies for treatment of obesity. However, the effect of diet and lifestyle interventionon MHO is unclear. Therefore, in this report, I will review the relationship between diet,lifestyle and MHO.
    01/2014; 15(1):21. DOI:10.4093/jkd.2014.15.1.21
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    ABSTRACT: Obesity may be the consequence of various environmental or genetic factors, which may be highly correlated with each other. We aimed to examine whether grandmaternal and maternal obesity and environmental risk factors are related to obesity in daughters. Daughters (n = 182) recruited from female students, their mothers (n = 147) and their grandmothers (n = 67) were included in this study. Multivariable logistic regression was used to analyze the association between the daughter's obesity and maternal, grandmaternal, and environmental factors. Maternal heights of 161-175cm (OD: 8.48, 95% CI: 3.61-19.93) and 156-160 cm (2.37, 1.14-4.91) showed positive associations with a higher height of daughter, compared to those of 149-155 cm. Mothers receiving a university or a higher education had a significant OR (3.82, 1.27-11.50) for a higher height of daughter compared to those having a low education (elementary school). Mother having the heaviest weight at current time (59-80 kg, 3.78, 1.73-8.28) and the heaviest weight at 20 years of age (51-65 kg, 3.17, 1.53-6.55) had significant associations with a higher height of daughters, compared to those having the lightest weight at the same times. There was no association between the height, weight, and BMI of daughters and the characteristics and education of her grandmothers. In conclusion, although genetic factors appear to influence the daughter's height more than environmental factors, the daughter's weight appears to be more strongly associated with individual factors than the genetic factors.
    Nutrition research and practice 10/2013; 7(5):400-8. DOI:10.4162/nrp.2013.7.5.400 · 1.44 Impact Factor

Publication Stats

1k Citations
279.26 Total Impact Points


  • 2015
    • Dankook University
      • Department of Molecular Biology
      Eidō, Chungcheongbuk-do, South Korea
  • 2007-2015
    • Chung-Ang University Hospital
      Sŏul, Seoul, South Korea
    • Kyoto University
      Kioto, Kyōto, Japan
  • 1999-2015
    • Chung-Ang University
      • • College of Medicine
      • • Department of Systems Biotechnology
      Sŏul, Seoul, South Korea
  • 2014
    • Dongguk University
      • College of the Pharmacy
      Sŏul, Seoul, South Korea
  • 2010-2014
    • National Cancer Center Korea
      • Division of Cancer Epidemiology and Prevention
      Kōyō, Gyeonggi Province, South Korea
    • Chonbuk National University
      • Department of Polymer Nano Science & Technology
      Tsiuentcheou, North Jeolla, South Korea
  • 2009-2014
    • Keimyung University
      • Dongsan Medical Center
      Sŏul, Seoul, South Korea
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 2007-2014
    • Ewha Womans University
      • • College of Health Sciences
      • • Department of Nutritional Science and Food Management
      Sŏul, Seoul, South Korea
  • 2013
    • University of Ulsan
      • Department of Surgery
      Urusan, Ulsan, South Korea
  • 2007-2013
    • Inje University
      • College of Medicine
      Kŭmhae, Gyeongsangnam-do, South Korea
  • 2002-2013
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
    • Korea Advanced Institute of Science and Technology
      • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2001-2013
    • Pusan National University
      • • College of Pharmacy
      • • Department of Obstetrics and Gynecology
      Tsau-liang-hai, Busan, South Korea
  • 2012
    • Korea University
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
    • Kyung Hee University
      • Graduate School of East-West Medical Science
      Sŏul, Seoul, South Korea
    • Catholic University of Korea
      • Department of Nursing
      Sŏul, Seoul, South Korea
    • Chungnam National University
      • Department of Biochemistry
      Sŏngnam, Gyeonggi Province, South Korea
  • 2011
    • CHA University
      Sŏul, Seoul, South Korea
    • Sungkyunkwan University
      • Department of Neurosurgery
      Sŏul, Seoul, South Korea
  • 2009-2010
    • Ajou University
      • Division of Energy Systems Research
      Sŏul, Seoul, South Korea
  • 2005
    • Inha University
      • Department of Nursing
      Seoul, Seoul, South Korea
  • 2004
    • Incheon St. Mary’s Hospital, Catholic Medical Center
      Bucheon, Gyeonggi Province, South Korea
    • Electronics and Telecommunications Research Institute
      • Components and Materials Research Laboratory
      Sŏul, Seoul, South Korea