Ming Zhou

Chongqing University, Ch’ung-ch’ing-shih, Chongqing Shi, China

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Publications (108)285.99 Total impact

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    ABSTRACT: Water oxidation is a critical step in water splitting to make hydrogen fuel. We report a hybrid material consisting of NiCoO2 nanowires grown on carbon fiber paper (denoted as NiCoO2@CFP) as a highly efficient oxygen evolution reaction (OER) electrocatalyst. In 0.1 M KOH, the highly nanostructured NiCoO2 catalyst presents a small overpotential of ∼0.303 V at a current density of 10 mA cm−2 and a low Tafel slope of ∼57 mV dec−1, comparable to the commercial precious RuO2 catalyst. Such a good performance for OER may be attributed to the NaCl-type structure of the NiCoO2 nanowires and CFP substrate, which can boost the formation of active Ni-Co layered hydroxide/oxyhydroxide species during the catalysis process. Additionally, the aligned 3D structure of NiCoO2@CFP plays an important role in the high catalytic activity for OER. These merits combined with the satisfactory stability of the hybrid material indicate that it is a promising material for water oxidation.
    Electrochimica Acta 08/2015; 174. DOI:10.1016/j.electacta.2015.05.159
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    ABSTRACT: Detection of partial discharge and analysis of SF6 gas components in gas-insulated switchgear are important for diagnosis and operating state assessment of power equipment. The gas-sensing properties of the existing TiO2 nanotube (TiO2NT) array-based and the Pt-doped TiO2NT-based sensors were investigated for the components of SF6 decomposition. Four sensors with different amounts of Pt-doped TiO2NTs are prepared using constant current method. The sensing responses of the sensors to the main decomposition gases of SF6 (i.e., SO2, SOF2 and SO2F2) are examined, and the gas-sensing characteristic curves are comparatively analyzed. In addition, the mechanisms of the sensitive responses are discussed. Results show that a higher doping amount of Pt benefits the detection of SO2F2, whereas a lower doping amount is suitable for detecting SO2, which is similar with the capabilities of the intrinsic TiO2NT sensor. Moreover, the working temperature of the Pt-doped TiO2NT sensor is lower than that of the intrinsic TiO2NT sensor.
    IEEE Transactions on Dielectrics and Electrical Insulation 06/2015; 22(3):1559-1566. DOI:10.1109/TDEI.2015.7116351
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    ABSTRACT: Studies indicate that the natural immune-related protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) plays an antitumor role in nasopharyngeal epithelial tissue. However, the detailed mechanism of the tumor-suppressor effect of SPLUNC1 in the inflammatory microenvironment of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) remains elusive. The aim of the present study was to explore how SPLUNC1 reduces the inflammatory response of NPC cells infected with EBV by regulating the Toll-like receptor (TLR)9/NF-κB signaling pathway. As detected by immunohistochemistry and western blotting, SPLUNC1 protein expression exhibited low or negative expression in the NPC epithelial samples/cells, while it demonstrated positive expression in normal nasopharyngeal epithelial tissues/cells; this pattern of expression was the contrary to that of TLR9. The poorly differentiated HNE2 cell line had the highest efficiency of transfer of infection with EBV by 'cell-to-cell' contact method. The group of EBV-infected HNE2 cells showed significantly higher activation of the expression of TLR9/NF-κB signaling pathway-associated factors (TLR9, CD14, MyD88, IKK, P-IKβα, P-NF-κB and NF-κB). The levels of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2 cell group after EBV infection were higher than these levels in the uninfected cell group (P<0.05); Meanwhile, after EBV infection, the expression levels of TLR9/NF-κB pathway associated-protein and inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α in the HNE2/SPLUNC1 cell group were lower than these levels in the HNE2/Vector cell group (P<0.05). After EBV-DNA direct transfection, cytokine mRNA expression levels of TLR9, IL-6, IL-8, IL-1β and TNF-α in the HNE2 cell group were significantly higher than these levels in the NP69 cell group (P<0.05). The expression levels of these cytokines in the HNE2/SPLUNC1 cell group were obviously lower than these levels in the HNE2/Vector cell group (P<0.05). These results suggest that EBV infection of NPC cells can activate the TLR9/NF-κB signaling pathway, promote the release of inflammatory cytokines and consequently enhance the inflammatory response, while SPLUNC1 can weaken the inflammatory response induced by EBV infection in NPC cells through the regulation of the TLR9/NF-κB signaling pathway and control of the tumor inflammatory microenvironment.
    Oncology Reports 04/2015; DOI:10.3892/or.2015.3913
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    ABSTRACT: Dimensionality and rational design of electrode architectures play a crucial role in determining materials' fundamental properties and the electrochemical performance of supercapacitor. For a proof-of-concept, Ni–Co layered double hydroxides (LDH), NiCo2O4 and NiCo2S4 nanosheets supported on carbon fiber paper (CFP) substrate are prepared by simple hydrothermal methods in this work. When tested as the pseudo-capacitor positive electrode, the self-support nanosheets on CFP demonstrate good performance and rate capability as well as excellent cycling life, which contributes to the unique hierarchical nanosheets structure supported on 3D conductive CFP substrate with open permeable channels, facilitating electrolyte penetration and ensuring more efficient ion diffusion and faster electron transport. The asymmetric supercapacitor based on pseudocapacitance of both electrodes is further first realized by using NiCo2S4 nanosheets and FeOOH nanorods as positive and negative materials, respectively. The obtained device can deliver a maximum power density of 8.6 kW kg−1 and energy density of 45.9 Wh kg−1 and even after 10000 reversible cycles at a cell voltage of 1.6 V in aqueous electrolyte, there still retained 86.4% of its initial capacitance.
    Electrochimica Acta 04/2015; 161. DOI:10.1016/j.electacta.2015.02.076
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    ABSTRACT: BRD7 is a bromodomain-containing protein (BCP), and recent evidence implicates the role of BCPs in the initiation and development of neurodevelopmental disorders. However, few studies have investigated the biological functions of BRD7 in the central nervous system. In our study, BRD7 was found to be widely expressed in various regions of the mouse brain, including the medial prefrontal cortex (mPFC), caudate putamen (CPu), hippocampus (Hip), midbrain (Mb), cerebellum (Cb), and mainly co-localized with neuron but not with glia. Using a BRD7 knockout mouse model and a battery of behavioral tests, we report that disruption of BRD7 results in impaired cognitive behavior, leaving the emotional behavior unaffected. Moreover, a series of proteins involved in synaptic plasticity were decreased in the medial prefrontal cortex and there was a concomitant decrease in neuronal spine density and dendritic branching in the medial prefrontal cortex. However no significant difference was found in the hippocampus compared to the wild-type mice. Thus, BRD7 might play a critical role in the regulation of synaptic plasticity and affect cognitive behavior. Copyright © 2015. Published by Elsevier B.V.
    Behavioural Brain Research 02/2015; 286. DOI:10.1016/j.bbr.2015.02.031
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    ABSTRACT: The proto-oncogene c-Myc encodes a transcription factor that is involved in the regulation of cellular proliferation, differentiation, and apoptosis. Several studies indicate that the over-expression of c-Myc is a frequent genetic abnormality in nasopharyngeal carcinoma (NPC). Therefore, specifically reducing its level by genetic means in established NPC cell lines helps to better understand its role in the pathogenesis of NPC. In this study, we, for the first time, successfully established and characterized NPC 5-8F cell lines with stably suppressed c-Myc expression by employing a DNA-based RNA interference approach. The suppression of c-Myc resulted in reduced cell growth, colony formation, and cell cycle progression in 5-8F cells. In vivo tumor formation assays revealed that the knockdown of c-Myc reduced the tumorigenic potential of 5-8F cells in nude mice. At the molecular level, we found that the knockdown of c-Myc could decrease the expression of several critical molecules involved in the Cdk/Rb/E2F pathway, including CDK4, cyclin D1, CDK2, pRb, E2F3, and DP2, and significantly reduce the promoter activity of cyclin D1. Taken together, these findings provide valuable mechanistic insights into the role of c-Myc in nasopharyngeal carcinogenesis and suggest that the knockdown of c-Myc may be a potential therapeutic approach for the treatment of NPC. © The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
    Acta Biochimica et Biophysica Sinica 01/2015; 47(3). DOI:10.1093/abbs/gmu129
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    ABSTRACT: Ni-based bimetallic alloys have superior physiochemical characteristics compared to monometallic Ni. In this study, new type of low cost bimetallic NimCon (n+m=4) electrocatalysts with high active surface were synthesized on Ti substrate through a hydrogen evolution assisted electrodeposition method. The as-prepared NimCon were characterized by XRD, EDS and SEM. It was revealed that the composition, surface morphology as well as the crystal phase structure of the bimetallic NimCon electrocatalysts were significantly changed with the increased content of cobalt. Electrochemical measurements showed that the bimetallic NimCon catalysts, compared with the monometallic Ni, have superior catalytic activity and stability toward the methanol electrooxidation reaction (MOR). Additionally, Ni2Co2 sample presented the highest oxidation current density and the best durability. The mechanism study based on electrochemical experiments and density functional theory based calculations showed that the doping of Co in NimCon can signally improve the surface coverage of the redox species, weaken the CO adsorption, as well as adjust the CH3OH adsorption. Such understanding is of important directive significance to design efficient non-precious catalysts.
    ACS Applied Materials & Interfaces 12/2014; 7(1). DOI:10.1021/am506554b
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    ABSTRACT: Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in nasopharyngeal carcinoma remains unclear. The aims of this study were to investigate the regulatory roles of the TP53 gene in regulating long non-coding RNA expression profiles and to study the function of a TP53-regulated long non-coding RNA (LOC401317) in the nasopharyngeal carcinoma cell line HNE2. Long non-coding RNA expression profiling indicated that 133 long non-coding RNAs were upregulated in the human NPC cell line HNE2 cells following TP53 overexpression, while 1057 were downregulated. Among these aberrantly expressed long non-coding RNAs, LOC401317 was the most significantly upregulated one. Further studies indicated that LOC401317 is directly regulated by p53 and that ectopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. LOC401317 inhibited cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression and promoted apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage. Collectively, these results suggest that LOC401317 is directly regulated by p53 and exerts antitumor effects in HNE2 nasopharyngeal carcinoma cells.
    PLoS ONE 11/2014; 9(11):e110674. DOI:10.1371/journal.pone.0110674
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    ABSTRACT: Our previous study demonstrated that the NGX6b gene acts as a suppressor in the invasion and migration of nasopharyngeal carcinoma (NPC). Recently we identified the novel isoform NGX6a which is longer than NGX6b. In this study, we firstly found that NGX6a was degraded in NPC cells and that this degradation was mediated by ezrin, a linker between membrane proteins and the cytoskeleton. Specific siRNAs against ezrin increase the protein level of NGX6a in these cells. During degradation, NGX6a is not ubiquitinated but is degraded through a proteasome-dependent pathway. The distribution pattern of ezrin was negatively associated with NGX6a in an immunochemistry (IHC) analysis of a nasopharyngeal carcinoma tissue microarray (TMA) and fetus multiple organ tissues and western blot analysis in nasopharyngeal (NP) and NPC cell lines, suggesting that ezrin and NGX6a are associated and are involved in the progression and invasion of NPC. By mapping the interacting binding sites, the seven-trans-membrane domain of NGX6a was found to be the critical region for the degradation of NGX6a, and the amino-terminus of ezrin is required for the induction of NGX6a degradation. The knockdown of ezrin or transfection of the NGX6a mutant CO, which has an EGF-like domain and a trans-membrane 1 domain, resulted in no degradation, significantly reducing the ability of invasion and migration of NPC cells. This study provides a novel molecular mechanism for the low expression of NGX6a in NPC cells and an important molecular event in the process of invasion and metastasis of nasopharyngeal carcinoma cells.
    Journal of Biological Chemistry 11/2014; 289(52). DOI:10.1074/jbc.M114.584771
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    ABSTRACT: a b s t r a c t Depression is a common psychiatric disorder associated with chronic stress. Insulin-like growth factor 2 (IGF2) is a growth factor that serves important roles in the brain during development and at adulthood. Here, the role of IGF2 expression in the hippocampus was investigated in a rat model of depression. A chronic restraint stress (CRS) model of depression was established in rats, exhibiting depression-like behavior as assessed with the sucrose preference test (SPT) and forced swimming test (FST), and with evaluation of the corticosterone levels. Hippocampal IGF2 levels were significantly lower in rats suffering CRS than in controls, as were levels of pERK1/2 and GluR1. Lentivirus-mediated hippocampal IGF2 overexpression alleviated depressive behavior in restrained rats, elevated the levels of pERK1/2 and GluR1 proteins, but it did not affect the expression of pGSK3b, GluR2, NMDAR1, and NMDAR2A. These results suggest the chronic restraint stress induces depressive behavior, which may be mediated by ERK-dependent IGF2 signaling, pointing to an antidepressant role for this molecular pathway.
    Neuropharmacology 10/2014; 89. DOI:10.1016/j.neuropharm.2014.10.011
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    ABSTRACT: A density functional theory (DFT) based method in conjunction with the projector augmented wave and pseudopotential methods have been applied to investigate the adsorption of Pt-4 and Pt3Ni on the anatase TiO2 (1 0 1) surface. Two stable Pt3Ni adsorptions with considerable adsorption energies on the anatase TiO2 (1 0 1) surface were identified. Analysis of the partial density (PDOS) of states and Bader charge suggest that the electronic structure of Pt is modified by Ni due to the electron transfer from Ni to Pt atoms in the Pt3Ni clusters. The 2cO (3cO)-PtNi-5cTi conformation of the adsorbed Pt3Ni on the anatase TiO2 (1 0 1) surface provides a more feasible model for electron injection through the Pt3Ni/TiO2 interface. The reactivity of Pt3Ni/TiO2 is superior to Pt-4/TiO2 and effectively manifests itself in the eased decomposition of O-H bonds derived by methanol and alleviative CO adsorption.
    Applied Surface Science 10/2014; 315:81–89. DOI:10.1016/j.apsusc.2014.06.198
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    ABSTRACT: Human SPLUNC1 can suppress NPC tumor formation, however, the correlation between SPLUNC1expression and NPC patient prognosis has not been reported. In this study, we used a large-scale sample of 1,015 tissue cores to detect SPLUNC1 expression and its association with patient prognosis. SPLUNC1 expression was reduced in NPC samples compared to non-tumor nasopharyngeal epithelial (NPE) tissues. Positive expression of SPLUNC1 in NPC predicted a better prognosis (Disease Free Survival (DFS): P=0.034, Overall Survival (OS): P=0.048). Cox's Proportional Hazards Model revealed that SPLUNC1 could be a significant prognostic factor affecting DFS (P=0.027). A cDNA microarray analyzed by SAM and IPA revealed that an indirect interaction existed between SPLUNC1 and retinoic acid (RA) in the cancer regulatory network. To further investigate the molecular mechanisms involved, we utilized several bioinformatics tools and identified 12 retinoid X receptors (RXRs) heterodimer binding sites in the promoter region of the SPLUNC1 gene. The transcriptional activity of the SPLUNC1 promoter was up-regulated significantly by all-trans-retinoic acid (ATRA). SPLUNC1 and RA receptor expression were induced significantly by ATRA, and removal of ATRA led to a progressive loss of SPLUNC1 and RA receptor expression. ATRA inhibited proliferation and induced the differentiation of NPC cells. Interestingly, over-expression of SPLUNC1 sensitized NPC cells to ATRA, whereas knockdown of SPLUNC1 in HNE1 cells increased cell viability. Under SPLUNC1 knockdown conditions, differentiation was reversed with ATRA treatment. We concluded that SPLUNC1 could potentially predict prognosis for NPC patients and play an important role in ATRA-induced growth inhibition and differentiation in NPC cells.This article is protected by copyright. All rights reserved.
    FEBS Journal 08/2014; 281(21). DOI:10.1111/febs.13020
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    ABSTRACT: Nonresolving inflammatory processes affect all stages of carcinogenesis. Lactoferrin, a member of the transferrin family, is involved in the innate immune response and anti-inflammatory, anti-microbial, and anti-tumor activities. We previously found that lactoferrin is significantly down-regulated in specimens of nasopharyngeal carcinoma (NPC) and negatively associated with tumor progression, metastasis, and prognosis of patients with NPC. Additionally, lactoferrin expression levels are decreased in colorectal cancer as compared with normal tissue. Lactoferrin levels are also increased in the various phases of inflammation and dysplasia in an azoxymethane-dextran sulfate sodium (AOM-DSS) model of colitis-associated colon cancer (CAC). We thus hypothesized that the anti-inflammatory function of lactoferrin may contribute to its anti-tumor activity. Here we generated a new Lactoferrin knockout mouse model in which the mice are fertile, develop normally, and display no gross morphological abnormalities. We then challenged these mice with chemically induced intestinal inflammation to investigate the role of lactoferrin in inflammation and cancer development. Lactoferrin knockout mice demonstrated a great susceptibility to inflammation-induced colorectal dysplasia, and this characteristic may be related to inhibition of NF-κB and AKT/mTOR signaling as well as regulation of cell apoptosis and proliferation. Our results suggest that the protective roles of lactoferrin in colorectal mucosal immunity and inflammation-related malignant transformation, along with a deficiency in certain components of the innate immune system, may lead to serious consequences under conditions of inflammatory insult.
    PLoS ONE 07/2014; 9(7):e103298. DOI:10.1371/journal.pone.0103298
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    ABSTRACT: Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. To identify novel biomarkers for the early detection of NPC patients, 2D-DIGE combined with MALDI-TOF-MS analysis was performed to identify differentially expressed proteins in the carcinogenesis and progression of NPC using LCM-purified normal nasopharyngeal epithelial tissues and various stages of NPC biopsies. As a result, 26 differentially expressed proteins were identified, of which two proteins with sharp expressional changes in the carcinogenic process, ENO1 and CYPA, were validated by western blot analysis and identified as critical seed proteins in the functional network. Immunohistochemistry assay was further performed to detect the expression of the two proteins with a tissue microarray that included various stages of NPC tissues. The ability of these proteins to detect NPC early was evaluated via a receiver operating characteristic analysis. The results indicated that the combination of the two proteins could perfectly discriminate NNET and AH from stage I of NPC with high sensitivity and specificity, which is more effective than using either of the two proteins individually. In summary, the combination of ENO1 and CYPA can serve as potential molecular markers for the early detection of NPC.
    Journal of Proteomics 07/2014; 109. DOI:10.1016/j.jprot.2014.06.025
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    ABSTRACT: An electrochemical study involving the pulse electrodeposition of platinum onto p-type silicon nanowires array in non-fluoride solution for photo enhanced electrochemical hydrogen generation is presented. Pt was deposited onto the surface of silicon nanowires array (light trapping layer) as a photocatalyst with a radial multi-layers nanocluster structure, of which the photocurrent density of hydrogen generated was increased by about 300% compared to the bare silicon nanowires array under simulated solar radiance, while the value of onset potential also positively shifted to 0.40 V. Furthermore, the impedance of Pt/silicon nanowires array was smaller than that of bare silicon nanowires array as indicated by EIS analysis. We tentatively ascribed the mechanism of enhancement to the effect of the Schottky junction at the Pt/silicon nanowires array interface.
    Journal of The Electrochemical Society 05/2014; 161(9):H458-H463. DOI:10.1149/2.0361409jes
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    ABSTRACT: In this paper we synthesize well aligned Ni–Co sulfide nanowire arrays (NWAs) with a Ni–Co molar ratio of 1:1 on 3D nickel foam by a facile two-step hydrothermal method. Owing to the low electronegativity of sulfur, Ni–Co sulfide NWAs exhibit a more flexible structure and much higher conductivity compared with Ni–Co oxide NWAs when used as active materials in supercapacitors. The electrochemistry tests show that these self-supported electrodes are able to deliver ultrahigh specific capacitance (2415 F g−1 and 1176 F g−1 at a current density of 2.5 mA cm−2 and 30 mA cm−2, respectively), together with a considerable areal capacitance (6.0 F cm−2 and 2.94 F cm−2 at a current density of 2.5 mA cm−2 and 30 mA cm−2, respectively), and good rate capability. More importantly, the asymmetric supercapacitor, composed of Ni–Co sulfide NWAs as the positive electrode and activated carbon as the negative electrode, reaches up to an energy density of 25 W h kg−1 and a power density of 3.57 kW kg−1 under a cell voltage of 1.8 V. Furthermore, the two assembled supercapacitors in series can power a 3 mm diameter red (2.0 V, 20 mA) round light-emitting diode (LED) indicator for more than 30 minutes after charging separately for a total time of 6 min. The superior electrochemistry capacity demonstrates that the self-standing Ni–Co sulfide nanowire arrays are promising for high-performance supercapacitor applications.
    04/2014; 2(18). DOI:10.1039/C3TA15373H
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    ABSTRACT: Inflammation has been recognized as a hallmark of cancer. Substantial evidence supports the finding that microRNAs not only play important roles in tumor initiation but also participate in the invasion and metastasis of numerous inflammation-related cancers. Investigation of the interrelation between miRNAs and inflammation-related cancers may provide novel preventive, diagnostic, and therapeutic strategies for cancers. Inflammation plays a critical role in carcinogenesis, and an inflammatory microenvironment is considered an essential component of almost all solid tumors. Metastasis is a critical aspect of carcinogenesis, since most cancer mortality is associated with metastatic tumors rather than the primary tumor. An increasing number of pro- and anti-metastatic miRNAs have been reported to regulate the metastasis of many inflammation-related cancers. Single-nucleotide polymorphisms (SNPs) are the most common variations in DNA sequences. These miRNA-related SNPs play a substantial role in much inflammation related cancer development, including hepatocellular carcinoma (HCC), lung cancer, and colorectal cancer.
    Cancer and Inflammation Mechanisms, 04/2014: pages 131-148; , ISBN: 9781118160305
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    ABSTRACT: Density functional theory based calculations have been employed to investigate structures and properties of coupled tetragonal pyramid (CTP) Pt7 based Pt(7-x)Nix (x=1, 2, 3) bimetallic clusters, and the reaction mechanism of methanol dehydrogenation to CO on Pt7 and PtNi bimetallic clusters. The models chosen to catalyze the methanol are Pt7 (CTP, quintet) cluster and Pt5Ni2 (I) cluster (two Pt atoms in the bottom of Pt7 (CTP) are replaced by Ni atoms) which is the most stable structure among all the isomers of Pt(7-x)Nix (x=1, 2, 3). The methanol dehydrogenation on Pt7 (CTP) cluster preferentially proceeds along the pathway of CH3OH→ CH2OH→CH2O→CHO→CO, while on Pt5Ni2 (І) the pathway of CH3OH→CH3O→CH2O→ CHO→CO is more favorable. In addition, the complete dehydrogenation product of methanol, CO, can more easily dissociate from Pt5Ni2 (I) than that on Pt7. Electronic configuration analysis shows that charge transfer from Ni to Pt and results in increase of the electron density in Pt 5d orbitals. Moreover, the density of states (DOS) at Fermi level of clusters reduces gradually as the increase of the doped Ni atoms and this improves the catalytic activity for methanol decomposition.
    Computational and Theoretical Chemistry 03/2014; 1032. DOI:10.1016/j.comptc.2014.01.006
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    ABSTRACT: We report the synthesis of mesoporous alumina by a template method and its applications as a new solid phase extraction adsorbent with abamectin and ivermectin as the target analytes by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Chromatographic separation was conducted on a C18 column using a gradient mobile phase consisting of methanol (solvent A) and 0.2% formic acid in a 5 mmol L−1 ammonium acetate buffer (solvent B) at a flow rate of 0.3 mL min−1. The linearity of the calibration curves was excellent and yielded correlation coefficients (r2 = 0.9990-0.9999) in a range of 0.02-0.50 mg L−1. Samples were spiked with known quantities of the analytes at three different concentration levels (0.05, 0.10 and 0.20 mg L−1), and the recoveries were in the range of 87.3-104.5% with the relative standard deviation (RSD) values ranging between 0.53% and 5.8%. The limits of detections and limits of quantization were 0.16 ng g−1 and 0.53 ng g−1, respectively. These results indicated that mesoporous alumina has enormous potential as a novel solid phase extraction adsorbent material in the food security field.
    Analytical methods 01/2014; 6(13):4734. DOI:10.1039/c4ay00107a
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    Acta Biochimica et Biophysica Sinica 12/2013; 46(2). DOI:10.1093/abbs/gmt131

Publication Stats

1k Citations
285.99 Total Impact Points

Institutions

  • 2011–2015
    • Chongqing University
      • Department of Chemical Engineering
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2003–2015
    • Cancer Research Institute
      New York, New York, United States
  • 2014
    • The Third Xiangya Hospital of the Central South University
      Ch’ang-sha-shih, Hunan, China
  • 2002–2014
    • Central South University
      • Cancer Research Institute
      Ch’ang-sha-shih, Hunan, China
  • 2011–2012
    • Beijing Institute Of Technology
      • School of Chemistry
      Peping, Beijing, China
  • 2010–2011
    • University of South Alabama
      • Department of Cell Biology and Neuroscience
      Mobile, Alabama, United States
  • 2002–2004
    • Xiangya Hospital of Central South University
      Ch’ang-sha-shih, Hunan, China
  • 1999–2001
    • Changsha Medical University
      Ch’ang-sha-shih, Hunan, China