-
J Kröger,
P Ferrari,
M Jenab,
C Bamia,
M Touvier,
H B Bueno-de-Mesquita,
M T Fahey,
V Benetou, M Schulz,
E Wirfält, [......],
Y T van der Schouw,
A Mattiello,
M Bellegotti,
D Engeset,
A Hjartåker,
R Egeberg,
K Overvad,
E Riboli,
S Bingham,
N Slimani
[show abstract]
[hide abstract]
ABSTRACT: To identify combinations of food groups that explain as much variation in absolute intakes of 23 key nutrients and food components as possible within the country-specific populations of the European Prospective Investigation into Cancer and Nutrition (EPIC).
The analysis covered single 24-h dietary recalls (24-HDR) from 36,034 subjects (13,025 men and 23,009 women), aged 35-74 years, from all 10 countries participating in the EPIC study. In a set of 39 food groups, reduced rank regression (RRR) was used to identify those combinations (RRR factors) that explain the largest proportion of variation in intake of 23 key nutrients and food components, namely, proteins, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, cholesterol, sugars (sum of mono- and disaccharides), starch, fibre, alcohol, calcium, iron, potassium, phosphorus, magnesium, vitamin D, beta-carotene, retinol and vitamins E, B1, B2, B6, B12 and C (RRR responses). Analyses were performed at the country level and for all countries combined.
In the country-specific analyses, the first RRR factor explained a considerable proportion of the total nutrient intake variation in all 10 countries (27.4-37.1%). The subsequent RRR factors were much less important in explaining the variation (<or=6%). Strong similarities were observed for the first country-specific RRR factor between the individual countries, largely characterized by consumption of bread, vegetable oils, red meat, milk, cheese, potatoes, margarine and processed meat. The highest explained variation was seen for protein, potassium, phosphorus and magnesium (50-70%), whereas sugars, beta-carotene, retinol and alcohol were only marginally explained (<or=5%). The explained proportion of the other nutrients ranged between these extremes.
A combination of food groups was identified that explained a considerable proportion of the nutrient intake variation in 24-HDRs in every country-specific EPIC population in a similar manner. This indicates that, despite the large variability in food and nutrient intakes reported in the EPIC, the variance of intake of important nutrients is explained, to a large extent, by similar food group combinations across countries.
European journal of clinical nutrition 11/2009; 63 Suppl 4:S263-74. · 3.07 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The term 'beer belly' expresses the common belief that beer consumption is a major determinant of waist circumference (WC). We studied the gender-specific associations between beer consumption and WC (partially in relation to body weight and hip circumference (HC) change).
Within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study (7876 men, 12 749 women), cross-sectional associations were investigated applying general linear models. Prospective analyses of baseline beer consumption and an 8.5-year WC change were assessed using multivariate general linear models and polytomous logistic regression. To test the site-specific effect of beer consumption on WC, an adjustment for concurrent changes in body weight and HC was carried out. In addition, the relationship between change in beer consumption and change in WC was studied.
A positive association in men and no association in women were seen between beer consumption and WC at baseline. Men consuming 1000 ml/d beer were at 17% higher risk for WC gain compared with very light consumers. Significantly lower odds for WC gain (odds ratio=0.88; 95% confidence interval 0.81, 0.96) were found in beer-abstaining women than in very-light-drinking women. The adjustment for concurrent body weight and HC change diminished effect estimates notably, explaining most of the association between beer and change in WC. Decreasing beer consumption was related to higher relative odds for WC loss, although not statistically significant.
Beer consumption leads to WC gain, which is closely related to concurrent overall weight gain. This study does not support the common belief of a site-specific effect of beer on the abdomen, the beer belly.
European journal of clinical nutrition 07/2009; 63(9):1143-9. · 3.07 Impact Factor
-
02/2008: pages 51 - 84; , ISBN: 9783527616725
-
S Rinaldi,
P H M Peeters,
I D Bezemer,
L Dossus,
C Biessy,
C Sacerdote,
F Berrino,
S Panico,
D Palli,
R Tumino, [......],
M Koliva,
G Kyriazi,
A Thrichopoulou,
M C Boutron-Ruault,
F Clavel-Chapelon,
P Ferrari,
N Slimani,
R Saracci,
E Riboli,
R Kaaks
[show abstract]
[hide abstract]
ABSTRACT: Women with a moderate intake of alcohol have higher concentrations of sex steroids in serum, and higher risk of developing breast cancer, compared to non-drinkers. In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC).
Serum levels of testosterone (T), androstenedione (Delta4), dehydroepiandrosterone sulphate (DHEAS), estrone (E1), estradiol (E2) and SHBG were measured by direct immunoassays. Free T (fT) and free E2 (fE2) were calculated according to mass action laws. Current alcohol intake exposure to alcohol was assessed from dietary questionnaires.
Pre-menopausal women who consumed more than 25 g/day of alcohol had about 30% higher DHEAS, T and fT, 20% higher Delta4 and about 40% higher E1, concentrations compared to women who were non-consumers. E2, fE2 and SHBG concentrations showed no association with current alcohol intake. In post-menopausal women, DHEAS, fT, T, Delta4, and E1 concentrations were between 10% and 20% higher in women who consumed more than 25 g/day of alcohol compared to non-consumers. E2 or fE2 were not associated with alcohol intake at all. SHBG levels were about 15% lower in alcohol consumers compared to non-consumers.
This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood.
Cancer Causes and Control 11/2006; 17(8):1033-43. · 2.88 Impact Factor
-
M Jenab,
E Riboli,
P Ferrari,
M Friesen,
J Sabate,
T Norat,
N Slimani,
A Tjønneland,
A Olsen,
K Overvad, [......],
S Bingham,
K-T Khaw,
N Allen,
T Key,
F Carneiro,
V Save,
G Del Giudice,
M Plebani,
R Kaaks,
C A Gonzalez
[show abstract]
[hide abstract]
ABSTRACT: Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC.
British Journal of Cancer 09/2006; 95(3):406-15. · 5.04 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A singlemode stationary acoustoelectric domain is obtained in GaAs under round-trip gain conditions when a large acoustic wave is externally excited in the specimen. From the power ratio of the discrete mode and the same mode in the multimode domain the number of modes in the multimode domain is determined to be of the order 105. A comparison with a local theory of nonlinear amplification shows good agreement with the measured harmonic content in the wave.Durch externe Anregung einer monochromatischen Schallwelle in GaAs wird bei Round-Trip-Schallverstärkung eine stationäre akustoelektrische Domäne erzeugt, die nur eine einzige Schallmode enthält. Das Verhältnis der Oszillationsamplitude der diskreten Schall-mode zur entsprechenden Amplitude in der Multimoden-Domäne bestimmt die Größenordnung der Modenzahl in der Multimoden-Domäne zu 105. Der Vergleich mit einer lokalen Theorie der nichtlinearen Schallverstärkung zeigt Übereinstimmung mit dem gemessenen Oberwellenanteil in der Einmoden-Domäne.
physica status solidi (a) 04/2006; 3(3):721 - 727. · 1.21 Impact Factor
-
P H Lahmann, M Schulz,
K Hoffmann,
H Boeing,
A Tjønneland,
A Olsen,
K Overvad,
T J Key,
N E Allen,
K-T Khaw,
S Bingham,
G Berglund,
E Wirfält,
F Berrino,
V Krogh,
A Trichopoulou,
P Lagiou,
D Trichopoulos,
R Kaaks,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: We examined prospectively the association between weight change during adulthood and breast cancer risk, using data on 1358 incident cases that developed during 5.8 years of follow-up among 40,429 premenopausal and 57,923 postmenopausal women from six European countries, taking part in the European prospective investigation into cancer and nutrition study. Multivariate Cox regression models were used to calculate hazard ratios according to weight change (kg), defined as the weight difference between age at enrollment and age 20 adjusted for other risk factors. Changes in weight were not associated with premenopausal breast cancer risk. In postmenopausal women, weight gain was positively associated with breast cancer risk only among noncurrent hormone replacement therapy (HRT) users (P-trend < or = 0.0002). Compared to women with a stable weight (+/-2 kg), the relative risk for women who gained 15-20 kg was 1.50 (95% confidence interval (CI) 1.06-2.13). The pooled RR per weight gain increment of 5 kg was 1.08 (95% CI 1.04-1.12). Weight gain was not associated with breast cancer risk in current HRT users, although, overall, these women experienced a much higher risk of breast cancer compared with nonusers. Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones.
British Journal of Cancer 10/2005; 93(5):582-9. · 5.04 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Monthly (April to November) hydroacoustic surveys and parallel gillnet catches were used to determine vendace Coregonus albula abundance, biomass and population dynamics in a deep oligotrophic lake. By hydroacoustic surveys, recruitment of 0+ year vendace could clearly be detected. In contrast, gillnet catches resulted in low numbers of 0+ year fish, and similarly under-represented proportions of the oldest vendace. Consequently, the correlation between hydroacoustics and gillnets with respect to fish numbers and geometric mean fish total length was high only for the age groups 1 + to 4+ years. Annual variability in hydroacoustic estimates offish abundance and biomass was high (CV=26–29%) which reflects the seasonal population dynamics of vendace.
Journal of Fish Biology 04/2005; 61(5):1109 - 1121. · 1.68 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The aim of this study was to examine the relationships of short-term weight gain, weight loss, and weight cycling on the odds of developing hypertension. Normotensive middle-aged German men and women (n=12,362) of the European Prospective Investigation into Cancer and Nutrition-Potsdam Study were assigned to categories of 2-year short-term weight changes that were self-reported to have occurred prior to recruitment into the study (gain only, loss only, weight cycling, stable). After 2 years of follow-up after recruitment, 180 cases of incident essential hypertension were identified. In logistic regression models, odds ratios were estimated for the associations between short-term weight changes and risk of developing hypertension. Obesity status (BMI>or=30 or BMI<30 kg/m2) modified the associations between short-term weight change and incidence of diagnosed hypertension. Among obese individuals, short-term weight gain occurring during the 2 years prior to recruitment (OR=2.79, 95% CI 1.19-6.56), weight loss (OR=6.74, 95% CI 2.58-17.6) and weight cycling (OR=4.29, 95% CI 1.55-11.9) were strongly positively associated with incident hypertension, adjusted for age and gender, compared to obese individuals with short-term stable weight. No significant associations between short-term weight changes and risk of diagnosed hypertension were detected among non-obese individuals. Short-term weight changes appeared to present strong risk factors for developing hypertension among obese individuals. The effect seen for weight cycling supports the hypothesis that weight cycling increases the risk of hypertension. The finding for short-term weight loss may be explained by subsequent weight regain and needs further investigation.
Journal of Human Hypertension 02/2005; 19(1):61-7. · 2.80 Impact Factor
-
A Hjartåker,
A Lagiou,
N Slimani,
E Lund,
M D Chirlaque,
E Vasilopoulou,
X Zavitsanos,
F Berrino,
C Sacerdote,
M C Ocké, [......],
S Nilsson,
A McTaggart,
E A Spencer,
K Overvad,
A Tjønneland,
F Clavel-Chapelon,
J Linseisen, M Schulz,
B Hemon,
E Riboli
[show abstract]
[hide abstract]
ABSTRACT: To describe and compare the consumption of dairy products in cohorts included in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Data from single 24-hour dietary recall interviews collected through a highly standardised computer-based program (EPIC-SOFT) in 27 redefined centres in 10 European countries between 1995 and 2000. From a total random sample of 36 900, 22 924 women and 13 031 men were selected after exclusion of subjects under 35 and over 74 years of age.
A high total consumption of dairy products was reported in most of the centres in Spain and in the UK cohort sampled from the general population, as well as in the Dutch, Swedish and Danish centres. A somewhat low consumption was reported in the Greek centre and in some of the Italian centres (Ragusa and Turin). In all centres and for both sexes, milk constituted the dairy sub-group with the largest proportion (in grams) of total dairy consumption, followed by yoghurt and other fermented milk products, and cheese. Still, there was a wide range in the contributions of the different dairy sub-groups between centres. The Spanish and Nordic centres generally reported a high consumption of milk, the Swedish and Dutch centres reported a high consumption of yoghurt and other fermented milk products, whereas the highest consumption of cheese was reported in the French centres.
The results demonstrate both quantitative and qualitative disparities in dairy product consumption among the EPIC centres. This offers a sound starting point for analyses of associations between dairy intake and chronic diseases such as cancer.
Public Health Nutrition 01/2003; 5(6B):1259-71. · 2.17 Impact Factor
-
J Linseisen,
E Bergström,
L Gafá,
C A González,
A Thiébaut,
A Trichopoulou,
R Tumino,
C Navarro Sánchez,
C Martínez Garcia,
I Mattisson, [......],
K Botsi,
A Naska,
S Sieri,
C Sacerdote,
M C Ocké,
P H M Peeters,
G Skeie,
D Engeset,
U R Charrondière,
N Slimani
[show abstract]
[hide abstract]
ABSTRACT: To evaluate the consumption of added fats and oils across the European centres and countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).
24-Hour dietary recalls were collected by means of standardised computer-guided interviews in 27 redefined EPIC centres across 10 European countries.
From an initial number of 36 900 subjects, single dietary recalls from 22 924 women and 13 031 men in the age range of 35-74 years were included.
Mean daily intake of added fats and oils varied between 16.2 g (Varese, Italy) and 41.1 g (Malmö, Sweden) in women and between 24.7 g (Ragusa, Italy) and 66.0 g (Potsdam, Germany) in men. Total mean lipid intake by consumption of added fats and oils, including those used for sauce preparation, ranged between 18.3 (Norway) and 37.2 g day-1 (Greece) in women and 28.4 (Heidelberg, Germany) and 51.2 g day-1 (Greece) in men. The Mediterranean EPIC centres with high olive oil consumption combined with low animal fat intake contrasted with the central and northern European centres where fewer vegetable oils, more animal fats and a high proportion of margarine were consumed. The consumption of added fats and oils of animal origin was highest in the German EPIC centres, followed by the French. The contribution of added fats and oils to total energy intake ranged from 8% in Norway to 22% in Greece.
The results demonstrate a high variation in dietary intake of added fats and oils in EPIC, providing a good opportunity to elucidate the role of dietary fats in cancer aetiology.
Public Health Nutrition 01/2003; 5(6B):1227-42. · 2.17 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: To evaluate the influence of recent weight changes (weight gain, loss and cycling) on subsequent weight changes.
Prospective cohort study with 2 y of follow-up. Data analysis with a polytomous logistic regression model.
A total of 18 001 non-smoking subjects, 6689 men and 11 312 women, from the general population.
Body height and weight measurements and interview data on lifestyle habits and medical history at baseline. For follow-up, self-administered questionnaires for assessment of body weight and incident diseases.
Recent changes in body weight, that is weight gain, weight loss and weight cycling, were significant predictors of subsequent weight changes in both men and women after controlling for age, baseline BMI and several lifestyle and behavioural characteristics as potential confounding factors. Weight cycling before baseline was the strongest predictor of subsequent large weight gain (> or =2 kg) with an odds ratio (OR) of 4.84 (95% confidence interval (CI) 3.34-7.02) in men. In women, prior weight loss was the strongest predictor of subsequent large weight gain (OR 4.77; 95% CI 3.63-6.03), followed by weight cycling (OR 3.02; 95% CI 2.15-4.25).
These data indicate the need for thorough weight history assessment to identify those who are most likely to gain weight. Effective weight control before the development of obesity or after intentional weight loss due to obesity should be a primary goal in the management of obesity.
International Journal of Obesity 03/2002; 26(3):403-9. · 4.69 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Gynaecologic surgeries and hormone medication increasingly interfere with the concept of determining menopausal status based on self-reported data about the last menstrual period-an approach frequently applied in epidemiological studies. This analysis compared different approaches of menopausal status determination, including a probabilistic approach that was developed to reduce misclassification of menopausal status.
Interview and questionnaire data relating to hormone status from about 16,000 German women were used to determine menopausal status using different approaches: menses based, age based, self-assessment based, and a probabilistic approach.
Applying strict menses-based criteria, 29.1% of the women were found to be with undetermined menopausal status. The probabilistic approach was applied to determine menopausal status and age at menopause for these women. The proposed approach uses the current age of the women with undetermined menopausal status, and the relative age-dependent frequencies of pre- or postmenopausal status among those with natural menopausal status to calculate weighting factors, which represent the probabilities of being pre- and postmenopausal of each woman previously undetermined. Correspondingly, the missing age at menopause was estimated with the same probabilistic approach. Applying various approaches to determine menopausal status, the ratio of pre- to postmenopausal women differed considerably, ranging from 1.03 to 1.61. In addition, considerable differences were observed with respect to the number of missing values for both menopausal status and age at menopause.
The probabilistic approach allowed to estimate menopausal status and age at menopause with the advantage that all available information from the entire study population and from the individual is used.
Maturitas 11/2001; 40(1):39-46. · 2.77 Impact Factor
-
C M Friedenreich,
A. Cust,
P.H. Lahmann,
K. Steindorf,
M.C. Boutron-Ruault,
F. Clavel-Chapelon,
S Mesrine,
J. Linseisen,
S. Rohrmann,
T. Pischon, [......],
P Vineis,
H.B. Bueno-de-Mesquita,
P.H.M. Peeters,
E.M. Monninkhof,
G Berglund,
J. Manjer,
N. Slimani,
P Ferrari,
R. Kaaks,
E Riboli
-
P.H.M. Peeters,
A Lukanova,
N Allen,
F Berrino,
T.J. Key,
L. Dossus,
S Rinaldi,
C.H. van Gils,
H.B. Bueno-de-Mesquita,
H Boeing, [......],
F Clavel,
A. Tjonneland,
A. Olsen,
K. Overvad,
M. Tetsche,
E Lund,
E Lundin,
G Berglund,
E Riboli,
R. Kaaks
-
A. Cust,
N.E. Allen,
S Rinaldi,
L. Dossus,
C M Friedenreich,
A. Olsen,
A. Tjonneland,
K. Overvad,
F. Clavel-Chapelon,
M.C. Boutron-Ruault, [......],
E. Ardanaz,
H.B. Bueno-de-Mesquita,
P.H.M. Peeters,
C.H. van Gils,
S Bingham,
K T Khaw,
T.J. Key,
N. Slimani,
E Riboli,
R. Kaaks
-
M. Al-Zoughool,
L. Dossus,
R. Kaaks,
F. Clavel-Chapelon,
A. Tjonneland,
A. Olsen,
K. Overvad,
M.C. Boutron-Ruault,
E. Gaulthier,
J. Linseisen, [......],
E Lundin,
G Hallmans,
K T Khaw,
S Bingham,
N Allen,
T.J. Key,
M. Jenab,
A. Cust,
S Rinaldi,
E Riboli
-
S Rinaldi,
L. Dossus,
A Lukanova,
P.H.M. Peeters,
N.E. Allen,
T.J. Key,
S Bingham,
K T Khaw,
D Trichopoulos,
A Trichopoulou, [......],
E Lundin,
A. Agren,
G Berglund,
J. Manjer,
M. Kumle,
E Lund,
N. Slimani,
R Saracci,
E Riboli,
R. Kaaks
-
P.H. Lahmann,
C M Friedenreich, M Schulz,
A. Cust,
A Lukanova,
R. Kaaks,
A. Tjonneland,
N.F. Johnsen,
K. Overvad,
A Fournier, [......],
E.M. Monninkhof,
P.H.M. Peeters,
H.B. Bueno-de-Mesquita,
A.M. May,
N Allen,
K T Khaw,
S Bingham,
S Rinaldi,
P Ferrari,
E Riboli
-
N Allen,
T Key,
Dossus. L,
S Rinaldi,
A. Cust,
A Lukanova,
P Peeters,
N Onland-Moret,
Petra Lahmann,
F Berrino, [......],
M.C. Boutron-Ruault,
S Bingham,
K T Khaw,
H.B. Bueno-de-Mesquita,
A Trichopoulou,
D Trichopoulos,
A Naska,
R. Tumino,
E Riboli,
R. Kaaks
