M M Petrova

Krasnoyarsk State Medical University, Красноярск, Krasnoyarskiy, Russia

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Publications (18)4.18 Total impact

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    ABSTRACT: The review concerns the novel approaches to Alzheimer’s disease pathogenesis represented in modern scientific literature, and aims at studying new possible targets for targeted pharmacotherapy of different stages of neurodegeneration. The multi-factorial disease results in disability and the loss of memory and cognitive functions causing life quality deterioration and the loss of legal capacity. The situation seems to be critical due to the fact that the majority of approved pharmaceuticals have just a symptomatic action rather than an adequate effect. For this reason there is the search for new target molecules for pharmacological intervention. Moreover, novel pharmaceuticals with more selective effect are being developed now. Modern concepts of Alzheimer’s disease pathogenesis are based on the recognized significance of the following pathological processes: neuronal damage and death, impaired neurogenesis and cell-to-cell interactions, neuroinflammation and vasculopathy development, while the accumulation of damaged proteins can be both a trigger mechanism, and also the result of the mentioned events. Based on the above stated ideas, there being developed the pharmacological approaches aimed at preventing pathologically damaged proteins from accumulating in brain, arresting aberrant neurotransmission, the correction of neuroinflammation and impaired neurogenesis, as well as the recovery of cell-to-cell interactions. The use of adequate animal models of Alzheimer’s disease is one of promising approaches to the development of novel pharmacotherapeutical strategies. © 2015, Nizhny Novgorod State Medical Academy. All rights reserved.
    Sovremennye Tehnologii v Medicine 09/2015; 7(3):138-148. DOI:10.17691/stm2015.7.3.19
  • N.Yu. Shimohina Shimohina · A.A. Savchenko · M.M. Petrova Petrova · M.S. Chernyaeva ·
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    ABSTRACT: Anxiety-depressive disorders (ADD) have a negative impact on the course and prognosis of patients with ischemic heart disease, but the mechanisms of their correlation are not studied enough. The purpose of this study was to elucidate special characteristics of hemostasis and immune system in patients with acute coronary syndrome (ACS) combined with ADD. We included into the study 60 patients during first 24 hours of ACS. ADD was identified in 27 patients (45%). Parameters of plasma and vascular-platelet hemostasis and phenotype of lymphocytes were determined in samples of blood taken during first 24 hours and on day 10 of hospitalization. We found that patients with ACS combined with ADD had procoagulant state of hemostasis, increased platelet aggregation, decreased content of lymphocytes and augmented immunoregulatory induction of inflammatory processes.
    Kardiologiia 08/2015; 55(8):12-20. DOI:10.18565/cardio.2015.8.12-20 · 0.12 Impact Factor

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    ABSTRACT: We undertook the analysis of cardiovascular risk factors and psycho-social factors in 230 patients with coronary heart disease (CHD) based at a city polyclinic. Ninety (31.1%) patients suffered depression (19-28 CES-D scores). Patients with and without depression were significantly different in terms of clinical and functional manifestations of stable angina of effort, cardiovascular risk factors, gender; and psycho-social factors. CHD with depression was associated with a higher FC of angina of effort, risk of adverse outcome (Duke index), frequency of concomitant pathology, psycho-social stress, loss of working capacity and a lower income levels. These patients treated with selective antidepressants (serotonin reuptake inhibitors) for 6 months experienced a marked decrease in the degree of depression and manifestation of its symptoms, improvedpsycho- social protection and quality of life compared with untreated patients. These data illustrate pathogenetic and behavioural mechanisms underlying the relationship between CHD and depression.
    Klinicheskaia meditsina 01/2014; 92(12):30-7.
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    ABSTRACT: The review contains current data on structural and functional brain plasticity mechanisms under the enriched environment. Enriched environment contains social and non-social stimuli acting on different aspects of the development and functioning of the brain. Special attention is devoted to the modeling of enriched environment in the experiment. Enriched environment implies the action of social stimuli, new objects, therefore the enriched environment in animals can be considered as an adequate model to study changes in brain structure and function in people during learning or acquiring complex skills. The review describes the theory of enriched environment's influence on neurogenesis, the neuron-glia relationships, and the impact of enriched environment on damaged brain as well as the possibilities of using the paradigm of enriched envimronmentfor neurorenhabilitation. Molecular mechanisms of synaptic transmission, which has a correlation with the performance of cognitive functions, are the possible target for the action of environmental factors at the brain under (patho)physiological conditions. The considerable progress has been done in understanding the mechanisms that mediate the effects of enriched environment on the brain, but still there are many non-resolved questions in the neurochemistry and neurobiology of this phenomenon. Overall, the experience-induced neuroplasticity is a unique mechanism for the development and recovery of brain functions. It opens new perspectives in neuropharmacology and neurorehabilitation.
    Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 12/2013; 68(6):39-48. DOI:10.15690/vramn.v68i6.672
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    ABSTRACT: Neurorehabilitation of poststroke cognitive impairments is an important medical problem. The purpose of the present study was to estimate the efficacy of new methods of restoration of impaired cognitive functions using computer correction programs. 43 poststroke patients aged 57-69, (male - 23, female - 20) were randomized into two groups. First group patients have been treated with the standard methods and supplementary neuropsychological computer training for 14days, 25-35min of duration per day. Control group received standard treatment according to Federal and local medical recommendations. Initial and achieved levels of cognitive functioning were estimated with the use of Mini Mental State Examination, Frontal Assessment Battery, the Clock Drawing Test, the Montreal Cognitive Assessment, Schulte's test, Hospital Anxiety and Depression Scale. We found that including the computer correction programs into the complex protocol of rehabilitation of post-stroke patients confirmed their efficacy in both clinical aspects and the Patient Global Impression Scale. Although the results are encouraging, further studies are required with larger samples and longer follow-up to identify characteristics of those patients who are most likely to benefit from computer training of cognitive functions.
    Journal of the neurological sciences 01/2013; 325(1-2). DOI:10.1016/j.jns.2012.12.024 · 2.47 Impact Factor
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    ABSTRACT: The review contains current data on molecular mechanisms which control NAD+ homeostasis in brain cells. It also deals with the role of NAD+-converting enzymes in regulation of functional activity, viability and intercellular communication of neuronal and glial cells. Special attention is paid to involvement of CD38 into regulation of NAD+ levels in brain cells in normal and pathological conditions.
    Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 12/2012;
  • N Iu Shimokhina · A A Savchenko · M M Petrova · D S Kaskaeva ·
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    ABSTRACT: The study of hemostasis and NAD(P)-dependent platelet dehydrogenases activity was made in 90 patients with cerebrovascular complications (development of ischemic stroke) of hypertension and coronary heart disease. On the basis of NADP-dependent platelet dehydrogenases activity we suggested a mode of prognostication a development of repeated cerebrovascular complications of thrombotic nature (the acute stroke, transitory ischemic attack, acute myocardial infarction, cardiovascular death). The proposed prognostic factor has heightened sensibility and specificity.
    Kardiologiia 07/2012; 52(6):14-8. · 0.12 Impact Factor
  • A I Inzhutova · A A Larionov · M M Petrova · A B Salmina ·
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    ABSTRACT: Activation of intracellular signaling and blebbing of the plasma membrane lead to rafting and clustering of membrane receptors. Lymphocyte with high receptor density at the cell pole interacts with endothelial cells, which leads to their hyperactivation. In this case, lymphocyte getting a response from the endothelial cell can release membrane particles, which interact with endothelial receptors and penetrate through gaps between endothelial cells forming aseptic inflammation and causing atherogenesis. Endotheliocytes also contribute to generation of active membrane microparticles. Hyperactivation of endothelial cells and constant stimulation by the lymphocytes and microparticles trigger programmed cell death resulting in exfoliation of the endothelial cell. The endothelial defect is replaced by endothelial cells of the vascular wall (in case of mild endothelial dysfunction) or by progenitor endothelial cells (in case of severe dysfunction).
    Bulletin of Experimental Biology and Medicine 06/2012; 153(2):201-5. DOI:10.1007/s10517-012-1676-x · 0.36 Impact Factor
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    ABSTRACT: The purpose of the present research was the estimation of efficiency of new methods of neurorehabilitation of impairments of cognitive functions with the use of computer programs of correction. Twenty six post-stroke patients aged 57- 69, (male - 12, female - 14) were examined and treated. In addition to usual restorative treatment all patients received a course of neuropsychological computer programs training within 14 days, 25-35 min of duration. Tasks included training of attention with use of the computed programs on the basis of Schulte's test, the task for training visual storing with a set of pictures and symbols, the switching test, correction optical and spatial gnosis with test of narrative images and the test of «arrangements of hands of the clock» with possibility of a feedback. Initial level cognitive impairments and results of restoration were estimated with the use of Mini Mental State Examination, Frontal Assessment Battery, the Clock Drawing Test, the Montreal Cognitive Assessment, Schulte's test. The first experience of inclusion of the computed programs of correction of cognitive impairments in schemes of neurorehabilitation has shown good effect concerning clinical displays, and concerning Patient Global Impression Scale. Although the results are encouraging, further studies are required with larger samples and longer follow-up to identify characteristics of those patients who are most likely to benefit from computed training of cognitive functions.
  • A I Inzhutova · A A Larionov · M M Petrova · A B Salmina ·
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    ABSTRACT: We present data of the study of effect of trimetazidine MB on the state of cellular membranes assessed on lymphocytes as highly sensitive model of hypoxia and endothelial dysfunction. Detection of external cytoplasmatic membrane blebbing and registration of quantity of membrane released microparticles by the method of phase-contrast microscopy were carried out in groups of patients with hypertensive disease without and with ischemic heart disease (IHD). It was found that number of cells in the state of terminal blebbing statistically significantly decreased and number of cells with intact cytoplasmic membrane increased at the background of intake of trimetazidine in all groups of patients. With correlation coefficient 0.76 (p<0.05) between content of membrane microparticles and terminal blebbing lowering of content of membrane released microparticles was noted in peripheral blood of patients of all studied groups. The investigation conducted allows to make conclusion that stabilization of cellular membranes is one of spectra of trimetazidine actions underlying improvement of self feeling of patients with vascular pathology.
    Kardiologiia 01/2011; 51(4):52-5. · 0.12 Impact Factor
  • N Iu Shimokhina · M M Petrova ·
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    ABSTRACT: This study of antiaggregative and anticoagulant activities of endothelium included 90 patients with cerebral complications of hypertensive disease and coronary heart disease in the acute and early rehabilitation period after ischemic stroke. The study revealed paradoxical prothrombotic activity of endothelium and compromised antithrombotic potential of the vascular wall.
    Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 01/2011;
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    ABSTRACT: In patients with complicated essential hypertension (ischemic stroke) and coronary heart disease, inductors of platelet aggregation in various doses induced "paradoxical" changes in platelet aggregation activity reflecting the degree of decompensation under conditions of persistent endothelial dysfunction. Aggregation inductors in low doses were shown to have a greater diagnostic significance. The content of endothelial dysfunction markers in the blood was persistently elevated under these conditions.
    Bulletin of Experimental Biology and Medicine 07/2010; 149(1):18-20. DOI:10.1007/s10517-010-0864-9 · 0.36 Impact Factor
  • N Iu Shimokhina · M M Petrova · A A Savchenko ·
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    ABSTRACT: We studied coagulation and vascular-platelet hemostasis in 77 patients at different phases of acute and in early recovery periods of ischemic stroke. All patients had concomitant hypertensive disease and ischemic heart disease. Despite antiaggregant therapy with acetyl salicylic acid hypercoagulable and prothrombotic states were found at all stages of examination.
    Kardiologiia 01/2010; 50(8):21-4. · 0.12 Impact Factor
  • A I Inzhutova · A B Salmina · M M Petrova · A A Larionov ·
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    ABSTRACT: We studied the role of receptor/ectoenzyme CD38 in the formation of endothelial damage and pathogenesis of endothelial dysfunction. CD38 was located in sites of protrusion of the outer cytoplasmic membrane. The majority of CD38+ accumulation sites coincided with the protrusion pole, while in some cells expression of CD38 was spread along the entire cell membrane surface or located on the pole opposite to the protrusion. We hypothesized that these states reflect the processes of rafting and clustering of the receptor, which are essential for cell-cell interactions in the pathogenesis of endothelial dysfunction.
    Bulletin of Experimental Biology and Medicine 07/2008; 145(6):703-6. DOI:10.1007/s10517-008-0170-y · 0.36 Impact Factor
  • A I Inzhutova · A B Salmina · M M Petrova ·
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    ABSTRACT: Endothelial dysfunction is considered in the paper from the point of view of pathology of cellular membranes presenting as vesiculation of cytoplasmatic membrane, release of membrane-bound microparticles, elevation of concentration of peeled off endotheliocytes in the blood. Comparative analysis of action of angiotensin converting enzyme inhibitors with various affinities to tissue renin-angiotensin-aldosterone system on the indicated parameters of pathology of cellular membranes and endothelial dysfunction has been conducted. The following mechanisms of stabilization of membranous homeostasis under influence of angiotensin converting enzyme inhibitor perindopril are discussed: action on apoptosis and activation of cells.
    Kardiologiia 02/2007; 47(8):49-52. · 0.12 Impact Factor
  • A I Inzhutova · M M Petrova · A B Salmina ·
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    ABSTRACT: The paper presents a comparison of the influence of angiotensin-converting enzyme (ACE) with high (perindopril) or low (enalapril) affinity to the endothelial renin-angiotensin-aldosterone system on the dynamics of the content of humoral endothelial dysfunction markers in patients with essential hypertension (EH) complicated by ischemic cerebral stroke. The subjects of the study were patients with EH complicated by acute cerebral ischemia, who received hospital treatment with perindopril (52 patients) or enalapril (58 patients). Changes in the physical properties of the cytoplasmatic membrane and phosphatidylserine exterialization were studied in peripheral blood on lymphocyte model. In peripheral blood plasma, the dynamics of sPECAM-1 titre and antiphospholipid antibodies (APLA) were studied. All the patients had high contents of blebbing and Annexin-positive lymphocytes, as well as high sPECAM-1 and APLA titres on the 1st day of hospital treatment. These variables decreased by the 20th day of hospital stay. In patients receiving perindopril the contents of endothelial dysfunction markers under study decreased more prominantly vs. patients in the other group. The elevation of endothelial dysfunction markers is a result of its progression and oxidative stress effect. Endothelial dysfunction can be corrected, which is proved by the decrease in the level of its markers by the 20th day of hospital treatment. The most prominent therapeutic effect of perindopril is a result of its high affinity to endothelial ACE and the inhibition of bradykinin degradation.
    Klinicheskaia meditsina 02/2007; 85(11):58-61.
  • N Iu Shimokhina · M M Petrova · A A Savchenko · M S Piliugina ·
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    ABSTRACT: To explore the dynamics of hemostasis in patients with acute coronary syndrome (ACS) in the combination with anxiety and depressive disorders (ADD) during therapy with valdoxan (agomelatine). We examined 196 male and female patients (mean age 64.2±0.8 years) in the first 24 hours of ACS. The patients were divided into three groups: patients with ACS without ADD (n=88), patients with ACS and ADD without valdoxan therapy (n=58) and patients with ACS and ADD treated with valdoxan (n=50). Coagulation and vascular-platelet hemostasis were studied in the first 24 hours of hospitalization and in the 10th day of hospitalization. Patients with ACS revealed high levels of fibrinogen, soluble fibrin-monomer complexes, D-dimer at all stages of the study. In patients with ADD, these parameters were significantly higher compared to patients without ADD. The levels of D-dimer in the 10th day were similar in patients with ADD treated with valdoxan and in patients with ACS without ADD. In both groups of patients with ADD, the levels of spontaneous aggregation in the first and 10th days of hospitalization were not significantly higher than in the control group and in patients with ACS without ADD. All patients with ACS had high values of platelet aggregation stimulated by adenosine diphosphate in dose 0.1 uM. In patients with ACS and ADD treated with valdoxan, a significant reduction of these parameters was noted in the 10th day of treatment compared to the first day of hospitalization. The high procoagulant activity of the hemostatic system was observed during all stages of the study in the patients with ACS and ADD who received a combined antithrombotic therapy without valdoxan.
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 115(2):30-36. · 0.05 Impact Factor