B Cardinaud

Publications (7)22.26 Total impact

• Article: Comparative aspects of dopaminergic neurotransmission in vertebrates.

  B Cardinaud, J M Gibert, K S Sugamori, J D Vincent, H B Niznik, P Vernier
  Annals of the New York Academy of Sciences 06/1998; 839:47-52. · 3.15 Impact Factor
• Article: Evolution and origin of the diversity of dopamine receptors in vertebrates.

  B Cardinaud, J M Gilbert, F Liu, K S Sugamori, J D Vincent, H B Niznik, P Vernier
  Advances in pharmacology (San Diego, Calif.) 02/1998; 42:936-40.
• Article: [Evolution of monoamine receptors and the origin of motivational and emotional systems in vertebrates].

  J D Vincent, B Cardinaud, P Vernier
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  ABSTRACT: The evolving vertebrate nervous system was accompanied by major gene duplication events generating novel organs and a sympathetic system. Vertebrate neural pathways synthesizing catecholamine neurotransmitters (dopamine and noradrenaline), were subsequently recruited to process increased information demands by mediating psychomotor functions such as selective attention/predictive reward and emotional drive via the activation of multiple G-protein linked catecholamine receptor subtypes. Here we show that the evolution of these receptor-mediated events were similarly driven by forces of gene duplication, at the cephalochordate/vertebrate transition. In the cephalochordate Amphioxus, a sister group to vertebrates, a single catecholamine receptor gene was found, which based on molecular phylogeny and functional analysis formed a monophyletic group with both vertebrate dopamine D1 and beta adrenergic receptor classes. In addition, the presence of dopamine but not of noradrenaline was assayed in Amphioxus. In contrast, two distinct genes homologous to jawed vertebrate dopamine D1 and beta adrenergic receptor genes were extant in representatives of the earliest craniates, lamprey and hagfish, paralleling high dopamine and noradrenaline content throughout the brain. These data suggest that a D1/beta receptor gene duplication was required to elaborate novel catecholamine psychomotor adaptive responses and that a noradrenergic system specifically emerged at the origin of vertebrate evolution.
  Bulletin de l'Académie nationale de médecine 02/1998; 182(7):1505-14; discussion 1515-6. · 0.25 Impact Factor
• Article: Expansion of the dopamine D1 receptor gene family: defining molecular, pharmacological, and functional criteria for D1A, D1B, D1C, and D1D receptors.

  H B Niznik, F Liu, K S Sugamori, B Cardinaud, P Vernier
  Advances in pharmacology (San Diego, Calif.) 02/1998; 42:404-8.
• Article: The classification of bioamine receptors. How helpful are molecular phylogenies?

  P Vernier, B Cardinaud, H Philippe, J D Vincent
  Annals of the New York Academy of Sciences 06/1997; 812:141-3. · 3.15 Impact Factor
• Article: Early emergence of three dopamine D1 receptor subtypes in vertebrates. Molecular phylogenetic, pharmacological, and functional criteria defining D1A, D1B, and D1C receptors in European eel Anguilla anguilla.

  B Cardinaud, K S Sugamori, S Coudouel, J D Vincent, H B Niznik, P Vernier
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  ABSTRACT: The existence of dopamine D1C and D1D receptors in Xenopus and chicken, respectively, challenged the established duality (D1A and D1B) of the dopamine D1 receptor class in vertebrates. To ascertain the molecular diversity of this gene family in early diverging vertebrates, we isolated four receptor-encoding sequences from the European eel Anguilla anguilla. Molecular phylogeny assigned two receptor sequences (D1A1 and D1A2) to the D1A subtype, and a third receptor to the D1B subtype. Additional sequence was orthologous to the Xenopus D1C receptor and to several other previously unclassified fish D1-like receptors. When expressed in COS-7 cells, eel D1A and D1B receptors display affinity profiles for dopaminergic ligands similar to those of other known vertebrate homologues. The D1C receptor exhibits pharmacological characteristics virtually identical to its Xenopus homologue. Functionally, while all eel D1 receptors stimulate adenylate cyclase, the eel D1B receptor exhibits greater constitutive activity than either D1A or D1C receptors. Semiquantitative reverse transcription-polymerase chain reaction reveals the differential distribution of D1A1, D1A2, D1B, and D1C receptor mRNA within the hypothalamic-pituitary axis of the eel brain. Taken together, these data suggest that the D1A, D1B, and D1C receptors arose prior to the evolutionary divergence of fish and tetrapods and exhibit molecular, pharmacological, and functional attributes that unambiguously allow for their classification as distinct D1 receptor subtypes in the vertebrate phylum.
  Journal of Biological Chemistry 02/1997; 272(5):2778-87. · 4.77 Impact Factor
• Article: An evolutionary view of drug-receptor interaction: the bioamine receptor family.

  P Vernier, B Cardinaud, O Valdenaire, H Philippe, J D Vincent
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  ABSTRACT: The large molecular diversity of receptors and their subtypes means that the pharmacologist is faced with many puzzling characterization questions. First, the molecular diversity of the receptors is deciphered only in part by a pharmacological approach, which precludes a satisfactory receptor classification based solely on pharmacological characteristics. Second, the physiological counterpart of the numerous subtypes of receptors specifically activated by single endogenous ligands remains unclear. Here, Philippe Vernier and colleagues use the example of the bioamine G protein-coupled receptors to show that many of the apparent inconsistencies that emerge from pharmacological and molecular characterizations of receptors can be better understood if the evolutionary history of the receptors is taken into account.
  Trends in Pharmacological Sciences 12/1995; 16(11):375-81. · 10.93 Impact Factor