M Itoh

Publications (2)1.24 Total impact

• Source

  Available from: tohoku.ac.jp

  Article: Further observations on cystic dilatation of the intrahepatic biliary system in biliary atresia after hepatic portoenterostomy: report on 10 cases.

  H Kawarasaki, M Itoh, K Mizuta, H Tanaka, M Makuuchi
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  ABSTRACT: This is a report on ten patients with cystic dilatation of the intrahepatic biliary system (CDIB) after hepatic portoenterostomy. They were five girls and five boys and the diagnosis of CDIB was made at ages 6 months to 11 years (mean age: 2.8 +/- 3.3 years). Follow-up ranged from one month to 15 years (mean: 5.5 +/- 4.9 years). In order to elucidate the factors which affect the clinical outcome of such patients, the types of CDIB (Type A: noncommunicating solitary cyst, Type B: communicating solitary cyst, Type C: multi-cystic dilatation), clinical symptoms at onset of CDIB and the method for the treatment were reviewed in relation to the outcome. For the purpose of understanding pathogenesis of CDIB, immunohistochemical study on hepatobiliary system was done with monoclonal antibody for cytokeratin. Outcome of the patients of Type C was poor, whereas the outcome of patients with type A and B was good. The outcome of preoperatively jaundiced patients was poor, but jaundice-free patients showed good outcome. Method of treatment was not related to the outcome. As epithelium of CDIB was positive for monoclonal antibody of cytokeratin, it was suspected that pathogenesis of CDIB might be related to peribiliary gland which originated from ductal plate.
  The Tohoku Journal of Experimental Medicine 02/1997; 181(1):175-83. · 1.24 Impact Factor
• Article: [Associated complication of biliary atresia: cystic dilatation of intrahepatic biliary system].

  H Kawarasaki, M Itoh, K Mizuta, H Tanaka
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  ABSTRACT: Cystic dilatation of intrahepatic biliary system (CDIB) was observed on 10 postoperative patients with biliary atresia (BA). Fever, jaundice and alcoholic stool were found when CDIB was diagnosed with ultrasonography and computed tomography assertained by cholangiography. CDIB was divided into three groups by the shape of intrahepatic biliary system. They were group A (n = 3); solitary non-communicating cyst, group B (n = 1); solitary communicating cyst and group C (n = 6); multi-cystic dilatation. Treatments of CDIB were percutaneous transhepatic bile drainage (PTBD) and reanastomosis of hepatic portoenterostomy. All of our patients of group A and B were doing well after PTBD in two and re-do Kasai operation in two. However, out of 6 patients of group C, two died without any treatments, three were transplanted liver from their parents and the rest one is still in the hospital and PTBD is continued. Outcome of CDIB is good in group A and B, and poor in group C.
  Nippon Geka Gakkai zasshi 09/1996; 97(8):653-6.