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ABSTRACT: We studied the structural and optical properties of scales in the longhorn beetle Sphingnotus mirabilis. Structural characterizations revealed that the scale interior possesses a disordered bicontinuous macroporous structure, resembling a phase-separated structure obtained by spinodal decomposition. Its optical response was investigated both experimentally and theoretically. Our results show that this structure has interesting optical properties due to the existence of only short-range order and the lack of well-defined local structures.
Physical Review E 07/2011; 84(1 Pt 1):011915. · 2.26 Impact Factor
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ABSTRACT: Congenital agammaglobulinemia is a humoral primary immunodeficiency and affected patients have extremely low levels of peripheral B cells and profound deficiency of all immunoglobulin isotypes. Mutations of the Bruton's tyrosine kinase (BTK) gene are responsible for most of the congenital agammaglobulinemia. In this study, the phenotypes of congenital agammaglobulinemia were investigated in 21 male children from 21 unrelated Chinese families. Sixteen different mutations of BTK gene were identified in 18 patients, and three patients did not have BTK gene mutations. Nine mutations had been reported previously including one gross deletion (c.722_2041del), one missense mutation (c.1764G>T), three non-sense mutations (c.194C>A, c.895C>T and c.1821G>A) and four invariant splice-site mutations (c.971+2T>C, c.1481+2T>A, c.1482-2A>G, c.1699-2A>G). Seven novel mutations were identified (c.373_441del, c. 504delG, c.537delC, c.851delA, c.1637G>A, c.1879T>C and c. 1482_1882 del). Ten of the eighteen mutations of BTK gene were located in the TK domain, four in the PH domain, three in the SH3 domain and one spanned the TH, SH3, SH2 and TK domain. Candidate genes of autosomal-recessive agammaglobulinemia, including IGHM, CD79a, CD79b and IGLL1, were screened in three patients without mutations in the BTK gene. A compound heterozygosity mutation in the IGHM gene (c.1956G>A, c.175_176insC) was identified in one patient. The results of our study further support that molecular genetic testing represents an important tool for early confirmed diagnosis of congenital agammaglobulinemia and may allow accurate carrier detection and prenatal diagnosis.
Scandinavian Journal of Immunology 11/2010; 72(5):454-9. · 2.23 Impact Factor
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ABSTRACT: Scales on the elytra of longhorn beetle Anoplophora graafi display diverse non-iridescent colors ranging from blue, green, yellow, and red to purple. By structural characterizations, optical measurements, and theoretical calculations, we found that the scale colors stem from an amorphous photonic structure possessing only short-range order: random close-packing of chitin nanoparticles. Our results showed that direction-independent photonic pseudogaps found in the photon density of states of the random close-packing photonic structure are the ultimate physical origin for non-iridescent coloration of scales. The color steering strategy of scales is ingenious, simply by varying the size of chitin nanoparticles. Revealed natural random close-packing photonic structures and the color steering strategy of scales could render valuable inspiration for the artificial fabrication and design of photonic structures and devices as well.
Optics Express 07/2010; 18(14):14430-8. · 3.59 Impact Factor
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ABSTRACT: In this paper, differences in 10 palatalized misarticulation patients between pre-and post-speech training were reported to discuss the training methods of palatalized misarticulation.
10 palatalized misarticulation patients (6 male, 4 female) with the age of 4-14 years were included in the study. All the patients had undergone systematic speech therapy,and their speech intelligibilities were analyzed.
All patients' speech intelligibilities after training were significantly higher than those before training. /s/, /z/, /c/, /d/, /t/, /zh/, /ch/, /sh/, /j/, /q/ and /x/ were often involved.
Palatalized misarticulation was caused by abnormal palato-lingual contact which leads to decreasement of speech intelligibility. Speech training is the only method to correct the wrong articulation position and articulation method. The key of training methods for palatalized misarticulation is to plane the dorsum and release the tongue's retroflex.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 10/2001; 10(3):204-6.
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ABSTRACT: OBJECTIVE:This study is to improve speech articulations of patients following cleft palate repair. METHODS: 20 cases were treated with systemic speech trainning. The methods included testing speech articulations of pre-and post-training blowing and systemic speech training whose program was consonant (first step), syllable (second), word (third), sentence (forth), and (fifth). RESULTS: It is showed that their articulations improved from 48.1% to 97.1% on average,and,the improvement in speech was highly significant statistically(P<0.0001).The younger the patient was,the shorter the training circle was. CONCLUSION: Speech training can correct habit of compensatory pathologic articulation and improve articluation of patient following cleft palate repair.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 06/1998; 7(2):104-6.
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ABSTRACT: The computer of nasopharyngeal fiberscope(NPF) for quantitative analysis was carried out to assess the palate articulation of 43 subjects,and normal articulation of 60 subjects.The rest,/a/,/s/and /m/ articulation of NPF pictures were calculated for veloparyngreal function via computer.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 07/1996; 5(2):63-4.
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ABSTRACT: This study was established the Chinese language of clear degree.The subjects of this study consisted of 50 patients with postoperative of cleft lip and palate,congenital velopharyngeal incompetence,and 30 control group were normal articulation of persons.The results of this study may be helpful for further clinic of the cleft lip and palate patients of speech therapeutics.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 10/1995; 4(3):125-7.
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ABSTRACT: This study detected 60 cases of patients of later surgical cleft palate repairing with different operative procedures,based on nasopharyngeal fiberscope and image processing detective system of nasopharyngeal function.They were divided into two groups,30 cases with Furlow's double reversing Z plasty,and others with traditional palatoplasty.The results were as follows:the type of velopharyngeal closure with later palatoplasty mainly were circus,semi-circus,and the rate of operative success only was 46.6%,which was lower than other reports.Author described that compensation of lateral and posterior pharyngeal wall made the type of velopharyngeal closure.The elder the age,the more the compensation is.For the late cleft palate repair,although the variable surgical procedure made a condition for speech improvement, patients with later cleft palate repair still can't improve their phonation.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 07/1994; 3(2):65-7.
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ABSTRACT: With monoclonal antibodies serum immunoglobulin G(IgG) subclasses were measured in seventy children aged 2 to 13 years with recurrent respiratory tract infections including upper respiratory tract infections, otitis media, sinusitis, asthmatic bronchitis and pneumonia. 211 healthy, aged-matched children served as control. IgG subclass deficiency was found in 19 out of the 70 patients (27.1%, single IgG1 deficiency in 7, IgG2 deficiency in 4, combined IgG1-IgG3 deficiency in 5, IgG1-IgG2-IgG3-IgG4 deficiency, IgG1-IgG2-IgG4 deficiency and IgG2-IgG4 deficiency each in 1). The incidence of IgG subclass deficiencies was in the sequence as follows: IgG1, 20%; IgG2, 10%; IgG3, 8.6% and IgG4, 4.3%. The results suggest that IgG subclass deficiency indicate a common disorder in children with recurrent respiratory tract infections.
Chinese medical journal 03/1991; 104(2):119-23. · 0.86 Impact Factor
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ABSTRACT: IgG subclass concentrations in sera of 17 patients with Kawasaki syndrome were determined. Significantly increased IgG1 (P less than 0.001) and IgG3 (P less than 0.001) were found in the patients compared with 22 age-matched healthy children, whereas IgG2 and IgG4 were normal or slightly decreased. IgG immune complexes were measured by protein A-enzyme-linked immunosorbent assay (ELISA) combined polyethylene glycol precipitations. Eight of 17 patients (47.1%) were found to have circulating immune complexes (CIC) values above the normal control range (geometric mean +2 SD). IgG subclass composition in CIC was analyzed. The subclasses in CIC were predominantly IgG1 and IgG3. Because the antibody responses to different antigens exhibit IgG subclass restriction, it would suggest that the change of serum and CIC IgG subclasses in Kawasaki syndrome may have relevance to the pathogenesis of the disease.
The Pediatric Infectious Disease Journal 09/1990; 9(8):544-7. · 3.58 Impact Factor
