Masahiko Kawaguchi

Nara Medical University, Kashihara, Nara, Japan

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Publications (207)451.74 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The Postoperative Quality of Recovery Scale (PQRS) is a multi-domain tracking scale to assess recovery after surgery. The PQRS is used in seven countries and five languages; however, the Japanese version of the PQRS (PQRSj) has not been established. We therefore translated the PQRS into Japanese, and examined the feasibility, reliability and validity of the PQRSj. The time taken to complete the test was measured to assess feasibility. Cronbach's alpha was calculated to assess reliability. The Mini Mental State Examination (MMSE) and the Japanese version of the Quality of Recovery Scale 40 (QoR-40 J) were performed for comparison with the PQRSj (validity). Fifty-one patients were enrolled in the study. The mean completion time was 3.9 min for baseline (feasibility). Cronbach's alpha was between 0.40 and 0.94 in each domain (reliability). A relationship was shown between cognitive domain and MMSE at baseline (r = 0.65, P < 0.01); however, no relationship was found between the other domains and the MMSE and QoR-40 J. Ceiling effects were observed in 78 % of the questions. These results indicate that the PQRSj can be used to assess recovery after surgery, although it may be better to revise some of the questions to improve the validity of the PQRSj.
    Journal of Anesthesia 11/2014; · 1.12 Impact Factor
  • Masahiko Kawaguchi, Yuu Tanaka, Hitoshi Furuya
    Journal of anesthesia. 10/2014;
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    ABSTRACT: Intraocular pressure(IOP) has been shown to increase during prone position spine surgery. The present study was conducted to evaluate IOP changes and predictive factors associated with increased IOP during prone position spine surgery.
    Journal of Anesthesia 09/2014; · 1.12 Impact Factor
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    ABSTRACT: Background Ki-67, cytokeratin 13, and/or cytokeratin 17 detection by immunohistochemistry has been reported to be useful for the diagnosis of oral precancerous lesions. However, the use of these markers remains controversial because of the lack of appropriately designed statistical studies. We assessed the hypothesis that Ki-67, cytokeratin 13, or cytokeratin 17 immunohistochemistry could facilitate the diagnosis of oral precancerous lesions and/or predict prognosis.Methods Epithelial dysplasia was classified as low grade (none or mild dysplasia) or high grade (moderate dysplasia, severe dysplasia, or carcinoma in situ). This study included 58 low-grade and 36 high-grade dysplasia cases. We used logistic regression to assess the diagnostic values of Ki-67, cytokeratin 13, and cytokeratin 17 for high-grade dysplasia. Correlations between these markers and the prognosis of oral atypical epithelium were assessed using the Cox proportional hazards model.ResultsKi-67 overexpression and cytokeratin 13 loss were independent diagnostic markers for high-grade dysplasia (odds ratios, 1.92 and 2.53; 95% confidence intervals, 1.03–3.58, and 1.19–5.38, respectively). The area under the curve of Ki-67 was 0.73 and that of cytokeratin 13 was 0.72. However, the combination of Ki-67 and cytokeratin 13 yielded the area under the curve of 0.78. Ki-67 overexpression was significantly associated with recurrence and/or malignant transformation of oral atypical epithelium (hazard ratio, 7.25; 95% confidence interval, 1.07–48.92).Conclusions Ki-67 overexpression and cytokeratin 13 loss may be useful for distinguishing oral precancerous lesions from reactive atypical epithelium. Moreover, Ki-67 overexpression may be a risk factor for recurrence and/or malignant transformation of oral atypical epithelium.
    Journal of Oral Pathology and Medicine 09/2014; · 1.87 Impact Factor
  • J. Ushiroda, S. Inoue, T. Kirita, M. Kawaguchi
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    ABSTRACT: Changes in airway dimensions can occur during general anaesthesia and surgery for a variety of reasons. This study explored factors associated with postoperative changes in airway dimensions. Patient airway volume was measured by acoustic reflectometory and neck muscle diameter by ultrasound echography in the pre- and post-anaesthetic periods in a total of 281 patients. Neck circumference was also assessed during these periods. A significant decrease in median (IQR [range]) total airway volume (from 63.8 (51.8–75.7 [14.7–103]) ml to 45.9 (33.5–57.2 [6.4–96.3]) ml, p < 0.0001), and a significant increase in muscle diameter (from 4.3 (3.3–5.6 [2.2–9.0]) mm to 5.8 (4.7–7.3 [2.8–1.3]) mm, p < 0.0001) and neck circumference (from 34.0 (32.5–37.0 [29.5–49.0]) cm to 35.0 (33.5–38.0 [30.5–50.5]) cm, p < 0.0001) were observed. It may be possible that changes in airway volume and neck circumference were influenced by surgical duration or peri-operative fluid management (ρ) = −0.31 (95% CI −0.24 to −0.01), p = 0.0301, −0.17 (−0.23 to −0.06), p = 0.0038, 0.23 (0.12–0.34), p < 0.0001, and 0.16 (0.05–0.27), p = 0.0062, respectively). The intra-oral space can significantly decrease and neck thickness increase after general anaesthesia, and might increase the risk of difficult laryngoscopy and intubation if airway management is required after extubation following general anaesthesia.
    Anaesthesia 08/2014; · 3.85 Impact Factor
  • Satoki Inoue, Ryuichi Abe, Yu Tanaka, Masahiko Kawaguchi
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    ABSTRACT: An urban legend that "you will get hurt if you go to hospital at the beginning of the fiscal year" is in circulation, because people in general suppose that inexperienced newcomers start to work at clinical practice during that time period. We tried to determine whether this urban legend was true or not by using data from our operation management system. We retrospectively conducted a study to investigate whether the number of cannulation failures, which was used as an index of patient disadvantages at clinical practice, could be affected by the volume of residents in clinical participation. The number of insertion trials per case was not prominent in the first month of the fiscal year. However, the number of insertion trials per case increased in proportion to the average number of residents per day. It seems that there was no evidence to support the urban legend that "you will get hurt if you go to hospital at the beginning of the fiscal year." However, our results suggest that rather than an urban legend, we are now confronting the fact that patients may suffer from medical disadvantages in the teaching hospitals.
    Journal of anesthesia. 07/2014;
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    ABSTRACT: Postoperative sore throat should be recognized seriously as an avoidable complication because of high incidence and dissatisfaction with anesthesia. The aim of the study was to identify the risk factors of postoperative sore throats in patients undergoing general anesthesia. We retrospectively studied 1,733 patients (above 18 years of age) who had undergone general anesthesia from January to December 2010 and who had visited Department of Anesthesia, postoperative anesthesia clinic. Age, ASA classification, position, airway device, methods of postoperative pain management and site of surgery were significantly identified as the associated factors for postoperative sore throat using univariate analysis. Under 65 year of age (odds ratio 2.3), operation of head and neck and pharynx (odds ratio 1.6), spine surgeries (odds ratio 0.33), laryngeal mask (odds ratio 0.47), and postoperative intravenous patient-controlled analgesia (IV-PCA, odds ratio 0.4) were significantly identified as the factors with multivariate studies. Six associated factors for postoperative sore throat were identified in this study.
    Masui. The Japanese journal of anesthesiology 04/2014; 63(4):401-5.
  • Journal of Anesthesia 01/2014; · 1.12 Impact Factor
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    ABSTRACT: It has been reported that multiple puncture more than or equal to 3 times is a factor associated with the development of CVC-related complications. The present retrospective study was undertaken to evaluate the predictors and risks of multiple puncture during the insertion of CVC. After the IRB approval, 1296 patients who underwent CVC in the operating room were enrolled. Data were collected using CVC report and the medical charts. Multiple puncture was defined as the puncture performed more than or equal to three times during the insertion of CVC. Univariate and multivariate logistic regression analysis were performed to assess the predictors of multiple puncture during the CVC insertion. Univariate analysis revealed that age less than 6 years, complications during insertion and the way to use ultrasound echo were associated with multiple puncture. Multivariate analysis also revealed that age less than 6 years was a significant predictor for multiple puncture (odds ratio 2.08, 95% CI 1.01-4.29). The results of the study indicate that the age less than 6 years is a significant predictor for multiple puncture during the CVC insertion.
    Masui. The Japanese journal of anesthesiology 01/2014; 63(1):62-7.
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    ABSTRACT: Airway changes generally occur in normal gravidas; however, these changes could cause critical situations in specific populations. This article presents the case of a difficult airway patient that went into shock because of atonic bleeding after vaginal delivery for stillbirth. A 32-yr-old woman with atonic bleeding after vaginal delivery for stillbirth was transferred to our hospital. She manifested shock, and her respiratory condition was progressively deteriorating. Airway obstruction caused by neck swelling and pharyngolaryngeal edema was apparent. We tried tracheal intubation using direct and indirect laryngoscopes. However, it turned out that insertion of the laryngoscopic devices to the oral cavity was impossible. After several attempts using the Trachlight™, successful intubation was finally made. After hysterectomy, she was admitted to the intensive care unit (ICU) and treated for five days. At discharge from the ICU, her Mallampati score was I-II. Her body weight decreased 60kg to 51kg during ICU stay. We believe that concomitant attacks of labor and delivery and fluid resuscitation probably worsened upper airway and neck edema enough to cause acute airway obstruction and difficult laryngoscopy.
    Brazilian journal of anesthesiology (Elsevier). 12/2013; 63(6):508-10.
  • Satoki Inoue, Yasumitsu Nomura, Masahiko Kawaguchi
    Journal of Anesthesia 11/2013; · 1.12 Impact Factor
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    ABSTRACT: Experiência e objetivos Em geral, alterações nas vias aéreas ocorrem em grávidas normais; no entanto, essas alterações podem gerar situações críticas em populações específicas. Objetivos Esse artigo apresenta o caso de uma paciente que entrou em choque por causa de sangramento atônico em seguida a parto vaginal de natimorto. Relato de caso Mulher com 32 anos com sangramento atônico em seguida a parto vaginal de natimorto foi transferida para nosso hospital. A paciente manifestou choque e seu estado respiratório estava em progressiva deterioração. Ficou evidenciada obstrução das vias aéreas causada por inchaço cervical e edema faringolaríngeo. Tentamos intubação traqueal utilizando laringoscopia direta e indireta. No entanto, não foi possível inserir qualquer dos dispositivos de laringoscopia tentados. Depois de várias tentativas com Trachlight™, finalmente obtivemos sucesso com a intubação. Depois da histerectomia, a paciente foi internada na unidade de terapia intensiva (UTI), onde ficou em tratamento durante cinco dias. Ao receber alta da UTI, tinha escore de Mallampati I-II. Durante sua estadia na UTI, seu peso diminuiu de 60 kg para 51 kg. Conclusões É provável que episódios simultâneos de trabalho de parto/parto e de ressuscitação com fluidos pioraram suficientemente o edema de via aérea e o inchaço cervical a ponto de causar obstrução aguda das vias aéreas e dificuldade na laringoscopia.
    Revista Brasileira de Anestesiologia 11/2013; 63(6):508–510. · 0.42 Impact Factor
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    ABSTRACT: We report a case of ventilation failure due to supraglottic air leakage with the use of uncuffed tracheotomy tube. A 4-year-old girl with 22q11.2 deletion syndrome after tracheotomy due to tracheomalacia developed left caudate bleeding and was admitted urgently. She required mechanical ventilation but suffered from a supraglottic air leakage which prevented adequate ventilation via a tracheostomy site. To stop the supraglottic air leakage, a size 1.5 laryngeal mask airway (LMA) was inserted into the oral pharynx and the cuff was inflated. The supraglottic air leakage was not detected under mandatory mechanical ventilation following seal of the connector of the LMA with a piece of tape. The respiratory condition of the patient improved gradually. The use of an LMA may be useful to stop or significantly decrease the air leak.
    Masui. The Japanese journal of anesthesiology 11/2013; 62(11):1360-1.
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    ABSTRACT: Opioids are widely used for perioperative pain management in cancer surgery patients. It has been reported that opioids may alter cancer recurrence or progression; however, there are no published reports regarding the effects of opioids on chemotherapy after cancer surgery. Here we investigated the effects of opioids (morphine or fentanyl) on cell proliferation and 5-fluorouracil sensitivity in the human colon cancer cell line, HCT116. First, we exposed cancer cells to the opioid at various concentrations for 6 or 24 h and evaluated cell proliferation using a MTT assay. Next, to simulate the potential postoperative situation in which anticancer drugs are administered after cancer surgery, cancer cells were incubated with the opioid for 6 or 24 h, followed by treatment with 5-fluorouracil for 48 h. Although fentanyl did not affect cell proliferation, morphine exposure for 6 h enhanced the proliferation. However, sensitivity of HCT116 cells to 5-fluorouracil was not altered in all treatment groups. The current study demonstrated that the opioids commonly used during postoperative periods do not affect 5-fluorouracil sensitivity in human colon cancer HCT116 cells.
    Journal of Anesthesia 10/2013; · 1.12 Impact Factor
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    ABSTRACT: The purpose of this study was to identify possible predictors of discontinuation of basal-flow of postoperative patient-controlled analgesia. We reviewed postoperative pain assessment records by the postoperative pain service team from April 2010 to July 2011 in which surgical patients were provided with intravenous or epidural patient-controlled analgesia (IV-PCA or Epi-PCA). From these data, we extracted cases with discontinuation of basal-flow of PCA, and candidate variables such as patients' characteristics, preoperative and intraoperative variables were assessed. Predictors with significant univariate association (P < 0.20) with the primary outcome were used to construct multivariable logistic regression models. We enrolled 685 patients for IV-PCA and 606 for Epi-PCA and obtained discontinuation groups (105 and 73 cases, respectively) with this cohort data. Results of multivariate analysis showed female, non-laparotomy, low body weight, and non-droperidol as independent risk factors for IV-PCA and low body weight, no-co-existing disease, and gastrointestinal surgery for Epi-PCA. There were no significant differences in pain intensity between discontinuation and non-discontinuation cases. The primary cause of discontinuation was PONV for IV-PCA and hypotension for Epi-PCA, respectively. We should apply IV-PCA for female slender surgical patients undergoing non-laparotomy with great caution and provide prevention for PON. We should pay attention to incidence of postoperative hypotenion when we administer Epi-PCA to slender gastrointestinal surgical patients without co-existing disease.
    Masui. The Japanese journal of anesthesiology 10/2013; 62(10):1166-72.
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    ABSTRACT: Postoperative visual dysfunction (POVD) after cardiovascular surgery rarely is reported, since it is more likely underdetected and underreported. This study was designed to verify the presence of POVD, including a variety of asymptomatic as well as symptomatic visual dysfunctions after cardiovascular surgery with cardiopulmonary bypass (CPB). A prospective observational study. Cardiothoracic surgery in a medical university hospital. Seventy-one patients undergoing elective cardiovascular surgery with CPB. None. All patients were assessed by a battery of 7 neuro-ophthalmic examinations preoperatively and postoperatively, including fundus, visual field, eye movement, color vision, visual acuity, intraocular pressure, and critical flicker frequency. Patients were considered to have POVD if they had postoperative new abnormal findings of neuro-ophthalmic examinations. One patient was excluded due to a failure of postoperative neuro-ophthalmic examinations. In 16 of 70 patients analyzed in this study, selective cerebral perfusion was required for aortic arch surgery. Of 70 patients, a total of 8 patients (11.4%) had postoperative new abnormal findings in neuro-ophthalmic examinations, including new visual field deficits in 4, reduced visual acuity in 4, and/or increased intraocular pressure in 1 patient. Of these 8 patients, symptomatic POVD was recognized in 1 patient (1.4%) with postoperative visual field deficit and reduced visual acuity. There were no new abnormal findings compared with preoperative results in postoperative funduscopy, eye movement, color vision, and critical flicker frequency. These results indicated that the asymptomatic as well as symptomatic POVD can develop after cardiovascular surgery with CPB, and their incidence may be relatively high.
    Journal of cardiothoracic and vascular anesthesia 10/2013; 27(5):884-9. · 1.06 Impact Factor
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    ABSTRACT: We report two cases in which development of laryngospasm and release of the spasm immediately after applying pressure in the "laryngospasm notch" was confirmed by ultrasonographic and fiberoptic examinations. A bronchoscopy was planned under propofol sedation using a laryngeal mask airway for a 61-year-old man after subtotal esophagotomy. When a bronchoscope was advanced into the trachea, the vocal cords suddenly closed. Immediately after pressure with the fingertips was applied to the "laryngospasm notch," the vocal cords opened, which was observed through the bronchoscope in real time. A 22-year-old woman presented for emergency caesarean section under general anesthesia. After the completion of the procedures, the patient was not yet following commands but her breathing was steady. Thus, extubation was performed; however, she began to display signs of respiratory stridor. An ultrasonographic examination revealed that the vocal cords were noted to close, which suggested that she was developing laryngospasm. With this diagnosis, pressure at the "laryngospasm notch" was applied. Immediately after this maneuver, the vocal cords opened. We reconfirmed that applying pressure in the "laryngospasm notch" was effective to release laryngospasm. Imaging studies, especially ultrasonographic examination, were useful for making the decision to apply pressure in the "laryngospasm notch."
    Journal of Anesthesia 03/2013; · 1.12 Impact Factor
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    ABSTRACT: OBJECTIVE: Subdural hematoma (SDH) is a frequent complication of spontaneous intracranial hypotension (SIH), in which epidural blood patch (EBP) may be applied as a treatment to stop cerebrospinal fluid (CSF) leak. However, a clinical course of SDH in SIH patients has not been sufficiently evaluated. We retrospectively evaluated the temporal relationships between EBP and SDH in the patients with SIH. METHODS: Twenty-nine consecutive patients, diagnosed as SIH, were studied. Clinical records and images were retrospectively evaluated. When orthostatic headache continued for 2 weeks regardless of conservative treatment, EBP was performed under fluoroscopy. RESULTS: We detected 13(45%) cases of SDH (mean age 44 years, 8 males and 5 females). In 6 patients, SDHs disappeared after effective EBP, i.e., after the disappearance of orthostatic headache. In 3 patients, SDHs were enlarged or recurred after effective EBP, and in 4 patients, SDHs were first detected after effective EBP. CONCLUSION: The knowledge of the presence of these types of SDH (enlarged or recurred or detected after EBP) may deserve clinical attention.
    Clinical neurology and neurosurgery 02/2013; · 1.30 Impact Factor
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    ABSTRACT: After introducing "BOKUTOH enhanced recvery after surgery (ERAS)" protocol for colorectal surgery in our hospital, the hospital stay after surgery was reduced from 10 days to 7. However, the patients' quality of life (QOL) throughout the perioperative period was not quantified. We assessed the QOL of these patients by using QoR-40J and SF-36v2J (Japanese versions of QoR-40 and SF-36v2) questionnaires. Twenty-seven colorectal cancer patients undergoing surgery and "BOKUTOH ERAS" protocol management were asked to answer both QoR-40 J and SF-36v2J questionnaires pre- and post-operatively. The scores were evaluated by using Mann-Whitney U-test. From preoperative score (183.5), the scores of QoR-40 J differed significantly on post-operating day (POD) 1 and POD3 (150.9 [15.7] and 168.1 [17.5] points, respectively). Before leaving the hospital (POD6) and after one month from surgery, both QoR40 J and SF-36v2J scores were similar to preoperative ones. Under "BOKUTOH ERAS" protocol management, patients who had had colorectal surgery were able to recover their QOL within 6 days. Thus, leaving hospital by 7 days after surgery was appropriate to our patients.
    Masui. The Japanese journal of anesthesiology 02/2013; 62(2):147-51.

Publication Stats

1k Citations
451.74 Total Impact Points


  • 1991–2014
    • Nara Medical University
      • • Department of Anesthesiology
      • • Department of Pathology
      Kashihara, Nara, Japan
  • 2008–2009
    • National Defense Medical College
      • Department of Anesthesiology
      Tokorozawa, Saitama-ken, Japan
  • 2004
    • CSU Mentor
      Long Beach, California, United States
  • 1992–1994
    • National Cerebral and Cardiovascular Center
      • Department of Cardiovascular Medicine
      Ōsaka, Ōsaka, Japan